JP2010529081A5 - - Google Patents

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Publication number
JP2010529081A5
JP2010529081A5 JP2010510783A JP2010510783A JP2010529081A5 JP 2010529081 A5 JP2010529081 A5 JP 2010529081A5 JP 2010510783 A JP2010510783 A JP 2010510783A JP 2010510783 A JP2010510783 A JP 2010510783A JP 2010529081 A5 JP2010529081 A5 JP 2010529081A5
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JP
Japan
Prior art keywords
difluorophenyl
ethylpyrrolidin
pyrrolidin
fluorophenyl
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010510783A
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English (en)
Japanese (ja)
Other versions
JP5444535B2 (ja
JP2010529081A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2008/056915 external-priority patent/WO2008148801A2/en
Publication of JP2010529081A publication Critical patent/JP2010529081A/ja
Publication of JP2010529081A5 publication Critical patent/JP2010529081A5/ja
Application granted granted Critical
Publication of JP5444535B2 publication Critical patent/JP5444535B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010510783A 2007-06-05 2008-06-04 皮質カテコールアミン作動性神経伝達の調節物質としての新規な二置換フェニルピロリジン Expired - Fee Related JP5444535B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US94199407P 2007-06-05 2007-06-05
US60/941,994 2007-06-05
SE0701387 2007-06-05
SE0701387-3 2007-06-05
PCT/EP2008/056915 WO2008148801A2 (en) 2007-06-05 2008-06-04 Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission

Publications (3)

Publication Number Publication Date
JP2010529081A JP2010529081A (ja) 2010-08-26
JP2010529081A5 true JP2010529081A5 (enExample) 2011-07-14
JP5444535B2 JP5444535B2 (ja) 2014-03-19

Family

ID=39743744

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010510783A Expired - Fee Related JP5444535B2 (ja) 2007-06-05 2008-06-04 皮質カテコールアミン作動性神経伝達の調節物質としての新規な二置換フェニルピロリジン

Country Status (16)

Country Link
US (1) US8188301B2 (enExample)
EP (1) EP2155671B8 (enExample)
JP (1) JP5444535B2 (enExample)
KR (1) KR20100038295A (enExample)
CN (1) CN101808987A (enExample)
AU (1) AU2008258599B2 (enExample)
BR (1) BRPI0812740A2 (enExample)
CA (1) CA2690091A1 (enExample)
CO (1) CO6251288A2 (enExample)
IL (1) IL202045A0 (enExample)
MX (1) MX2009012787A (enExample)
NZ (1) NZ581364A (enExample)
RU (1) RU2471781C2 (enExample)
UA (1) UA98783C2 (enExample)
WO (1) WO2008148801A2 (enExample)
ZA (1) ZA200908592B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008258599B2 (en) 2007-06-05 2013-06-13 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
EP2367786B1 (en) * 2008-11-24 2013-01-09 NSAB, Filial af NeuroSearch Sweden AB, Sverige Novel 1 -alkyl- 3 -hydroxy- 3 -phenylazetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
WO2010058017A1 (en) 2008-11-24 2010-05-27 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Novel 3-phenyl-azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
WO2010058019A1 (en) 2008-11-24 2010-05-27 Nsab, Filial Af Neurosearch Sweden Ab, Sverige 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission
BRPI0923225A2 (pt) 2008-12-02 2016-10-04 Chiralgen Ltd metodo para sintese de acidos nucleicos modificados no atomo de fosforo
TW201026666A (en) * 2008-12-16 2010-07-16 Astrazeneca Ab Quaternary piperidine derivatives and uses thereof
EP2451461A4 (en) 2009-07-06 2013-05-29 Ontorii Inc NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF
DK2620428T3 (da) * 2010-09-24 2019-07-01 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
CN107365339A (zh) 2011-07-19 2017-11-21 波涛生命科学有限公司 合成官能化核酸的方法
WO2014010250A1 (en) 2012-07-13 2014-01-16 Chiralgen, Ltd. Asymmetric auxiliary group
SG11201500243WA (en) 2012-07-13 2015-04-29 Shin Nippon Biomedical Lab Ltd Chiral nucleic acid adjuvant
DK2872147T3 (da) 2012-07-13 2023-02-20 Wave Life Sciences Ltd Fremgangsmåde til fremstilling af kirale oligonukleotider
EP3095461A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
WO2015108046A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
EP3095459A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
EP3094728B1 (en) 2014-01-16 2022-03-09 Wave Life Sciences Ltd. Chiral design
HK1245251B (en) 2015-05-20 2020-04-24 综合研究实验室瑞典股份公司 Novel azetidine derivatives useful as modulators of cortical cathecolaminergic neurotransmission
WO2017138588A1 (ja) 2016-02-10 2017-08-17 住友化学株式会社 １－メチルピロリジン－３－オールの製造方法
EP3625213B1 (en) 2017-05-19 2023-03-08 Integrative Research Laboratories Sweden AB (+)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine fumarate, a process for its preparation and uses thereof

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2878264A (en) * 1959-03-17 Substituted amino alcohols
DE1144279B (de) 1957-09-26 1963-02-28 Robins Co Inc A H Verfahren zur Herstellung von 3-Aryl-3-hydroxypyrrolidinen und deren Salzen
US3118907A (en) * 1961-08-14 1964-01-21 Mead Johnson & Co 3-substituted-3-pyrrolidinols
BE704683A (enExample) 1966-11-07 1968-02-15
US3647790A (en) * 1969-04-08 1972-03-07 American Home Prod Ouinoxalinyl-oxazolidines and -oxazines
US5128362A (en) * 1988-01-15 1992-07-07 Abbott Laboratories 1-aminomethyl-1,2,3,4-tetrahydronaphthalenes
DE3802175A1 (de) 1988-01-26 1989-08-03 Hoechst Ag N-phenylbenzamide und n-phenylbenzamidoxime, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als schaedlingsbekaempfungsmittel
DE3835291A1 (de) * 1988-04-19 1989-11-02 Bayer Ag 1,3-disubstituierte pyrrolidine
US5444083A (en) * 1989-02-03 1995-08-22 Eisai Co., Ltd. Pyrrolidine compound and pharmaceutical use
DK0641320T3 (da) 1991-04-17 2001-08-20 Upjohn Co Substituerede (S)-3-phenylpiperidinderivater, deres fremstilling og deres anvendelse som dopaminautoreceptorantagonister
EP0586229A1 (en) * 1992-09-01 1994-03-09 Zeneca Limited 3-Hydroxy-3-(subst-akyl)-pyrrolidines as 5-lipoxygenase inhibitors
US5665754A (en) * 1993-09-20 1997-09-09 Glaxo Wellcome Inc. Substituted pyrrolidines
WO1997024325A1 (en) 1995-12-28 1997-07-10 Takeda Chemical Industries, Ltd. DIPHENYLMETHANE DERIVATIVES AS MIP-1α/RANTES RECEPTOR ANTAGONISTS
SK492001A3 (en) 1998-07-20 2001-08-06 Merck Patent Gmbh Biphenyl derivatives
US7271176B2 (en) * 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US20020169155A1 (en) * 1998-09-04 2002-11-14 Millennium Pharmaceuticals, Inc. Chemokine receptor anagonists and methods of use therefor
DE19840611A1 (de) * 1998-09-05 2000-03-09 Klaus Wanner GABA-uptake-Inhibitoren mit Pyrrolidinstruktur
AU5273100A (en) 1999-05-17 2000-12-05 Foxboro Company, The Methods and apparatus for control configuration with versioning, security, composite blocks, edit selection, object swapping, formulaic values and other aspects
ECSP003637A (es) 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
SE9904723D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission II
WO2005028438A1 (ja) 2003-09-22 2005-03-31 Banyu Pharmaceutical Co., Ltd. 新規ピペリジン誘導体
SE0401465D0 (sv) * 2004-06-08 2004-06-08 Carlsson A Research Ab New substituted piperdines as modulators of dopamine neurotransmission
US7700587B2 (en) * 2004-09-07 2010-04-20 Florida A&M University Haloperidol analogs
US7598279B2 (en) 2005-04-22 2009-10-06 Sk Holdings Co., Ltd. Neurotherapeutic azole compounds
JP2008540395A (ja) 2005-05-03 2008-11-20 ファイザー・インク アミドレソルシノール化合物
WO2007053145A1 (en) 2005-11-04 2007-05-10 Florida A & M University Haloperidol analogs
ES2412007T3 (es) 2005-12-21 2013-07-09 Janssen Pharmaceutica, N.V. Derivados de pirazinona sustituida novedosos para uso en enfermedades mediadas por MCH-1
JP2010529080A (ja) 2007-06-05 2010-08-26 エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ 皮質カテコールアミン作動性神経伝達の調節因子としての新規な二置換フェニルピロリジン
AU2008258599B2 (en) 2007-06-05 2013-06-13 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission

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