RU2471781C2 - Новые двузамещенные фенилпирролидины в качестве модуляторов кортикальной катехоламинергической нейротрансмиссии - Google Patents

Новые двузамещенные фенилпирролидины в качестве модуляторов кортикальной катехоламинергической нейротрансмиссии Download PDF

Info

Publication number
RU2471781C2
RU2471781C2 RU2009143104/04A RU2009143104A RU2471781C2 RU 2471781 C2 RU2471781 C2 RU 2471781C2 RU 2009143104/04 A RU2009143104/04 A RU 2009143104/04A RU 2009143104 A RU2009143104 A RU 2009143104A RU 2471781 C2 RU2471781 C2 RU 2471781C2
Authority
RU
Russia
Prior art keywords
difluorophenyl
ethylpyrrolidin
pyrrolidin
fluorophenyl
chloro
Prior art date
Application number
RU2009143104/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2009143104A (ru
Inventor
Клас СОНЕССОН
Ларс СВАНСОН
Фредрик ПЕТТЕРССОН
Николас ВАТЕРС
Сусанна ВАТЕРС
Original Assignee
НСАБ, Филиаль аф НьюроСёрч Свиден АБ, Сверийе
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by НСАБ, Филиаль аф НьюроСёрч Свиден АБ, Сверийе filed Critical НСАБ, Филиаль аф НьюроСёрч Свиден АБ, Сверийе
Publication of RU2009143104A publication Critical patent/RU2009143104A/ru
Application granted granted Critical
Publication of RU2471781C2 publication Critical patent/RU2471781C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2009143104/04A 2007-06-05 2008-06-04 Новые двузамещенные фенилпирролидины в качестве модуляторов кортикальной катехоламинергической нейротрансмиссии RU2471781C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0701387 2007-06-05
SE0701387-3 2007-06-05
PCT/EP2008/056915 WO2008148801A2 (en) 2007-06-05 2008-06-04 Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission

Publications (2)

Publication Number Publication Date
RU2009143104A RU2009143104A (ru) 2011-07-20
RU2471781C2 true RU2471781C2 (ru) 2013-01-10

Family

ID=39743744

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2009143104/04A RU2471781C2 (ru) 2007-06-05 2008-06-04 Новые двузамещенные фенилпирролидины в качестве модуляторов кортикальной катехоламинергической нейротрансмиссии

Country Status (16)

Country Link
US (1) US8188301B2 (enExample)
EP (1) EP2155671B8 (enExample)
JP (1) JP5444535B2 (enExample)
KR (1) KR20100038295A (enExample)
CN (1) CN101808987A (enExample)
AU (1) AU2008258599B2 (enExample)
BR (1) BRPI0812740A2 (enExample)
CA (1) CA2690091A1 (enExample)
CO (1) CO6251288A2 (enExample)
IL (1) IL202045A0 (enExample)
MX (1) MX2009012787A (enExample)
NZ (1) NZ581364A (enExample)
RU (1) RU2471781C2 (enExample)
UA (1) UA98783C2 (enExample)
WO (1) WO2008148801A2 (enExample)
ZA (1) ZA200908592B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2155671B8 (en) 2007-06-05 2018-02-21 Integrative Research Laboratories Sweden AB Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
EP2367787B1 (en) 2008-11-24 2013-01-09 NSAB, Filial af NeuroSearch Sweden AB, Sverige 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission
US20110257148A1 (en) * 2008-11-24 2011-10-20 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Novel 1-alkyl-3-hydroxy-3-phenylazetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
WO2010058017A1 (en) 2008-11-24 2010-05-27 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Novel 3-phenyl-azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
CN102282155B (zh) 2008-12-02 2017-06-09 日本波涛生命科学公司 磷原子修饰的核酸的合成方法
AR074755A1 (es) * 2008-12-16 2011-02-09 Astrazeneca Ab Derivados cuaternarios de piperidina y sus usos
WO2011005761A1 (en) 2009-07-06 2011-01-13 Ontorii, Inc Novel nucleic acid prodrugs and methods use thereof
WO2012039448A1 (ja) * 2010-09-24 2012-03-29 株式会社キラルジェン 不斉補助基
EP2734208B1 (en) 2011-07-19 2017-03-01 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
CN104661664B (zh) 2012-07-13 2020-07-03 波涛生命科学有限公司 手性控制
AU2013288048A1 (en) 2012-07-13 2015-01-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
AU2013287630B2 (en) 2012-07-13 2017-05-25 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant
EP3095459A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
EP3095460A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
CN113278617A (zh) 2014-01-16 2021-08-20 波涛生命科学有限公司 手性设计
EP3297987B1 (en) * 2015-05-20 2019-05-15 Integrative Research Laboratories Sweden AB Novel azetidine derivatives useful as modulators of cortical cathecolaminergic neurotransmission
CN108698989B (zh) 2016-02-10 2021-05-11 住友化学株式会社 用于制备1-甲基吡咯烷-3-醇的方法
CA3064136A1 (en) * 2017-05-19 2018-11-22 Integrative Research Laboratories Sweden Ab (+)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine or pharmaceutically acceptable salts thereof, a process for preparation thereof and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3118907A (en) * 1961-08-14 1964-01-21 Mead Johnson & Co 3-substituted-3-pyrrolidinols
WO1992018475A2 (en) * 1991-04-17 1992-10-29 The Upjohn Company Substituted phenylazacycloalkanes as cns agents
RU2024506C1 (ru) * 1989-02-03 1994-12-15 Эйсай Ко., Лтд. Производные пирролидина и способ их получения
WO2005121092A1 (en) * 2004-06-08 2005-12-22 A. Carlsson Research Ab New substituted piperidines as modulators of dopamine neurotransmission

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2878264A (en) * 1959-03-17 Substituted amino alcohols
CH372667A (de) 1957-09-26 1963-10-31 Robins Co Inc A H Verfahren zur Herstellung von 3-Aryl-3-pyrrolidinolen
BE704683A (enExample) 1966-11-07 1968-02-15
US3647790A (en) * 1969-04-08 1972-03-07 American Home Prod Ouinoxalinyl-oxazolidines and -oxazines
US5128362A (en) * 1988-01-15 1992-07-07 Abbott Laboratories 1-aminomethyl-1,2,3,4-tetrahydronaphthalenes
DE3802175A1 (de) 1988-01-26 1989-08-03 Hoechst Ag N-phenylbenzamide und n-phenylbenzamidoxime, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als schaedlingsbekaempfungsmittel
DE3835291A1 (de) * 1988-04-19 1989-11-02 Bayer Ag 1,3-disubstituierte pyrrolidine
EP0586229A1 (en) * 1992-09-01 1994-03-09 Zeneca Limited 3-Hydroxy-3-(subst-akyl)-pyrrolidines as 5-lipoxygenase inhibitors
US5665754A (en) * 1993-09-20 1997-09-09 Glaxo Wellcome Inc. Substituted pyrrolidines
WO1997024325A1 (en) 1995-12-28 1997-07-10 Takeda Chemical Industries, Ltd. DIPHENYLMETHANE DERIVATIVES AS MIP-1α/RANTES RECEPTOR ANTAGONISTS
HUP0102622A3 (en) 1998-07-20 2002-12-28 Merck Patent Gmbh Biphenyl derivatives, process for producing them and pharmaceutical compositions containing them
US20020169155A1 (en) * 1998-09-04 2002-11-14 Millennium Pharmaceuticals, Inc. Chemokine receptor anagonists and methods of use therefor
US7271176B2 (en) * 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
DE19840611A1 (de) * 1998-09-05 2000-03-09 Klaus Wanner GABA-uptake-Inhibitoren mit Pyrrolidinstruktur
AU5025600A (en) 1999-05-17 2000-12-05 Foxboro Company, The Process control configuration system with parameterized objects
ECSP003637A (es) 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
SE9904723D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission II
CN1902177A (zh) 2003-09-22 2007-01-24 万有制药株式会社 新哌啶衍生物
US7700587B2 (en) * 2004-09-07 2010-04-20 Florida A&M University Haloperidol analogs
US7598279B2 (en) 2005-04-22 2009-10-06 Sk Holdings Co., Ltd. Neurotherapeutic azole compounds
EP1879863A1 (en) 2005-05-03 2008-01-23 Pfizer, Inc. Amide resorcinol compounds
WO2007053145A1 (en) 2005-11-04 2007-05-10 Florida A & M University Haloperidol analogs
CA2626220A1 (en) 2005-12-21 2007-06-28 Janssen Pharmaceutica N.V. Novel substituted pyrazinone derivatives for use in mch-1 mediated diseases
EP2155671B8 (en) 2007-06-05 2018-02-21 Integrative Research Laboratories Sweden AB Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
US20100197760A1 (en) 2007-06-05 2010-08-05 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3118907A (en) * 1961-08-14 1964-01-21 Mead Johnson & Co 3-substituted-3-pyrrolidinols
RU2024506C1 (ru) * 1989-02-03 1994-12-15 Эйсай Ко., Лтд. Производные пирролидина и способ их получения
WO1992018475A2 (en) * 1991-04-17 1992-10-29 The Upjohn Company Substituted phenylazacycloalkanes as cns agents
WO2005121092A1 (en) * 2004-06-08 2005-12-22 A. Carlsson Research Ab New substituted piperidines as modulators of dopamine neurotransmission

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. Med. Chem. Am. Chem. Soc, v.37, №17, 1994, 2735-2753. Bioorganic & Medicinal Chemistry Letters, v.7, №3, 1997, 241-246. *
J. of Medicinal Chemistry, v.7, No.1, 1964, 60-67. J. Med. Chem. Am. Chem. Soc, v.37, No.17, 1994, 2735-2753. Bioorganic & Medicinal Chemistry Letters, v.7, No.3, 1997, 241-246. *
J. of Medicinal Chemistry, v.7, №1, 1964, 60-67. *

Also Published As

Publication number Publication date
WO2008148801A3 (en) 2009-01-29
WO2008148801A2 (en) 2008-12-11
JP2010529081A (ja) 2010-08-26
KR20100038295A (ko) 2010-04-14
AU2008258599B2 (en) 2013-06-13
ZA200908592B (en) 2011-02-23
AU2008258599A1 (en) 2008-12-11
EP2155671B1 (en) 2017-12-20
CN101808987A (zh) 2010-08-18
CA2690091A1 (en) 2008-12-11
JP5444535B2 (ja) 2014-03-19
EP2155671B8 (en) 2018-02-21
CO6251288A2 (es) 2011-02-21
US8188301B2 (en) 2012-05-29
NZ581364A (en) 2011-10-28
UA98783C2 (en) 2012-06-25
IL202045A0 (en) 2010-06-16
WO2008148801A8 (en) 2009-12-10
BRPI0812740A2 (pt) 2016-07-19
MX2009012787A (es) 2009-12-15
RU2009143104A (ru) 2011-07-20
EP2155671A2 (en) 2010-02-24
US20100179211A1 (en) 2010-07-15

Similar Documents

Publication Publication Date Title
RU2471781C2 (ru) Новые двузамещенные фенилпирролидины в качестве модуляторов кортикальной катехоламинергической нейротрансмиссии
RU2498988C2 (ru) Ингибиторы активности протеинтирозинкиназы
JP2010529081A5 (enExample)
RU98117314A (ru) Тропановые производные, их получение и применение
RU2015143610A (ru) Лечение катаплексии
MA42442A (fr) Dérivés d'éthynyle comme modulateurs du récepteur métabotropique au glutamate
MY144483A (en) 1,2,3,4-tetrasubstituted indole for the treatment of respiratory diseases
EA201000808A1 (ru) Индольные соединения и способы лечения висцеральной боли
CR20200584A (es) Compuestos tetrahidro-1h-pirazino [2,1-a] isoindolilquinolina para el tratamiento de enfermedades autoinmunes
EA200801041A1 (ru) Ингибиторы мек и способы их применения
RU2008146816A (ru) Фармацевтическая комбинация, содержащая 3-(3-диметиламино-1-этил-2-метилпропил)фенол и парацетамол
JP2018511647A5 (enExample)
RU2012101947A (ru) Способы лечения и профилактики усталости
RU2016131875A (ru) Производные n-фениллактама, способные стимулировать нейрогенез, и их применение при лечении заболеваний нервной системы
EA200601212A1 (ru) Ингибиторы фосфодиэстеразы, получение и их терапевтическое применение
RU2015112914A (ru) Бензимидазолы в качестве активных агентов для центральной нервной системы
DK1678172T3 (da) Azabicykliske forbindelser til lindring af smerte og behandling af sygdomme i centralnervesystemet
JP2021513972A (ja) 社会的機能障害の治療方法
JP2017502063A5 (enExample)
RU2016104890A (ru) Производные 1,7-нафтиридина
RU2011120817A (ru) Произволные 3-фенил-3-метоксипирролидина в качестве модуляторов кортикальной катехоламинергической нейротрансмиссии
RU2006110545A (ru) Новое медицинское применение избирательных антагонистов св1-рецептора
AR032756A1 (es) Metodo de tratamiento para inhibir el progreso o para aliviar una condicion que se alivia por un antagonista de 5-ht3 o del receptor nicotinico neuronal y uso de 1-amino-alquilciclohexanos
CR20220231A (es) Compuestos de 1,8-naftiridin-2-ona para el tratamiento de una enfermedad autoinmunitaria
MA45665B1 (fr) Dérivés d'éthynyle

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20130605