CA2690091A1 - New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission - Google Patents

New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission Download PDF

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Publication number
CA2690091A1
CA2690091A1 CA2690091A CA2690091A CA2690091A1 CA 2690091 A1 CA2690091 A1 CA 2690091A1 CA 2690091 A CA2690091 A CA 2690091A CA 2690091 A CA2690091 A CA 2690091A CA 2690091 A1 CA2690091 A1 CA 2690091A1
Authority
CA
Canada
Prior art keywords
difluorophenyl
pyrrolidin
mmol
chloro
fluorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2690091A
Other languages
English (en)
French (fr)
Inventor
Clas Sonesson
Lars Swanson
Fredrik Pettersson
Nicholas Waters
Susanna Waters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NSAB Filial af Neurosearch Sweden AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2690091A1 publication Critical patent/CA2690091A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2690091A 2007-06-05 2008-06-04 New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission Abandoned CA2690091A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US94199407P 2007-06-05 2007-06-05
US60/941,994 2007-06-05
SE0701387 2007-06-05
SE0701387-3 2007-06-05
PCT/EP2008/056915 WO2008148801A2 (en) 2007-06-05 2008-06-04 Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission

Publications (1)

Publication Number Publication Date
CA2690091A1 true CA2690091A1 (en) 2008-12-11

Family

ID=39743744

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2690091A Abandoned CA2690091A1 (en) 2007-06-05 2008-06-04 New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission

Country Status (16)

Country Link
US (1) US8188301B2 (enExample)
EP (1) EP2155671B8 (enExample)
JP (1) JP5444535B2 (enExample)
KR (1) KR20100038295A (enExample)
CN (1) CN101808987A (enExample)
AU (1) AU2008258599B2 (enExample)
BR (1) BRPI0812740A2 (enExample)
CA (1) CA2690091A1 (enExample)
CO (1) CO6251288A2 (enExample)
IL (1) IL202045A0 (enExample)
MX (1) MX2009012787A (enExample)
NZ (1) NZ581364A (enExample)
RU (1) RU2471781C2 (enExample)
UA (1) UA98783C2 (enExample)
WO (1) WO2008148801A2 (enExample)
ZA (1) ZA200908592B (enExample)

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EP2367786B1 (en) * 2008-11-24 2013-01-09 NSAB, Filial af NeuroSearch Sweden AB, Sverige Novel 1 -alkyl- 3 -hydroxy- 3 -phenylazetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
WO2010058017A1 (en) 2008-11-24 2010-05-27 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Novel 3-phenyl-azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
WO2010058019A1 (en) 2008-11-24 2010-05-27 Nsab, Filial Af Neurosearch Sweden Ab, Sverige 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission
BRPI0923225A2 (pt) 2008-12-02 2016-10-04 Chiralgen Ltd metodo para sintese de acidos nucleicos modificados no atomo de fosforo
TW201026666A (en) * 2008-12-16 2010-07-16 Astrazeneca Ab Quaternary piperidine derivatives and uses thereof
EP2451461A4 (en) 2009-07-06 2013-05-29 Ontorii Inc NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF
DK2620428T3 (da) * 2010-09-24 2019-07-01 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
CN107365339A (zh) 2011-07-19 2017-11-21 波涛生命科学有限公司 合成官能化核酸的方法
WO2014010250A1 (en) 2012-07-13 2014-01-16 Chiralgen, Ltd. Asymmetric auxiliary group
SG11201500243WA (en) 2012-07-13 2015-04-29 Shin Nippon Biomedical Lab Ltd Chiral nucleic acid adjuvant
DK2872147T3 (da) 2012-07-13 2023-02-20 Wave Life Sciences Ltd Fremgangsmåde til fremstilling af kirale oligonukleotider
EP3095461A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
WO2015108046A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
EP3095459A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
EP3094728B1 (en) 2014-01-16 2022-03-09 Wave Life Sciences Ltd. Chiral design
HK1245251B (en) 2015-05-20 2020-04-24 综合研究实验室瑞典股份公司 Novel azetidine derivatives useful as modulators of cortical cathecolaminergic neurotransmission
WO2017138588A1 (ja) 2016-02-10 2017-08-17 住友化学株式会社 １－メチルピロリジン－３－オールの製造方法
EP3625213B1 (en) 2017-05-19 2023-03-08 Integrative Research Laboratories Sweden AB (+)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine fumarate, a process for its preparation and uses thereof

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AU2008258599B2 (en) 2007-06-05 2013-06-13 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission

Also Published As

Publication number Publication date
NZ581364A (en) 2011-10-28
EP2155671B1 (en) 2017-12-20
JP5444535B2 (ja) 2014-03-19
WO2008148801A2 (en) 2008-12-11
BRPI0812740A2 (pt) 2016-07-19
IL202045A0 (en) 2010-06-16
EP2155671A2 (en) 2010-02-24
CO6251288A2 (es) 2011-02-21
MX2009012787A (es) 2009-12-15
KR20100038295A (ko) 2010-04-14
AU2008258599B2 (en) 2013-06-13
WO2008148801A8 (en) 2009-12-10
AU2008258599A1 (en) 2008-12-11
EP2155671B8 (en) 2018-02-21
JP2010529081A (ja) 2010-08-26
RU2471781C2 (ru) 2013-01-10
RU2009143104A (ru) 2011-07-20
US20100179211A1 (en) 2010-07-15
CN101808987A (zh) 2010-08-18
UA98783C2 (en) 2012-06-25
US8188301B2 (en) 2012-05-29
ZA200908592B (en) 2011-02-23
WO2008148801A3 (en) 2009-01-29

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20140604