JP2010524884A5 - - Google Patents

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Publication number
JP2010524884A5
JP2010524884A5 JP2010503491A JP2010503491A JP2010524884A5 JP 2010524884 A5 JP2010524884 A5 JP 2010524884A5 JP 2010503491 A JP2010503491 A JP 2010503491A JP 2010503491 A JP2010503491 A JP 2010503491A JP 2010524884 A5 JP2010524884 A5 JP 2010524884A5
Authority
JP
Japan
Prior art keywords
dihydro
methyl
amino
dione
piperidinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010503491A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010524884A (ja
JP5389013B2 (ja
Filing date
Publication date
Priority claimed from GB0707705A external-priority patent/GB0707705D0/en
Priority claimed from GB0720569A external-priority patent/GB0720569D0/en
Priority claimed from GB0805311A external-priority patent/GB0805311D0/en
Application filed filed Critical
Priority claimed from PCT/EP2008/054621 external-priority patent/WO2008128942A1/en
Publication of JP2010524884A publication Critical patent/JP2010524884A/ja
Publication of JP2010524884A5 publication Critical patent/JP2010524884A5/ja
Application granted granted Critical
Publication of JP5389013B2 publication Critical patent/JP5389013B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010503491A 2007-04-20 2008-04-16 抗菌剤としての三環式含窒素化合物 Active JP5389013B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0707705.0 2007-04-20
GB0707705A GB0707705D0 (en) 2007-04-20 2007-04-20 Compounds
GB0720569.3 2007-10-19
GB0720569A GB0720569D0 (en) 2007-10-19 2007-10-19 Compounds
GB0805311A GB0805311D0 (en) 2008-03-20 2008-03-20 Compounds
GB0805311.8 2008-03-20
PCT/EP2008/054621 WO2008128942A1 (en) 2007-04-20 2008-04-16 Tricyclic nitrogen containing compounds as antibacterial agents

Publications (3)

Publication Number Publication Date
JP2010524884A JP2010524884A (ja) 2010-07-22
JP2010524884A5 true JP2010524884A5 (https=) 2011-06-02
JP5389013B2 JP5389013B2 (ja) 2014-01-15

Family

ID=39580226

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010503491A Active JP5389013B2 (ja) 2007-04-20 2008-04-16 抗菌剤としての三環式含窒素化合物

Country Status (31)

Country Link
US (1) US8389524B2 (https=)
EP (1) EP2137196B1 (https=)
JP (1) JP5389013B2 (https=)
KR (1) KR101567096B1 (https=)
CN (1) CN101687887B (https=)
AR (1) AR066111A1 (https=)
AT (1) ATE483717T1 (https=)
AU (1) AU2008240764C1 (https=)
BR (1) BRPI0810064B8 (https=)
CA (1) CA2684659C (https=)
CL (1) CL2008001122A1 (https=)
CO (1) CO6251368A2 (https=)
CR (2) CR11123A (https=)
CY (1) CY1111248T1 (https=)
DE (1) DE602008002912D1 (https=)
DK (1) DK2137196T3 (https=)
DO (1) DOP2009000240A (https=)
EA (1) EA015821B1 (https=)
HR (1) HRP20100574T1 (https=)
IL (1) IL201204A0 (https=)
MA (1) MA31324B1 (https=)
MX (1) MX2009011317A (https=)
MY (1) MY149347A (https=)
NZ (1) NZ579877A (https=)
PE (1) PE20090274A1 (https=)
PL (1) PL2137196T3 (https=)
PT (1) PT2137196E (https=)
SI (1) SI2137196T1 (https=)
TW (1) TWI431006B (https=)
UY (1) UY31038A1 (https=)
WO (1) WO2008128942A1 (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080064173A (ko) * 2005-10-21 2008-07-08 글락소 그룹 리미티드 항균제로서 유용한 페리 축합 트리시클릭 화합물
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
GB0608263D0 (en) 2006-04-26 2006-06-07 Glaxo Group Ltd Compounds
AU2008313660B2 (en) 2007-10-19 2013-11-07 Boehringer Ingelheim International Gmbh Substituted piperidino-dihydrothienopyrimidines
EP2205609B1 (de) 2007-10-19 2017-03-29 Boehringer Ingelheim International GmbH Heterocyclus-substituierte piperazino-dihydrothienopyrimidine
WO2009050236A1 (de) 2007-10-19 2009-04-23 Boehringer Ingelheim International Gmbh Neue piperazino-dihydrothienopyrimidin-derivate
ES2411930T3 (es) 2008-02-20 2013-07-09 Actelion Pharmaceuticals Ltd. Compuestos antibióticos azatricíclicos
JP2011520944A (ja) * 2008-05-23 2011-07-21 グラクソ グループ リミテッド 窒素含有三環式化合物および抗菌剤としてのその使用
BRPI0912995A2 (pt) * 2008-05-23 2015-10-13 Glaxo Group Ltd compostos tricíclicos contendo nitrogênio e sua utilização como agentes antibacterianos
BRPI0920895A8 (pt) 2008-10-07 2017-12-26 Actelion Pharmaceuticals Ltd Compostos antibióticos de oxazolidinona tricíclica
WO2010043714A1 (en) 2008-10-17 2010-04-22 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
CA2749163A1 (en) 2009-01-14 2010-07-22 The Salk Institute For Biological Studies Methods for screening and compounds that protect against amyloid diseases
AR076222A1 (es) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen
TW201130854A (en) 2009-12-22 2011-09-16 Bayer Schering Pharma Ag Pyridinone derivatives and pharmaceutical compositions thereof
CA2797708C (en) * 2010-05-04 2016-08-16 Alkermes Pharma Ireland Limited Process for synthesizing oxidized lactam compounds
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
US9802954B2 (en) 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
CN103113291B (zh) * 2013-02-04 2015-03-04 浙江大学 一种3位烯基吡啶衍生物的合成方法
JP6453216B2 (ja) * 2013-07-23 2019-01-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ縮合環化合物
JP6546654B2 (ja) 2014-08-22 2019-07-17 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 淋菌感染を治療するための三環式含窒素化合物
MX385384B (es) * 2016-06-22 2025-03-18 Univ Vanderbilt Moduladores alostericos positivos del receptor muscarinico de acetilcolina m4
WO2018195098A1 (en) 2017-04-17 2018-10-25 Ohio State Innovation Foundation Type ii topoisomerase inhibitors and methods of making and using thereof
WO2020201833A1 (en) 2019-04-03 2020-10-08 Glaxomithkline Intellectual Property Development Limited Gepotidacin for use in the treatment of bacterial urinary tract infections
CN114173789A (zh) * 2019-07-05 2022-03-11 葛兰素史克知识产权发展有限公司 用于治疗由生殖支原体引起的感染的组合
ES3004932T3 (en) 2020-04-02 2025-03-13 Glaxosmithkline Ip Dev Ltd Regimen for treating a neisseria gonorrhoeae infection with gepotidacin
EP4143188A1 (en) * 2020-04-29 2023-03-08 GlaxoSmithKline Intellectual Property Development Limited Crystalline forms of gepotidacin
CN111494241B (zh) * 2020-06-01 2023-03-24 湖北洁世达环保科技有限公司 一种纸巾柔润保湿液
CA3210313A1 (en) * 2021-02-05 2022-08-11 Glaxosmithkline Intellectual Property Development Limited Oral solid dose formulations
US20250099535A1 (en) 2022-01-21 2025-03-27 Glaxosmithkline Intellectual Property Development Limited Gepotidacin and vancomycin for use in the treatment of an infection caused by staphylococcus saprophyticus
EP4316463A1 (en) 2022-08-02 2024-02-07 GlaxoSmithKline Intellectual Property Development Limited Novel formulation
CN119546302A (zh) 2022-09-26 2025-02-28 葛兰素史密斯克莱知识产权发展有限公司 用于治疗细菌性前列腺炎的吉泊达星
CN121537412B (zh) * 2026-01-16 2026-04-03 南京道尔医药研究院有限公司 一种吉泊达星甲磺酸盐的制备方法

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403610B1 (en) 1999-09-17 2002-06-11 Aventis Pharma S.A. Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them
US6525049B2 (en) 2000-07-05 2003-02-25 Pharmacia & Upjohn Company Pyrroloquinolones as antiviral agents
US6624159B2 (en) 2000-07-12 2003-09-23 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
CZ2003243A3 (cs) 2000-07-26 2003-09-17 Smithkline Beecham P. L. C. Aminopiperidinové chinoliny a jejich azaisosterické analogy s antibakteriální aktivitou
US6603005B2 (en) 2000-11-15 2003-08-05 Aventis Pharma S.A. Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them
GB0031088D0 (en) 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
EP1345903A1 (en) 2000-12-21 2003-09-24 Ciba SC Holding AG Crystalline forms of cerivastatin sodium
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
US6602884B2 (en) 2001-03-13 2003-08-05 Aventis Pharma S.A. Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0118238D0 (en) 2001-07-26 2001-09-19 Smithkline Beecham Plc Medicaments
AU2002350217A1 (en) 2001-12-04 2003-06-17 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
WO2003064431A2 (en) 2002-01-29 2003-08-07 Glaxo Group Limited Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them
EP1470125A1 (en) 2002-01-29 2004-10-27 Glaxo Group Limited Aminopiperidine derivatives
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
TW200406413A (en) 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
GB0217294D0 (en) 2002-07-25 2002-09-04 Glaxo Group Ltd Medicaments
FR2844270B1 (fr) 2002-09-11 2006-05-19 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
FR2844268B1 (fr) 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
WO2004035569A2 (de) 2002-10-10 2004-04-29 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue verbindungen mit antibakterieller aktivität
DE60331849D1 (de) 2002-11-05 2010-05-06 Glaxosmithkline Llc Antibakterielle wirkstoffe
ATE479683T1 (de) 2002-11-05 2010-09-15 Glaxo Group Ltd Antibakterielle mittel
TW200427688A (en) 2002-12-18 2004-12-16 Glaxo Group Ltd Antibacterial agents
TW200507841A (en) 2003-03-27 2005-03-01 Glaxo Group Ltd Antibacterial agents
US7232833B2 (en) 2003-03-28 2007-06-19 Novexel 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
DE10316081A1 (de) 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
US7348434B2 (en) 2003-08-08 2008-03-25 Antony Bigot 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
FR2867472B1 (fr) 2004-03-12 2008-07-18 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
US7691850B2 (en) 2004-06-15 2010-04-06 Glaxo Group Limited Antibacterial agents
FR2872164B1 (fr) 2004-06-29 2006-11-17 Aventis Pharma Sa Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
US20070254872A1 (en) 2004-07-08 2007-11-01 Glaxo Group Limited Antibacterial Agents
US20080194547A1 (en) 2004-07-09 2008-08-14 Glaxo Group Limited Antibacterial Agents
US7648984B2 (en) 2004-07-13 2010-01-19 Glaxo Group Limited Antibacterial agents
US20070270417A1 (en) 2004-07-22 2007-11-22 Glaxo Group Limited Antibacterial Agents
US7655648B2 (en) 2004-08-02 2010-02-02 Glaxo Group Limited Antibacterial agents
US20070161627A1 (en) 2004-08-09 2007-07-12 Miller William H Antibacterial agents
DE102004041163A1 (de) 2004-08-25 2006-03-02 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
CA2580621A1 (en) 2004-09-24 2006-03-30 Actelion Pharmaceuticals Ltd New bicyclic antibiotics
WO2006038172A1 (en) 2004-10-05 2006-04-13 Actelion Pharmaceuticals Ltd New piperidine antibiotics
JP5314244B2 (ja) 2004-10-27 2013-10-16 富山化学工業株式会社 新規な含窒素複素環化合物およびその塩
EP1846418A4 (en) 2005-01-25 2009-12-23 Glaxo Group Ltd ANTIBACTERIAL ACTIVE SUBSTANCES
JP2008528598A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
US7709472B2 (en) 2005-01-25 2010-05-04 Glaxo Group Limited Antibacterial agents
US7648980B2 (en) 2005-01-25 2010-01-19 Glaxo Group Limited Antibacterial agents
JP2008528604A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
WO2006099884A1 (en) 2005-03-24 2006-09-28 Actelion Percurex Ag Beta-aminoalcohol antibiotics
NZ562034A (en) 2005-03-31 2009-10-30 Janssen Pharmaceutica Nv Bicyclic pyrazole compounds as antibacterial agents
EP1891078A1 (en) 2005-05-24 2008-02-27 AstraZeneca AB Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
WO2006126171A2 (en) 2005-05-25 2006-11-30 Actelion Pharmaceuticals Ltd New antibiotic derivatives
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
WO2006137485A1 (ja) * 2005-06-24 2006-12-28 Toyama Chemical Co., Ltd. 新規な含窒素複素環化合物およびその塩
KR20080064173A (ko) 2005-10-21 2008-07-08 글락소 그룹 리미티드 항균제로서 유용한 페리 축합 트리시클릭 화합물
ATE465163T1 (de) 2005-12-22 2010-05-15 Glaxo Group Ltd Heterocyclische verbindungen, ihre herstellung und ihre verwendung als antibakterielle mittel
WO2007115947A1 (en) 2006-04-06 2007-10-18 Glaxo Group Limited Pyrrolo-quinoxalinone derivatives as antibacterials
EP2007377A4 (en) 2006-04-06 2011-08-17 Glaxo Group Ltd ANTIBACTERIAL ACTIVE SUBSTANCES
GB0608263D0 (en) * 2006-04-26 2006-06-07 Glaxo Group Ltd Compounds
US20100256124A1 (en) 2006-06-09 2010-10-07 David Thomas Davies Substituted 1-Methyl-1H-Quinolin-2-Ones And 1-Methyl-1H-1,5-Naphthyridin-2-Ones As Antibacterials
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
GB0705672D0 (en) * 2007-03-23 2007-05-02 Glaxo Group Ltd Compounds
EP1980251A1 (en) 2007-04-13 2008-10-15 Glaxo Group Limited Pyrrolo[3,2,1-ij]quinoline-4-one derivatives for treating tuberculosis
GB0707706D0 (en) 2007-04-20 2007-05-30 Glaxo Group Ltd Compounds
GB0707708D0 (en) 2007-04-20 2007-05-30 Glaxo Group Ltd Compounds
EP2005995A1 (en) 2007-06-22 2008-12-24 Glaxo Group Limited Heterocyclic compounds for the treatment of tuberculosis
GB0800367D0 (en) 2008-01-09 2008-02-20 Glaxo Group Ltd Compounds

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