JP2010520307A5 - - Google Patents
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- Publication number
- JP2010520307A5 JP2010520307A5 JP2009552883A JP2009552883A JP2010520307A5 JP 2010520307 A5 JP2010520307 A5 JP 2010520307A5 JP 2009552883 A JP2009552883 A JP 2009552883A JP 2009552883 A JP2009552883 A JP 2009552883A JP 2010520307 A5 JP2010520307 A5 JP 2010520307A5
- Authority
- JP
- Japan
- Prior art keywords
- ylidenemethyl
- thiazolidine
- benzonitrile
- dioxo
- phenoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- CAKOHXXVOIJVTM-JMIUGGIZSA-N COc(cc(/C=C(/C(N1CC[n]2ncnc2)=O)\SC1=O)cc1)c1Oc(cc1)c(C(F)(F)F)cc1C#N Chemical compound COc(cc(/C=C(/C(N1CC[n]2ncnc2)=O)\SC1=O)cc1)c1Oc(cc1)c(C(F)(F)F)cc1C#N CAKOHXXVOIJVTM-JMIUGGIZSA-N 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89345807P | 2007-03-07 | 2007-03-07 | |
| PCT/US2008/056018 WO2008109731A2 (en) | 2007-03-07 | 2008-03-06 | Substituted phenoxy n-alkylated thiazoledinedione as estrogen related receptor-alpha modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010520307A JP2010520307A (ja) | 2010-06-10 |
| JP2010520307A5 true JP2010520307A5 (enExample) | 2011-03-24 |
Family
ID=39720674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009552883A Pending JP2010520307A (ja) | 2007-03-07 | 2008-03-06 | エストロゲン関連受容体−アルファモジュレーターとしての置換フェノキシｎ−アルキル置換チアゾリジンジオン |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8119669B2 (enExample) |
| EP (1) | EP2132188B1 (enExample) |
| JP (1) | JP2010520307A (enExample) |
| KR (1) | KR20090118103A (enExample) |
| CN (1) | CN101679326B (enExample) |
| AR (1) | AR065656A1 (enExample) |
| AT (1) | ATE537157T1 (enExample) |
| AU (1) | AU2008222749A1 (enExample) |
| BR (1) | BRPI0808662B8 (enExample) |
| CA (1) | CA2679965A1 (enExample) |
| CL (1) | CL2008000669A1 (enExample) |
| CY (1) | CY1112778T1 (enExample) |
| DK (1) | DK2132188T3 (enExample) |
| EA (1) | EA200970838A1 (enExample) |
| ES (1) | ES2377165T3 (enExample) |
| HR (1) | HRP20120160T1 (enExample) |
| IL (1) | IL200758A0 (enExample) |
| MX (1) | MX2009009519A (enExample) |
| NZ (1) | NZ579418A (enExample) |
| PL (1) | PL2132188T3 (enExample) |
| PT (1) | PT2132188E (enExample) |
| RS (1) | RS52247B (enExample) |
| SI (1) | SI2132188T1 (enExample) |
| TW (1) | TW200902507A (enExample) |
| WO (1) | WO2008109731A2 (enExample) |
| ZA (1) | ZA200906953B (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| CN101679322A (zh) * | 2007-03-07 | 2010-03-24 | 詹森药业有限公司 | 用作雌激素相关性受体-α调节剂的取代苯氧基噻唑烷二酮类化合物 |
| BRPI0817101A2 (pt) | 2007-09-14 | 2017-05-09 | Addex Pharmaceuticals Sa | 4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas |
| DK2203439T3 (da) | 2007-09-14 | 2011-04-18 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituerede 4-phenyl-3,4,5,6-tetrahydro-2H,1'H-[1,4']-bipyridinyl-2'-oner |
| KR20100080597A (ko) | 2007-09-14 | 2010-07-09 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | １,３-이치환된-４-페닐-1ｈ-피리딘-2-온 |
| MX2010005110A (es) | 2007-11-14 | 2010-09-09 | Ortho Mcneil Janssen Pharm | Derivados de imidazo[1,2-a]piridina y su uso como moduladores alostericos positivos de los receptores de glutamato metabotropico 2. |
| EP2254576B1 (en) * | 2008-02-22 | 2013-08-28 | The Ohio State University Research Foundation | Androgen receptor-ablative agents |
| AU2009289784B2 (en) | 2008-09-02 | 2012-03-22 | Addex Pharma S.A. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| US8697689B2 (en) | 2008-10-16 | 2014-04-15 | Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| RU2512283C2 (ru) | 2008-11-28 | 2014-04-10 | Янссен Фармасьютикалз, Инк. | Производные индола и бензоксазина в качестве модуляторов метаботропных глутаматных рецепторов |
| JO2907B1 (en) | 2009-05-12 | 2015-09-15 | اديكس فرما اس ايه | Pyridine derivatives 1, 2, 4 trisolo [4, 3-A] and their uses as positive LLs for 2MGLUR receptors |
| NZ596053A (en) | 2009-05-12 | 2013-05-31 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| JP2011057643A (ja) * | 2009-09-14 | 2011-03-24 | Sumitomo Chemical Co Ltd | ３型１７β−ヒドロキシステロイドデヒドロゲナーゼを阻害するための化合物の使用およびそのための医薬組成物 |
| JP2011057644A (ja) * | 2009-09-14 | 2011-03-24 | Sumitomo Chemical Co Ltd | ３型１７β−ヒドロキシステロイドデヒドロゲナーゼを阻害するための化合物の使用およびそのための医薬組成物 |
| EP2536717B1 (en) | 2010-02-17 | 2014-06-04 | Janssen Pharmaceutica, N.V. | Aminothiazolones as estrogen related receptor-alpha modulators |
| EP2661435B1 (en) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| CN103298810B (zh) | 2010-11-08 | 2016-03-16 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| WO2012153775A1 (ja) * | 2011-05-10 | 2012-11-15 | 国立大学法人神戸大学 | Ras機能阻害作用を有するチオキソチアゾリジン誘導体 |
| WO2013018929A1 (en) | 2011-08-04 | 2013-02-07 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
| CN102949364A (zh) * | 2011-08-30 | 2013-03-06 | 天津药物研究院 | 一种含有效成分盐酸维拉佐酮的缓释片 |
| US10660882B2 (en) | 2012-03-26 | 2020-05-26 | Nippon Chemiphar Co., Ltd. | Prophylactic or therapeutic agent for giant cell tumors occurring in bone and soft tissue or for chondrosarcoma |
| WO2014060477A1 (en) * | 2012-10-17 | 2014-04-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting and treating bone metastases in prostate cancer patients |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| EP3632428A1 (en) | 2013-09-25 | 2020-04-08 | Nippon Chemiphar Co., Ltd. | Zaltoprofen for use in the prophylactic or therapeutic treatment of giant cell tumors occurring in bone and soft tissue or of chondrosarcoma |
| HUE045610T2 (hu) | 2014-01-21 | 2020-01-28 | Janssen Pharmaceutica Nv | 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait vagy ortosztérikus agonistáit tartalmazó kombinációk és alkalmazásuk |
| EA033889B1 (ru) | 2014-01-21 | 2019-12-05 | Янссен Фармацевтика Нв | Комбинация на основе лиганда sv2a и положительного аллостерического модулятора метаботропного глутаматергического рецептора 2 подтипа |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| US10071164B2 (en) * | 2014-08-11 | 2018-09-11 | Yale University | Estrogen-related receptor alpha based protac compounds and associated methods of use |
| CN108366992A (zh) | 2015-11-02 | 2018-08-03 | 耶鲁大学 | 蛋白水解靶向嵌合体化合物及其制备和应用方法 |
| EP4316477A1 (en) * | 2018-08-22 | 2024-02-07 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Methods for treating cardiac valve disease |
| EP3870292A4 (en) | 2018-10-26 | 2022-11-09 | The Research Foundation for The State University of New York | COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA |
| CN112538038B (zh) * | 2019-09-20 | 2022-05-20 | 暨南大学 | 2-吲哚酮类ERRα反向激动剂及其药物组合物和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5037842A (en) | 1990-06-05 | 1991-08-06 | Pfizer Inc. | Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents |
| HK1043113A1 (zh) * | 1999-07-01 | 2002-09-06 | Geron Corporation | 端粒酶抑制劑及其使用方法 |
| JP2001072592A (ja) * | 1999-07-01 | 2001-03-21 | Kyowa Hakko Kogyo Co Ltd | テロメラーゼ阻害剤 |
| AU2001257022B2 (en) | 2000-04-13 | 2005-02-03 | Mayo Foundation For Medical Education And Research | Abeta 42 lowering agents |
| DE10131899A1 (de) | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
| JP2006500399A (ja) * | 2002-04-30 | 2006-01-05 | メルク エンド カムパニー インコーポレーテッド | ナトリウムチャンネルブロッカーとしての、アリール−結合−アリール置換された、チアゾリジン−ジオンおよびオキサゾリジン−ジオン |
| EP1398029A1 (en) | 2002-09-10 | 2004-03-17 | LION Bioscience AG | NR3B1 nuclear receptor binding 3-substituted pyrazole derivatives |
| WO2006004555A1 (en) | 2004-06-30 | 2006-01-12 | Paysetter Pte Ltd | System and method for facilitating transfer of physical money and/or credit |
| AU2005275279A1 (en) * | 2004-07-14 | 2006-02-23 | Janssen Pharmaceutica N.V. | Arylidenes for the treatment of estrogen related receptor-alpha mediated diseases |
| JP4931824B2 (ja) | 2004-10-22 | 2012-05-16 | エグゼリクシス， インコーポレイテッド | 薬学的組成物 |
-
2008
- 2008-03-06 EP EP08731517A patent/EP2132188B1/en active Active
- 2008-03-06 NZ NZ579418A patent/NZ579418A/en not_active IP Right Cessation
- 2008-03-06 MX MX2009009519A patent/MX2009009519A/es active IP Right Grant
- 2008-03-06 PT PT08731517T patent/PT2132188E/pt unknown
- 2008-03-06 AT AT08731517T patent/ATE537157T1/de active
- 2008-03-06 JP JP2009552883A patent/JP2010520307A/ja active Pending
- 2008-03-06 ES ES08731517T patent/ES2377165T3/es active Active
- 2008-03-06 CA CA002679965A patent/CA2679965A1/en not_active Abandoned
- 2008-03-06 WO PCT/US2008/056018 patent/WO2008109731A2/en not_active Ceased
- 2008-03-06 BR BRPI0808662A patent/BRPI0808662B8/pt not_active IP Right Cessation
- 2008-03-06 SI SI200830561T patent/SI2132188T1/sl unknown
- 2008-03-06 EA EA200970838A patent/EA200970838A1/ru unknown
- 2008-03-06 KR KR1020097020832A patent/KR20090118103A/ko not_active Withdrawn
- 2008-03-06 CL CL2008000669A patent/CL2008000669A1/es unknown
- 2008-03-06 HR HR20120160T patent/HRP20120160T1/hr unknown
- 2008-03-06 US US12/043,291 patent/US8119669B2/en not_active Expired - Fee Related
- 2008-03-06 RS RS20120106A patent/RS52247B/sr unknown
- 2008-03-06 TW TW097107936A patent/TW200902507A/zh unknown
- 2008-03-06 PL PL08731517T patent/PL2132188T3/pl unknown
- 2008-03-06 CN CN2008800153616A patent/CN101679326B/zh not_active Expired - Fee Related
- 2008-03-06 AU AU2008222749A patent/AU2008222749A1/en not_active Abandoned
- 2008-03-06 DK DK08731517.2T patent/DK2132188T3/da active
- 2008-03-07 AR ARP080100963A patent/AR065656A1/es not_active Application Discontinuation
-
2009
- 2009-09-06 IL IL200758A patent/IL200758A0/en unknown
- 2009-10-06 ZA ZA2009/06953A patent/ZA200906953B/en unknown
-
2012
- 2012-01-10 US US13/346,808 patent/US9034852B2/en not_active Expired - Fee Related
- 2012-03-07 CY CY20121100232T patent/CY1112778T1/el unknown
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