CN101679326B - 作为雌激素相关α受体调节剂的取代的苯氧基N-烷基化的噻唑烷二酮 - Google Patents

作为雌激素相关α受体调节剂的取代的苯氧基N-烷基化的噻唑烷二酮 Download PDF

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CN101679326B
CN101679326B CN2008800153616A CN200880015361A CN101679326B CN 101679326 B CN101679326 B CN 101679326B CN 2008800153616 A CN2008800153616 A CN 2008800153616A CN 200880015361 A CN200880015361 A CN 200880015361A CN 101679326 B CN101679326 B CN 101679326B
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ethyl
trifluoromethyl
benzonitrile
dioxo
thiazolidine
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CN101679326A (zh
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M·高尔
L·L·西尔勒
D·伦策佩里斯
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Janssen Pharmaceutica NV
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
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    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Diabetes (AREA)
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  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
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  • Urology & Nephrology (AREA)
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  • Dermatology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2008800153616A 2007-03-07 2008-03-06 作为雌激素相关α受体调节剂的取代的苯氧基N-烷基化的噻唑烷二酮 Expired - Fee Related CN101679326B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89345807P 2007-03-07 2007-03-07
US60/893,458 2007-03-07
PCT/US2008/056018 WO2008109731A2 (en) 2007-03-07 2008-03-06 Substituted phenoxy n-alkylated thiazoledinedione as estrogen related receptor-alpha modulators

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CN101679326A CN101679326A (zh) 2010-03-24
CN101679326B true CN101679326B (zh) 2012-12-12

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US (2) US8119669B2 (enExample)
EP (1) EP2132188B1 (enExample)
JP (1) JP2010520307A (enExample)
KR (1) KR20090118103A (enExample)
CN (1) CN101679326B (enExample)
AR (1) AR065656A1 (enExample)
AT (1) ATE537157T1 (enExample)
AU (1) AU2008222749A1 (enExample)
BR (1) BRPI0808662B8 (enExample)
CA (1) CA2679965A1 (enExample)
CL (1) CL2008000669A1 (enExample)
CY (1) CY1112778T1 (enExample)
DK (1) DK2132188T3 (enExample)
EA (1) EA200970838A1 (enExample)
ES (1) ES2377165T3 (enExample)
HR (1) HRP20120160T1 (enExample)
IL (1) IL200758A0 (enExample)
MX (1) MX2009009519A (enExample)
NZ (1) NZ579418A (enExample)
PL (1) PL2132188T3 (enExample)
PT (1) PT2132188E (enExample)
RS (1) RS52247B (enExample)
SI (1) SI2132188T1 (enExample)
TW (1) TW200902507A (enExample)
WO (1) WO2008109731A2 (enExample)
ZA (1) ZA200906953B (enExample)

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BRPI0808662B1 (pt) 2020-09-29
US8119669B2 (en) 2012-02-21
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