JP2010519181A5 - - Google Patents
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- Publication number
- JP2010519181A5 JP2010519181A5 JP2009548468A JP2009548468A JP2010519181A5 JP 2010519181 A5 JP2010519181 A5 JP 2010519181A5 JP 2009548468 A JP2009548468 A JP 2009548468A JP 2009548468 A JP2009548468 A JP 2009548468A JP 2010519181 A5 JP2010519181 A5 JP 2010519181A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- amino
- alkyl
- heteroaryl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88799407P | 2007-02-02 | 2007-02-02 | |
| US60/887,994 | 2007-02-02 | ||
| US1231007P | 2007-12-07 | 2007-12-07 | |
| US61/012,310 | 2007-12-07 | ||
| PCT/US2008/052778 WO2008097835A2 (en) | 2007-02-02 | 2008-02-01 | Compositions and methods for the treatment of metabolic disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014005460A Division JP5878937B2 (ja) | 2007-02-02 | 2014-01-15 | 代謝障害を処置するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010519181A JP2010519181A (ja) | 2010-06-03 |
| JP2010519181A5 true JP2010519181A5 (OSRAM) | 2012-03-08 |
| JP5461197B2 JP5461197B2 (ja) | 2014-04-02 |
Family
ID=39682342
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009548468A Expired - Fee Related JP5461197B2 (ja) | 2007-02-02 | 2008-02-01 | 代謝障害を処置するための組成物および方法 |
| JP2014005460A Expired - Fee Related JP5878937B2 (ja) | 2007-02-02 | 2014-01-15 | 代謝障害を処置するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014005460A Expired - Fee Related JP5878937B2 (ja) | 2007-02-02 | 2014-01-15 | 代謝障害を処置するための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8207196B2 (OSRAM) |
| EP (1) | EP2120580B1 (OSRAM) |
| JP (2) | JP5461197B2 (OSRAM) |
| CN (1) | CN101674730B (OSRAM) |
| AU (1) | AU2008214095B2 (OSRAM) |
| CA (1) | CA2677264C (OSRAM) |
| WO (1) | WO2008097835A2 (OSRAM) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9187485B2 (en) | 2007-02-02 | 2015-11-17 | Baylor College Of Medicine | Methods and compositions for the treatment of cancer and related hyperproliferative disorders |
| US9212179B2 (en) * | 2007-02-02 | 2015-12-15 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic disorders |
| CA2677264C (en) * | 2007-02-02 | 2021-11-30 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic disorders |
| US9233941B2 (en) * | 2007-02-02 | 2016-01-12 | Baylor College Of Medicine | Methods and compositions for the treatment of body weight related disorders |
| US9029411B2 (en) | 2008-01-25 | 2015-05-12 | Millennium Pharmaceuticals, Inc. | Thiophenes and uses thereof |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| US9139589B2 (en) | 2009-01-30 | 2015-09-22 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| US9090601B2 (en) | 2009-01-30 | 2015-07-28 | Millennium Pharmaceuticals, Inc. | Thiazole derivatives |
| US8796314B2 (en) | 2009-01-30 | 2014-08-05 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| US8450350B2 (en) | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
| EP3159331A1 (en) | 2010-05-05 | 2017-04-26 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
| MA34797B1 (fr) | 2010-08-11 | 2014-01-02 | Millennium Pharm Inc | Hétéroaryles et leurs utilisations |
| JP2013533318A (ja) | 2010-08-11 | 2013-08-22 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | ヘテロアリールおよびその使用 |
| US9062038B2 (en) | 2010-08-11 | 2015-06-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| AU2011303597A1 (en) * | 2010-09-17 | 2013-04-11 | Purdue Pharma L.P. | Pyridine compounds and the uses thereof |
| WO2012048303A2 (en) * | 2010-10-07 | 2012-04-12 | Columbia University | METHOD FOR TREATING CANCER HARBORING A p53 MUTATION |
| PH12013500723A1 (en) | 2010-10-13 | 2017-08-23 | Millennium Pharm Inc | Heteroaryls and uses thereof |
| KR101762724B1 (ko) * | 2011-01-25 | 2017-07-28 | 더 리젠츠 오브 더 유니버시티 오브 미시건 | Bcl-2/bcl-xl 억제제 및 이를 이용한 치료 방법 |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013110007A1 (en) * | 2012-01-18 | 2013-07-25 | The Trustees Of Columbia University In The City Of New York | USE OF FATOSTATIN FOR TREATING CANCER HAVING A p53 MUTATION |
| JP6228198B2 (ja) | 2012-06-25 | 2017-11-08 | トーマス・ジェファーソン・ユニバーシティThomas Jefferson University | 異常な脂質生合成シグナル伝達を有するがんを処置するための組成物および方法 |
| US20140275178A1 (en) * | 2013-03-13 | 2014-09-18 | Musc Foundation For Research Development | Thiazole compounds, compositions and methods for treatment of degenerative diseases and disorders |
| DK3038622T3 (en) * | 2013-08-28 | 2018-07-16 | Medivation Tech Llc | HETEROCYCLIC RELATIONS AND PROCEDURES FOR USE |
| CN107074839A (zh) * | 2013-08-29 | 2017-08-18 | 贝勒医学院 | 用于治疗代谢和体重相关的病症的组合物和方法 |
| KR20160115999A (ko) * | 2014-02-14 | 2016-10-06 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 치료제로서의 인간 안드로겐 수용체 dna-결합 도메인(dbd) 화합물 및 그의 사용 방법 |
| US9873689B2 (en) | 2014-11-07 | 2018-01-23 | Fgh Biotech, Inc. | Synthesis of fatostatin based polycyclic compounds |
| WO2016105491A1 (en) * | 2014-12-23 | 2016-06-30 | Fgh Biotech | Compositions of fatostatin based heterocyclic compounds and uses thereof |
| CN107635981B (zh) * | 2015-02-17 | 2020-08-04 | 中国科学院广州生物医药与健康研究院 | 用于诱导白色脂肪组织褐变的化合物和方法 |
| EP3265088A1 (en) | 2015-03-04 | 2018-01-10 | Medivation Technologies LLC | Srebp blockers for use in treating liver fibrosis, elevated cholesterol and insulin resistance |
| WO2016141258A1 (en) | 2015-03-04 | 2016-09-09 | Medivation Technologies, Inc. | Sterol regulatory element-binding proteins (srebps) inhibitors |
| WO2016191864A1 (en) * | 2015-05-29 | 2016-12-08 | Changiz Taghibiglou | Polypeptides and antibodies to treat skin conditions associated with overproduction of sebum |
| CA3008395A1 (en) | 2015-11-06 | 2017-05-11 | The Children's Hospital Of Philadelphia | Compositions and methods for the treatment of fatty acid metabolism disorders |
| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| WO2017190086A1 (en) | 2016-04-29 | 2017-11-02 | Fgh Biotech, Inc. | Di-substituted pyrazole compounds for the treatment of diseases |
| CA3036195A1 (en) | 2016-09-07 | 2018-03-15 | Fgh Biotech, Inc. | Di-substituted pyrazole compounds for the treatment of diseases |
| KR101869308B1 (ko) * | 2017-02-28 | 2018-06-20 | 대구가톨릭대학교산학협력단 | Srebp-1 디코이 올리고디옥시뉴클레오티드 및 이를 유효성분으로 함유하는 지방간 질환의 예방 또는 치료용 약학 조성물 |
| US12090129B2 (en) | 2017-11-22 | 2024-09-17 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| JP2021512160A (ja) | 2018-01-29 | 2021-05-13 | カピュラス セラピューティクス リミテッド ライアビリティ カンパニー | 6員の中央環を含むsrebp阻害剤 |
| WO2020132700A1 (en) * | 2018-12-21 | 2020-06-25 | Fgh Biotech Inc. | Methods of using inhibitors of srebp in combination with niclosamide and analogs thereof |
| CN113631163A (zh) * | 2019-01-28 | 2021-11-09 | 卡普勒斯疗法有限责任公司 | 包括噻吩中心环的srebp抑制剂 |
| US12472200B2 (en) | 2019-05-15 | 2025-11-18 | Axcess Global Sciences, Llc | Autobiotic compositions and method for promoting healthy gut microbiome |
| US11969430B1 (en) | 2023-03-10 | 2024-04-30 | Axcess Global Sciences, Llc | Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance |
| US12167993B2 (en) | 2019-06-21 | 2024-12-17 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11950616B2 (en) | 2019-06-21 | 2024-04-09 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US20220315528A1 (en) * | 2019-08-21 | 2022-10-06 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibitors of phospholipid synthesis and methods of use |
| WO2021154735A1 (en) * | 2020-01-27 | 2021-08-05 | Capulus Therapeutics, Llc | Srebp inhibitors comprising a thiophene central ring |
| US12186297B2 (en) | 2020-08-26 | 2025-01-07 | Axcess Global Sciences, Llc | Compositions and methods for increasing lean-to-fat mass ratio |
| WO2023230495A2 (en) * | 2022-05-25 | 2023-11-30 | Amgen Inc. | Rnai constructs for inhibiting scap expression and methods of use thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4791200A (en) * | 1987-06-22 | 1988-12-13 | Ortho Pharmaceutical Corporation | 2-substituted-4-aryl-substituted thiazoles |
| US5725871A (en) | 1989-08-18 | 1998-03-10 | Danbiosyst Uk Limited | Drug delivery compositions comprising lysophosphoglycerolipid |
| US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| US5466468A (en) | 1990-04-03 | 1995-11-14 | Ciba-Geigy Corporation | Parenterally administrable liposome formulation comprising synthetic lipids |
| DK1130017T3 (da) * | 1990-11-30 | 2005-10-10 | Otsuka Pharma Co Ltd | Azolderivater og deres anvendelse som superoxidradikalinhibitorer |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| JPH04282326A (ja) * | 1991-03-08 | 1992-10-07 | Yuki Gosei Kogyo Co Ltd | 非対称な三環系化合物の製造法 |
| CA2110899C (en) | 1991-06-21 | 2006-08-08 | Jacob G. Michael | Orally administrable therapeutic proteins and method of making |
| US5756353A (en) | 1991-12-17 | 1998-05-26 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol-and liposome-based delivery |
| DE69312487T2 (de) | 1992-05-18 | 1997-11-27 | Minnesota Mining & Mfg | Einrichtung zur transmucosalen wirkstoffabgabe |
| US5792451A (en) | 1994-03-02 | 1998-08-11 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
| WO1994022846A1 (en) * | 1993-03-30 | 1994-10-13 | Pfizer Inc. | Compounds enhancing antitumor activity of other cytotoxic agents |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| US5580579A (en) | 1995-02-15 | 1996-12-03 | Nano Systems L.L.C. | Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| MY128323A (en) | 1996-09-30 | 2007-01-31 | Otsuka Pharma Co Ltd | Thiazole derivatives for inhibition of cytokine production and of cell adhesion |
| JPH1179993A (ja) * | 1997-09-05 | 1999-03-23 | Sumitomo Pharmaceut Co Ltd | 免疫抑制剤 |
| JPH11186479A (ja) | 1997-12-22 | 1999-07-09 | Toyo Commun Equip Co Ltd | 放熱板付き表面実装部品 |
| JP2000080086A (ja) * | 1998-07-01 | 2000-03-21 | Takeda Chem Ind Ltd | レチノイド関連受容体機能調節剤 |
| EP1092711A4 (en) * | 1998-07-01 | 2002-07-31 | Takeda Chemical Industries Ltd | RETINOID ASSOCIATED RECEPTOR REGULATORS |
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| PL369598A1 (en) * | 2001-02-21 | 2005-05-02 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| US7153889B2 (en) * | 2002-11-12 | 2006-12-26 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
| US20040242673A1 (en) * | 2003-05-16 | 2004-12-02 | Ambit Biosciences Corporation | Heterocyclic compounds and uses thereof |
| US20050288340A1 (en) * | 2004-06-29 | 2005-12-29 | Pfizer Inc | Substituted heteroaryl- and phenylsulfamoyl compounds |
| PE20060417A1 (es) | 2004-08-03 | 2006-06-13 | Wyeth Corp | Indazoles como moduladores de lxrs |
| AR051597A1 (es) * | 2004-11-01 | 2007-01-24 | Merck & Co Inc | Moduladores de los receptores de estrogeno |
| WO2006080406A1 (ja) * | 2005-01-28 | 2006-08-03 | Taisho Pharmaceutical Co., Ltd. | 三環性化合物 |
| WO2006133559A1 (en) * | 2005-06-14 | 2006-12-21 | Merck Frosst Canada Ltd. | Reversible inhibitors of monoamine oxidase a and b |
| WO2007001973A1 (en) | 2005-06-28 | 2007-01-04 | Astrazeneca Ab | New use |
| EP1962892A4 (en) * | 2005-11-22 | 2011-10-12 | Univ South Florida | INHIBITION OF CELL PROLIFERATION |
| CA2677264C (en) * | 2007-02-02 | 2021-11-30 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic disorders |
| US9328205B2 (en) * | 2011-10-04 | 2016-05-03 | Dow Corning Corporation | Iron(III) containing complex and condensation reaction catalysts, methods for preparing the catalysts, and compositions containing the catalysts |
-
2008
- 2008-02-01 CA CA2677264A patent/CA2677264C/en active Active
- 2008-02-01 US US12/024,530 patent/US8207196B2/en active Active
- 2008-02-01 JP JP2009548468A patent/JP5461197B2/ja not_active Expired - Fee Related
- 2008-02-01 CN CN200880008035.2A patent/CN101674730B/zh active Active
- 2008-02-01 AU AU2008214095A patent/AU2008214095B2/en not_active Ceased
- 2008-02-01 WO PCT/US2008/052778 patent/WO2008097835A2/en not_active Ceased
- 2008-02-01 EP EP08728809.8A patent/EP2120580B1/en active Active
-
2012
- 2012-05-31 US US13/484,702 patent/US8927578B2/en active Active
- 2012-05-31 US US13/484,685 patent/US8778976B2/en active Active
-
2014
- 2014-01-15 JP JP2014005460A patent/JP5878937B2/ja not_active Expired - Fee Related
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