CA2677264C - Compositions and methods for the treatment of metabolic disorders - Google Patents
Compositions and methods for the treatment of metabolic disorders Download PDFInfo
- Publication number
- CA2677264C CA2677264C CA2677264A CA2677264A CA2677264C CA 2677264 C CA2677264 C CA 2677264C CA 2677264 A CA2677264 A CA 2677264A CA 2677264 A CA2677264 A CA 2677264A CA 2677264 C CA2677264 C CA 2677264C
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- Canada
- Prior art keywords
- compound
- propylpyridin
- thiazol
- substituted
- metabolic disorder
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Classifications
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
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| PCT/US2008/052778 WO2008097835A2 (en) | 2007-02-02 | 2008-02-01 | Compositions and methods for the treatment of metabolic disorders |
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| US9212179B2 (en) * | 2007-02-02 | 2015-12-15 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic disorders |
| CA2677264C (en) * | 2007-02-02 | 2021-11-30 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic disorders |
| US9233941B2 (en) * | 2007-02-02 | 2016-01-12 | Baylor College Of Medicine | Methods and compositions for the treatment of body weight related disorders |
| US9029411B2 (en) | 2008-01-25 | 2015-05-12 | Millennium Pharmaceuticals, Inc. | Thiophenes and uses thereof |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| US9139589B2 (en) | 2009-01-30 | 2015-09-22 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| US9090601B2 (en) | 2009-01-30 | 2015-07-28 | Millennium Pharmaceuticals, Inc. | Thiazole derivatives |
| US8796314B2 (en) | 2009-01-30 | 2014-08-05 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| US8450350B2 (en) | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
| EP3159331A1 (en) | 2010-05-05 | 2017-04-26 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
| MA34797B1 (fr) | 2010-08-11 | 2014-01-02 | Millennium Pharm Inc | Hétéroaryles et leurs utilisations |
| JP2013533318A (ja) | 2010-08-11 | 2013-08-22 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | ヘテロアリールおよびその使用 |
| US9062038B2 (en) | 2010-08-11 | 2015-06-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| AU2011303597A1 (en) * | 2010-09-17 | 2013-04-11 | Purdue Pharma L.P. | Pyridine compounds and the uses thereof |
| WO2012048303A2 (en) * | 2010-10-07 | 2012-04-12 | Columbia University | METHOD FOR TREATING CANCER HARBORING A p53 MUTATION |
| PH12013500723A1 (en) | 2010-10-13 | 2017-08-23 | Millennium Pharm Inc | Heteroaryls and uses thereof |
| KR101762724B1 (ko) * | 2011-01-25 | 2017-07-28 | 더 리젠츠 오브 더 유니버시티 오브 미시건 | Bcl-2/bcl-xl 억제제 및 이를 이용한 치료 방법 |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013110007A1 (en) * | 2012-01-18 | 2013-07-25 | The Trustees Of Columbia University In The City Of New York | USE OF FATOSTATIN FOR TREATING CANCER HAVING A p53 MUTATION |
| JP6228198B2 (ja) | 2012-06-25 | 2017-11-08 | トーマス・ジェファーソン・ユニバーシティＴｈｏｍａｓ Ｊｅｆｆｅｒｓｏｎ Ｕｎｉｖｅｒｓｉｔｙ | 異常な脂質生合成シグナル伝達を有するがんを処置するための組成物および方法 |
| US20140275178A1 (en) * | 2013-03-13 | 2014-09-18 | Musc Foundation For Research Development | Thiazole compounds, compositions and methods for treatment of degenerative diseases and disorders |
| DK3038622T3 (en) * | 2013-08-28 | 2018-07-16 | Medivation Tech Llc | HETEROCYCLIC RELATIONS AND PROCEDURES FOR USE |
| CN107074839A (zh) * | 2013-08-29 | 2017-08-18 | 贝勒医学院 | 用于治疗代谢和体重相关的病症的组合物和方法 |
| KR20160115999A (ko) * | 2014-02-14 | 2016-10-06 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 치료제로서의 인간 안드로겐 수용체 dna-결합 도메인(dbd) 화합물 및 그의 사용 방법 |
| US9873689B2 (en) | 2014-11-07 | 2018-01-23 | Fgh Biotech, Inc. | Synthesis of fatostatin based polycyclic compounds |
| WO2016105491A1 (en) * | 2014-12-23 | 2016-06-30 | Fgh Biotech | Compositions of fatostatin based heterocyclic compounds and uses thereof |
| CN107635981B (zh) * | 2015-02-17 | 2020-08-04 | 中国科学院广州生物医药与健康研究院 | 用于诱导白色脂肪组织褐变的化合物和方法 |
| EP3265088A1 (en) | 2015-03-04 | 2018-01-10 | Medivation Technologies LLC | Srebp blockers for use in treating liver fibrosis, elevated cholesterol and insulin resistance |
| WO2016141258A1 (en) | 2015-03-04 | 2016-09-09 | Medivation Technologies, Inc. | Sterol regulatory element-binding proteins (srebps) inhibitors |
| WO2016191864A1 (en) * | 2015-05-29 | 2016-12-08 | Changiz Taghibiglou | Polypeptides and antibodies to treat skin conditions associated with overproduction of sebum |
| CA3008395A1 (en) | 2015-11-06 | 2017-05-11 | The Children's Hospital Of Philadelphia | Compositions and methods for the treatment of fatty acid metabolism disorders |
| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| WO2017190086A1 (en) | 2016-04-29 | 2017-11-02 | Fgh Biotech, Inc. | Di-substituted pyrazole compounds for the treatment of diseases |
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| KR101869308B1 (ko) * | 2017-02-28 | 2018-06-20 | 대구가톨릭대학교산학협력단 | Srebp-1 디코이 올리고디옥시뉴클레오티드 및 이를 유효성분으로 함유하는 지방간 질환의 예방 또는 치료용 약학 조성물 |
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| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| JP2021512160A (ja) | 2018-01-29 | 2021-05-13 | カピュラス セラピューティクス リミテッド ライアビリティ カンパニー | ６員の中央環を含むｓｒｅｂｐ阻害剤 |
| WO2020132700A1 (en) * | 2018-12-21 | 2020-06-25 | Fgh Biotech Inc. | Methods of using inhibitors of srebp in combination with niclosamide and analogs thereof |
| CN113631163A (zh) * | 2019-01-28 | 2021-11-09 | 卡普勒斯疗法有限责任公司 | 包括噻吩中心环的srebp抑制剂 |
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2008
- 2008-02-01 CA CA2677264A patent/CA2677264C/en active Active
- 2008-02-01 US US12/024,530 patent/US8207196B2/en active Active
- 2008-02-01 JP JP2009548468A patent/JP5461197B2/ja not_active Expired - Fee Related
- 2008-02-01 CN CN200880008035.2A patent/CN101674730B/zh active Active
- 2008-02-01 AU AU2008214095A patent/AU2008214095B2/en not_active Ceased
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| Publication number | Publication date |
|---|---|
| US8778976B2 (en) | 2014-07-15 |
| US8927578B2 (en) | 2015-01-06 |
| CA2677264A1 (en) | 2008-08-14 |
| JP2014088431A (ja) | 2014-05-15 |
| US8207196B2 (en) | 2012-06-26 |
| WO2008097835A3 (en) | 2008-10-30 |
| CN101674730B (zh) | 2014-09-10 |
| US20090131475A1 (en) | 2009-05-21 |
| JP2010519181A (ja) | 2010-06-03 |
| US20130005768A1 (en) | 2013-01-03 |
| EP2120580B1 (en) | 2017-12-27 |
| US20130012538A1 (en) | 2013-01-10 |
| JP5878937B2 (ja) | 2016-03-08 |
| EP2120580A4 (en) | 2011-09-28 |
| CN101674730A (zh) | 2010-03-17 |
| EP2120580A2 (en) | 2009-11-25 |
| JP5461197B2 (ja) | 2014-04-02 |
| AU2008214095A1 (en) | 2008-08-14 |
| AU2008214095B2 (en) | 2014-07-10 |
| WO2008097835A2 (en) | 2008-08-14 |
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