JP2010512795A5 - - Google Patents
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- Publication number
- JP2010512795A5 JP2010512795A5 JP2009543078A JP2009543078A JP2010512795A5 JP 2010512795 A5 JP2010512795 A5 JP 2010512795A5 JP 2009543078 A JP2009543078 A JP 2009543078A JP 2009543078 A JP2009543078 A JP 2009543078A JP 2010512795 A5 JP2010512795 A5 JP 2010512795A5
- Authority
- JP
- Japan
- Prior art keywords
- lipase
- seq
- amylase
- protease
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004367 Lipase Substances 0.000 claims 11
- 102000004882 Lipase Human genes 0.000 claims 11
- 108090001060 Lipase Proteins 0.000 claims 11
- 235000019421 lipase Nutrition 0.000 claims 11
- 239000004382 Amylase Substances 0.000 claims 10
- 102000013142 Amylases Human genes 0.000 claims 10
- 108010065511 Amylases Proteins 0.000 claims 10
- 108091005804 Peptidases Proteins 0.000 claims 10
- 239000004365 Protease Substances 0.000 claims 10
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 10
- 235000019418 amylase Nutrition 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 102220479102 CD59 glycoprotein_N33Q_mutation Human genes 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 208000035467 Pancreatic insufficiency Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 230000001079 digestive effect Effects 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 235000019626 lipase activity Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102200012371 rs879255637 Human genes 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87119606P | 2006-12-21 | 2006-12-21 | |
| US60/871,196 | 2006-12-21 | ||
| PCT/US2007/087168 WO2008079685A2 (en) | 2006-12-21 | 2007-12-12 | Lipase variants for pharmaceutical use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010512795A JP2010512795A (ja) | 2010-04-30 |
| JP2010512795A5 true JP2010512795A5 (OSRAM) | 2011-02-03 |
| JP5406040B2 JP5406040B2 (ja) | 2014-02-05 |
Family
ID=38043020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009543078A Active JP5406040B2 (ja) | 2006-12-21 | 2007-12-12 | 医薬使用のためのリパーゼ変異体 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US8273348B2 (OSRAM) |
| EP (6) | EP2261328B1 (OSRAM) |
| JP (1) | JP5406040B2 (OSRAM) |
| KR (1) | KR20090101930A (OSRAM) |
| CN (2) | CN105112386A (OSRAM) |
| AR (1) | AR064494A1 (OSRAM) |
| AU (1) | AU2007337150A1 (OSRAM) |
| BR (1) | BRPI0721103A2 (OSRAM) |
| CA (3) | CA2961041C (OSRAM) |
| IL (1) | IL198893A0 (OSRAM) |
| MX (1) | MX2009006597A (OSRAM) |
| NO (1) | NO20092729L (OSRAM) |
| RU (1) | RU2009128067A (OSRAM) |
| TW (1) | TW200829698A (OSRAM) |
| WO (1) | WO2008079685A2 (OSRAM) |
| ZA (1) | ZA200903598B (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005227090B2 (en) | 2004-03-22 | 2010-12-09 | Abbott Laboratories Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
| PL2278002T3 (pl) | 2005-07-29 | 2017-12-29 | Abbott Laboratories Gmbh | Pankreatyna o zmniejszonej zawartości wirusowej |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| EP2261328B1 (en) | 2006-12-21 | 2013-11-20 | Novozymes A/S | Lipase variants for pharmaceutical use |
| US8637101B2 (en) | 2008-02-29 | 2014-01-28 | Dsm Ip Assets B.V. | Lipases with high specificity towards short chain fatty acids and uses thereof |
| AR070498A1 (es) * | 2008-02-29 | 2010-04-07 | Procter & Gamble | Composicion detergente que comprende lipasa |
| AR070491A1 (es) * | 2008-02-29 | 2010-04-07 | Novozymes As | Variante de enzima lipolitica con estabilidad aumentada y polinucleotidos que la codifican |
| CN102652175B (zh) | 2009-12-09 | 2016-02-10 | 宝洁公司 | 织物和家居护理产品 |
| BR112013032861A2 (pt) | 2011-07-22 | 2017-01-24 | Novozymes North America Inc | métodos para aumentar a atividade da enzima celulolítica durante a hidrólise do material celulósico, para hidrolisar um material celulósico pré-tratado, para a produção de um produto da fermentação, e para a fermentação de um material celulósico pré-tratado |
| US8268305B1 (en) | 2011-09-23 | 2012-09-18 | Bio-Cat, Inc. | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
| DK3382003T3 (da) * | 2011-12-29 | 2021-09-06 | Novozymes As | Detergentsammensætninger med lipasevarianter |
| DK3211074T3 (da) * | 2012-02-03 | 2020-06-02 | Novozymes As | Lipasevarianter og polynukleotider, som koder for dem |
| CN104204198B (zh) * | 2012-04-02 | 2018-09-25 | 诺维信公司 | 脂肪酶变体以及编码其的多核苷酸 |
| EP3842531A1 (en) * | 2012-10-12 | 2021-06-30 | Danisco US Inc. | Compositions and method comprising a lipolytic enzyme variant |
| CN115521831A (zh) | 2013-05-14 | 2022-12-27 | 诺维信公司 | 洗涤剂组合物 |
| ES2797483T3 (es) * | 2013-07-19 | 2020-12-02 | Danisco Us Inc | Composiciones y métodos comprendiendo una variante de enzima lipolítica |
| US10287562B2 (en) * | 2014-11-20 | 2019-05-14 | Novoszymes A/S | Alicyclobacillus variants and polynucleotides encoding same |
| US10457921B2 (en) | 2014-12-05 | 2019-10-29 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| US11268076B2 (en) | 2014-12-09 | 2022-03-08 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| US20180355404A1 (en) | 2015-04-07 | 2018-12-13 | Novozymes A/S | Methods for selecting enzymes having lipase activity |
| US10920203B2 (en) * | 2015-07-01 | 2021-02-16 | Novozymes A/S | Methods of reducing odor |
| CN107995922B (zh) * | 2015-07-03 | 2021-12-28 | 诺维信公司 | 在亚硫酸盐的存在下具有改进的稳定性的洗涤剂组合物 |
| EP3485008B1 (en) | 2016-07-18 | 2024-01-31 | Novozymes A/S | Lipase variants, polynucleotides encoding same and the use thereof |
| CN110462037A (zh) * | 2017-01-30 | 2019-11-15 | 学校法人日本医科大学 | 腺相关病毒(aav)衣壳蛋白的突变体 |
| US11286443B2 (en) * | 2017-09-27 | 2022-03-29 | The Procter & Gamble Company | Detergent compositions comprising lipases |
| CN117448299A (zh) | 2017-09-27 | 2024-01-26 | 诺维信公司 | 脂肪酶变体和包含此类脂肪酶变体的微囊组合物 |
| US20210071157A1 (en) * | 2018-02-08 | 2021-03-11 | Novozymes A/S | Lipase Variants and Compositions Thereof |
| CA3109082A1 (en) * | 2018-08-16 | 2020-02-20 | Isolere Bio, Inc. | Genetically encoded polypeptide for affinity capture and purification of biologics |
| CN111334369B (zh) * | 2020-03-11 | 2022-10-21 | 陕西科技大学 | 一种酶法制备卵磷脂型pufa的方法 |
| CN115803083A (zh) * | 2020-06-24 | 2023-03-14 | 基利安股份公司 | 新脂肪酶 |
| US20240035005A1 (en) * | 2020-10-29 | 2024-02-01 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
| CN113846074B (zh) * | 2021-10-20 | 2022-10-21 | 南京林业大学 | 一种疏棉状嗜热丝孢菌脂肪酶突变体g91c及其应用 |
| EP4525615A2 (en) | 2022-05-14 | 2025-03-26 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
| EP4544015A2 (en) * | 2022-06-24 | 2025-04-30 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK173590D0 (da) * | 1990-06-06 | 1990-07-19 | Novo Nordisk As | Rekombinante terapeutiske lipaser |
| DK46693D0 (OSRAM) | 1993-04-23 | 1993-04-23 | Novo Nordisk As | |
| US5869438A (en) | 1990-09-13 | 1999-02-09 | Novo Nordisk A/S | Lipase variants |
| CA2092615A1 (en) * | 1990-09-13 | 1992-03-14 | Allan Svendsen | Lipase variants |
| WO1992010755A1 (en) | 1990-12-05 | 1992-06-25 | Novo Nordisk A/S | Proteins with changed epitopes and methods for the production thereof |
| EP0585285B1 (en) | 1991-05-01 | 1998-08-12 | Novo Nordisk A/S | Stabilized enzymes |
| DK39693D0 (da) | 1993-04-02 | 1993-04-02 | Novo Nordisk As | Enzym |
| AU7807394A (en) | 1993-10-04 | 1995-05-01 | Novo Nordisk A/S | An enzyme preparation comprising a modified enzyme |
| ATE222604T1 (de) | 1994-02-22 | 2002-09-15 | Novozymes As | Methode zur herstellung einer variante eines lipolytischen enzymes |
| JPH10509324A (ja) | 1994-11-24 | 1998-09-14 | ノボ ノルディスク アクティーゼルスカブ | 抑制されたアレルゲン性を有するポリペプチドの製造のための方法 |
| EP0796324A1 (en) | 1994-12-07 | 1997-09-24 | Novo Nordisk A/S | Polypeptide with reduced allergenicity |
| CA2209617C (en) | 1995-01-26 | 2002-05-28 | Novo Nordisk A/S | Animal feed additives comprising xylanase |
| US6495357B1 (en) * | 1995-07-14 | 2002-12-17 | Novozyme A/S | Lipolytic enzymes |
| CN1193346A (zh) | 1995-07-14 | 1998-09-16 | 诺沃挪第克公司 | 一种具有脂解活性的修饰酶 |
| CN1192780B (zh) | 1995-08-11 | 2010-08-04 | 诺沃奇梅兹有限公司 | 新的脂解酶 |
| WO1998030682A1 (en) | 1997-01-10 | 1998-07-16 | Novo Nordisk A/S | Enzyme coupled with polymeric molecules for skin care |
| EP1017794A1 (en) | 1997-02-06 | 2000-07-12 | Novo Nordisk A/S | Polypeptide-polymer conjugates having added and/or removed attachment groups |
| ATE375387T1 (de) | 1997-06-25 | 2007-10-15 | Novozymes As | Modifiziertes polypeptid |
| AU3247699A (en) | 1998-02-17 | 1999-09-06 | Novo Nordisk A/S | Lipase variant |
| CN1247776C (zh) * | 1998-02-17 | 2006-03-29 | 诺维信公司 | 脂肪酶变体 |
| CN1323345A (zh) | 1998-10-13 | 2001-11-21 | 诺沃奇梅兹有限公司 | 具有降低的免疫应答的修饰多肽 |
| NZ511291A (en) | 1998-10-30 | 2003-08-29 | Novozymes As | A method for selecting a protein variant that has reduced immunogenicity as compared with the parent or wild-type protein |
| AU774156B2 (en) | 1998-10-30 | 2004-06-17 | Novozymes A/S | Glycosylated proteins having reduced allergenicity |
| NZ511340A (en) | 1998-11-27 | 2003-07-25 | Novozymes As | Lipolytic enzyme variants |
| US7312062B2 (en) * | 1998-11-27 | 2007-12-25 | Novozymes A/S | Lipolytic enzyme variants |
| JP4938174B2 (ja) | 1999-03-17 | 2012-05-23 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糖尿病を治療するための医薬品 |
| EP1171581A1 (en) * | 1999-03-31 | 2002-01-16 | Novozymes A/S | Lipase variant |
| EP2278000A1 (en) | 1999-03-31 | 2011-01-26 | Novozymes A/S | Lipase variant |
| PL203212B1 (pl) | 2000-02-08 | 2009-09-30 | Dsm Ip Assets Bv | Zastosowanie trwałej w kwasie proteazy w karmie zwierzęcej oraz w wytwarzaniu kompozycji do stosowania w karmie zwierzęcej, dodatek do karmy zwierzęcej, kompozycja karmy zwierzęcej i sposób obróbki białek roślinnych |
| US20020192792A1 (en) * | 2000-04-28 | 2002-12-19 | Palle Schneider | Laccase mutants |
| ES2323947T3 (es) | 2001-01-10 | 2009-07-28 | Novozymes A/S | Variante de enzima lipolitica. |
| AR032392A1 (es) | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
| EP1360278B1 (en) | 2001-02-07 | 2009-09-23 | Novozymes A/S | Lipase variants |
| EP2295556B1 (en) * | 2002-01-16 | 2014-10-29 | Novozymes A/S | Lipolytic enzymes variants and methods for their production |
| BRPI0407108A (pt) | 2003-02-06 | 2006-01-24 | Novozymes As | Método para produzir uma imunoglobulina funcional humana |
| EP1625216B1 (en) | 2003-05-09 | 2012-11-21 | Novozymes A/S | Variant lipolytic enzymes |
| US20060251763A1 (en) | 2003-06-19 | 2006-11-09 | Patkar Shamkant A | Phospholipase variants |
| DK1639107T3 (da) | 2003-06-19 | 2013-11-18 | Novozymes As | Forbedrede proteaser og fremgangsmåder til fremstilling deraf |
| CA2553731A1 (en) | 2004-01-21 | 2005-08-04 | Novozymes A/S | Production of a monoclonal antibody in a heterokaryon fungus or in a fungal host cell |
| AU2005227090B2 (en) | 2004-03-22 | 2010-12-09 | Abbott Laboratories Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
| DK1809320T3 (da) | 2004-10-14 | 2010-11-15 | Cystic Fibrosis Foundation The | Præparater indeholdende lipase, protease og amylase til behandling af pankreatisk insufficiens |
| US20080138856A1 (en) | 2005-02-10 | 2008-06-12 | Novozymes A/S | Enzymatic Enantioselective Ester or Amide Hydrolysis or Synthesis |
| MX2007015471A (es) | 2005-06-24 | 2008-04-04 | Novozymes As | Amilasas para uso farmaceutico. |
| MX2007015474A (es) | 2005-06-24 | 2008-04-22 | Novozymes As | Proteasas para uso farmaceutico. |
| WO2006136159A2 (en) | 2005-06-24 | 2006-12-28 | Novozymes A/S | Lipases for pharmaceutical use |
| WO2007080197A2 (en) * | 2006-01-16 | 2007-07-19 | Novozymes A/S | Immobilised enzymes |
| ES2629334T3 (es) * | 2006-01-23 | 2017-08-08 | Novozymes A/S | Variantes de lipasa |
| WO2007087242A2 (en) * | 2006-01-23 | 2007-08-02 | The Procter & Gamble Company | A composition comprising a lipase and a bleach catalyst |
| EP2261328B1 (en) * | 2006-12-21 | 2013-11-20 | Novozymes A/S | Lipase variants for pharmaceutical use |
-
2007
- 2007-12-12 EP EP10172609.9A patent/EP2261328B1/en active Active
- 2007-12-12 EP EP12155317.6A patent/EP2455461B1/en active Active
- 2007-12-12 KR KR1020097014850A patent/KR20090101930A/ko not_active Withdrawn
- 2007-12-12 EP EP07869130A patent/EP2099907A2/en not_active Withdrawn
- 2007-12-12 JP JP2009543078A patent/JP5406040B2/ja active Active
- 2007-12-12 CN CN201510504893.8A patent/CN105112386A/zh active Pending
- 2007-12-12 AU AU2007337150A patent/AU2007337150A1/en not_active Abandoned
- 2007-12-12 CA CA2961041A patent/CA2961041C/en active Active
- 2007-12-12 CN CN200780051638.6A patent/CN101743308B/zh active Active
- 2007-12-12 EP EP12155315A patent/EP2455460A3/en not_active Withdrawn
- 2007-12-12 CA CA2670643A patent/CA2670643C/en active Active
- 2007-12-12 RU RU2009128067/10A patent/RU2009128067A/ru not_active Application Discontinuation
- 2007-12-12 WO PCT/US2007/087168 patent/WO2008079685A2/en not_active Ceased
- 2007-12-12 US US12/519,868 patent/US8273348B2/en active Active
- 2007-12-12 EP EP12155294.7A patent/EP2455459B1/en active Active
- 2007-12-12 MX MX2009006597A patent/MX2009006597A/es not_active Application Discontinuation
- 2007-12-12 CA CA3081308A patent/CA3081308C/en active Active
- 2007-12-12 EP EP12155319.2A patent/EP2455462B1/en active Active
- 2007-12-12 BR BRPI0721103-1A patent/BRPI0721103A2/pt not_active IP Right Cessation
- 2007-12-18 TW TW096148377A patent/TW200829698A/zh unknown
- 2007-12-21 AR ARP070105859A patent/AR064494A1/es not_active Application Discontinuation
-
2009
- 2009-05-21 IL IL198893A patent/IL198893A0/en unknown
- 2009-05-25 ZA ZA200903598A patent/ZA200903598B/xx unknown
- 2009-07-20 NO NO20092729A patent/NO20092729L/no not_active Application Discontinuation
-
2012
- 2012-08-16 US US13/587,043 patent/US9029115B2/en active Active
-
2015
- 2015-04-06 US US14/679,563 patent/US9539311B2/en active Active
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