CA3081308C - Lipase variants for pharmaceutical use - Google Patents
Lipase variants for pharmaceutical use Download PDFInfo
- Publication number
- CA3081308C CA3081308C CA3081308A CA3081308A CA3081308C CA 3081308 C CA3081308 C CA 3081308C CA 3081308 A CA3081308 A CA 3081308A CA 3081308 A CA3081308 A CA 3081308A CA 3081308 C CA3081308 C CA 3081308C
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- Prior art keywords
- lipase
- seq
- enzyme
- amino acids
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Landscapes
- Health & Medical Sciences (AREA)
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- Detergent Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Applications Claiming Priority (3)
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| US87119606P | 2006-12-21 | 2006-12-21 | |
| US60/871,196 | 2006-12-21 | ||
| CA2961041A CA2961041C (en) | 2006-12-21 | 2007-12-12 | Lipase variants for pharmaceutical use |
Related Parent Applications (1)
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| CA2961041A Division CA2961041C (en) | 2006-12-21 | 2007-12-12 | Lipase variants for pharmaceutical use |
Publications (2)
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| CA3081308A1 CA3081308A1 (en) | 2008-07-03 |
| CA3081308C true CA3081308C (en) | 2024-02-20 |
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| CA2670643A Active CA2670643C (en) | 2006-12-21 | 2007-12-12 | Lipase variants for pharmaceutical use |
| CA2961041A Active CA2961041C (en) | 2006-12-21 | 2007-12-12 | Lipase variants for pharmaceutical use |
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| CA2670643A Active CA2670643C (en) | 2006-12-21 | 2007-12-12 | Lipase variants for pharmaceutical use |
| CA2961041A Active CA2961041C (en) | 2006-12-21 | 2007-12-12 | Lipase variants for pharmaceutical use |
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| WO2005092370A1 (en) | 2004-03-22 | 2005-10-06 | Solvay Pharmaceuticals Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
| ES2597381T3 (es) | 2005-07-29 | 2017-01-18 | Abbott Laboratories Gmbh | Procesos para la fabricación de polvo de pancreatina con bajo contenido en virus |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| EP2455462B1 (en) * | 2006-12-21 | 2016-03-16 | Novozymes A/S | Lipase variants for pharmaceutical use |
| US8637101B2 (en) | 2008-02-29 | 2014-01-28 | Dsm Ip Assets B.V. | Lipases with high specificity towards short chain fatty acids and uses thereof |
| WO2009111258A2 (en) * | 2008-02-29 | 2009-09-11 | The Procter & Gamble Company | Detergent composition comprising lipase |
| MX337307B (es) * | 2008-02-29 | 2016-02-25 | Novozymes As | Variante de enzima lipolitica con estabilidad mejorada y polinucleotidos que codifican para la misma. |
| EP2510092A1 (en) | 2009-12-09 | 2012-10-17 | The Procter & Gamble Company | Fabric and home care products |
| DK2734633T3 (da) | 2011-07-22 | 2019-06-11 | Novozymes North America Inc | Fremgangsmåder til forbehandling af celluloseholdigt materiale og forbedring af hydrolyse deraf |
| US8268305B1 (en) | 2011-09-23 | 2012-09-18 | Bio-Cat, Inc. | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
| ES2887576T3 (es) * | 2011-12-29 | 2021-12-23 | Novozymes As | Composiciones detergentes con variantes de lipasa |
| MX391773B (es) | 2012-02-03 | 2025-03-21 | Novozymes As | Variantes de lipasa y polinucleótidos que las codifican. |
| US9909109B2 (en) | 2012-04-02 | 2018-03-06 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| HK1209785A1 (en) * | 2012-10-12 | 2016-04-08 | Danisco Us Inc. | Compositions and methods comprising a lipolytic enzyme variant |
| RU2020101263A (ru) * | 2013-05-14 | 2020-02-17 | Новозимс А/С | Моющие композиции |
| MX371497B (es) * | 2013-07-19 | 2020-01-31 | Danisco Us Inc | Composiciones y metodos que comprenden una variante de enzima lipolitica. |
| US10287562B2 (en) * | 2014-11-20 | 2019-05-14 | Novoszymes A/S | Alicyclobacillus variants and polynucleotides encoding same |
| WO2016087401A1 (en) * | 2014-12-05 | 2016-06-09 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| WO2016091870A1 (en) * | 2014-12-09 | 2016-06-16 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| WO2016164596A2 (en) | 2015-04-07 | 2016-10-13 | Novozymes A/S | Methods for selecting enzymes having lipase activity |
| WO2017001673A1 (en) * | 2015-07-01 | 2017-01-05 | Novozymes A/S | Methods of reducing odor |
| CN107995922B (zh) * | 2015-07-03 | 2021-12-28 | 诺维信公司 | 在亚硫酸盐的存在下具有改进的稳定性的洗涤剂组合物 |
| WO2018015295A1 (en) * | 2016-07-18 | 2018-01-25 | Novozymes A/S | Lipase variants, polynucleotides encoding same and the use thereof |
| EP3575398A4 (en) * | 2017-01-30 | 2020-11-11 | Nippon Medical School Foundation | ADENO-ASSOCIATED VIRUS (AAV) CAPSIDE PROTEIN MUTANT |
| CA3073362A1 (en) * | 2017-09-27 | 2019-04-04 | Novozymes A/S | Lipase variants and microcapsule compositions comprising such lipase variants |
| MX2020003779A (es) * | 2017-09-27 | 2020-08-03 | Procter & Gamble | Composiciones detergentes que comprenden lipasas. |
| US20210071156A1 (en) * | 2018-02-08 | 2021-03-11 | Novozymes A/S | Lipase Variants and Compositions Thereof |
| WO2020037100A1 (en) * | 2018-08-16 | 2020-02-20 | Isolere Bio, Inc. | Genetically encoded polypeptide for affinity capture and purification of biologics |
| CN111334369B (zh) * | 2020-03-11 | 2022-10-21 | 陕西科技大学 | 一种酶法制备卵磷脂型pufa的方法 |
| EP4172325A1 (en) * | 2020-06-24 | 2023-05-03 | Cilian AG | New lipase enzyme |
| BR112023008326A2 (pt) * | 2020-10-29 | 2023-12-12 | Novozymes As | Variantes de lipase e composições compreendendo tais variantes de lipase |
| CN113846074B (zh) * | 2021-10-20 | 2022-10-21 | 南京林业大学 | 一种疏棉状嗜热丝孢菌脂肪酶突变体g91c及其应用 |
| EP4525615A2 (en) | 2022-05-14 | 2025-03-26 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
| EP4544015A2 (en) * | 2022-06-24 | 2025-04-30 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
Family Cites Families (49)
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| DK173590D0 (da) | 1990-06-06 | 1990-07-19 | Novo Nordisk As | Rekombinante terapeutiske lipaser |
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| JP3469234B2 (ja) * | 1990-09-13 | 2003-11-25 | ノボザイムス アクティーゼルスカブ | リパーゼ変異体 |
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| ATE169678T1 (de) | 1991-05-01 | 1998-08-15 | Novo Nordisk As | Stabilisierte enzyme |
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| EP0746618B1 (en) | 1994-02-22 | 2002-08-21 | Novozymes A/S | A method of preparing a variant of a lipolytic enzyme |
| EP0793726A1 (en) | 1994-11-24 | 1997-09-10 | Novo Nordisk A/S | A process for producing polypeptides with reduced allergenicity |
| MX9704137A (es) | 1994-12-07 | 1997-09-30 | Novo Nordisk As | Polipeptidos de alergenicidad reducida. |
| ES2169219T5 (es) | 1995-01-26 | 2009-09-01 | Novozymes A/S | Aditivos alimenticios para animales que comprenden xilanasa. |
| DE69633825T2 (de) | 1995-07-14 | 2005-11-10 | Novozymes A/S | Modifiziertes enzym mit lipolytischer aktivität |
| US6495357B1 (en) * | 1995-07-14 | 2002-12-17 | Novozyme A/S | Lipolytic enzymes |
| DE69632538T2 (de) | 1995-08-11 | 2005-05-19 | Novozymes A/S | Neuartige lipolytische enzyme |
| JP2002510963A (ja) | 1997-01-10 | 2002-04-09 | ノボザイムス アクティーゼルスカブ | スキンケア用酵素修飾体 |
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| ATE375387T1 (de) | 1997-06-25 | 2007-10-15 | Novozymes As | Modifiziertes polypeptid |
| ATE328070T1 (de) * | 1998-02-17 | 2006-06-15 | Novozymes As | Lipasevariante |
| AU3247699A (en) | 1998-02-17 | 1999-09-06 | Novo Nordisk A/S | Lipase variant |
| EP1121424A1 (en) | 1998-10-13 | 2001-08-08 | Novozymes A/S | A modified polypeptide with reduced immune response |
| DE69938435D1 (de) | 1998-10-30 | 2008-05-08 | Novozymes As | Niedrigallergene Proteinvarianten |
| ES2289824T3 (es) * | 1998-10-30 | 2008-02-01 | Novozymes A/S | Proteinas glicosiladas con alergenicidad reducida. |
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| US7312062B2 (en) * | 1998-11-27 | 2007-12-25 | Novozymes A/S | Lipolytic enzyme variants |
| CA2367355C (en) | 1999-03-17 | 2012-06-05 | Solvay Pharmaceuticals Gmbh | Medicinal product for the treatment of diabetes |
| EP1171581A1 (en) | 1999-03-31 | 2002-01-16 | Novozymes A/S | Lipase variant |
| EP2278000A1 (en) * | 1999-03-31 | 2011-01-26 | Novozymes A/S | Lipase variant |
| CA2395343C (en) | 2000-02-08 | 2009-06-30 | F. Hoffmann-La Roche Ag | Use of acid-stable proteases in animal feed |
| AU2001254623A1 (en) * | 2000-04-28 | 2001-11-12 | Novozymes A/S | Production and use of protein variants having modified immunogenicity |
| AU2002219020B2 (en) * | 2001-01-10 | 2007-05-24 | Novozymes A/S | Thermostable lipolytic enzyme variant |
| AR032392A1 (es) | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
| ATE443759T1 (de) | 2001-02-07 | 2009-10-15 | Novozymes As | Lipasevarianten |
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| EP1639107B1 (en) | 2003-06-19 | 2013-08-14 | Novozymes A/S | Improved proteases and methods for producing them |
| EP1711529A1 (en) | 2004-01-21 | 2006-10-18 | Novozymes A/S | Production of a monoclonal antibody in a heterokaryon fungus or in a fungal host cell |
| WO2005092370A1 (en) | 2004-03-22 | 2005-10-06 | Solvay Pharmaceuticals Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
| DK1809320T3 (da) | 2004-10-14 | 2010-11-15 | Cystic Fibrosis Foundation The | Præparater indeholdende lipase, protease og amylase til behandling af pankreatisk insufficiens |
| EP1851311A2 (en) | 2005-02-10 | 2007-11-07 | Novozymes A/S | Enzymatic enantioselective ester or amide hydrolysis or synthesis |
| US8017351B2 (en) | 2005-06-24 | 2011-09-13 | Novozymes A/S | Amylases for pharmaceutical use |
| MX2007015472A (es) | 2005-06-24 | 2008-04-17 | Novozymes As | Lipasas para uso farmaceutico. |
| BRPI0611936A2 (pt) | 2005-06-24 | 2011-02-22 | Solvay Pharm Gmbh | protease, uso de uma protease, composição farmacêutica, e, método para o tratamento de doença |
| WO2007080197A2 (en) * | 2006-01-16 | 2007-07-19 | Novozymes A/S | Immobilised enzymes |
| DK1979477T3 (en) * | 2006-01-23 | 2017-06-26 | Novozymes As | lipase variants |
| AR059154A1 (es) * | 2006-01-23 | 2008-03-12 | Procter & Gamble | Una composicion que comprende una lipasa y un catalizador de blanqueador |
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- 2007-12-12 JP JP2009543078A patent/JP5406040B2/ja active Active
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- 2007-12-18 TW TW096148377A patent/TW200829698A/zh unknown
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2009
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2012
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2015
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