JP2010507392A - 胎盤細胞集団で骨欠損を治療するための方法及び組成物 - Google Patents

胎盤細胞集団で骨欠損を治療するための方法及び組成物 Download PDF

Info

Publication number
JP2010507392A
JP2010507392A JP2009534633A JP2009534633A JP2010507392A JP 2010507392 A JP2010507392 A JP 2010507392A JP 2009534633 A JP2009534633 A JP 2009534633A JP 2009534633 A JP2009534633 A JP 2009534633A JP 2010507392 A JP2010507392 A JP 2010507392A
Authority
JP
Japan
Prior art keywords
cells
stem cells
placental
population
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009534633A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010507392A5 (enExample
Inventor
ダブリュー.エドインゲル ジャメス
ジェイ.ハリリ ロベルト
ワング ジア‐ルン
イエ クイアン
エス.ラバズゾ クリステン
ペレイラ マリアン
ダウン アブラムソン サスチャ
Original Assignee
アントフロゲネシス コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アントフロゲネシス コーポレーション filed Critical アントフロゲネシス コーポレーション
Publication of JP2010507392A publication Critical patent/JP2010507392A/ja
Publication of JP2010507392A5 publication Critical patent/JP2010507392A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/50Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843Connective tissue
    • A61L27/3847Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0605Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0668Mesenchymal stem cells from other natural sources
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/38Vitamins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/42Organic phosphate, e.g. beta glycerophosphate
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/38Hormones with nuclear receptors
    • C12N2501/39Steroid hormones
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C12N2506/025Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells from extra-embryonic cells, e.g. trophoblast, placenta
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/03Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/10Mineral substrates
    • C12N2533/18Calcium salts, e.g. apatite, Mineral components from bones, teeth, shells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/54Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Botany (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
JP2009534633A 2006-10-23 2007-10-23 胎盤細胞集団で骨欠損を治療するための方法及び組成物 Pending JP2010507392A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85397106P 2006-10-23 2006-10-23
US85562906P 2006-10-30 2006-10-30
US99702207P 2007-09-28 2007-09-28
PCT/US2007/022545 WO2008051568A2 (en) 2006-10-23 2007-10-23 Methods and compositions for treatment of bone defects with placental cell populations

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013110672A Division JP2013216661A (ja) 2006-10-23 2013-05-27 胎盤細胞集団で骨欠損を治療するための方法及び組成物

Publications (2)

Publication Number Publication Date
JP2010507392A true JP2010507392A (ja) 2010-03-11
JP2010507392A5 JP2010507392A5 (enExample) 2010-12-16

Family

ID=39325178

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009534633A Pending JP2010507392A (ja) 2006-10-23 2007-10-23 胎盤細胞集団で骨欠損を治療するための方法及び組成物
JP2013110672A Pending JP2013216661A (ja) 2006-10-23 2013-05-27 胎盤細胞集団で骨欠損を治療するための方法及び組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013110672A Pending JP2013216661A (ja) 2006-10-23 2013-05-27 胎盤細胞集団で骨欠損を治療するための方法及び組成物

Country Status (16)

Country Link
US (5) US8562972B2 (enExample)
EP (5) EP2084268B1 (enExample)
JP (2) JP2010507392A (enExample)
KR (1) KR20090076989A (enExample)
CN (3) CN101631852A (enExample)
AU (1) AU2007309447B2 (enExample)
CA (2) CA2667359C (enExample)
DK (1) DK2084268T3 (enExample)
ES (1) ES2709205T3 (enExample)
IL (1) IL198008A (enExample)
MX (1) MX2009004238A (enExample)
NZ (3) NZ606814A (enExample)
PL (1) PL2084268T3 (enExample)
PT (1) PT2084268T (enExample)
WO (1) WO2008051568A2 (enExample)
ZA (1) ZA200902233B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012509087A (ja) * 2008-11-19 2012-04-19 アンスロジェネシス コーポレーション 羊膜由来接着細胞
JP2013544250A (ja) * 2010-11-23 2013-12-12 エタブリスモン フランセ ドュ サン 骨吸収に付随する疾患の治療におけるhla−gアイソフォームの使用
JP2018501189A (ja) * 2014-11-19 2018-01-18 ステムバイオス テクノロジーズ,インコーポレイテッド 骨欠損を治療するための体性幹細胞

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700353B2 (en) * 1998-07-22 2010-04-20 E-P Therapeutics, Inc. Compositions and methods for inducing apoptosis in tumor cells
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
MXPA03005014A (es) * 2000-12-06 2004-09-10 Robert J Hariri Metodo para recolectar celulas madres de la placenta.
EP2316463B1 (en) 2001-02-14 2017-04-12 Anthrogenesis Corporation Tissue matrices comprising placental stem cells, and methods of making them
US7498171B2 (en) 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
BR0316695A (pt) * 2002-11-26 2005-10-18 Anthrogenesis Corp Unidade citoterapêutica, kit para tratamento, método de tratamento de uma enfermidade, biblioteca de unidades citoterapêuticas e método de tratamento de um paciente
ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
EP1738253A4 (en) * 2004-03-26 2009-07-22 Celgene Corp SYSTEMS AND METHOD FOR PROVIDING A STEM CELL BENCH
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
PL1957633T3 (pl) 2005-10-13 2014-05-30 Anthrogenesis Corp Immunomodulacja z zastosowaniem komórek macierzystych łożyska
AU2006304274B2 (en) * 2005-10-13 2012-08-16 Celularity Inc. Production of oligodendrocytes from placenta-derived stem cells
AU2006332679A1 (en) * 2005-12-29 2007-07-12 Anthrogenesis Corporation Co-culture of placental stem cells and stem cells from a second source
EP2471904B1 (en) 2005-12-29 2018-10-24 Celularity, Inc. Placental stem cell populations
CN101374941A (zh) 2005-12-29 2009-02-25 人类起源公司 采集和保存胎盘干细胞的改良组合物及其使用方法
US20090221072A1 (en) * 2006-02-15 2009-09-03 Chen Thomas T Compositions and methods for modulating cell differentiation
US20090318355A1 (en) * 2006-02-15 2009-12-24 Chen Thomas T Compositions and methods for promoting tissue repair and wound healing
US7993918B2 (en) 2006-08-04 2011-08-09 Anthrogenesis Corporation Tumor suppression using placental stem cells
CA2667359C (en) 2006-10-23 2014-07-22 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
EP2687220A3 (en) 2007-02-12 2014-05-14 Anthrogenesis Corporation Treatment of inflammatory diseases using placental stem cells
CA2677679A1 (en) 2007-02-12 2008-08-21 Anthrogenesis Corporation Hepatocytes and chondrocytes from adherent placental stem cells; and cd34+, cd45- placental stem cell-enriched cell populations
US9200253B1 (en) 2007-08-06 2015-12-01 Anthrogenesis Corporation Method of producing erythrocytes
SI2200622T2 (sl) * 2007-09-19 2015-09-30 Pluristem Ltd. Adherentne celice iz adipoznih ali placentnih tkiv in njihova uporaba pri terapiji
US20090104164A1 (en) * 2007-09-26 2009-04-23 Celgene Cellular Therapeutics Angiogenic cells from human placental perfusate
RU2536242C2 (ru) 2007-09-28 2014-12-20 Антродженезис Корпорейшн Угнетение опухолей с помощью плацентарного перфузата человека и выделенных из плаценты человека вспомогательных натуральных клеток-киллеров
KR20110050521A (ko) * 2008-08-20 2011-05-13 안트로제네시스 코포레이션 개선된 세포 조성물 및 그의 제조 방법
US8828376B2 (en) 2008-08-20 2014-09-09 Anthrogenesis Corporation Treatment of stroke using isolated placental cells
AU2009283161A1 (en) * 2008-08-22 2010-02-25 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
WO2010040262A1 (zh) * 2008-10-10 2010-04-15 深圳市嘉天源生物科技有限公司 分离动物胚胎间质性干细胞并提取其分泌物的方法
WO2011002959A1 (en) 2009-07-02 2011-01-06 Anthrogenesis Corporation Method of producing erythrocytes without feeder cells
US8926552B2 (en) * 2009-08-12 2015-01-06 Medtronic, Inc. Particle delivery
WO2011029102A2 (en) * 2009-09-07 2011-03-10 The Regents Of The University Of Colorado, A Body Corporate Cd117+cells and uses thereof
JP2013518108A (ja) * 2010-01-26 2013-05-20 アントフロゲネシス コーポレーション 胎盤幹細胞を用いる骨関連癌の治療
CA2790325A1 (en) 2010-02-18 2011-08-25 Osiris Therapeutics, Inc. Immunocompatible amniotic membrane products
CN102933703A (zh) * 2010-04-07 2013-02-13 人类起源公司 使用胎盘干细胞的血管生成
AU2011237743A1 (en) 2010-04-08 2012-11-01 Anthrogenesis Corporation Treatment of sarcoidosis using placental stem cells
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US9249392B2 (en) * 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
JP5996533B2 (ja) 2010-07-13 2016-09-21 アントフロゲネシス コーポレーション ナチュラルキラー細胞を生成させる方法
US8679474B2 (en) 2010-08-04 2014-03-25 StemBios Technologies, Inc. Somatic stem cells
CA2815097A1 (en) * 2010-10-18 2012-04-26 Sunshine Biotech Inc. Human multipotent embryonic stem cell-like progenitor cells
WO2012068378A1 (en) * 2010-11-17 2012-05-24 Wake Forest University Health Sciences Stem cell differentiation using keratin biomaterials
AU2011329839B2 (en) 2010-11-17 2016-12-08 Wake Forest University Health Sciences Keratin compositions for treatment of bone deficiency or injury
AR093183A1 (es) 2010-12-31 2015-05-27 Anthrogenesis Corp Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras
KR101395214B1 (ko) * 2011-04-18 2014-05-16 고려대학교 산학협력단 태반유래세포에 조건화된 배양 배지, 및 이를 이용한 무동물 및 무지지세포 줄기세포 배양 방법
WO2012149486A1 (en) 2011-04-28 2012-11-01 Tissuetech, Inc. Methods of modulating bone remodeling
PT2714059T (pt) * 2011-06-01 2019-02-04 Celularity Inc Tratamento da dor utilizando células estaminais da placenta
CN103796659A (zh) * 2011-07-13 2014-05-14 车比奥及戴奥斯泰有限公司 包含胶原、透明质酸衍生物和哺乳动物脐带来源干细胞的软骨细胞治疗物
US9925221B2 (en) 2011-09-09 2018-03-27 Celularity, Inc. Treatment of amyotrophic lateral sclerosis using placental stem cells
US20130309210A1 (en) * 2012-05-18 2013-11-21 Regen Biopharma, Inc Acceleration of hematopoietic reconstitution by placental endothelial and endothelial progenitor cells
EP2861238A4 (en) 2012-06-05 2016-03-16 Capricor Inc OPTIMIZED METHODS FOR GENERATING CARDIAC STEM CELLS FROM CARDIAC TISSUE AND THEIR USE IN CARDIAC THERAPY
JP6433896B2 (ja) 2012-08-13 2018-12-05 シーダーズ−サイナイ・メディカル・センターCedars−Sinai Medical Center 組織再生のためのエキソソームおよびマイクロリボ核酸
TWI687519B (zh) 2012-12-06 2020-03-11 美商幹細胞生物科技股份有限公司 Lgr5+體幹細胞
AU2014215458A1 (en) 2013-02-05 2015-08-13 Anthrogenesis Corporation Natural killer cells from placenta
CN103173405B (zh) * 2013-03-21 2017-11-07 北京京蒙高科干细胞技术有限公司 一种人胎盘成肌纤维母细胞的简易分离及鉴定方法
EP3064577B1 (en) * 2013-11-01 2020-09-09 Kyoto University Novel chondrocyte induction method
KR20210121277A (ko) * 2013-11-15 2021-10-07 안트로제네시스 코포레이션 사람 태반 관류액 세포를 포함하는 조성물, 상기 세포의 부분모집단 및 이의 용도
WO2015105356A1 (ko) * 2014-01-08 2015-07-16 사회복지법인 삼성생명공익재단 순수 영양막층으로부터 유래된 줄기세포 및 이를 포함하는 세포치료제
JP6545690B2 (ja) 2014-01-08 2019-07-17 サムスン ライフ パブリック ウェルフェア ファウンデーション 栄養膜基底層から由来した幹細胞及びそれを含む細胞治療剤
GB201406716D0 (en) * 2014-04-15 2014-05-28 Insphero Ag Method of preparing cells for 3D tissue culture
WO2015175776A1 (en) * 2014-05-14 2015-11-19 NuTech Medical, Inc. Placental membrane preparations and methods of making and using same for regenerating cartilage and spinal intervertebral discs
CA2962444C (en) 2014-10-03 2023-09-05 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
US20160159869A1 (en) * 2014-12-09 2016-06-09 Northwestern University Bmp-2-binding peptide amphiphile nanofibers
EP3297694A1 (en) 2015-05-21 2018-03-28 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
EP3302065A4 (en) * 2015-05-28 2019-04-10 Celularity, Inc. PLACENTIAL STEM CELLS FOR RECOVERING THE REGENERATIVE MOTOR, CORRECTING PROTEOMIC DEFECTS AND EXTENDING THE LIFE
US11253551B2 (en) 2016-01-11 2022-02-22 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
WO2018057542A1 (en) 2016-09-20 2018-03-29 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
EP3612191A4 (en) 2017-04-19 2020-12-30 Cedars-Sinai Medical Center METHODS AND COMPOSITIONS FOR TREATING SKELETAL MUSCLE DYSTROPHY
US12031136B2 (en) 2017-10-24 2024-07-09 Oklahoma Medical Research Foundation Treatment for skeletal diseases caused by intracellular protein trafficking defects
CN111727238B (zh) * 2017-10-27 2024-06-25 阿里斯制药有限公司 非人动物胎儿组织提取物、生产提取物的方法及其用途
EP3727351A4 (en) 2017-12-20 2021-10-06 Cedars-Sinai Medical Center MANIPULATED EXTRACELLULAR VESICLES FOR ENHANCED RELEASE INTO TISSUE
KR102413235B1 (ko) * 2017-12-22 2022-06-24 고려대학교 산학협력단 체세포에서 전능성 줄기세포로의 역분화 유도용 태반유래세포 조건화 배지 및 이를 이용한 역분화 유도 방법
CN108324993B (zh) * 2018-01-15 2020-11-03 朱剑虹 一种诱导毛发再生的干细胞复合体、其制备方法及应用
WO2019152549A1 (en) 2018-02-05 2019-08-08 Cedars-Sinai Medical Center Methods for therapeutic use of exosomes and y-rnas
US20220160787A1 (en) * 2019-03-15 2022-05-26 Celularity Inc. Placenta derived adherent cells for improved xenoplantation
CN114096289B (zh) * 2019-10-30 2023-09-01 爱恩斯生物科技(昆山)有限公司 含有骨无机质成分的复合脱钙骨组合物及其制备方法
CN115282339B (zh) * 2022-07-28 2023-02-28 四川大学 一种交联透明质酸/羟基磷灰石可注射材料、制备方法及应用
KR102739922B1 (ko) * 2024-02-22 2024-12-11 유한회사 스템메디케어 면역관용화된 태아 줄기세포 유래 세포외소포의 골관절염 치료용 약학조성물로서의 용도, 세포외소포 제조방법 및 이를 이용한 골관절염 치료용 조성물
CN118421565B (zh) * 2024-03-21 2024-11-29 中国人民解放军军事科学院军事医学研究院 重组骨软骨干细胞及其制备方法与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080822A1 (en) * 2002-03-27 2003-10-02 Nipro Corporation Placenta-origin mesenchymal cells and medicinal use thereof
JP2004528021A (ja) * 2001-02-14 2004-09-16 アンスロジェネシス コーポレーション 分娩後の哺乳動物の胎盤、その使用およびそれに由来する胎盤幹細胞
JP2006517975A (ja) * 2003-02-13 2006-08-03 アンスロジェネシス コーポレーション 疾患、障害または症状を患っている個体を治療するための臍帯血の使用

Family Cites Families (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080A (en) * 1858-04-27 Improvement in harvesters
US4798824A (en) 1985-10-03 1989-01-17 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
US5863531A (en) * 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
US5004681B1 (en) 1987-11-12 2000-04-11 Biocyte Corp Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
US5192553A (en) 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
WO1991006666A1 (en) 1989-11-06 1991-05-16 Cell Genesys, Inc. Production of proteins using homologous recombination
US5197985A (en) * 1990-11-16 1993-03-30 Caplan Arnold I Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
US5733542A (en) * 1990-11-16 1998-03-31 Haynesworth; Stephen E. Enhancing bone marrow engraftment using MSCS
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5190556A (en) 1991-03-19 1993-03-02 O.B. Tech, Inc. Cord cutter sampler
US5356373A (en) 1991-11-15 1994-10-18 Miles Inc. Method and apparatus for autologous transfusions in premature infants
US5552267A (en) 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5372581A (en) 1993-07-21 1994-12-13 Minneapolis Children's Services Corporation Method and apparatus for placental blood collection
IL107483A0 (en) 1993-11-03 1994-02-27 Yeda Res & Dev Bone marrow transplantation
US6288030B1 (en) * 1993-12-22 2001-09-11 Amgen Inc. Stem cell factor formulations and methods
US5942496A (en) 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
JPH10505250A (ja) * 1994-06-06 1998-05-26 ケース ウエスターン リザーブ ユニバーシティ 組織再生のためのバイオマトリックス
US6174333B1 (en) * 1994-06-06 2001-01-16 Osiris Therapeutics, Inc. Biomatrix for soft tissue regeneration using mesenchymal stem cells
US5516532A (en) * 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5736396A (en) * 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5716616A (en) * 1995-03-28 1998-02-10 Thomas Jefferson University Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects
US5830708A (en) 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
US5800539A (en) 1995-11-08 1998-09-01 Emory University Method of allogeneic hematopoietic stem cell transplantation without graft failure or graft vs. host disease
WO1997018298A1 (en) * 1995-11-14 1997-05-22 Regents Of The University Of Minnesota Ex vivo culture of stem cells
CA2237890C (en) * 1995-11-16 2011-03-29 Case Western Reserve University In vitro chondrogenic induction of human mesenchymal stem cells
EP2311471A3 (en) * 1996-04-19 2013-05-15 Osiris Therapeutics, Inc. Regeneration and augmentation of bone using mesenchymal stem cells
US5827740A (en) 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
US6358737B1 (en) * 1996-07-31 2002-03-19 Board Of Regents, The University Of Texas System Osteocyte cell lines
US5919702A (en) * 1996-10-23 1999-07-06 Advanced Tissue Science, Inc. Production of cartilage tissue using cells isolated from Wharton's jelly
JP4441115B2 (ja) * 1998-03-13 2010-03-31 オシリス セラピューティクス,インコーポレイテッド ヒト非自己間葉幹細胞を使用する方法と利用
US6835377B2 (en) 1998-05-13 2004-12-28 Osiris Therapeutics, Inc. Osteoarthritis cartilage regeneration
DK1082410T3 (da) * 1998-05-29 2007-11-26 Osiris Therapeutics Inc Humane CD45 - og/eller fibroblast mesenchymale stamceller
US6713245B2 (en) * 1998-07-06 2004-03-30 Diacrin, Inc. Methods for storing neural cells such that they are suitable for transplantation
DE60034045T2 (de) 1999-04-16 2007-11-22 WM. Marsh Rice University, Houston Mit Polypropylenfumarat-Diacrylat-Makromeren vernetzte biologisch abbaubare Polypropylenfumarat-Netzwerke
US6355699B1 (en) 1999-06-30 2002-03-12 Ethicon, Inc. Process for manufacturing biomedical foams
US8147824B2 (en) 1999-08-05 2012-04-03 Athersys, Inc. Immunomodulatory properties of multipotent adult progenitor cells and uses thereof
US7838289B2 (en) * 2001-02-14 2010-11-23 Abt Holding Company Assay utilizing multipotent adult stem cells
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US8075881B2 (en) * 1999-08-05 2011-12-13 Regents Of The University Of Minnesota Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure
US6685936B2 (en) * 1999-10-12 2004-02-03 Osiris Therapeutics, Inc. Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation
ATE271691T1 (de) 2000-01-12 2004-08-15 Ventana Med Syst Inc Verfahren zum nachweis der effektivität einer krebstherapie
WO2001075094A1 (en) 2000-04-04 2001-10-11 Thomas Jefferson University Application of myeloid-origin cells to the nervous system
MXPA03005014A (es) 2000-12-06 2004-09-10 Robert J Hariri Metodo para recolectar celulas madres de la placenta.
US20080152629A1 (en) * 2000-12-06 2008-06-26 James Edinger Placental stem cell populations
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
EP2316463B1 (en) * 2001-02-14 2017-04-12 Anthrogenesis Corporation Tissue matrices comprising placental stem cells, and methods of making them
CA2396536A1 (en) 2001-08-10 2003-02-10 Saiko Uchida Human stem cells originated from human amniotic mesenchymal cell layer
US20030044976A1 (en) * 2001-08-27 2003-03-06 Advanced Cell Technology De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
EP1288293A1 (en) 2001-08-30 2003-03-05 Norio Sakuragawa Human neural stem cells originated from human amniotic mesenchymal cell layer
US9969980B2 (en) 2001-09-21 2018-05-15 Garnet Biotherapeutics Cell populations which co-express CD49c and CD90
CA2468171C (en) * 2001-11-15 2015-10-06 Children's Medical Center Corporation Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof
US7799324B2 (en) 2001-12-07 2010-09-21 Geron Corporation Using undifferentiated embryonic stem cells to control the immune system
JP3934539B2 (ja) 2001-12-12 2007-06-20 独立行政法人科学技術振興機構 胎盤等由来の成体又は生後組織の前駆細胞
IL162648A0 (en) * 2001-12-21 2005-11-20 Mount Sinai Hospital Corp Cellular compositions and methods of making and using them
NZ534643A (en) * 2002-02-13 2010-06-25 Anthrogenesis Corp Embryonic-like stem cells derived from post-partum mammalian placenta and uses and methods of treatment using said cells
US7736892B2 (en) * 2002-02-25 2010-06-15 Kansas State University Research Foundation Cultures, products and methods using umbilical cord matrix cells
US20030161818A1 (en) * 2002-02-25 2003-08-28 Kansas State University Research Foundation Cultures, products and methods using stem cells
US20030187515A1 (en) 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
MXPA04009997A (es) * 2002-04-12 2004-12-13 Celgene Corp Modulacion de la diferenciacion de celulas madre y progenitoras, ensayos y usos de las mismas.
US7498171B2 (en) 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
EP1497435A4 (en) 2002-04-19 2005-07-27 Univ Pittsburgh STEM CELLS DERIVED FROM PLAZENTA AND THEIR USES
US20040161419A1 (en) * 2002-04-19 2004-08-19 Strom Stephen C. Placental stem cells and uses thereof
JP2005528105A (ja) 2002-05-30 2005-09-22 セルジーン・コーポレーション 細胞分化をモジュレートするため、並びに骨髄増殖性疾患及び骨髄異形成症候群を治療するためのjnk又はmkk阻害剤の使用方法
US7422736B2 (en) 2002-07-26 2008-09-09 Food Industry Research And Development Institute Somatic pluripotent cells
WO2004013275A2 (fr) 2002-07-31 2004-02-12 Yves Saint-Laurent Parfums Cellules souches issues de tissu adipeux et cellules differenciees issues de ces cellules
BR0316695A (pt) 2002-11-26 2005-10-18 Anthrogenesis Corp Unidade citoterapêutica, kit para tratamento, método de tratamento de uma enfermidade, biblioteca de unidades citoterapêuticas e método de tratamento de um paciente
WO2004087896A2 (en) 2003-03-31 2004-10-14 Pfizer Products Inc. Hepatocyte differentiation of stem cells
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US7510873B2 (en) * 2003-06-27 2009-03-31 Ethicon, Incorporated Postpartum cells isolated from umbilical cord tissue, and methods of making and using the same
CN1565643A (zh) * 2003-07-03 2005-01-19 中国人民解放军军事医学科学院基础医学研究所 一种基于骨髓间充质干细胞的组织工程化软骨
US7569385B2 (en) * 2003-08-14 2009-08-04 The Regents Of The University Of California Multipotent amniotic fetal stem cells
US20050089513A1 (en) * 2003-10-28 2005-04-28 Norio Sakuragawa Side population cells originated from human amnion and their uses
JP2005151907A (ja) 2003-11-27 2005-06-16 Shigeo Saito 胎盤又は羊膜由来ヒト幹細胞及びその樹立方法並びに臓器への分化誘導方法
EP1694328A4 (en) * 2003-12-02 2010-02-17 Celgene Corp METHOD AND COMPOSITIONS FOR THE TREATMENT AND SUPPLY OF HEMOGLOBINOPATHY AND ANEMIA
US20050176139A1 (en) * 2004-01-12 2005-08-11 Yao-Chang Chen Placental stem cell and methods thereof
US20050266391A1 (en) 2004-01-15 2005-12-01 Bennett Brydon L Methods for preserving tissue
EP1738253A4 (en) 2004-03-26 2009-07-22 Celgene Corp SYSTEMS AND METHOD FOR PROVIDING A STEM CELL BENCH
WO2005105992A1 (en) 2004-04-21 2005-11-10 New York Eye & Ear Infirmary Chondrocyte culture formulations
JP2006006249A (ja) * 2004-06-28 2006-01-12 Hiroshima Univ 羊膜由来細胞の培養方法及びその利用
US7244759B2 (en) * 2004-07-28 2007-07-17 Celgene Corporation Isoindoline compounds and methods of making and using the same
US20080292597A1 (en) 2004-07-29 2008-11-27 David A Steenblock Umbilical Cord Stem Cell Composition & Method of Treating Neurological Diseases
US7909806B2 (en) 2004-09-23 2011-03-22 Anthrogenesis Corporation Cord blood and placenta collection kit
US7147626B2 (en) * 2004-09-23 2006-12-12 Celgene Corporation Cord blood and placenta collection kit
US20060171930A1 (en) 2004-12-21 2006-08-03 Agnieszka Seyda Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
US20060166361A1 (en) * 2004-12-21 2006-07-27 Agnieszka Seyda Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same
AU2005322133B2 (en) 2004-12-23 2011-06-30 Ethicon Incorporated Treatment of Parkinson's disease and related disorders using postpartum derived cells
WO2006071773A2 (en) * 2004-12-23 2006-07-06 Ethicon Incoporated Treatment of osteochondral diseases using postpartum-derived cells and products thereof
US9056093B2 (en) * 2005-01-07 2015-06-16 Wake Forest University Health Sciences Regeneration of pancreatic islets by amniotic fluid stem cell therapy
AU2006202209B2 (en) * 2005-05-27 2011-04-14 Lifescan, Inc. Amniotic fluid derived cells
KR20080031735A (ko) * 2005-06-10 2008-04-10 셀진 코포레이션 인간 태반 콜라겐 조성물, 그의 제조 방법, 그의 사용 방법및 상기 조성물을 포함하는 키트
JP2008544818A (ja) * 2005-06-30 2008-12-11 アントフロゲネシス コーポレーション 胎盤由来コラーゲンバイオ線維を用いた鼓膜の修復
EP1919500A2 (en) * 2005-07-13 2008-05-14 Anthrogenesis Corporation Treatment of leg ulcers using placenta derived collagen biofabric
US20070021762A1 (en) * 2005-07-13 2007-01-25 Qing Liu Ocular plug formed from placenta derived collagen biofabric
WO2007011693A2 (en) * 2005-07-14 2007-01-25 Medistem Laboratories, Inc. Compositions of placentally-derived stem cells for the treatment of cancer
WO2007024441A2 (en) 2005-08-19 2007-03-01 Bio Regenerate, Inc. Compositions of cells enriched for combinations of various stem and progenitor cell populations, methods of use thereof and methods of private banking thereof
AU2006304274B2 (en) * 2005-10-13 2012-08-16 Celularity Inc. Production of oligodendrocytes from placenta-derived stem cells
PL1957633T3 (pl) * 2005-10-13 2014-05-30 Anthrogenesis Corp Immunomodulacja z zastosowaniem komórek macierzystych łożyska
JP5289970B2 (ja) 2005-12-16 2013-09-11 エシコン・インコーポレイテッド 組織適合性不適合な移植における逆免疫反応を抑制するための組成物および方法
US8741638B2 (en) * 2005-12-19 2014-06-03 DePuy Synthes Products, LLC In vitro expansion of postpartum-derived cells in roller bottles
US8278102B2 (en) 2005-12-22 2012-10-02 Jane Ennis Viable cells from frozen umbilical cord tissue
ES2628129T3 (es) * 2005-12-28 2017-08-01 DePuy Synthes Products, Inc. Tratamiento de la enfermedad vascular periférica utilizando células derivadas del posparto
CN101374941A (zh) 2005-12-29 2009-02-25 人类起源公司 采集和保存胎盘干细胞的改良组合物及其使用方法
EP2471904B1 (en) * 2005-12-29 2018-10-24 Celularity, Inc. Placental stem cell populations
AU2006332679A1 (en) 2005-12-29 2007-07-12 Anthrogenesis Corporation Co-culture of placental stem cells and stem cells from a second source
US20070253931A1 (en) 2006-01-12 2007-11-01 Osiris Therapeutics, Inc. Use of mesenchymal stem cells for treating genetic diseases and disorders
NZ744465A (en) 2006-01-23 2023-04-28 Abt Holding Co Mapc therapeutics without adjunctive immunosuppressive treatment
EP1845154A1 (en) 2006-04-12 2007-10-17 RNL Bio Co., Ltd. Multipotent stem cells derived from placenta tissue and cellular therapeutic agents comprising the same
JP2009539378A (ja) * 2006-06-09 2009-11-19 アントフロゲネシス コーポレーション 胎盤環境及び幹細胞を培養するためのその使用
US20070287176A1 (en) 2006-06-13 2007-12-13 Alireza Rezania Chorionic villus derived cells
US7993918B2 (en) 2006-08-04 2011-08-09 Anthrogenesis Corporation Tumor suppression using placental stem cells
US8105634B2 (en) * 2006-08-15 2012-01-31 Anthrogenesis Corporation Umbilical cord biomaterial for medical use
US8122763B2 (en) * 2006-09-01 2012-02-28 Avair, Llc Breathing gas supply visual broadcast apparatus
WO2008042441A1 (en) * 2006-10-03 2008-04-10 Anthrogenesis Corporation Use of umbilical cord biomaterial for ocular surgery
US8071135B2 (en) * 2006-10-04 2011-12-06 Anthrogenesis Corporation Placental tissue compositions
KR101595108B1 (ko) * 2006-10-06 2016-02-18 안트로제네시스 코포레이션 천연(텔로펩티드) 태반 콜라겐 조성물
CA2667359C (en) 2006-10-23 2014-07-22 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
EP2687220A3 (en) 2007-02-12 2014-05-14 Anthrogenesis Corporation Treatment of inflammatory diseases using placental stem cells
CA2677679A1 (en) 2007-02-12 2008-08-21 Anthrogenesis Corporation Hepatocytes and chondrocytes from adherent placental stem cells; and cd34+, cd45- placental stem cell-enriched cell populations
US9200253B1 (en) 2007-08-06 2015-12-01 Anthrogenesis Corporation Method of producing erythrocytes
US20090104164A1 (en) * 2007-09-26 2009-04-23 Celgene Cellular Therapeutics Angiogenic cells from human placental perfusate
RU2536242C2 (ru) 2007-09-28 2014-12-20 Антродженезис Корпорейшн Угнетение опухолей с помощью плацентарного перфузата человека и выделенных из плаценты человека вспомогательных натуральных клеток-киллеров
WO2009061447A2 (en) * 2007-11-07 2009-05-14 Anthrogenesis Corporation Treatment of premature birth complications
US8828376B2 (en) * 2008-08-20 2014-09-09 Anthrogenesis Corporation Treatment of stroke using isolated placental cells
KR20110050521A (ko) * 2008-08-20 2011-05-13 안트로제네시스 코포레이션 개선된 세포 조성물 및 그의 제조 방법
AU2009283161A1 (en) * 2008-08-22 2010-02-25 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
WO2010059828A1 (en) * 2008-11-19 2010-05-27 Anthrogenesis Corporation Amnion derived adherent cells
RU2570550C2 (ru) * 2008-11-21 2015-12-10 Антродженезис Корпорейшн Лечение заболеваний, расстройств или патологических состояний легких с использованием плацентарных клеток
JP5481177B2 (ja) 2008-12-09 2014-04-23 富士フイルム株式会社 アゾ顔料、アゾ顔料の製造方法、アゾ顔料を含む分散物、及び着色組成物
WO2011002959A1 (en) 2009-07-02 2011-01-06 Anthrogenesis Corporation Method of producing erythrocytes without feeder cells
JP5996533B2 (ja) 2010-07-13 2016-09-21 アントフロゲネシス コーポレーション ナチュラルキラー細胞を生成させる方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004528021A (ja) * 2001-02-14 2004-09-16 アンスロジェネシス コーポレーション 分娩後の哺乳動物の胎盤、その使用およびそれに由来する胎盤幹細胞
WO2003080822A1 (en) * 2002-03-27 2003-10-02 Nipro Corporation Placenta-origin mesenchymal cells and medicinal use thereof
JP2006517975A (ja) * 2003-02-13 2006-08-03 アンスロジェネシス コーポレーション 疾患、障害または症状を患っている個体を治療するための臍帯血の使用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HUMAN CELL, JPN6012057898, August 2006 (2006-08-01), pages 18, ISSN: 0002376332 *
REPRODUCTION, vol. 130, JPN6013061286, 2005, pages 529 - 537, ISSN: 0002702675 *
STEM CELLS DEVELOP., vol. 15, JPN6012057896, 2006, pages 507 - 522, ISSN: 0002376331 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012509087A (ja) * 2008-11-19 2012-04-19 アンスロジェネシス コーポレーション 羊膜由来接着細胞
JP2013544250A (ja) * 2010-11-23 2013-12-12 エタブリスモン フランセ ドュ サン 骨吸収に付随する疾患の治療におけるhla−gアイソフォームの使用
JP2018501189A (ja) * 2014-11-19 2018-01-18 ステムバイオス テクノロジーズ,インコーポレイテッド 骨欠損を治療するための体性幹細胞

Also Published As

Publication number Publication date
EP2084268B1 (en) 2018-09-26
US9339520B2 (en) 2016-05-17
CN103255098A (zh) 2013-08-21
EP2420567A2 (en) 2012-02-22
NZ576194A (en) 2012-02-24
NZ606814A (en) 2014-10-31
CA2667359C (en) 2014-07-22
AU2007309447B2 (en) 2014-04-03
CA2667359A1 (en) 2008-05-02
DK2084268T3 (en) 2019-01-21
CA2850793A1 (en) 2008-05-02
ZA200902233B (en) 2010-07-28
PT2084268T (pt) 2019-01-28
NZ595854A (en) 2013-04-26
US20170056452A1 (en) 2017-03-02
WO2008051568A2 (en) 2008-05-02
EP2420568A2 (en) 2012-02-22
JP2013216661A (ja) 2013-10-24
IL198008A0 (en) 2011-08-01
US20080213228A1 (en) 2008-09-04
US10105399B2 (en) 2018-10-23
ES2709205T3 (es) 2019-04-15
US20220096564A1 (en) 2022-03-31
IL198008A (en) 2013-03-24
EP3483263A1 (en) 2019-05-15
EP2420567A3 (en) 2015-09-30
US20190262406A1 (en) 2019-08-29
AU2007309447A1 (en) 2008-05-02
KR20090076989A (ko) 2009-07-13
PL2084268T3 (pl) 2019-08-30
EP2418271A3 (en) 2015-09-30
EP2084268A2 (en) 2009-08-05
MX2009004238A (es) 2009-05-14
US20140017211A1 (en) 2014-01-16
CN101631852A (zh) 2010-01-20
EP2420568A3 (en) 2015-09-30
EP2418271A2 (en) 2012-02-15
US8562972B2 (en) 2013-10-22
CN104099290A (zh) 2014-10-15
WO2008051568A3 (en) 2008-07-24
WO2008051568A9 (en) 2008-09-12

Similar Documents

Publication Publication Date Title
US20220096564A1 (en) Methods and compositions for treatment of bone defects with placental cell populations
JP5550235B2 (ja) 胎盤幹細胞集団
HK40006584A (en) Methods and compositions for treatment of bone defects with placental cell populations
HK1139707A (en) Methods and compositions for treatment of bone defects with placental cell populations
HK1166515A (en) Methods and compositions for treatment of bone defects with placental cell populations
HK1167159A (en) Methods and compositions for treatment of bone defects with placental cell populations
HK1166997A (en) Methods and compositions for treatment of bone defects with placental cell populations
AU2014201880A1 (en) Methods and compositions for treatment of bone defects with placental cell populations
HK1129422B (en) Placental stem cell populations
HK1129422A (en) Placental stem cell populations
HK1184817B (en) Placental stem cell populations

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101022

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20101022

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121127

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130225

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130304

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130527

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131217

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140312

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140319

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140617

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20141202

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20150512