|
CA2377468C
(en)
*
|
1999-07-27 |
2010-04-20 |
Phylos, Inc. |
Peptide acceptor ligation methods
|
|
EP1257695B1
(en)
|
2000-01-11 |
2007-03-07 |
Nanogen Recognomics GmbH |
Biomolecules having multiple attachment moieties for binding to a substrate surface
|
|
EP1268769A2
(de)
*
|
2000-03-31 |
2003-01-02 |
Memorec Stoffel GmbH Medizinisch-Molekulare Entwicklung |
Verfahren zur extraktion von nukleinsäuren
|
|
US6962781B1
(en)
*
|
2000-05-19 |
2005-11-08 |
Proteonova, Inc. |
In vitro evolution of nucleic acids and encoded polypeptide
|
|
US7410761B2
(en)
*
|
2000-05-19 |
2008-08-12 |
Proteonova, Inc. |
System for rapid identification and selection of nucleic acids and polypeptides, and method thereof
|
|
US20040229271A1
(en)
|
2000-05-19 |
2004-11-18 |
Williams Richard B. |
Compositions and methods for the identification and selection of nucleic acids and polypeptides
|
|
WO2003044194A1
(en)
*
|
2001-11-16 |
2003-05-30 |
Proteonova, Inc. |
Selection and evolution of nucleic acids and polypeptides
|
|
EP1309730B1
(en)
*
|
2000-08-11 |
2008-11-26 |
Nanogen Recognomics GmbH |
New hydrazide building blocks and hydrazide modified biomolecules
|
|
US7129229B2
(en)
|
2000-08-11 |
2006-10-31 |
Nanogen Recognomics Gmbh |
Hydrazide building blocks and hydrazide modified biomolecules
|
|
JP4963142B2
(ja)
*
|
2000-12-14 |
2012-06-27 |
学校法人慶應義塾 |
遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法
|
|
EP1401850A1
(en)
|
2001-06-20 |
2004-03-31 |
Nuevolution A/S |
Nucleoside derivatives for library preparation
|
|
US20060234231A1
(en)
*
|
2001-06-20 |
2006-10-19 |
Nuevolution A/S |
Microarrays displaying encoded molecules
|
|
US6893822B2
(en)
|
2001-07-19 |
2005-05-17 |
Nanogen Recognomics Gmbh |
Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
|
|
CA2456105A1
(en)
*
|
2001-07-31 |
2003-02-13 |
Phylos, Inc. |
Modular assembly of nucleic acid-protein fusion multimers
|
|
DE10147074A1
(de)
*
|
2001-09-25 |
2003-05-08 |
Beru Ag |
Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung
|
|
US7125669B2
(en)
|
2001-11-27 |
2006-10-24 |
Compound Therapeutics, Inc. |
Solid-phase immobilization of proteins and peptides
|
|
DE20200926U1
(de)
*
|
2002-01-23 |
2002-04-18 |
Hegenscheidt-MFD GmbH & Co. KG, 41812 Erkelenz |
Festwalzgerät einer Festwalzmaschine für Kurbelwellen
|
|
NZ535144A
(en)
*
|
2002-03-15 |
2006-03-31 |
Nuevolution As |
An improved method for synthesising templated molecules
|
|
WO2003078627A2
(en)
*
|
2002-03-15 |
2003-09-25 |
Nuevolution A/S |
A building block capable of functional entity transfer to nucleophil
|
|
US20050221318A1
(en)
*
|
2002-03-15 |
2005-10-06 |
Gouliaev Alex H |
Building block forming a c-c bond upon reaction
|
|
US20050247001A1
(en)
*
|
2002-03-15 |
2005-11-10 |
Nuevolution A/S |
Building block forming a c-c or a c-hetero atom bond uponreaction
|
|
WO2004013070A2
(en)
|
2002-08-01 |
2004-02-12 |
Nuevolution A/S |
Multi-step synthesis of templated molecules
|
|
US20040058886A1
(en)
*
|
2002-08-08 |
2004-03-25 |
Dharmacon, Inc. |
Short interfering RNAs having a hairpin structure containing a non-nucleotide loop
|
|
CA2544153C
(en)
*
|
2002-10-30 |
2020-02-25 |
Nuevolution A/S |
Method for the synthesis of a bifunctional complex
|
|
AU2003291964A1
(en)
|
2002-12-19 |
2004-07-14 |
Nuevolution A/S |
Quasirandom structure and function guided synthesis methods
|
|
WO2004074429A2
(en)
|
2003-02-21 |
2004-09-02 |
Nuevolution A/S |
Method for producing second-generation library
|
|
EP1597394A2
(en)
*
|
2003-02-21 |
2005-11-23 |
Nuevolution A/S |
A method for obtaining structural information about an encoded molecule
|
|
DK2236606T3
(da)
*
|
2003-03-20 |
2014-02-10 |
Nuevolution As |
Kodning af små molekyler ved ligering
|
|
WO2004110964A2
(en)
*
|
2003-06-16 |
2004-12-23 |
Nuevolution A/S |
Encoded molecules by translation (emt)
|
|
US20050095627A1
(en)
*
|
2003-09-03 |
2005-05-05 |
The Salk Institute For Biological Studies |
Multiple antigen detection assays and reagents
|
|
WO2005026387A1
(en)
|
2003-09-18 |
2005-03-24 |
Nuevolution A/S |
A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
|
|
CN1906307B
(zh)
*
|
2003-11-20 |
2011-08-24 |
圣诺菲·帕斯图尔公司 |
纯化百日咳毒素的方法及其中有用的肽
|
|
RU2402567C2
(ru)
|
2003-12-05 |
2010-10-27 |
Бристоль-Майерз Сквибб Компани |
Ингибиторы рецепторов фактора роста эндотелия сосудов типа 2
|
|
CA2548465A1
(en)
*
|
2003-12-12 |
2005-08-11 |
Proteonova, Inc. |
System and methods for nucleic acid and polypeptide selection
|
|
WO2005078122A2
(en)
*
|
2004-02-17 |
2005-08-25 |
Nuevolution A/S |
Method for enrichment involving elimination by mismatch hybridisation
|
|
WO2005090566A2
(en)
*
|
2004-03-22 |
2005-09-29 |
Nuevolution A/S |
Ligational encoding using building block oligonucleotides
|
|
CA2467321A1
(en)
*
|
2004-05-14 |
2005-11-14 |
Paul J. Santerre |
Polymeric coupling agents and pharmaceutically-active polymers made therefrom
|
|
US8445413B2
(en)
|
2004-10-15 |
2013-05-21 |
National Institute Of Advanced Industrial Science And Technology |
Linker for constructing mRNA-puromycin-protein conjugate
|
|
US10206998B2
(en)
|
2005-01-12 |
2019-02-19 |
Proteonova, Inc. |
Modular targeted therapeutic agents and methods of making same
|
|
JP2008526973A
(ja)
|
2005-01-12 |
2008-07-24 |
プロテオノヴァ、 インコーポレイテッド |
標的治療薬を作製する方法
|
|
ES2547554T3
(es)
|
2005-11-16 |
2015-10-07 |
Ambrx, Inc. |
Métodos y composiciones que comprenden aminoácidos no naturales
|
|
ES2901551T3
(es)
|
2005-12-01 |
2022-03-22 |
Nuevolution As |
Métodos de codificación enzimática para la síntesis eficiente de bibliotecas grandes
|
|
US7749957B2
(en)
|
2006-04-06 |
2010-07-06 |
E.I. Du Pont De Nemours And Company |
Clay-binding peptides and methods of use
|
|
AU2007325838B2
(en)
|
2006-11-22 |
2013-09-19 |
Bristol-Myers Squibb Company |
Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR
|
|
US9080256B2
(en)
|
2007-02-12 |
2015-07-14 |
Proteonova, Inc. |
Generation of library of soluble random polypeptides linked to mRNA
|
|
US7829311B2
(en)
|
2007-07-25 |
2010-11-09 |
E.I. Du Pont De Nemours And Company |
Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate
|
|
US7951559B2
(en)
*
|
2007-07-25 |
2011-05-31 |
E.I. Du Pont De Nemours And Company |
Recombinant peptide production using a cross-linkable solubility tag
|
|
US7678883B2
(en)
|
2007-07-25 |
2010-03-16 |
E.I. Du Pont De Nemours And Company |
Solubility tags for the expression and purification of bioactive peptides
|
|
US7794963B2
(en)
|
2007-11-02 |
2010-09-14 |
E.I. Du Pont De Nemours And Company |
Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins
|
|
NZ585702A
(en)
|
2007-11-30 |
2013-08-30 |
Abbott Lab |
Protein formulations and methods of making same
|
|
US8883146B2
(en)
|
2007-11-30 |
2014-11-11 |
Abbvie Inc. |
Protein formulations and methods of making same
|
|
MX2010008874A
(es)
|
2008-02-14 |
2010-09-22 |
Bristol Myers Squibb Co |
Terapeuticos dirigidos a base de proteinas manipuladas que se unen al receptor de factor de crecimiento epidermico.
|
|
US9296810B2
(en)
|
2008-05-02 |
2016-03-29 |
Novartis Ag |
Fibronectin-based binding molecules and uses thereof
|
|
CN102076851A
(zh)
*
|
2008-05-02 |
2011-05-25 |
Epi中心科技公司 |
Rna的选择性的5′连接标记
|
|
EP2291399B1
(en)
|
2008-05-22 |
2014-06-25 |
Bristol-Myers Squibb Company |
Multivalent fibronectin based scaffold domain proteins
|
|
WO2010011944A2
(en)
|
2008-07-25 |
2010-01-28 |
Wagner Richard W |
Protein screeing methods
|
|
EP2342562B1
(en)
*
|
2008-09-30 |
2013-09-18 |
AbbVie Inc. |
Improved method of rna display
|
|
TWI496582B
(zh)
|
2008-11-24 |
2015-08-21 |
必治妥美雅史谷比公司 |
雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子
|
|
US20100158846A1
(en)
*
|
2008-12-18 |
2010-06-24 |
E. I. Du Pont De Nemours And Company |
Hair-binding peptides
|
|
US20100158837A1
(en)
|
2008-12-18 |
2010-06-24 |
E. I. Du Pont De Nemours And Company |
Iron oxide-binding peptides
|
|
US20100158822A1
(en)
|
2008-12-18 |
2010-06-24 |
E .I. Du Pont De Nemours And Company |
Peptides that bind to silica-coated particles
|
|
US8287845B2
(en)
*
|
2008-12-18 |
2012-10-16 |
E I Du Pont De Nemours And Company |
Hair-binding peptides
|
|
BRPI1014677A2
(pt)
*
|
2009-03-30 |
2016-04-12 |
Du Pont |
sistemas baseados em peptídeos para distribuição de agentes cosméticos
|
|
US8481678B2
(en)
|
2009-03-30 |
2013-07-09 |
E I Du Pont De Nemours And Company |
Peptide-based tooth whitening reagents
|
|
JP5733784B2
(ja)
*
|
2009-09-24 |
2015-06-10 |
国立大学法人埼玉大学 |
ｃＤＮＡ／ｍＲＮＡ−タンパク質連結体の効率的合成法
|
|
WO2011051327A2
(en)
|
2009-10-30 |
2011-05-05 |
Novartis Ag |
Small antibody-like single chain proteins
|
|
WO2011051466A1
(en)
|
2009-11-02 |
2011-05-05 |
Novartis Ag |
Anti-idiotypic fibronectin-based binding molecules and uses thereof
|
|
WO2011092233A1
(en)
|
2010-01-29 |
2011-08-04 |
Novartis Ag |
Yeast mating to produce high-affinity combinations of fibronectin-based binders
|
|
IN2012DN06588A
(enExample)
|
2010-02-10 |
2015-10-23 |
Novartis Ag |
|
|
HUE030724T2
(en)
*
|
2010-04-09 |
2017-06-28 |
Univ Utrecht Holding Bv |
Recombinant multimer influenza proteins
|
|
CA2832672A1
(en)
|
2010-04-16 |
2011-10-20 |
Nuevolution A/S |
Bi-functional complexes and methods for making and using such complexes
|
|
TW201138808A
(en)
|
2010-05-03 |
2011-11-16 |
Bristol Myers Squibb Co |
Serum albumin binding molecules
|
|
ES2573108T3
(es)
|
2010-05-26 |
2016-06-06 |
Bristol-Myers Squibb Company |
Proteínas de armazón a base de fibronectina que tienen estabilidad mejorada
|
|
AU2011283646B2
(en)
|
2010-07-30 |
2015-07-09 |
Novartis Ag |
Fibronectin cradle molecules and libraries thereof
|
|
DE102010056289A1
(de)
|
2010-12-24 |
2012-06-28 |
Geneart Ag |
Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
|
|
ES2873375T3
(es)
|
2011-03-15 |
2021-11-03 |
X Body Inc |
Métodos de cribado de anticuerpos
|
|
SI3418380T1
(sl)
|
2011-04-28 |
2022-10-28 |
The Board Of Trustees Of The Leland Stanford Junior University |
Identifikacija polinukleotidov, povezanih z vzorcem
|
|
US9422550B2
(en)
|
2011-08-01 |
2016-08-23 |
The General Hospital Corporation |
Protein and peptide libraries
|
|
DK2771022T3
(da)
|
2011-10-11 |
2020-09-28 |
Viela Bio Inc |
Cd40l-specifikke tn3-afledte skeletter (scaffolds) og fremgangsmåder til anvendelse deraf
|
|
CA2857721C
(en)
|
2011-12-05 |
2022-05-31 |
X-Body, Inc. |
Pdgf receptor beta binding polypeptides
|
|
WO2014142020A1
(ja)
*
|
2013-03-13 |
2014-09-18 |
国立大学法人東京大学 |
核酸リンカー
|
|
SG11201510312RA
(en)
|
2013-06-28 |
2016-01-28 |
X Body Inc |
Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes
|
|
CN103382579B
(zh)
*
|
2013-07-06 |
2015-10-21 |
中国科学院成都生物研究所 |
一种体外筛选多肽的方法
|
|
CN105705947B
(zh)
|
2013-09-23 |
2019-04-02 |
X博迪公司 |
用于生成对抗细胞表面抗原的结合剂的方法和组合物
|
|
WO2015101516A1
(en)
*
|
2013-12-31 |
2015-07-09 |
F. Hoffmann-La Roche Ag |
Enrichment of full-length oligonucleotides via transcription/translation-mediated purification
|
|
WO2015120058A2
(en)
|
2014-02-05 |
2015-08-13 |
Molecular Templates, Inc. |
Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
|
|
KR102472862B1
(ko)
|
2014-03-20 |
2022-12-05 |
브리스톨-마이어스 스큅 컴퍼니 |
혈청 알부민-결합 피브로넥틴 유형 iii 도메인
|
|
JP6478392B2
(ja)
*
|
2014-12-26 |
2019-03-06 |
国立研究開発法人産業技術総合研究所 |
核酸リンカー
|
|
US10683340B2
(en)
|
2015-03-12 |
2020-06-16 |
Medimmune, Llc |
Method of purifying albumin-fusion proteins
|
|
EP3353199B1
(en)
|
2015-09-23 |
2020-02-19 |
Bristol-Myers Squibb Company |
Fast-off rate serum albumin binding fibronectin type iii domains
|
|
CN119574873A
(zh)
|
2016-05-02 |
2025-03-07 |
Encodia公司 |
采用核酸编码的大分子分析
|
|
CA3027951A1
(en)
|
2016-06-15 |
2017-12-21 |
Genecapture, Inc. |
Compositions, methods and devices comprising stem-loop captor molecules
|
|
MA45491A
(fr)
|
2016-06-27 |
2019-05-01 |
Juno Therapeutics Inc |
Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
|
|
WO2018005559A1
(en)
|
2016-06-27 |
2018-01-04 |
Juno Therapeutics, Inc. |
Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
|
|
EP3604326B1
(en)
|
2017-03-21 |
2026-01-07 |
FUJIFILM Corporation |
Peptide compound and method for producing same, composition for screening use, and method for selecting peptide compound
|
|
CN112272703B
(zh)
|
2017-10-31 |
2024-12-27 |
Encodia公司 |
采用核酸编码和/或标签进行分析的试剂盒
|
|
SG11202003664TA
(en)
|
2017-11-30 |
2020-05-28 |
Arrakis Therapeutics Inc |
Nucleic acid-binding photoprobes and uses thereof
|
|
US20210113457A1
(en)
|
2018-02-02 |
2021-04-22 |
Ripple Therapeutics Corporation |
Glass formulations and uses thereof
|
|
TWI830718B
(zh)
*
|
2018-02-09 |
2024-02-01 |
日商住友化學股份有限公司 |
核酸分子之製造方法
|
|
US20210115485A1
(en)
*
|
2018-03-30 |
2021-04-22 |
Sumitomo Chemical Company, Limited |
Method for producing single-strand rna
|
|
WO2019236644A1
(en)
*
|
2018-06-05 |
2019-12-12 |
Arrakis Therapeutics, Inc. |
Encoded libraries and methods of use for screening nucleic acid targets
|
|
WO2020154815A1
(en)
|
2019-02-01 |
2020-08-06 |
Ripple Therapeutics Corporation |
Crystalline forms of dexamethasone dimers and uses thereof
|
|
US12509469B2
(en)
|
2019-08-07 |
2025-12-30 |
Ripple Therapeutics Corporation |
Compositions and methods for the treatment of pain and dependence disorders
|
|
CN115956083A
(zh)
|
2020-05-01 |
2023-04-11 |
波纹疗法公司 |
异二聚体组合物及用于治疗眼部病症的方法
|