JP2015504869A5 - - Google Patents
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- Publication number
- JP2015504869A5 JP2015504869A5 JP2014547433A JP2014547433A JP2015504869A5 JP 2015504869 A5 JP2015504869 A5 JP 2015504869A5 JP 2014547433 A JP2014547433 A JP 2014547433A JP 2014547433 A JP2014547433 A JP 2014547433A JP 2015504869 A5 JP2015504869 A5 JP 2015504869A5
- Authority
- JP
- Japan
- Prior art keywords
- cell binding
- binding agent
- mixture
- agent
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940127089 cytotoxic agent Drugs 0.000 claims 26
- 239000002254 cytotoxic agent Substances 0.000 claims 26
- 239000000203 mixture Substances 0.000 claims 24
- 239000011230 binding agent Substances 0.000 claims 23
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims 15
- 231100000599 cytotoxic agent Toxicity 0.000 claims 15
- 238000000034 method Methods 0.000 claims 11
- 238000005377 adsorption chromatography Methods 0.000 claims 8
- 230000001588 bifunctional effect Effects 0.000 claims 4
- 238000009295 crossflow filtration Methods 0.000 claims 4
- 238000001914 filtration Methods 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 238000001556 precipitation Methods 0.000 claims 4
- 238000001179 sorption measurement Methods 0.000 claims 4
- 239000003431 cross linking reagent Substances 0.000 claims 3
- 239000006227 byproduct Substances 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 231100000433 cytotoxic Toxicity 0.000 claims 2
- 230000001472 cytotoxic effect Effects 0.000 claims 2
- 239000004971 Cross linker Substances 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161570139P | 2011-12-13 | 2011-12-13 | |
| US61/570,139 | 2011-12-13 | ||
| PCT/US2012/069527 WO2013090590A1 (en) | 2011-12-13 | 2012-12-13 | Use of n-hydroxysuccinimide to improve conjugate stability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015504869A JP2015504869A (ja) | 2015-02-16 |
| JP2015504869A5 true JP2015504869A5 (enExample) | 2016-01-28 |
Family
ID=48613179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547433A Pending JP2015504869A (ja) | 2011-12-13 | 2012-12-13 | 複合体安定性を改善するためのｎ−ヒドロキシスクシンイミドの使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20140350228A1 (enExample) |
| EP (1) | EP2790724A4 (enExample) |
| JP (1) | JP2015504869A (enExample) |
| KR (1) | KR20140107418A (enExample) |
| CN (1) | CN104093425A (enExample) |
| AU (1) | AU2012352210A1 (enExample) |
| BR (1) | BR112014014464A2 (enExample) |
| CA (1) | CA2859444A1 (enExample) |
| EA (1) | EA201491173A1 (enExample) |
| HK (1) | HK1203364A1 (enExample) |
| IL (1) | IL233086A0 (enExample) |
| MX (1) | MX2014007125A (enExample) |
| SG (2) | SG10201604747WA (enExample) |
| WO (1) | WO2013090590A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101267841B (zh) | 2005-08-24 | 2012-10-10 | 免疫原公司 | 制备美登木素生物碱抗体缀合物的方法 |
| SG10201810743WA (en) | 2009-06-03 | 2018-12-28 | Immunogen Inc | Conjugation methods |
| MX339927B (es) | 2011-03-29 | 2016-06-16 | Immunogen Inc | Preparacion de conjugados de maitansinoides y anticuerpos mediante un proceso de una etapa. |
| SG11201502429YA (en) | 2012-10-04 | 2015-04-29 | Immunogen Inc | Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates |
| WO2014202775A1 (en) * | 2013-06-21 | 2014-12-24 | Innate Pharma | Enzymatic conjugation of polypeptides |
| CN106267225B (zh) * | 2015-05-29 | 2020-03-06 | 上海新理念生物医药科技有限公司 | 三马来酰亚胺型连接子及其应用 |
| WO2017178828A1 (en) | 2016-04-14 | 2017-10-19 | Polytherics Limited | Conjugates and conjugating reagents comprising a linker that includes at least two (-ch2-ch2-0-) units in a ring |
| GB201615725D0 (en) | 2016-09-15 | 2016-11-02 | Polytherics Ltd | Novel cytotoxic agents and conjugates thereof |
| CN113336823A (zh) * | 2021-05-28 | 2021-09-03 | 联宁（苏州）生物制药有限公司 | 一种用于抗体偶联药物连接子lnd1067的合成方法 |
| WO2025151380A1 (en) * | 2024-01-08 | 2025-07-17 | Azvlz, Inc. | Functionalized conjugation crosslinkers and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2835829B1 (fr) * | 2002-02-13 | 2007-09-14 | Centre Nat Rech Scient | Nouveau procede de preparation de biopuces a adn ou a proteines et leurs applications |
| DE10242076A1 (de) * | 2002-09-11 | 2004-03-25 | Fresenius Kabi Deutschland Gmbh | HAS-Allergen-Konjugate |
| CN101267841B (zh) * | 2005-08-24 | 2012-10-10 | 免疫原公司 | 制备美登木素生物碱抗体缀合物的方法 |
| WO2007059195A1 (en) * | 2005-11-14 | 2007-05-24 | University Of Southern California | Integrin-binding small molecules |
| ES2435779T3 (es) * | 2007-07-19 | 2013-12-23 | Sanofi | Agentes citotóxicos que comprenden nuevos derivados de tomaimicina y su uso terapéutico |
| CN105198908B (zh) * | 2009-02-05 | 2019-12-24 | 伊缪诺金公司 | 新型苯并二氮杂*衍生物 |
| SG10201810743WA (en) * | 2009-06-03 | 2018-12-28 | Immunogen Inc | Conjugation methods |
-
2012
- 2012-12-13 CN CN201280068773.2A patent/CN104093425A/zh active Pending
- 2012-12-13 HK HK15103864.0A patent/HK1203364A1/xx unknown
- 2012-12-13 WO PCT/US2012/069527 patent/WO2013090590A1/en not_active Ceased
- 2012-12-13 EA EA201491173A patent/EA201491173A1/ru unknown
- 2012-12-13 AU AU2012352210A patent/AU2012352210A1/en not_active Abandoned
- 2012-12-13 SG SG10201604747WA patent/SG10201604747WA/en unknown
- 2012-12-13 BR BR112014014464A patent/BR112014014464A2/pt not_active IP Right Cessation
- 2012-12-13 CA CA 2859444 patent/CA2859444A1/en not_active Abandoned
- 2012-12-13 MX MX2014007125A patent/MX2014007125A/es unknown
- 2012-12-13 SG SG11201403179QA patent/SG11201403179QA/en unknown
- 2012-12-13 KR KR20147019143A patent/KR20140107418A/ko not_active Withdrawn
- 2012-12-13 JP JP2014547433A patent/JP2015504869A/ja active Pending
- 2012-12-13 US US14/365,305 patent/US20140350228A1/en not_active Abandoned
- 2012-12-13 EP EP12856692.4A patent/EP2790724A4/en not_active Withdrawn
-
2014
- 2014-06-12 IL IL233086A patent/IL233086A0/en unknown
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