JP2018510864A5 - - Google Patents
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- JP2018510864A5 JP2018510864A5 JP2017547459A JP2017547459A JP2018510864A5 JP 2018510864 A5 JP2018510864 A5 JP 2018510864A5 JP 2017547459 A JP2017547459 A JP 2017547459A JP 2017547459 A JP2017547459 A JP 2017547459A JP 2018510864 A5 JP2018510864 A5 JP 2018510864A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acids
- antibody
- terminal extension
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562130673P | 2015-03-10 | 2015-03-10 | |
| US62/130,673 | 2015-03-10 | ||
| PCT/US2016/020192 WO2016144608A1 (en) | 2015-03-10 | 2016-03-01 | Antibodies conjugatable by transglutaminase and conjugates made therefrom |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018510864A JP2018510864A (ja) | 2018-04-19 |
| JP2018510864A5 true JP2018510864A5 (enExample) | 2019-04-11 |
Family
ID=55538626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547459A Pending JP2018510864A (ja) | 2015-03-10 | 2016-03-01 | トランスグルタミナーゼによって結合可能な抗体およびそれによって製造される結合体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10676773B2 (enExample) |
| EP (1) | EP3268048B1 (enExample) |
| JP (1) | JP2018510864A (enExample) |
| CN (1) | CN107406496A (enExample) |
| ES (1) | ES2736106T3 (enExample) |
| WO (1) | WO2016144608A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3419670A2 (en) | 2016-02-26 | 2019-01-02 | Regeneron Pharmaceuticals, Inc. | Optimized transglutaminase site-specific antibody conjugation |
| EP3272864A1 (en) | 2016-07-20 | 2018-01-24 | Paul Scherrer Institut | Solid-phase immobilization of microbial transglutaminase mtg on microbeads for protein conjugation |
| US10398783B2 (en) | 2016-10-20 | 2019-09-03 | Bristol-Myers Squibb Company | Antiproliferative compounds and conjugates made therefrom |
| US10457681B2 (en) | 2017-08-16 | 2019-10-29 | Bristol_Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor |
| US10494370B2 (en) | 2017-08-16 | 2019-12-03 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor |
| US10508115B2 (en) | 2017-08-16 | 2019-12-17 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor |
| US10487084B2 (en) | 2017-08-16 | 2019-11-26 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor |
| US10472361B2 (en) | 2017-08-16 | 2019-11-12 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor |
| AU2018337671B2 (en) | 2017-09-19 | 2021-03-04 | Paul Scherrer Institut | Transglutaminase conjugation method and linker |
| WO2019209811A1 (en) | 2018-04-24 | 2019-10-31 | Bristol-Myers Squibb Company | Macrocyclic toll-like receptor 7 (tlr7) agonists |
| JP7458997B2 (ja) | 2018-05-29 | 2024-04-01 | ブリストル－マイヤーズ スクイブ カンパニー | プロドラッグおよび複合体に使用する修飾自己切断部分ならびにその使用方法および製造方法 |
| US11554120B2 (en) | 2018-08-03 | 2023-01-17 | Bristol-Myers Squibb Company | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor |
| DK3886914T3 (da) * | 2018-11-30 | 2023-07-03 | Bristol Myers Squibb Co | Antistof omfattende en glutaminholdig letkæde-c-terminal forlængelse, konjugater deraf og fremgangsmåder samt anvendelser |
| WO2020123425A2 (en) | 2018-12-12 | 2020-06-18 | Bristol-Myers Squibb Company | Antibodies modified for transglutaminase conjugation, conjugates thereof, and methods and uses |
| CN113613679A (zh) | 2019-03-19 | 2021-11-05 | 保罗·谢勒学院 | 基于甘氨酸的接头的转谷氨酰胺酶缀合方法 |
| HRP20240979T1 (hr) | 2020-05-19 | 2024-10-25 | Les Laboratoires Servier | Para-amino-benzil povezivači, postupak njihove pripreme i njihova upotreba u konjugatima |
| EP4213886A1 (en) | 2020-09-18 | 2023-07-26 | Araris Biotech AG | Transglutaminase conjugation method with amino acid-based linkers |
| JP7789396B2 (ja) | 2020-10-25 | 2025-12-22 | アラリス バイオテック アーゲー | 抗体－リンカーコンジュゲートを生成するための手段および方法 |
| EP4410830A4 (en) * | 2021-09-30 | 2026-07-08 | Ajinomoto Kk | CONJUGATE OF ANTIBODY AND FUNCTIONAL SUBSTANCE OR ITS SALT, DERIVATIVE OF ANTIBODY AND COMPOUND OR ITS SALTS FOR USE IN THE PRODUCTION OF A CONJUGATE OR ITS SALT |
| EP4422695A1 (en) | 2021-10-25 | 2024-09-04 | Araris Biotech AG | Methods for producing antibody-linker conjugates |
| KR20240150807A (ko) | 2022-02-22 | 2024-10-16 | 아라리스 바이오테크 아게 | 2개 이상의 페이로드를 포함하는 펩티드 링커 |
| US20230408497A1 (en) * | 2022-06-20 | 2023-12-21 | Sysmex Corporation | Labeled polypeptide, modified polypeptide, production method for these polypeptides, reagent containing these polypeptides, and measurement method for target substance |
| WO2025082990A1 (en) | 2023-10-15 | 2025-04-24 | Araris Biotech Ag | Antibody-drug conjugates using two different types of topoisomerase i inhibitors |
| US20250282776A1 (en) | 2024-03-05 | 2025-09-11 | Bristol-Myers Squibb Company | Bicyclic TLR7 Agonists and Uses Thereof |
| WO2025188694A1 (en) | 2024-03-05 | 2025-09-12 | Bristol-Myers Squibb Company | Tricyclic tlr7 agonists and uses thereof |
| WO2026013234A1 (en) | 2024-07-10 | 2026-01-15 | Araris Biotech Ag | Triple-payload antibody-drug conjugates (adcs) |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| EP0725145A4 (en) | 1994-08-23 | 1997-06-11 | Drug Delivery System Inst Ltd | PROTEIN MODIFICATION PROCESS |
| JPH11513391A (ja) | 1995-10-03 | 1999-11-16 | ザ スクリップス リサーチ インスティテュート | Ｃｃ−１０６５ 及びズオカーマイシンのｃｂｉ 類縁体 |
| WO2000043492A2 (en) | 1999-01-22 | 2000-07-27 | Smithkline Beecham Corporation | Method of site specific labeling of proteins and uses therefor |
| JP4118462B2 (ja) | 1999-07-19 | 2008-07-16 | 株式会社リコー | 携帯電子機器 |
| CA2476166C (en) * | 2002-02-14 | 2011-11-15 | Immunomedics, Inc. | Anti-cd20 antibodies and fusion proteins thereof and methods of use |
| KR20060080535A (ko) | 2003-05-14 | 2006-07-10 | 이뮤노젠 아이엔씨 | 약물 콘쥬게이트 조성물 |
| WO2004106939A2 (en) | 2003-06-03 | 2004-12-09 | Paul Scherrer Institut | Method for the linkage of bifunctional chelating agents and (radioactive) transition metal complexes to proteins and peptides |
| ES2605443T3 (es) | 2003-11-06 | 2017-03-14 | Seattle Genetics, Inc. | Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia |
| US7778814B2 (en) | 2004-03-30 | 2010-08-17 | Siemens Aktiengesellschaft | Method and device for simulating an automation system |
| WO2007038868A2 (en) | 2005-10-03 | 2007-04-12 | The University Of British Columbia | Novel enediyne compound and uses thereof |
| PE20080316A1 (es) | 2006-05-25 | 2008-04-10 | Bristol Myers Squibb Co | Compuestos de aziridinil-epotilona |
| AR062448A1 (es) | 2006-05-25 | 2008-11-12 | Endocyte Inc | Conjugados de analogos de aziridinil-epotilona y composiciones farmaceuticas que comprenden los mismos |
| US20100150950A1 (en) | 2006-12-14 | 2010-06-17 | Medarex, Inc. | Human antibodies that bind cd70 and uses thereof |
| TWI412367B (zh) | 2006-12-28 | 2013-10-21 | 梅達雷克斯有限責任公司 | 化學鏈接劑與可裂解基質以及其之綴合物 |
| EP2185188B1 (en) | 2007-08-22 | 2014-08-06 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions |
| HRP20150074T1 (hr) | 2007-10-01 | 2015-03-13 | Bristol-Myers Squibb Company | Humana antitijela koja se vežu za mezotelin i njihove uporabe |
| US20110184147A1 (en) | 2008-07-04 | 2011-07-28 | Kyushu University, National University Corporation | Enzyme substrate for labeling of protein |
| US8394922B2 (en) | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
| MX368648B (es) | 2010-04-15 | 2019-10-09 | Seattle Genetics Inc | Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas. |
| CN103068405A (zh) | 2010-04-15 | 2013-04-24 | 西雅图基因公司 | 靶向吡咯并苯并二氮杂卓结合物 |
| CA2813411C (en) * | 2010-11-05 | 2016-08-02 | Rinat Neuroscience Corporation | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| US9399641B2 (en) | 2011-09-20 | 2016-07-26 | Medimmune Limited | Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates |
| BR112014013526A8 (pt) * | 2011-12-05 | 2017-06-13 | Igenica Biotherapeutics Inc | conjugados de anticorpo-fármaco e compostos, composições e métodos relacionados |
| CA2858806A1 (en) | 2011-12-23 | 2013-06-27 | Innate Pharma | Enzymatic conjugation of polypeptides |
| PL2814829T3 (pl) | 2012-02-13 | 2017-06-30 | Bristol-Myers Squibb Company | Związki enediyny, ich koniugaty oraz zastosowanie i sposoby ich wytwarzania |
| CN104363919A (zh) * | 2012-06-01 | 2015-02-18 | Ibc药品公司 | 具有改进的体内稳定性、药物代谢动力学和功效的多聚体复合物 |
| KR20150058236A (ko) * | 2012-08-20 | 2015-05-28 | 글리크닉 인코포레이티드 | 항원 결합 및 다가 fc 감마 수용체 결합 활성을 가진 분자 |
| MX340090B (es) * | 2012-11-05 | 2016-06-23 | Pfizer | Analogos de spliceostatina. |
| EP2916872B1 (en) | 2012-11-09 | 2019-02-27 | Innate Pharma | Recognition tags for tgase-mediated conjugation |
| DK2956173T3 (en) | 2013-02-14 | 2017-07-17 | Bristol Myers Squibb Co | TUBULYSIS RELATIONSHIPS, METHODS OF PRODUCING AND USING THEREOF |
| WO2014202773A1 (en) | 2013-06-20 | 2014-12-24 | Innate Pharma | Enzymatic conjugation of polypeptides |
| KR20160042871A (ko) | 2013-06-21 | 2016-04-20 | 이나뜨 파르마, 에스.아. | 폴리펩티드의 효소적 콘쥬게이션 |
-
2016
- 2016-03-01 ES ES16710382T patent/ES2736106T3/es active Active
- 2016-03-01 CN CN201680014722.XA patent/CN107406496A/zh active Pending
- 2016-03-01 WO PCT/US2016/020192 patent/WO2016144608A1/en not_active Ceased
- 2016-03-01 JP JP2017547459A patent/JP2018510864A/ja active Pending
- 2016-03-01 US US15/555,594 patent/US10676773B2/en active Active
- 2016-03-01 EP EP16710382.9A patent/EP3268048B1/en active Active
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