JP2018510864A5 - - Google Patents
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- JP2018510864A5 JP2018510864A5 JP2017547459A JP2017547459A JP2018510864A5 JP 2018510864 A5 JP2018510864 A5 JP 2018510864A5 JP 2017547459 A JP2017547459 A JP 2017547459A JP 2017547459 A JP2017547459 A JP 2017547459A JP 2018510864 A5 JP2018510864 A5 JP 2018510864A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acids
- antibody
- terminal extension
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562130673P | 2015-03-10 | 2015-03-10 | |
| US62/130,673 | 2015-03-10 | ||
| PCT/US2016/020192 WO2016144608A1 (en) | 2015-03-10 | 2016-03-01 | Antibodies conjugatable by transglutaminase and conjugates made therefrom |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018510864A JP2018510864A (ja) | 2018-04-19 |
| JP2018510864A5 true JP2018510864A5 (enExample) | 2019-04-11 |
Family
ID=55538626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547459A Pending JP2018510864A (ja) | 2015-03-10 | 2016-03-01 | トランスグルタミナーゼによって結合可能な抗体およびそれによって製造される結合体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10676773B2 (enExample) |
| EP (1) | EP3268048B1 (enExample) |
| JP (1) | JP2018510864A (enExample) |
| CN (1) | CN107406496A (enExample) |
| ES (1) | ES2736106T3 (enExample) |
| WO (1) | WO2016144608A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11786603B2 (en) | 2016-02-26 | 2023-10-17 | Regeneron Pharmaceuticals, Inc. | Optimized transglutaminase site-specific antibody conjugation |
| EP3272864A1 (en) | 2016-07-20 | 2018-01-24 | Paul Scherrer Institut | Solid-phase immobilization of microbial transglutaminase mtg on microbeads for protein conjugation |
| WO2018075842A1 (en) | 2016-10-20 | 2018-04-26 | Bristol-Myers Squibb Company | Condensed benzodiazepine derivatives and conjugates made therefrom |
| US10487084B2 (en) | 2017-08-16 | 2019-11-26 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor |
| US10508115B2 (en) | 2017-08-16 | 2019-12-17 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor |
| US10494370B2 (en) | 2017-08-16 | 2019-12-03 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor |
| US10472361B2 (en) | 2017-08-16 | 2019-11-12 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor |
| US10457681B2 (en) | 2017-08-16 | 2019-10-29 | Bristol_Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor |
| CA3177215A1 (en) | 2017-09-19 | 2019-03-28 | Daiichi Sankyo Company, Limited | Antibody-pyrrolobenzodiazepine derivative conjugate |
| WO2019209811A1 (en) | 2018-04-24 | 2019-10-31 | Bristol-Myers Squibb Company | Macrocyclic toll-like receptor 7 (tlr7) agonists |
| SG11202011739SA (en) | 2018-05-29 | 2020-12-30 | Bristol Myers Squibb Co | Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making |
| US11554120B2 (en) | 2018-08-03 | 2023-01-17 | Bristol-Myers Squibb Company | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor |
| KR102861586B1 (ko) * | 2018-11-30 | 2025-09-17 | 브리스톨-마이어스 스큅 컴퍼니 | 글루타민-함유 경쇄 c-말단 연장부를 포함하는 항체, 그의 접합체, 및 방법 및 용도 |
| JP7514836B2 (ja) * | 2018-12-12 | 2024-07-11 | ブリストル－マイヤーズ スクイブ カンパニー | トランスグルタミナーゼによるコンジュゲーションのための改変抗体、ならびにそのコンジュゲート、方法および用途 |
| KR20220144753A (ko) | 2019-03-19 | 2022-10-27 | 폴 슈레 앙스띠뛰 | 글리신 기반 링커를 사용한 트랜스글루타미나제 컨쥬게이션 방법 |
| CA3183613A1 (en) | 2020-05-19 | 2021-11-25 | Les Laboratoires Servier | Para-amino-benzyl linkers, process for their preparation and their use in conjugates |
| KR20230069211A (ko) * | 2020-09-18 | 2023-05-18 | 아라리스 바이오테크 아게 | 아미노산-기반 링커를 사용한 트란스글루타미나제 접합 방법 |
| WO2022084560A1 (en) | 2020-10-25 | 2022-04-28 | Araris Biotech Ag | Means and methods for producing antibody-linker conjugates |
| KR20240073035A (ko) * | 2021-09-30 | 2024-05-24 | 아지노모토 가부시키가이샤 | 항체 및 기능성 물질의 컨쥬게이트 또는 그 염, 및 그 제조에 사용되는 항체 유도체 및 화합물 또는 그 염 |
| EP4422695A1 (en) | 2021-10-25 | 2024-09-04 | Araris Biotech AG | Methods for producing antibody-linker conjugates |
| CN118742328A (zh) | 2022-02-22 | 2024-10-01 | 阿拉里斯生物技术股份公司 | 包含两个或更多个有效载荷的肽接头 |
| US20230408497A1 (en) * | 2022-06-20 | 2023-12-21 | Sysmex Corporation | Labeled polypeptide, modified polypeptide, production method for these polypeptides, reagent containing these polypeptides, and measurement method for target substance |
| WO2025082990A1 (en) | 2023-10-15 | 2025-04-24 | Araris Biotech Ag | Antibody-drug conjugates using two different types of topoisomerase i inhibitors |
| WO2025188694A1 (en) | 2024-03-05 | 2025-09-12 | Bristol-Myers Squibb Company | Tricyclic tlr7 agonists and uses thereof |
| WO2025188693A1 (en) | 2024-03-05 | 2025-09-12 | Bristol-Myers Squibb Company | Bicyclic tlr7 agonists and uses thereof |
| WO2026013234A1 (en) | 2024-07-10 | 2026-01-15 | Araris Biotech Ag | Triple-payload antibody-drug conjugates (adcs) |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| CA2155762C (en) | 1994-08-23 | 2000-04-25 | Haruya Sato | Protein modification method |
| NZ321172A (en) | 1995-10-03 | 2000-02-28 | Scripps Research Inst | CBI analogs of CC-1065 and the duocarmycins |
| EP1151299A4 (en) | 1999-01-22 | 2003-06-04 | Smithkline Beecham Corp | PROCESS OF LOCATION-SPECIFIC MARKING OF PROTEINS AND APPLICATIONS |
| JP4118462B2 (ja) | 1999-07-19 | 2008-07-16 | 株式会社リコー | 携帯電子機器 |
| RU2004127458A (ru) * | 2002-02-14 | 2005-10-27 | Иммуномедикс, Инк. (Us) | Анти-cd20 антитела, их гибридные белки и способы их использования |
| US7374762B2 (en) | 2003-05-14 | 2008-05-20 | Immunogen, Inc. | Drug conjugate composition |
| US20070184537A1 (en) | 2003-06-03 | 2007-08-09 | Paul Scherrer Institut | Method for the linkage of bifunctional chelating agents and (radioactive) transition metal complexes to proteins and peptides |
| EP3434275A1 (en) | 2003-11-06 | 2019-01-30 | Seattle Genetics, Inc. | Assay for cancer cells based on the use of auristatin conjugates with antibodies |
| US7778814B2 (en) | 2004-03-30 | 2010-08-17 | Siemens Aktiengesellschaft | Method and device for simulating an automation system |
| WO2007038868A2 (en) | 2005-10-03 | 2007-04-12 | The University Of British Columbia | Novel enediyne compound and uses thereof |
| PE20080316A1 (es) | 2006-05-25 | 2008-04-10 | Bristol Myers Squibb Co | Compuestos de aziridinil-epotilona |
| PE20080102A1 (es) | 2006-05-25 | 2008-02-11 | Bristol Myers Squibb Co | Conjugados de analogos de aziridinil-epotilona y composiciones farmaceuticas que comprenden los mismos |
| AU2007333098A1 (en) | 2006-12-14 | 2008-06-19 | Medarex, Inc. | Human antibodies that bind CD70 and uses thereof |
| TWI412367B (zh) | 2006-12-28 | 2013-10-21 | 梅達雷克斯有限責任公司 | 化學鏈接劑與可裂解基質以及其之綴合物 |
| EP2185188B1 (en) | 2007-08-22 | 2014-08-06 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions |
| SI2195017T1 (sl) | 2007-10-01 | 2015-01-30 | Bristol-Myers Squibb Company | Človeška protitelesa, ki vežejo mezotelin in njihova uporaba |
| WO2010002042A1 (ja) | 2008-07-04 | 2010-01-07 | 国立大学法人 九州大学 | タンパク質ラベル化用酵素基質 |
| US8394922B2 (en) | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
| JP5870400B2 (ja) | 2010-04-15 | 2016-03-01 | シアトル ジェネティクス，インコーポレーテッド | 標的化ピロロベンゾジアゼピンコンジュゲート |
| ES2623057T3 (es) | 2010-04-15 | 2017-07-10 | Medimmune Limited | Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas |
| CA2930801C (en) * | 2010-11-05 | 2019-05-28 | Rinat Neuroscience Corporation | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| SG11201400770SA (en) | 2011-09-20 | 2014-04-28 | Spirogen Sarl | Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates |
| AU2012348017A1 (en) * | 2011-12-05 | 2014-07-03 | Igenica Biotherapeutics, Inc. | Antibody-drug conjugates and related compounds, compositions, and methods |
| AU2012356894B2 (en) | 2011-12-23 | 2018-01-18 | Araris Biotech Ltd. | Enzymatic conjugation of polypeptides |
| SMT201700137T1 (it) | 2012-02-13 | 2017-05-08 | Bristol Myers Squibb Co | Composti di endiini, loro coniugati, e loro usi e metodi |
| ES2672974T3 (es) * | 2012-06-01 | 2018-06-19 | Ibc Pharmaceuticals, Inc. | Complejos multiméricos con estabilidad in vivo, farmacocinética y eficacia mejoradas |
| KR20150058236A (ko) * | 2012-08-20 | 2015-05-28 | 글리크닉 인코포레이티드 | 항원 결합 및 다가 fc 감마 수용체 결합 활성을 가진 분자 |
| ES2656298T3 (es) * | 2012-11-05 | 2018-02-26 | Pfizer Inc. | Análogos de ayustoestatina |
| EP2916872B1 (en) | 2012-11-09 | 2019-02-27 | Innate Pharma | Recognition tags for tgase-mediated conjugation |
| LT2956173T (lt) | 2013-02-14 | 2017-06-26 | Bristol-Myers Squibb Company | Tubulizino junginiai, gavimo ir panaudojimo būdai |
| WO2014202773A1 (en) | 2013-06-20 | 2014-12-24 | Innate Pharma | Enzymatic conjugation of polypeptides |
| JP6744212B2 (ja) | 2013-06-21 | 2020-08-19 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | ポリペプチドの酵素的結合 |
-
2016
- 2016-03-01 ES ES16710382T patent/ES2736106T3/es active Active
- 2016-03-01 CN CN201680014722.XA patent/CN107406496A/zh active Pending
- 2016-03-01 WO PCT/US2016/020192 patent/WO2016144608A1/en not_active Ceased
- 2016-03-01 EP EP16710382.9A patent/EP3268048B1/en active Active
- 2016-03-01 US US15/555,594 patent/US10676773B2/en active Active
- 2016-03-01 JP JP2017547459A patent/JP2018510864A/ja active Pending
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