JP2018510864A5 - - Google Patents
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- JP2018510864A5 JP2018510864A5 JP2017547459A JP2017547459A JP2018510864A5 JP 2018510864 A5 JP2018510864 A5 JP 2018510864A5 JP 2017547459 A JP2017547459 A JP 2017547459A JP 2017547459 A JP2017547459 A JP 2017547459A JP 2018510864 A5 JP2018510864 A5 JP 2018510864A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acids
- antibody
- terminal extension
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 23
- 150000001413 amino acids Chemical class 0.000 claims 20
- 210000004899 c-terminal region Anatomy 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 150000001412 amines Chemical class 0.000 claims 8
- 239000000611 antibody drug conjugate Substances 0.000 claims 8
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 125000000524 functional group Chemical group 0.000 claims 7
- 125000003277 amino group Chemical group 0.000 claims 4
- 108060008539 Transglutaminase Proteins 0.000 claims 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- 102000003601 transglutaminase Human genes 0.000 claims 2
- 239000000562 conjugate Substances 0.000 claims 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562130673P | 2015-03-10 | 2015-03-10 | |
| US62/130,673 | 2015-03-10 | ||
| PCT/US2016/020192 WO2016144608A1 (en) | 2015-03-10 | 2016-03-01 | Antibodies conjugatable by transglutaminase and conjugates made therefrom |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018510864A JP2018510864A (ja) | 2018-04-19 |
| JP2018510864A5 true JP2018510864A5 (enExample) | 2019-04-11 |
Family
ID=55538626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547459A Pending JP2018510864A (ja) | 2015-03-10 | 2016-03-01 | トランスグルタミナーゼによって結合可能な抗体およびそれによって製造される結合体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10676773B2 (enExample) |
| EP (1) | EP3268048B1 (enExample) |
| JP (1) | JP2018510864A (enExample) |
| CN (1) | CN107406496A (enExample) |
| ES (1) | ES2736106T3 (enExample) |
| WO (1) | WO2016144608A1 (enExample) |
Families Citing this family (25)
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|---|---|---|---|---|
| EP3419670A2 (en) * | 2016-02-26 | 2019-01-02 | Regeneron Pharmaceuticals, Inc. | Optimized transglutaminase site-specific antibody conjugation |
| EP3272864A1 (en) | 2016-07-20 | 2018-01-24 | Paul Scherrer Institut | Solid-phase immobilization of microbial transglutaminase mtg on microbeads for protein conjugation |
| WO2018075842A1 (en) | 2016-10-20 | 2018-04-26 | Bristol-Myers Squibb Company | Condensed benzodiazepine derivatives and conjugates made therefrom |
| US10508115B2 (en) | 2017-08-16 | 2019-12-17 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor |
| US10487084B2 (en) | 2017-08-16 | 2019-11-26 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor |
| US10494370B2 (en) | 2017-08-16 | 2019-12-03 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor |
| US10472361B2 (en) | 2017-08-16 | 2019-11-12 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor |
| US10457681B2 (en) | 2017-08-16 | 2019-10-29 | Bristol_Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor |
| NZ762376A (en) | 2017-09-19 | 2022-08-26 | Scherrer Inst Paul | Transglutaminase conjugation method and linker |
| WO2019209811A1 (en) | 2018-04-24 | 2019-10-31 | Bristol-Myers Squibb Company | Macrocyclic toll-like receptor 7 (tlr7) agonists |
| SG11202011739SA (en) | 2018-05-29 | 2020-12-30 | Bristol Myers Squibb Co | Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making |
| US11554120B2 (en) | 2018-08-03 | 2023-01-17 | Bristol-Myers Squibb Company | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor |
| WO2020112588A1 (en) | 2018-11-30 | 2020-06-04 | Bristol-Myers Squibb Company | Antibody comprising a glutamine-containing light chain c-terminal extension, conjugates thereof, and methods and uses |
| US12478686B2 (en) | 2018-12-12 | 2025-11-25 | Bristol-Myers Squibb Company | Antibodies modified for transglutaminase conjugation, conjugates thereof, and methods and uses |
| JP7629902B2 (ja) | 2019-03-19 | 2025-02-14 | パウル・シェラー・インスティトゥート | グリシンベースリンカーを用いたトランスグルタミナーゼコンジュゲーション法 |
| MA65766B1 (fr) | 2020-05-19 | 2024-06-28 | Les Laboratoires Servier | Lieurs para-amino-benzyliques, leur procédé de préparation et leur utilisation dans des conjugués |
| CN116406302A (zh) | 2020-09-18 | 2023-07-07 | 阿拉里斯生物技术股份公司 | 用基于氨基酸的接头的谷氨酰胺转胺酶缀合方法 |
| AU2021366341A1 (en) | 2020-10-25 | 2023-06-22 | Araris Biotech Ag | Means and methods for producing antibody-linker conjugates |
| EP4410830A1 (en) * | 2021-09-30 | 2024-08-07 | Ajinomoto Co., Inc. | Conjugate of antibody and functional substance or salt thereof, and antibody derivative and compound or salts thereof to be used in producing conjugate or salt thereof |
| JP2024539989A (ja) | 2021-10-25 | 2024-10-31 | アラリス バイオテック アーゲー | 抗体－リンカーコンジュゲートを生成する方法 |
| CN118742328A (zh) | 2022-02-22 | 2024-10-01 | 阿拉里斯生物技术股份公司 | 包含两个或更多个有效载荷的肽接头 |
| US20230408497A1 (en) * | 2022-06-20 | 2023-12-21 | Sysmex Corporation | Labeled polypeptide, modified polypeptide, production method for these polypeptides, reagent containing these polypeptides, and measurement method for target substance |
| WO2025082990A1 (en) | 2023-10-15 | 2025-04-24 | Araris Biotech Ag | Antibody-drug conjugates using two different types of topoisomerase i inhibitors |
| WO2025188693A1 (en) | 2024-03-05 | 2025-09-12 | Bristol-Myers Squibb Company | Bicyclic tlr7 agonists and uses thereof |
| WO2025188694A1 (en) | 2024-03-05 | 2025-09-12 | Bristol-Myers Squibb Company | Tricyclic tlr7 agonists and uses thereof |
Family Cites Families (34)
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|---|---|---|---|---|
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| EP0725145A4 (en) | 1994-08-23 | 1997-06-11 | Drug Delivery System Inst Ltd | PROTEIN MODIFICATION PROCESS |
| US6548530B1 (en) | 1995-10-03 | 2003-04-15 | The Scripps Research Institute | CBI analogs of CC-1065 and the duocarmycins |
| WO2000043492A2 (en) | 1999-01-22 | 2000-07-27 | Smithkline Beecham Corporation | Method of site specific labeling of proteins and uses therefor |
| JP4118462B2 (ja) | 1999-07-19 | 2008-07-16 | 株式会社リコー | 携帯電子機器 |
| EP2295468B1 (en) * | 2002-02-14 | 2015-07-08 | Immunomedics, Inc. | Anti-CD20 antibodies and fusion proteins thereof and methods of use |
| CN1816356A (zh) | 2003-05-14 | 2006-08-09 | 免疫原公司 | 药物缀合物组合物 |
| US20070184537A1 (en) | 2003-06-03 | 2007-08-09 | Paul Scherrer Institut | Method for the linkage of bifunctional chelating agents and (radioactive) transition metal complexes to proteins and peptides |
| BR122018071808B8 (pt) | 2003-11-06 | 2020-06-30 | Seattle Genetics Inc | conjugado |
| US7778814B2 (en) | 2004-03-30 | 2010-08-17 | Siemens Aktiengesellschaft | Method and device for simulating an automation system |
| WO2007038868A2 (en) | 2005-10-03 | 2007-04-12 | The University Of British Columbia | Novel enediyne compound and uses thereof |
| PE20080102A1 (es) | 2006-05-25 | 2008-02-11 | Bristol Myers Squibb Co | Conjugados de analogos de aziridinil-epotilona y composiciones farmaceuticas que comprenden los mismos |
| AR061181A1 (es) | 2006-05-25 | 2008-08-13 | Bristol Myers Squibb Co | Compuestos de aziridinil-epotilona |
| IN2009KN02404A (enExample) | 2006-12-14 | 2015-08-07 | Medarex Inc | |
| TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
| US8865875B2 (en) | 2007-08-22 | 2014-10-21 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions |
| AU2008308956B2 (en) | 2007-10-01 | 2013-03-14 | Bristol-Myers Squibb Company | Human antibodies that bind mesothelin, and uses thereof |
| JPWO2010002042A1 (ja) | 2008-07-04 | 2011-12-22 | 国立大学法人九州大学 | タンパク質ラベル化用酵素基質 |
| US8394922B2 (en) | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
| NZ602932A (en) | 2010-04-15 | 2014-08-29 | Seattle Genetics Inc | Targeted pyrrolobenzodiazapine conjugates |
| MX368648B (es) | 2010-04-15 | 2019-10-09 | Seattle Genetics Inc | Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas. |
| US9676871B2 (en) | 2010-11-05 | 2017-06-13 | Pfizer Inc. | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| MX341524B (es) | 2011-09-20 | 2016-08-24 | Medimmune Ltd | Pirrolobenzodiazepinas como compuestos pbd dimericos asimetricos para inclusion en conjugados dirigidos. |
| WO2013085925A1 (en) * | 2011-12-05 | 2013-06-13 | Igenica, Inc. | Antibody-drug conjugates and related compounds, compositions, and methods |
| EP2793949B1 (en) | 2011-12-23 | 2018-08-22 | Innate Pharma | Enzymatic conjugation of antibodies |
| TW201336851A (zh) | 2012-02-13 | 2013-09-16 | 必治妥美雅史谷比公司 | 烯二炔化合物，其共軛物及彼等之用途與方法 |
| EP2854845B1 (en) * | 2012-06-01 | 2018-03-28 | IBC Pharmaceuticals, Inc. | Multimeric complexes with improved in vivo stability, pharmacokinetics and efficacy |
| KR20150058236A (ko) * | 2012-08-20 | 2015-05-28 | 글리크닉 인코포레이티드 | 항원 결합 및 다가 fc 감마 수용체 결합 활성을 가진 분자 |
| KR101762047B1 (ko) * | 2012-11-05 | 2017-07-27 | 화이자 인코포레이티드 | 스플라이세오스타틴 유사체 |
| EP2916872B1 (en) | 2012-11-09 | 2019-02-27 | Innate Pharma | Recognition tags for tgase-mediated conjugation |
| HUE033626T2 (en) | 2013-02-14 | 2017-12-28 | Bristol Myers Squibb Co | Tubulysin compounds, methods of preparation and use |
| WO2014202773A1 (en) | 2013-06-20 | 2014-12-24 | Innate Pharma | Enzymatic conjugation of polypeptides |
| CA2914189C (en) | 2013-06-21 | 2023-03-14 | Innate Pharma | Enzymatic conjugation of polypeptides |
-
2016
- 2016-03-01 ES ES16710382T patent/ES2736106T3/es active Active
- 2016-03-01 CN CN201680014722.XA patent/CN107406496A/zh active Pending
- 2016-03-01 JP JP2017547459A patent/JP2018510864A/ja active Pending
- 2016-03-01 WO PCT/US2016/020192 patent/WO2016144608A1/en not_active Ceased
- 2016-03-01 US US15/555,594 patent/US10676773B2/en active Active
- 2016-03-01 EP EP16710382.9A patent/EP3268048B1/en active Active