JP2016539190A5 - - Google Patents
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- Publication number
- JP2016539190A5 JP2016539190A5 JP2016554939A JP2016554939A JP2016539190A5 JP 2016539190 A5 JP2016539190 A5 JP 2016539190A5 JP 2016554939 A JP2016554939 A JP 2016554939A JP 2016554939 A JP2016554939 A JP 2016554939A JP 2016539190 A5 JP2016539190 A5 JP 2016539190A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- formula
- group
- heteroarylene
- alkenylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 35
- 229920001184 polypeptide Polymers 0.000 claims description 32
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 32
- 125000004450 alkenylene group Chemical group 0.000 claims description 11
- 125000002947 alkylene group Chemical group 0.000 claims description 11
- 125000004419 alkynylene group Chemical group 0.000 claims description 11
- 125000002993 cycloalkylene group Chemical group 0.000 claims description 10
- 125000005647 linker group Chemical group 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 239000000412 dendrimer Substances 0.000 claims description 6
- 125000005549 heteroarylene group Chemical group 0.000 claims description 6
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims description 6
- SUNMBRGCANLOEG-UHFFFAOYSA-N 1,3-dichloroacetone Chemical group ClCC(=O)CCl SUNMBRGCANLOEG-UHFFFAOYSA-N 0.000 claims description 4
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims description 4
- 150000001412 amines Chemical class 0.000 claims description 4
- -1 carboxy-substituted aniline Chemical group 0.000 claims description 4
- 239000003638 chemical reducing agent Substances 0.000 claims description 4
- 229920000736 dendritic polymer Polymers 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
- 235000001014 amino acid Nutrition 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 239000012062 aqueous buffer Substances 0.000 claims description 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine Substances NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 2
- 229920000587 hyperbranched polymer Polymers 0.000 claims description 2
- 150000002576 ketones Chemical class 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 2
- 150000003003 phosphines Chemical class 0.000 claims description 2
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims description 2
- 125000006850 spacer group Chemical group 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- 239000011593 sulfur Substances 0.000 claims description 2
- 125000004434 sulfur atom Chemical group 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 2
- 229960005486 vaccine Drugs 0.000 claims description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 150000002923 oximes Chemical class 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361909236P | 2013-11-26 | 2013-11-26 | |
| US61/909,236 | 2013-11-26 | ||
| US201462002614P | 2014-05-23 | 2014-05-23 | |
| US62/002,614 | 2014-05-23 | ||
| PCT/IB2014/066300 WO2015079376A1 (en) | 2013-11-26 | 2014-11-24 | Methods for oxime conjugation to ketone-modified polypeptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016539190A JP2016539190A (ja) | 2016-12-15 |
| JP2016539190A5 true JP2016539190A5 (enExample) | 2018-01-18 |
| JP6609563B2 JP6609563B2 (ja) | 2019-11-20 |
Family
ID=52117931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016554939A Expired - Fee Related JP6609563B2 (ja) | 2013-11-26 | 2014-11-24 | ケトンで修飾されたポリペプチドをオキシム複合化する方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10172948B2 (enExample) |
| EP (1) | EP3074048B1 (enExample) |
| JP (1) | JP6609563B2 (enExample) |
| KR (1) | KR20160088429A (enExample) |
| CN (1) | CN105764530B (enExample) |
| AU (1) | AU2014356126B2 (enExample) |
| CA (1) | CA2928087A1 (enExample) |
| EA (1) | EA201691075A1 (enExample) |
| ES (1) | ES2729643T3 (enExample) |
| IL (1) | IL245244A0 (enExample) |
| MX (1) | MX2016006674A (enExample) |
| TW (1) | TWI572361B (enExample) |
| UY (1) | UY35854A (enExample) |
| WO (1) | WO2015079376A1 (enExample) |
| ZA (1) | ZA201602603B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013350802B2 (en) | 2012-11-30 | 2016-07-14 | Novartis Ag | Methods for making conjugates from disulfide-containing proteins |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| JP2017529837A (ja) | 2014-09-03 | 2017-10-12 | イミュノジェン・インコーポレーテッド | 細胞結合剤及び細胞毒性剤を含む複合体 |
| EP3310813A1 (en) | 2015-06-17 | 2018-04-25 | Novartis AG | Antibody drug conjugates |
| WO2017051254A1 (en) * | 2015-09-25 | 2017-03-30 | Legochem Biosciences, Inc. | Compositions and methods related to anti-egfr antibody drug conjugates |
| MA43348A (fr) | 2015-10-01 | 2018-08-08 | Novo Nordisk As | Conjugués de protéines |
| MA44334A (fr) | 2015-10-29 | 2018-09-05 | Novartis Ag | Conjugués d'anticorps comprenant un agoniste du récepteur de type toll |
| RS65660B1 (sr) | 2015-11-25 | 2024-07-31 | Ligachem Biosciences Inc | Konјugati koji sadrže samozapaljive grupe i postupci povezani sa njima |
| JP7327899B2 (ja) | 2015-11-25 | 2023-08-16 | レゴケム バイオサイエンシズ， インク． | 分岐リンカーを含む抗体－薬物複合体及びそれらに関連する方法 |
| WO2018092867A1 (ja) * | 2016-11-18 | 2018-05-24 | 国立大学法人鹿児島大学 | ＩｇＧ結合ペプチドを含む固相担体及びＩｇＧの分離方法 |
| EP3604311A4 (en) | 2017-03-29 | 2021-01-13 | LegoChem Biosciences, Inc. | PYRROLOBENZODIAZEPINE DIMERIC PRECURSOR AND ASSOCIATED LIGAND-BOND CONJUGATE COMPOUND |
| AR111651A1 (es) | 2017-04-28 | 2019-08-07 | Novartis Ag | Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación |
| BR112020022299A2 (pt) | 2018-05-09 | 2021-02-23 | Legochem Biosciences, Inc. | composições e métodos relacionados a conjugados de anticorpo-fármaco anti-cd19 |
| EP3827116A4 (en) | 2018-07-23 | 2022-05-11 | The Governors of the University of Alberta | Genetically-encoded bicyclic peptide libraries |
| SG11202104652SA (en) * | 2018-11-28 | 2021-06-29 | Univ Alberta | Genetically-encoded macrocyclic peptide libraries bearing a pharmacophore |
| KR20210028544A (ko) | 2019-09-04 | 2021-03-12 | 주식회사 레고켐 바이오사이언스 | 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6239110B1 (en) | 1990-02-22 | 2001-05-29 | W.R. Grace & Co. -Conn. | Synthetic analogs of thrombospondin and therapeutic use thereof |
| WO1999013063A1 (en) | 1997-09-09 | 1999-03-18 | Nycomed Imaging As | Factor vii fragments and analogs thereof and their use in the treatment of blood clottng disorders |
| WO1999013062A1 (en) | 1997-09-09 | 1999-03-18 | Nycomed Imaging As | Factors vii fragments and analogs thereof and their use in the treatment of blood clotting disorders |
| GB0316294D0 (en) * | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| US8673848B2 (en) * | 2012-01-27 | 2014-03-18 | Novartis Ag | Synthetic apelin mimetics for the treatment of heart failure |
| WO2008157380A2 (en) | 2007-06-15 | 2008-12-24 | Adherex Technologies Inc. | Chemically modified cyclic peptides containing cell adhesion recognition (car) sequences and uses therefor |
| US20110172126A1 (en) | 2008-09-03 | 2011-07-14 | Xenome Ltd | Libraries of peptide conjugates and methods for making them |
| EP2549276B1 (en) | 2009-08-10 | 2015-02-25 | UCL Business PLC | Reversible covalent linkage of functional molecules |
| EP2906598A1 (en) | 2012-10-09 | 2015-08-19 | Igenica Biotherapeutics, Inc. | Anti-c16orf54 antibodies and methods of use thereof |
| DK2920196T3 (da) | 2012-11-15 | 2021-06-14 | Univ Brandeis | Binding af cysteinrester under anvendelse af cykliske disulfider |
| AU2013350802B2 (en) * | 2012-11-30 | 2016-07-14 | Novartis Ag | Methods for making conjugates from disulfide-containing proteins |
-
2014
- 2014-11-24 JP JP2016554939A patent/JP6609563B2/ja not_active Expired - Fee Related
- 2014-11-24 AU AU2014356126A patent/AU2014356126B2/en not_active Ceased
- 2014-11-24 EP EP14815051.9A patent/EP3074048B1/en not_active Not-in-force
- 2014-11-24 MX MX2016006674A patent/MX2016006674A/es unknown
- 2014-11-24 ES ES14815051T patent/ES2729643T3/es active Active
- 2014-11-24 CN CN201480064270.7A patent/CN105764530B/zh not_active Expired - Fee Related
- 2014-11-24 KR KR1020167016645A patent/KR20160088429A/ko not_active Withdrawn
- 2014-11-24 CA CA2928087A patent/CA2928087A1/en not_active Abandoned
- 2014-11-24 US US14/551,187 patent/US10172948B2/en active Active
- 2014-11-24 EA EA201691075A patent/EA201691075A1/ru unknown
- 2014-11-24 WO PCT/IB2014/066300 patent/WO2015079376A1/en not_active Ceased
- 2014-11-25 UY UY0001035854A patent/UY35854A/es not_active Application Discontinuation
- 2014-11-25 TW TW103140861A patent/TWI572361B/zh not_active IP Right Cessation
-
2016
- 2016-04-15 ZA ZA2016/02603A patent/ZA201602603B/en unknown
- 2016-04-20 IL IL245244A patent/IL245244A0/en unknown
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