JP2011528710A5 - - Google Patents
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- JP2011528710A5 JP2011528710A5 JP2011520030A JP2011520030A JP2011528710A5 JP 2011528710 A5 JP2011528710 A5 JP 2011528710A5 JP 2011520030 A JP2011520030 A JP 2011520030A JP 2011520030 A JP2011520030 A JP 2011520030A JP 2011528710 A5 JP2011528710 A5 JP 2011528710A5
- Authority
- JP
- Japan
- Prior art keywords
- oligosaccharide
- infection
- composition
- carrier
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 58
- 239000000203 mixture Substances 0.000 claims description 45
- 229920001542 oligosaccharide Polymers 0.000 claims description 40
- 150000002482 oligosaccharides Chemical class 0.000 claims description 40
- 208000015181 infectious disease Diseases 0.000 claims description 29
- 150000001875 compounds Chemical class 0.000 claims description 27
- 239000000178 monomer Substances 0.000 claims description 23
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims description 18
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims description 18
- 229960002442 glucosamine Drugs 0.000 claims description 18
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 9
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims description 8
- 206010041925 Staphylococcal infections Diseases 0.000 claims description 7
- 230000002194 synthesizing effect Effects 0.000 claims description 7
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 6
- 230000028993 immune response Effects 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- OTORAPMCRFGVJV-UHFFFAOYSA-N 4-acetylsulfanylbutanoic acid Chemical compound CC(=O)SCCCC(O)=O OTORAPMCRFGVJV-UHFFFAOYSA-N 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 229960000814 tetanus toxoid Drugs 0.000 claims description 3
- 208000034950 Acinetobacter Infections Diseases 0.000 claims description 2
- 241000606748 Actinobacillus pleuropneumoniae Species 0.000 claims description 2
- 208000004429 Bacillary Dysentery Diseases 0.000 claims description 2
- 206010073031 Burkholderia infection Diseases 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 206010061259 Klebsiella infection Diseases 0.000 claims description 2
- 201000005702 Pertussis Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 206010040550 Shigella infections Diseases 0.000 claims description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
- 208000025087 Yersinia pseudotuberculosis infectious disease Diseases 0.000 claims description 2
- 125000003277 amino group Chemical group 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000004927 fusion Effects 0.000 claims description 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 2
- 241000894007 species Species 0.000 claims description 2
- 208000015339 staphylococcus aureus infection Diseases 0.000 claims description 2
- 230000004936 stimulating effect Effects 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims 4
- 241000191940 Staphylococcus Species 0.000 claims 3
- ZHCAAFJSYLFLPX-UHFFFAOYSA-N nitrocyclohexatriene Chemical group [O-][N+](=O)C1=CC=C=C[CH]1 ZHCAAFJSYLFLPX-UHFFFAOYSA-N 0.000 claims 2
- NIANZCQUVKPGSF-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 2,2,2-trifluoroacetate Chemical compound FC(F)(F)C(=O)ON1C(=O)CCC1=O NIANZCQUVKPGSF-UHFFFAOYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 210000000628 antibody-producing cell Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000006501 nitrophenyl group Chemical group 0.000 claims 1
- -1 succinimidyl Chemical group 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 241000295644 Staphylococcaceae Species 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 0 CCC1(CCN*(C)C(CCCS)O)CC1 Chemical compound CCC1(CCN*(C)C(CCCS)O)CC1 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- KWEDUNSJJZVRKR-UHFFFAOYSA-N carbononitridic azide Chemical class [N-]=[N+]=NC#N KWEDUNSJJZVRKR-UHFFFAOYSA-N 0.000 description 1
- 229910052736 halogen Chemical class 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13549308P | 2008-07-21 | 2008-07-21 | |
| US61/135,493 | 2008-07-21 | ||
| US20815509P | 2009-02-20 | 2009-02-20 | |
| US61/208,155 | 2009-02-20 | ||
| PCT/US2009/004206 WO2010011284A2 (en) | 2008-07-21 | 2009-07-21 | Methods and compositions relating to synthetic beta-1,6 glucosamine oligosaccharides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528710A JP2011528710A (ja) | 2011-11-24 |
| JP2011528710A5 true JP2011528710A5 (enExample) | 2012-09-06 |
| JP5555230B2 JP5555230B2 (ja) | 2014-07-23 |
Family
ID=41570770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011520030A Expired - Fee Related JP5555230B2 (ja) | 2008-07-21 | 2009-07-21 | β−１，６−グルコサミンオリゴ糖を合成するための方法および組成物 |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US8492364B2 (enExample) |
| EP (2) | EP2315747B1 (enExample) |
| JP (1) | JP5555230B2 (enExample) |
| KR (4) | KR101573648B1 (enExample) |
| CN (2) | CN105085349B (enExample) |
| AU (1) | AU2009274630B2 (enExample) |
| BR (1) | BRPI0916365A2 (enExample) |
| CA (1) | CA2731384C (enExample) |
| CO (1) | CO6341620A2 (enExample) |
| DK (1) | DK2315747T3 (enExample) |
| ES (1) | ES2660594T3 (enExample) |
| HK (1) | HK1254488A1 (enExample) |
| IL (2) | IL210789A (enExample) |
| MX (2) | MX2011000823A (enExample) |
| NZ (1) | NZ591103A (enExample) |
| PT (1) | PT2315747T (enExample) |
| RU (1) | RU2532911C2 (enExample) |
| WO (1) | WO2010011284A2 (enExample) |
| ZA (1) | ZA201101000B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003295520B8 (en) | 2002-11-12 | 2011-05-19 | The Brigham And Women's Hospital, Inc. | Polysaccharide vaccine for Staphylococcal infections |
| CA2567748A1 (en) | 2004-04-21 | 2005-11-03 | The Brigham And Women's Hospital, Inc. | Poly-n-acetyl glucosamine (pnag/dpnag)-binding peptides and methods of use thereof |
| JP5555230B2 (ja) | 2008-07-21 | 2014-07-23 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | β−１，６−グルコサミンオリゴ糖を合成するための方法および組成物 |
| US20130116423A1 (en) | 2010-04-23 | 2013-05-09 | A. Stewart Campbell | Synthetic Oligosaccharides for Staphylococcus Vaccine |
| FR2967677B1 (fr) * | 2010-11-18 | 2014-05-16 | Centre Nat Rech Scient | Derives de polysaccharides comprenant un motif alcene et reaction de couplage par chimie thio-clic |
| WO2012145626A1 (en) * | 2011-04-22 | 2012-10-26 | Ancora Pharmaceuticals Inc. | Synthetic oligosaccharides for staphylococcus vaccine |
| CA3241764A1 (en) | 2012-05-30 | 2013-12-05 | The Brigham And Women's Hospital, Inc. | Polysaccharide compositions and methods of use |
| WO2014158963A1 (en) | 2013-03-12 | 2014-10-02 | Wellstat Vaccines, Llc | Antibodies targeted to fungal cell wall polysaccharides |
| US9597433B2 (en) | 2013-08-23 | 2017-03-21 | University Of Houston System | Non-pathogenic biofilms and uses thereof |
| PH12019500399B1 (en) | 2016-09-02 | 2024-05-15 | Sanofi Pasteur Inc | Neisseria meningitidis vaccine |
| WO2020163512A1 (en) | 2019-02-05 | 2020-08-13 | The Brigham And Women's Hospital, Inc. | Polysaccharide compositions for use in treating filariasis |
| JP2022546812A (ja) * | 2019-08-27 | 2022-11-09 | アロペックス・インコーポレイテッド | 抗菌性ワクチン組成物 |
| US11173199B2 (en) * | 2019-11-13 | 2021-11-16 | Alopexx Inc. | Low contaminant compositions |
| BR112022009924A2 (pt) * | 2019-11-22 | 2022-08-09 | Alopexx Inc | Métodos para fornecer terapia contínua contra pnag compreendendo micróbios |
| US10828360B1 (en) | 2020-02-04 | 2020-11-10 | OneBioPharma, Inc. | Methods for inhibiting biofilm formation |
| CN112920237B (zh) * | 2021-01-27 | 2022-06-14 | 山东大学 | 一种糖基受体、酶法合成寡糖链的快速分离的方法及应用 |
| WO2022189361A1 (en) * | 2021-03-08 | 2022-09-15 | Universiteit Gent | Conjugates including multiple saccharidic chains on a linear protein and uses in mammals feed |
| WO2025137258A1 (en) * | 2023-12-21 | 2025-06-26 | Board Of Trustees Of Michigan State University | Development of pnag-based vaccines |
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- 2009-07-21 KR KR1020147017111A patent/KR101573648B1/ko not_active Expired - Fee Related
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