JP2006513166A5 - - Google Patents
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- JP2006513166A5 JP2006513166A5 JP2004552204A JP2004552204A JP2006513166A5 JP 2006513166 A5 JP2006513166 A5 JP 2006513166A5 JP 2004552204 A JP2004552204 A JP 2004552204A JP 2004552204 A JP2004552204 A JP 2004552204A JP 2006513166 A5 JP2006513166 A5 JP 2006513166A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- polysaccharide
- isolated
- subject
- daltons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000004676 glycans Chemical class 0.000 claims 110
- 239000005017 polysaccharide Substances 0.000 claims 110
- 229920001282 polysaccharide Polymers 0.000 claims 110
- 239000000203 mixture Substances 0.000 claims 95
- 241000191940 Staphylococcus Species 0.000 claims 42
- 238000002360 preparation method Methods 0.000 claims 28
- 208000015181 infectious disease Diseases 0.000 claims 26
- 238000000034 method Methods 0.000 claims 24
- 230000001580 bacterial effect Effects 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 20
- 239000002671 adjuvant Substances 0.000 claims 16
- 239000011230 binding agent Substances 0.000 claims 16
- 230000028993 immune response Effects 0.000 claims 16
- 241000283984 Rodentia Species 0.000 claims 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 10
- 238000004519 manufacturing process Methods 0.000 claims 10
- 239000000523 sample Substances 0.000 claims 9
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 8
- 229960002442 glucosamine Drugs 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 6
- 238000006467 substitution reaction Methods 0.000 claims 6
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 5
- 208000035143 Bacterial infection Diseases 0.000 claims 5
- 208000022362 bacterial infectious disease Diseases 0.000 claims 5
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 210000000628 antibody-producing cell Anatomy 0.000 claims 4
- 239000002585 base Substances 0.000 claims 4
- 230000000850 deacetylating effect Effects 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 230000003472 neutralizing effect Effects 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 210000004989 spleen cell Anatomy 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 3
- 239000003899 bactericide agent Substances 0.000 claims 3
- 210000005056 cell body Anatomy 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 230000004936 stimulating effect Effects 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 108010067770 Endopeptidase K Proteins 0.000 claims 2
- 108090000988 Lysostaphin Proteins 0.000 claims 2
- 102000016943 Muramidase Human genes 0.000 claims 2
- 108010014251 Muramidase Proteins 0.000 claims 2
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 2
- 101710163270 Nuclease Proteins 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010041925 Staphylococcal infections Diseases 0.000 claims 2
- 241000191967 Staphylococcus aureus Species 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 230000000844 anti-bacterial effect Effects 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 229960000274 lysozyme Drugs 0.000 claims 2
- 239000004325 lysozyme Substances 0.000 claims 2
- 235000010335 lysozyme Nutrition 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 230000001376 precipitating effect Effects 0.000 claims 2
- 238000004513 sizing Methods 0.000 claims 2
- 238000012360 testing method Methods 0.000 claims 2
- 108090001008 Avidin Proteins 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 claims 1
- 241000282472 Canis lupus familiaris Species 0.000 claims 1
- 241000283707 Capra Species 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 241000283086 Equidae Species 0.000 claims 1
- 241000282326 Felis catus Species 0.000 claims 1
- 125000003047 N-acetyl group Chemical group 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 241000288906 Primates Species 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 241000282887 Suidae Species 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000003637 basic solution Substances 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 230000000855 fungicidal effect Effects 0.000 claims 1
- 239000000417 fungicide Substances 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 210000004915 pus Anatomy 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 208000015339 staphylococcus aureus infection Diseases 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42542502P | 2002-11-12 | 2002-11-12 | |
| US60/425,425 | 2002-11-12 | ||
| PCT/US2003/036358 WO2004043405A2 (en) | 2002-11-12 | 2003-11-12 | Polysaccharide vaccine for staphylococcal infections |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012222333A Division JP2013010789A (ja) | 2002-11-12 | 2012-10-04 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
| JP2014231224A Division JP6335102B2 (ja) | 2002-11-12 | 2014-11-14 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006513166A JP2006513166A (ja) | 2006-04-20 |
| JP2006513166A5 true JP2006513166A5 (enExample) | 2006-12-07 |
| JP5814494B2 JP5814494B2 (ja) | 2015-11-17 |
Family
ID=32312989
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004552204A Expired - Fee Related JP5814494B2 (ja) | 2002-11-12 | 2003-11-12 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
| JP2012222333A Pending JP2013010789A (ja) | 2002-11-12 | 2012-10-04 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
| JP2014231224A Expired - Fee Related JP6335102B2 (ja) | 2002-11-12 | 2014-11-14 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
| JP2016171443A Pending JP2016204388A (ja) | 2002-11-12 | 2016-09-02 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
| JP2019035315A Pending JP2019089845A (ja) | 2002-11-12 | 2019-02-28 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012222333A Pending JP2013010789A (ja) | 2002-11-12 | 2012-10-04 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
| JP2014231224A Expired - Fee Related JP6335102B2 (ja) | 2002-11-12 | 2014-11-14 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
| JP2016171443A Pending JP2016204388A (ja) | 2002-11-12 | 2016-09-02 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
| JP2019035315A Pending JP2019089845A (ja) | 2002-11-12 | 2019-02-28 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ感染に対する多糖類ワクチン |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10919956B2 (enExample) |
| EP (1) | EP1565478B1 (enExample) |
| JP (5) | JP5814494B2 (enExample) |
| KR (1) | KR101062525B1 (enExample) |
| CN (1) | CN100351260C (enExample) |
| AU (1) | AU2003295520B8 (enExample) |
| BR (1) | BRPI0316018B8 (enExample) |
| CA (1) | CA2501077C (enExample) |
| DK (1) | DK1565478T3 (enExample) |
| ES (1) | ES2648046T3 (enExample) |
| IL (3) | IL167532A (enExample) |
| MX (1) | MXPA05005045A (enExample) |
| NO (1) | NO341730B1 (enExample) |
| NZ (1) | NZ539153A (enExample) |
| PL (1) | PL229487B1 (enExample) |
| PT (1) | PT1565478T (enExample) |
| WO (1) | WO2004043405A2 (enExample) |
| ZA (1) | ZA200502607B (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE171528T1 (de) | 1992-12-28 | 1998-10-15 | Yoshiki Kogyo Kk | Hebelmechanismus mit festem drehpunkt, drehendem krafteinleitungspunkt und drehendem kraftangriffspunkt und eine einrichtung mit einem derartigen hebel. |
| US7252828B2 (en) | 1998-07-15 | 2007-08-07 | The Brigham And Women's Hospital, Inc. | Polysaccharide vaccine for staphylococcal infections |
| KR101062525B1 (ko) | 2002-11-12 | 2011-09-06 | 더 브리검 앤드 우먼즈 하스피털, 인크. | 포도상구균 감염에 대한 다당류 백신 |
| WO2004043407A2 (en) | 2002-11-12 | 2004-05-27 | The Brigham And Women's Hospital, Inc. | Methods and products for treating staphylococcal infections |
| EP2455402A1 (en) | 2004-04-21 | 2012-05-23 | The Brigham and Women's Hospital, Inc. | Poly-N-acetyl glucosamine (PNAG/DPNAG)-binding peptides and methods of use thereof |
| EP1793849A2 (en) * | 2004-09-22 | 2007-06-13 | GlaxoSmithKline Biologicals SA | Immunogenic composition for use in vaccination against staphylococcei |
| EP2298341A3 (en) | 2004-10-21 | 2011-07-13 | Wyeth LLC | Immunogenic compositions of staphylococcus epidermidis polypeptide and polynucleotide antigens |
| AR060188A1 (es) | 2006-03-30 | 2008-05-28 | Glaxosmithkline Biolog Sa | Procedimiento de conjugacion |
| MX337528B (es) | 2006-03-30 | 2016-03-09 | Glaxosmithkline Biolog Sa | Composición inmunogénica que comprende un sacárido capsular estafilocócico o-acetilado y una proteína estafilocócica. |
| KR20200058579A (ko) | 2006-06-06 | 2020-05-27 | 얀센 백신스 앤드 프리벤션 비.브이. | 장내구균에 대한 사멸활성을 갖는 인간결합분자 및 그것의 용도 |
| CA2881717C (en) | 2006-06-06 | 2018-06-12 | Cecilia Anna Wilhelmina Geuijen | Human binding molecules having killing activity against staphylococci and uses thereof |
| WO2009114520A2 (en) * | 2008-03-10 | 2009-09-17 | Pharmain Corporation | Compositions for treatment with metallopeptidases, methods of making and using the same |
| JP5555230B2 (ja) | 2008-07-21 | 2014-07-23 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | β−１，６−グルコサミンオリゴ糖を合成するための方法および組成物 |
| CN102333540B (zh) | 2008-10-06 | 2015-04-22 | 芝加哥大学 | 与细菌eap、emp和/或adsa蛋白相关的组合物和方法 |
| US9567379B2 (en) | 2009-04-03 | 2017-02-14 | The University Of Chicago | Compositions and methods related to protein A (SpA) variants |
| CN107096020A (zh) | 2009-06-22 | 2017-08-29 | 惠氏有限责任公司 | 金黄色葡萄球菌抗原的免疫原性组合物 |
| SA114350400B1 (ar) | 2009-06-22 | 2016-05-26 | ويث ال ال سي | تركيبات وطرق لتحضير تركيبات مولدة للمناعة لمقترن بولي سكاريد كبسولي للنمط المصلي 5 و 8 من المكورات العنقودية الذهبية |
| GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| MX373250B (es) | 2009-09-30 | 2020-05-04 | Glaxosmithkline Biologicals S A Star | Conjugación de polisacáridos capsulares de tipo 5 y de tipo 8 de staphylococcus aureus. |
| ES2626416T3 (es) * | 2009-10-30 | 2017-07-25 | Glaxosmithkline Biologicals Sa | Purificación de sacáridos capsulares de Staphilococcus aureus de tipo 5 y de tipo 8 |
| EP2547361B1 (en) | 2010-03-17 | 2020-10-28 | SOCPRA - Sciences et Génie, s.e.c. | Bacterial vaccine components from staphylococcus aureus and uses thereof |
| JP2013523818A (ja) | 2010-04-05 | 2013-06-17 | ザ・ユニバーシティー・オブ・シカゴ | 免疫反応のエンハンサーとしてのプロテインＡ（ＳｐＡ）抗体に関連する組成物および方法 |
| EP2560981A2 (en) * | 2010-04-23 | 2013-02-27 | Ancora Pharmaceuticals Inc. | Synthetic oligosaccharides for staphylococcus vaccine |
| WO2012003474A2 (en) | 2010-07-02 | 2012-01-05 | The University Of Chicago | Compositions and methods related to protein a (spa) variants |
| US9095540B2 (en) | 2010-09-09 | 2015-08-04 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens |
| WO2013162746A1 (en) | 2012-04-26 | 2013-10-31 | University Of Chicago | Staphylococcal coagulase antigens and methods of their use |
| US20150147328A1 (en) * | 2012-05-07 | 2015-05-28 | Mogam Biotechnology Institute | Vaccine composition for preventing staphyllococcus aureus infection |
| EP2854822B1 (en) * | 2012-05-30 | 2020-07-22 | The Brigham and Women's Hospital, Inc. | Polysaccharide compositions and methods of use |
| US20170189473A1 (en) * | 2014-05-29 | 2017-07-06 | Green Cross Corporation | Composition for preventing or treating staphylococcus aureus infection |
| WO2017010845A1 (ko) * | 2015-07-15 | 2017-01-19 | 재단법인 목암생명과학연구소 | 포도상구균 감염 질환의 예방 또는 치료용 조성물 |
| KR101847051B1 (ko) | 2016-04-26 | 2018-04-09 | 한국외국어대학교 연구산학협력단 | 병원균에 대한 항생활성을 갖는 펩타이드 및 이를 포함하는 항생 펩타이드 조성물 |
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| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| US12397014B2 (en) | 2019-02-05 | 2025-08-26 | The Brigham And Women's Hospital, Inc. | Polysaccharide compositions for use in treating filariasis |
| US20200355139A1 (en) | 2019-05-10 | 2020-11-12 | Mazda Motor Corporation | Engine piston and method for manufacturing the same |
| JP2022546812A (ja) * | 2019-08-27 | 2022-11-09 | アロペックス・インコーポレイテッド | 抗菌性ワクチン組成物 |
| US11173199B2 (en) | 2019-11-13 | 2021-11-16 | Alopexx Inc. | Low contaminant compositions |
| US10828360B1 (en) | 2020-02-04 | 2020-11-10 | OneBioPharma, Inc. | Methods for inhibiting biofilm formation |
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