JP2018193386A5 - - Google Patents
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- Publication number
- JP2018193386A5 JP2018193386A5 JP2018137861A JP2018137861A JP2018193386A5 JP 2018193386 A5 JP2018193386 A5 JP 2018193386A5 JP 2018137861 A JP2018137861 A JP 2018137861A JP 2018137861 A JP2018137861 A JP 2018137861A JP 2018193386 A5 JP2018193386 A5 JP 2018193386A5
- Authority
- JP
- Japan
- Prior art keywords
- monoclonal antibody
- possessed
- variable region
- heavy chain
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013039625 | 2013-02-28 | ||
| JP2013039625 | 2013-02-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503025A Division JP6490574B2 (ja) | 2013-02-28 | 2014-02-27 | 不溶性フィブリンに対する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018193386A JP2018193386A (ja) | 2018-12-06 |
| JP2018193386A5 true JP2018193386A5 (enExample) | 2019-03-14 |
| JP7012360B2 JP7012360B2 (ja) | 2022-02-14 |
Family
ID=51428352
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503025A Active JP6490574B2 (ja) | 2013-02-28 | 2014-02-27 | 不溶性フィブリンに対する抗体 |
| JP2018137861A Active JP7012360B2 (ja) | 2013-02-28 | 2018-07-23 | 不溶性フィブリンに対する抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503025A Active JP6490574B2 (ja) | 2013-02-28 | 2014-02-27 | 不溶性フィブリンに対する抗体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9429584B2 (enExample) |
| EP (2) | EP2963059B1 (enExample) |
| JP (2) | JP6490574B2 (enExample) |
| ES (1) | ES2673583T3 (enExample) |
| WO (1) | WO2014133093A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016167227A1 (ja) * | 2015-04-13 | 2016-10-20 | 国立研究開発法人国立がん研究センター | 不溶性フィブリンに対する抗体 |
| JP2018527350A (ja) | 2015-09-01 | 2018-09-20 | イミュンワーク インク．Ｉｍｍｕｎｗｏｒｋ Ｉｎｃ． | 血餅形成の予防及び／又は血栓症の治療のための分子構築物 |
| SG10201912529SA (en) | 2016-11-18 | 2020-02-27 | Astellas Pharma Inc | Novel anti-human muc1 antibody fab fragment |
| FI3548515T3 (fi) * | 2016-12-01 | 2026-03-04 | Regeneron Pharma | Radioleimattuja anti-PD-L1-vasta-aineita immuno-PET-kuvantamiseen |
| AU2018219909B2 (en) | 2017-02-10 | 2025-02-27 | Regeneron Pharmaceuticals, Inc. | Radiolabeled anti-LAG3 antibodies for immuno-PET imaging |
| CA3060719A1 (en) * | 2017-05-02 | 2018-11-08 | National Cancer Center Japan | Plasmin-cleavable anti-insoluble fibrin antibody-drug conjugate |
| TWI795415B (zh) | 2017-07-07 | 2023-03-11 | 日商安斯泰來製藥股份有限公司 | 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段 |
| IL316355A (en) | 2017-07-24 | 2024-12-01 | Regeneron Pharma | Anti-CD8 antibodies and their uses |
| MX2020012351A (es) | 2018-05-17 | 2021-01-29 | Astellas Pharma Inc | Complejo que tiene fragmento fab de anticuerpo anti-muc1 de humano, enlazador peptido y/o ligando. |
| WO2020061059A1 (en) * | 2018-09-17 | 2020-03-26 | Icahn School Of Medicine At Mount Sinai | Anti-lilrb2 antibodies and methods of use thereof |
| EP3865154A4 (en) | 2018-10-10 | 2022-11-09 | Astellas Pharma Inc. | PHARMACEUTICAL COMPOSITION CONTAINING ANTIBODY FAB FRAGMENT COMPLEX AT LABELED ANTI-HUMAN SITE |
| WO2021163989A1 (en) * | 2020-02-21 | 2021-08-26 | Yinnuolai Biotech Ltd. | Anti-baff receptor antibodies and uses thereof |
| AU2021246398A1 (en) * | 2020-03-31 | 2022-11-03 | National Cancer Center | Fusion protein suitable for dissolving fibrin clot, and pharmaceutical composition containing said fusion protein |
| WO2021200932A1 (ja) | 2020-03-31 | 2021-10-07 | 国立研究開発法人国立がん研究センター | フィブリンに結合する抗体および当該抗体を含む医薬組成物 |
| EP3916009B1 (en) * | 2020-05-26 | 2023-06-28 | Sartorius Lab Instruments GmbH & Co. KG | Recombinant proteins based on fibrinogen |
| EP4506458A1 (en) | 2022-04-08 | 2025-02-12 | RIN Institute Inc. | Antibody binding to fibrin, fibrinolytic protein containing antibody, and pharmaceutical formulation containing protein |
| CN118240085B (zh) * | 2022-10-08 | 2025-05-09 | 东莞市朋志生物科技有限公司 | 抗纤维蛋白降解产物抗体、检测纤维蛋白降解产物的试剂和试剂盒 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4916070A (en) | 1986-04-14 | 1990-04-10 | The General Hospital Corporation | Fibrin-specific antibodies and method of screening for the antibodies |
| US5120834A (en) * | 1988-06-13 | 1992-06-09 | American Biogenetic Sciences, Inc. | Fibrin-specific monoclonal antibody |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| ES2087997T3 (es) | 1990-01-12 | 1996-08-01 | Cell Genesys Inc | Generacion de anticuerpos xenogenicos. |
| ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
| JPH11206387A (ja) | 1991-08-28 | 1999-08-03 | Genpharm Internatl Inc | 異種免疫グロブリンを作る方法及びそのためのトランスジェニックマウス |
| US5648267A (en) | 1992-11-13 | 1997-07-15 | Idec Pharmaceuticals Corporation | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same |
| JPH08509612A (ja) | 1993-04-26 | 1996-10-15 | ジェンファーム インターナショナル インコーポレイテッド | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| CU22615A1 (es) | 1994-06-30 | 2000-02-10 | Centro Inmunologia Molecular | Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos |
| KR100261941B1 (ko) | 1994-07-13 | 2000-07-15 | 나가야마 오사무 | 사람의 인터루킨-8에 대한 재구성 사람항체 |
| JPH11505107A (ja) | 1995-04-28 | 1999-05-18 | アブジェニックス インク． | 免疫したゼノマウス（ＸｅｎｏＭｏｕｓｅ）に由来するヒト抗体 |
| JPH08301900A (ja) | 1995-04-28 | 1996-11-19 | Shima Kenkyusho:Kk | 可溶性フィブリン複合体に対するモノクローナル抗体 |
| JPH09104700A (ja) | 1995-10-09 | 1997-04-22 | Bio Rinkusu Kk | 抗ヒト可溶性フィブリン抗体及びそれを用いた免疫学的測定法 |
| JP2001354700A (ja) | 2000-06-12 | 2001-12-25 | Bio Links Kk | モノクロ−ナル抗体及びヒトフィブリン分解産物の測定方法 |
| EP1345967B1 (en) | 2000-12-22 | 2011-08-10 | Grad, Carole, Legal representative of Kaplan, Howard | Phage display libraries of human v h fragments |
| DE60239467D1 (de) | 2001-06-26 | 2011-04-28 | Agen Biomedical Ltd | Von dd 3b6/22 abgeleitete humanisierte antikörper mit spezifität für das d-dimer fragment von fibrin |
| JP4088328B2 (ja) | 2004-12-28 | 2008-05-21 | 第一化学薬品株式会社 | 抗ヒト可溶性フィブリンモノクローナル抗体及び当該抗体を用いる免疫学的測定方法 |
| JP5222521B2 (ja) | 2004-12-28 | 2013-06-26 | 積水メディカル株式会社 | 抗ヒト可溶性フィブリンモノクローナル抗体の製造方法 |
| CA2632822C (en) * | 2005-12-12 | 2018-08-28 | Ruth Greferath | A beta 1-42 specific monoclonal antibodies with therapeutic properties |
| CA2642848C (en) * | 2006-03-03 | 2016-07-12 | Amorfix Life Sciences Ltd. | Methods and compositions to treat and detect misfolded-sod1 mediated diseases |
| EP2128124A4 (en) | 2007-02-05 | 2012-09-05 | Univ Osaka | NEW HEXATRI B-CARBONYL CONNECTION |
| JP5593488B2 (ja) | 2008-11-17 | 2014-09-24 | 独立行政法人国立がん研究センター | 癌間質の構成因子に対して特異的結合能を有する物質と抗腫瘍性化合物との複合体による新規の癌ターゲティング治療 |
| JP5805363B2 (ja) * | 2009-06-26 | 2015-11-04 | 和興フィルタテクノロジー株式会社 | 可溶性凝集体、免疫寛容誘導剤及びその製造方法 |
| JP2012000072A (ja) | 2010-06-18 | 2012-01-05 | Japan Health Science Foundation | 新規な抗フィブリン抗体 |
| AR086250A1 (es) * | 2011-05-05 | 2013-11-27 | Hoffmann La Roche | Polipeptido de fusion presentador de una secuencia de aminoacidos y utilizacion del mismo |
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2014
- 2014-02-27 US US14/770,864 patent/US9429584B2/en active Active
- 2014-02-27 EP EP14757745.6A patent/EP2963059B1/en active Active
- 2014-02-27 WO PCT/JP2014/054925 patent/WO2014133093A1/ja not_active Ceased
- 2014-02-27 ES ES14757745.6T patent/ES2673583T3/es active Active
- 2014-02-27 JP JP2015503025A patent/JP6490574B2/ja active Active
- 2014-02-27 EP EP18155006.2A patent/EP3339327A3/en not_active Withdrawn
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2018
- 2018-07-23 JP JP2018137861A patent/JP7012360B2/ja active Active