JP2018193386A5 - - Google Patents
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- Publication number
- JP2018193386A5 JP2018193386A5 JP2018137861A JP2018137861A JP2018193386A5 JP 2018193386 A5 JP2018193386 A5 JP 2018193386A5 JP 2018137861 A JP2018137861 A JP 2018137861A JP 2018137861 A JP2018137861 A JP 2018137861A JP 2018193386 A5 JP2018193386 A5 JP 2018193386A5
- Authority
- JP
- Japan
- Prior art keywords
- monoclonal antibody
- possessed
- variable region
- heavy chain
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000009123 Fibrin Human genes 0.000 claims 2
- 108010073385 Fibrin Proteins 0.000 claims 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 229950003499 fibrin Drugs 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000008946 Fibrinogen Human genes 0.000 claims 1
- 108010049003 Fibrinogen Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940012952 fibrinogen Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013039625 | 2013-02-28 | ||
| JP2013039625 | 2013-02-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503025A Division JP6490574B2 (ja) | 2013-02-28 | 2014-02-27 | 不溶性フィブリンに対する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018193386A JP2018193386A (ja) | 2018-12-06 |
| JP2018193386A5 true JP2018193386A5 (enExample) | 2019-03-14 |
| JP7012360B2 JP7012360B2 (ja) | 2022-02-14 |
Family
ID=51428352
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503025A Active JP6490574B2 (ja) | 2013-02-28 | 2014-02-27 | 不溶性フィブリンに対する抗体 |
| JP2018137861A Active JP7012360B2 (ja) | 2013-02-28 | 2018-07-23 | 不溶性フィブリンに対する抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503025A Active JP6490574B2 (ja) | 2013-02-28 | 2014-02-27 | 不溶性フィブリンに対する抗体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9429584B2 (enExample) |
| EP (2) | EP2963059B1 (enExample) |
| JP (2) | JP6490574B2 (enExample) |
| ES (1) | ES2673583T3 (enExample) |
| WO (1) | WO2014133093A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016167227A1 (ja) * | 2015-04-13 | 2016-10-20 | 国立研究開発法人国立がん研究センター | 不溶性フィブリンに対する抗体 |
| JP2018527350A (ja) | 2015-09-01 | 2018-09-20 | イミュンワーク インク．Ｉｍｍｕｎｗｏｒｋ Ｉｎｃ． | 血餅形成の予防及び／又は血栓症の治療のための分子構築物 |
| UA126388C2 (uk) | 2016-11-18 | 2022-09-28 | Астеллас Фарма Інк. | Fab-фрагмент антитіла до muc1 людини |
| AU2017367734B2 (en) * | 2016-12-01 | 2025-01-09 | Regeneron Pharmaceuticals, Inc. | Radiolabeled anti-PD-l1 antibodies for immuno-PET imaging |
| BR112019016336A2 (pt) | 2017-02-10 | 2020-03-31 | Regeneron Pharmaceuticals, Inc. | Conjugado de anticorpo radiorrotulado, método para imageamento de um tecido que expressa lag3 e para tratar um tumor, e, composto. |
| SG11201910113PA (en) * | 2017-05-02 | 2019-11-28 | Nat Cancer Center Japan | Plasmin-cleavable anti-insoluble fibrin antibody-drug conjugate |
| TWI795415B (zh) * | 2017-07-07 | 2023-03-11 | 日商安斯泰來製藥股份有限公司 | 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段 |
| BR112020001360A2 (pt) | 2017-07-24 | 2020-08-11 | Regeneron Pharmaceuticals, Inc. | anticorpo monoclonal isolado ou fragmento de ligação a antígeno deste que se liga a cd8, composição farmacêutica, molécula de ácido nucleico, vetor de expressão, célula hospedeira, conjugado de anticorpo, métodos para gerar imagens de um tecido que expressa cd8, para tratar um sujeito tendo um tumor sólido, para prever uma resposta positiva a uma terapia antitumoral, para monitorar uma resposta de um tumor em um sujeito a uma terapia antitumoral, para prever ou monitorar a eficácia da terapia antitumoral e para monitorar a presença de células t em um tumor ao longo do tempo, e, composto. |
| WO2019221269A1 (ja) | 2018-05-17 | 2019-11-21 | アステラス製薬株式会社 | 抗ヒトＭＵＣ１抗体Ｆａｂフラグメント、ペプチドリンカー及び／又は配位子を含む複合体 |
| JP2022501428A (ja) * | 2018-09-17 | 2022-01-06 | アイカーン スクール オブ メディスン アット マウント シナイ | 抗ｌｉｌｒｂ２抗体およびその使用の方法 |
| SG11202103670XA (en) | 2018-10-10 | 2021-05-28 | Astellas Pharma Inc | Pharmaceutical composition containing tagged site-antihuman antibody fab fragment complex |
| WO2021163989A1 (en) * | 2020-02-21 | 2021-08-26 | Yinnuolai Biotech Ltd. | Anti-baff receptor antibodies and uses thereof |
| US12509507B2 (en) | 2020-03-31 | 2025-12-30 | National Cancer Center | Fusion protein suitable for dissolving fibrin clot, and pharmaceutical composition containing said fusion protein |
| CA3178880A1 (en) * | 2020-03-31 | 2021-10-07 | National Cancer Center | Fibrin-binding antibody and pharmaceutical composition containing antibody |
| EP3916009B1 (en) * | 2020-05-26 | 2023-06-28 | Sartorius Lab Instruments GmbH & Co. KG | Recombinant proteins based on fibrinogen |
| WO2023195535A1 (ja) | 2022-04-08 | 2023-10-12 | 株式会社凜研究所 | フィブリンに結合する抗体および当該抗体を含むフィブリン溶解性タンパク質および当該タンパク質を含む医薬製剤 |
| CN118240085B (zh) * | 2022-10-08 | 2025-05-09 | 东莞市朋志生物科技有限公司 | 抗纤维蛋白降解产物抗体、检测纤维蛋白降解产物的试剂和试剂盒 |
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| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4916070A (en) | 1986-04-14 | 1990-04-10 | The General Hospital Corporation | Fibrin-specific antibodies and method of screening for the antibodies |
| US5120834A (en) * | 1988-06-13 | 1992-06-09 | American Biogenetic Sciences, Inc. | Fibrin-specific monoclonal antibody |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| DK0546073T3 (da) | 1990-08-29 | 1998-02-02 | Genpharm Int | Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer |
| WO1994025585A1 (en) | 1993-04-26 | 1994-11-10 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| JPH11206387A (ja) | 1991-08-28 | 1999-08-03 | Genpharm Internatl Inc | 異種免疫グロブリンを作る方法及びそのためのトランスジェニックマウス |
| US5648267A (en) | 1992-11-13 | 1997-07-15 | Idec Pharmaceuticals Corporation | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same |
| CU22615A1 (es) | 1994-06-30 | 2000-02-10 | Centro Inmunologia Molecular | Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos |
| AU701342B2 (en) | 1994-07-13 | 1999-01-28 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human interleukin-8 |
| JPH11505107A (ja) | 1995-04-28 | 1999-05-18 | アブジェニックス インク． | 免疫したゼノマウス（ＸｅｎｏＭｏｕｓｅ）に由来するヒト抗体 |
| JPH08301900A (ja) | 1995-04-28 | 1996-11-19 | Shima Kenkyusho:Kk | 可溶性フィブリン複合体に対するモノクローナル抗体 |
| JPH09104700A (ja) | 1995-10-09 | 1997-04-22 | Bio Rinkusu Kk | 抗ヒト可溶性フィブリン抗体及びそれを用いた免疫学的測定法 |
| JP2001354700A (ja) | 2000-06-12 | 2001-12-25 | Bio Links Kk | モノクロ−ナル抗体及びヒトフィブリン分解産物の測定方法 |
| EP1345967B1 (en) | 2000-12-22 | 2011-08-10 | Grad, Carole, Legal representative of Kaplan, Howard | Phage display libraries of human v h fragments |
| WO2003000736A1 (en) | 2001-06-26 | 2003-01-03 | Agen Biomedical Limited | Humanized antibodies derived from dd-3b6/22, specific for the d-dimer fragment of fibrin |
| CA2594289A1 (en) | 2004-12-28 | 2006-07-06 | Daiichi Pure Chemicals Co., Ltd. | Anti-human soluble fibrin monoclonal antibody and immunological assay method using the antibody |
| JP5222521B2 (ja) | 2004-12-28 | 2013-06-26 | 積水メディカル株式会社 | 抗ヒト可溶性フィブリンモノクローナル抗体の製造方法 |
| KR101591206B1 (ko) * | 2005-12-12 | 2016-02-04 | 에이씨 이뮨 에스.에이. | 치료적 특성을 갖는 베타 1-42 특이적인 단일클론성 항체 |
| CA2642848C (en) * | 2006-03-03 | 2016-07-12 | Amorfix Life Sciences Ltd. | Methods and compositions to treat and detect misfolded-sod1 mediated diseases |
| JP5013378B2 (ja) | 2007-02-05 | 2012-08-29 | 国立大学法人大阪大学 | 新規ヘキサトリエン−β−カルボニル化合物 |
| EP2359852A4 (en) | 2008-11-17 | 2015-05-20 | Nat Cancer Ct | NEW CANCERED THERAPY WITH A SUBSTANCE COMPLEX SPECIFICALLY BINDING TO A TUMOR STREAM FACTOR AND ANTITUMIR COMPOUND |
| JP5805363B2 (ja) * | 2009-06-26 | 2015-11-04 | 和興フィルタテクノロジー株式会社 | 可溶性凝集体、免疫寛容誘導剤及びその製造方法 |
| JP2012000072A (ja) | 2010-06-18 | 2012-01-05 | Japan Health Science Foundation | 新規な抗フィブリン抗体 |
| AR086250A1 (es) * | 2011-05-05 | 2013-11-27 | Hoffmann La Roche | Polipeptido de fusion presentador de una secuencia de aminoacidos y utilizacion del mismo |
-
2014
- 2014-02-27 JP JP2015503025A patent/JP6490574B2/ja active Active
- 2014-02-27 ES ES14757745.6T patent/ES2673583T3/es active Active
- 2014-02-27 US US14/770,864 patent/US9429584B2/en active Active
- 2014-02-27 WO PCT/JP2014/054925 patent/WO2014133093A1/ja not_active Ceased
- 2014-02-27 EP EP14757745.6A patent/EP2963059B1/en active Active
- 2014-02-27 EP EP18155006.2A patent/EP3339327A3/en active Pending
-
2018
- 2018-07-23 JP JP2018137861A patent/JP7012360B2/ja active Active