JP2018198596A5 - - Google Patents
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- Publication number
- JP2018198596A5 JP2018198596A5 JP2018128111A JP2018128111A JP2018198596A5 JP 2018198596 A5 JP2018198596 A5 JP 2018198596A5 JP 2018128111 A JP2018128111 A JP 2018128111A JP 2018128111 A JP2018128111 A JP 2018128111A JP 2018198596 A5 JP2018198596 A5 JP 2018198596A5
- Authority
- JP
- Japan
- Prior art keywords
- pad4
- antibody according
- antibody
- seq
- pad4 antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101000735566 Homo sapiens Protein-arginine deiminase type-4 Proteins 0.000 claims 4
- 102100035731 Protein-arginine deiminase type-4 Human genes 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 206010003246 arthritis Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015044518 | 2015-03-06 | ||
| JP2015044518 | 2015-03-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505334A Division JP6369922B2 (ja) | 2015-03-06 | 2016-03-07 | 新規抗ｐａｄ４抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018198596A JP2018198596A (ja) | 2018-12-20 |
| JP2018198596A5 true JP2018198596A5 (enExample) | 2019-04-18 |
| JP6675739B2 JP6675739B2 (ja) | 2020-04-01 |
Family
ID=56880525
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505334A Active JP6369922B2 (ja) | 2015-03-06 | 2016-03-07 | 新規抗ｐａｄ４抗体 |
| JP2018128111A Active JP6675739B2 (ja) | 2015-03-06 | 2018-07-05 | 新規抗ｐａｄ４抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505334A Active JP6369922B2 (ja) | 2015-03-06 | 2016-03-07 | 新規抗ｐａｄ４抗体 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US11447569B2 (enExample) |
| EP (2) | EP4223786A3 (enExample) |
| JP (2) | JP6369922B2 (enExample) |
| ES (1) | ES2952132T3 (enExample) |
| WO (1) | WO2016143753A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11447569B2 (en) | 2015-03-06 | 2022-09-20 | Public University Corporation Yokohama City University | Anti-PAD4 antibody |
| JP7422069B2 (ja) | 2017-09-19 | 2024-01-25 | トロピック バイオサイエンシーズ ユーケー リミテッド | 真核細胞において遺伝子発現をサイレンシングするための非コードｒｎａ分子の特異性の改変 |
| WO2019131769A1 (ja) * | 2017-12-26 | 2019-07-04 | 公立大学法人名古屋市立大学 | 新規抗ｐａｄ４抗体 |
| US11254736B2 (en) | 2019-02-15 | 2022-02-22 | Integral Molecular, Inc. | Antibodies comprising a common light chain and uses thereof |
| CN119708241A (zh) | 2019-02-15 | 2025-03-28 | 因特格尔莫来库乐有限公司 | 密封蛋白6抗体及其用途 |
| CN111733151B (zh) * | 2020-07-13 | 2021-11-12 | 山东新创生物科技有限公司 | 一种基于padi4作为肿瘤标志物制得的抗原、抗体及应用 |
| WO2022035834A1 (en) * | 2020-08-10 | 2022-02-17 | Integral Molecular, Inc. | Methods and compositions for making antibody libraries and antibodies isolated from the same |
| AR124914A1 (es) | 2021-02-18 | 2023-05-17 | Mitsubishi Tanabe Pharma Corp | Nuevo anticuerpo anti-pad4 |
| US20250003951A1 (en) * | 2021-04-21 | 2025-01-02 | Oxford University Innovation Limited | Method and composition |
| EP4558529A1 (en) * | 2022-07-22 | 2025-05-28 | Bristol-Myers Squibb Company | Antibodies binding to human pad4 and uses thereof |
| CN120282987A (zh) | 2022-11-30 | 2025-07-08 | 因特格尔莫来库乐有限公司 | 包括双特异性型式的针对紧密连接蛋白6的抗体 |
| AR131398A1 (es) | 2022-12-19 | 2025-03-12 | Astrazeneca Ab | Tratamiento de enfermedades autoinmunitarias |
| WO2024233254A2 (en) * | 2023-05-05 | 2024-11-14 | The Johns Hopkins University | Human monoclonal antibodies for treating subjects suffering from pulmonary fibrosis |
| WO2025024265A1 (en) | 2023-07-21 | 2025-01-30 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad4 modulators |
| WO2025122927A1 (en) * | 2023-12-06 | 2025-06-12 | Integral Molecular, Inc. | Antibodies directed to claudin 18.2, including bispecific formats thereof |
| AU2024406222A1 (en) | 2023-12-20 | 2026-06-04 | Bristol-Myers Squibb Company | Antibodies targeting il-18 receptor beta (il-18rβ) and related methods |
| WO2026020127A2 (en) | 2024-07-19 | 2026-01-22 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad2 modulators |
| WO2026136763A1 (en) | 2024-12-19 | 2026-06-25 | Bristol-Myers Squibb Company | Genetic predictor for il18 driven disease |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JP4304274B2 (ja) | 2004-03-04 | 2009-07-29 | 国立大学法人広島大学 | ニワトリ−ヒトキメラ抗体発現用ベクターおよびこれを用いたニワトリ−ヒトキメラ抗体生産方法、並びにその利用 |
| US7745690B2 (en) | 2004-03-09 | 2010-06-29 | Nagoya Industrial Science Research Institute | Transgenic nonhuman mammal representing the pathologic conditions of human rheumatoid arthritis |
| JP5252339B2 (ja) * | 2007-12-25 | 2013-07-31 | 地方独立行政法人東京都健康長寿医療センター | Ｐａｄ４及び抗ｐａｄ４抗体の測定方法並びに関節リウマチの検出方法 |
| WO2011066372A2 (en) * | 2009-11-25 | 2011-06-03 | The Johns Hopkins University | Citrullination of human peptidylarginine deiminase 4 (pad-4) regulates its function and immunogenicity |
| JPWO2012026309A1 (ja) | 2010-08-23 | 2013-10-28 | 公立大学法人横浜市立大学 | 抗ｐａｄ４抗体医薬の創成 |
| WO2013143026A1 (en) | 2012-03-31 | 2013-10-03 | Abmart (Shanghai) Co., Ltd | Peptide and antibody libraries and uses thereof |
| US11447569B2 (en) | 2015-03-06 | 2022-09-20 | Public University Corporation Yokohama City University | Anti-PAD4 antibody |
| WO2016155745A1 (en) * | 2015-03-27 | 2016-10-06 | Rigshospitalet | Cross-reactive anti-pad antibodies |
-
2016
- 2016-03-07 US US15/555,808 patent/US11447569B2/en active Active
- 2016-03-07 ES ES16761721T patent/ES2952132T3/es active Active
- 2016-03-07 EP EP23165932.7A patent/EP4223786A3/en active Pending
- 2016-03-07 JP JP2017505334A patent/JP6369922B2/ja active Active
- 2016-03-07 WO PCT/JP2016/057030 patent/WO2016143753A1/ja not_active Ceased
- 2016-03-07 EP EP16761721.6A patent/EP3266872B1/en active Active
-
2018
- 2018-07-05 JP JP2018128111A patent/JP6675739B2/ja active Active
-
2022
- 2022-09-19 US US17/933,229 patent/US12448464B2/en active Active
-
2025
- 2025-10-20 US US19/362,651 patent/US20260116998A1/en active Pending