RU2020142534A - Композиция для лечения рака, объединяющая анти-cd26 антитело и другое противораковое средство - Google Patents
Композиция для лечения рака, объединяющая анти-cd26 антитело и другое противораковое средство Download PDFInfo
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- RU2020142534A RU2020142534A RU2020142534A RU2020142534A RU2020142534A RU 2020142534 A RU2020142534 A RU 2020142534A RU 2020142534 A RU2020142534 A RU 2020142534A RU 2020142534 A RU2020142534 A RU 2020142534A RU 2020142534 A RU2020142534 A RU 2020142534A
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- 206010028980 Neoplasm Diseases 0.000 title 1
- 230000001093 anti-cancer Effects 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 239000012634 fragment Substances 0.000 claims 9
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 208000006178 malignant mesothelioma Diseases 0.000 claims 4
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 2
- 229940034982 antineoplastic agent Drugs 0.000 claims 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 2
- 229960004316 cisplatin Drugs 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 2
- 229960002584 gefitinib Drugs 0.000 claims 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
- 229960005277 gemcitabine Drugs 0.000 claims 2
- QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical compound C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 claims 2
- 229960005079 pemetrexed Drugs 0.000 claims 2
- 230000010261 cell growth Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000009089 cytolysis Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
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Claims (15)
1. Фармацевтическая композиция, включающая анти-CD26 антитело или его фрагмент и противоопухолевое средство.
2. Фармацевтическая композиция по п.1, при этом противоопухолевое средство представляет собой одно или несколько лекарственных средств, выбранных из группы, включающей цисплатин, пеметрексед, гефитиниб и гемцитабин.
3. Фармацевтическая композиция по п. 1 или 2, при этом анти-CD26 антитело или его фрагмент представляют собой гуманизированное антитело или его фрагмент.
4. Фармацевтическая композиция по п.3, при этом гуманизированное антитело или его фрагмент включает вариабельный участок тяжелой цепи, включающий аминокислотную последовательность, имеющую 80% или большую идентичность с аминокислотной последовательностью, выбранной из группы, включающей SEQ ID NO: 8-14, и вариабельный участок легкой цепи, включающий аминокислотную последовательность, имеющую 80% или большую идентичность с аминокислотной последовательностью, выбранной из группы, включающей SEQ ID NO: 1-7.
5. Фармацевтическая композиция по п.3, при этом гуманизированное антитело или его фрагмент включает вариабельный участок тяжелой цепи, включающий аминокислотную последовательность, имеющую 80% или большую идентичность с аминокислотной последовательностью, выбранной из группы, включающей SEQ ID NO: 1-7, и вариабельный участок легкой цепи, включающий аминокислотную последовательность, имеющую 80% или большую идентичность с аминокислотной последовательностью, выбранной из группы, включающей SEQ ID NO: 8-14.
6. Фармацевтическая композиция по п.3, при этом гуманизированное антитело или его фрагмент включает по меньшей мере одну тяжелую цепь, включающую аминокислотную последовательность, имеющую 90% или большую идентичность с аминокислотной последовательностью SEQ ID NO: 17, и по меньшей мере одну легкую цепь, включающую аминокислотную последовательность, имеющую 90% или большую идентичность с аминокислотной последовательностью SEQ ID NO: 18.
7. Фармацевтическая композиция по п.3, при этом гуманизированное антитело или его фрагмент включает по меньшей мере одну тяжелую цепь, включающую аминокислотную последовательность от позиции 20 до позиции 465 аминокислотной последовательности SEQ ID NO: 17, и по меньшей мере одну легкую цепь, включающую аминокислотную последовательность от позиции 21 до позиции 234 аминокислотной последовательности SEQ ID NO: 18.
8. Фармацевтическая композиция по п.3, при этом гуманизированное антитело или его фрагмент связывается с одним или несколькими пептидами, выбранными из группы, включающей SEQ ID NO: 19-28.
9. Фармацевтическая композиция по п.3, при этом гуманизированное антитело продуцировано штаммом, обозначенным s604069.YST-pABMC148 (x411) имеющим номер депонирования PTA-7695, Американская коллекция типовых культур (ATCC).
10. Фармацевтическая композиция по любому из пп. 1-9, при этом фрагмент выбирают из группы, включающей Fab, Fab', Fab'-SH, Fv, scFv и F(ab')2.
11. Фармацевтическая композиция по любому из пп. 1-10 для лечения злокачественной мезотелиомы.
12. Ингибитор роста клеток злокачественной мезотелиомы, включающий фармацевтическую композицию по любому из пп. 1-10.
13. Агент для лизиса клеток злокачественной мезотелиомы, включающий фармацевтическую композицию по любому из пп. 1-10.
14. Применение анти-CD26 антитела и противоопухолевого средства при изготовлении фармацевтической композиции для лечения злокачественной мезотелиомы.
15. Применение по п.14, при этом противоопухолевое средство представляет собой одно или несколько лекарственных средств, выбранных из группы, включающей цисплатин, пеметрексед, гефитиниб и гемцитабин.
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CN109709337B (zh) * | 2018-12-28 | 2021-09-14 | 江苏众红生物工程创药研究院有限公司 | 人cd26的免疫组化检测试剂盒及其临床应用 |
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US20210023238A1 (en) * | 2019-07-23 | 2021-01-28 | City Of Hope | Triptolide antibody conjugates |
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US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
CN112725286B (zh) * | 2021-03-30 | 2021-06-29 | 中国农业科学院蜜蜂研究所 | 一种分泌雷公藤甲素单克隆抗体的杂交瘤细胞株及其应用 |
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