JP2017521090A5 - - Google Patents
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- Publication number
- JP2017521090A5 JP2017521090A5 JP2017512466A JP2017512466A JP2017521090A5 JP 2017521090 A5 JP2017521090 A5 JP 2017521090A5 JP 2017512466 A JP2017512466 A JP 2017512466A JP 2017512466 A JP2017512466 A JP 2017512466A JP 2017521090 A5 JP2017521090 A5 JP 2017521090A5
- Authority
- JP
- Japan
- Prior art keywords
- polyplex
- cancer
- cooh
- target moiety
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920000642 polymer Polymers 0.000 claims 26
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 17
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 17
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 17
- 102000001301 EGF receptor Human genes 0.000 claims 15
- 108060006698 EGF receptor Proteins 0.000 claims 15
- 201000011510 cancer Diseases 0.000 claims 15
- 229920001223 polyethylene glycol Polymers 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 10
- 125000002947 alkylene group Chemical group 0.000 claims 9
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 9
- SOAPXKSPJAZNGO-WDSKDSINSA-N (2s)-2-[[(1s)-1,3-dicarboxypropyl]carbamoylamino]pentanedioic acid Chemical group OC(=O)CC[C@@H](C(O)=O)NC(=O)N[C@H](C(O)=O)CCC(O)=O SOAPXKSPJAZNGO-WDSKDSINSA-N 0.000 claims 8
- 239000002202 Polyethylene glycol Substances 0.000 claims 7
- 206010060862 Prostate cancer Diseases 0.000 claims 6
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 6
- 125000003277 amino group Chemical group 0.000 claims 6
- 238000004581 coalescence Methods 0.000 claims 6
- 125000002993 cycloalkylene group Chemical group 0.000 claims 5
- 125000005647 linker group Chemical group 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 4
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 4
- 125000004450 alkenylene group Chemical group 0.000 claims 4
- 125000004419 alkynylene group Chemical group 0.000 claims 4
- 210000002865 immune cell Anatomy 0.000 claims 4
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 4
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 4
- 125000006585 (C6-C10) arylene group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 101710181478 Envelope glycoprotein GP350 Proteins 0.000 claims 1
- 241000257303 Hymenoptera Species 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 101000851196 Mus musculus Pro-epidermal growth factor Proteins 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- 108091036414 Polyinosinic:polycytidylic acid Proteins 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000005218 alkyleneheteroaryl group Chemical group 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 229940022353 herceptin Drugs 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 0 CC(CC(N(CCCO)**N)=*)=C Chemical compound CC(CC(N(CCCO)**N)=*)=C 0.000 description 3
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020139643A JP7406475B2 (ja) | 2014-05-14 | 2020-08-20 | 改善されたポリエチレンイミンポリエチレングリコールベクター |
| JP2023211790A JP2024028995A (ja) | 2014-05-14 | 2023-12-15 | 改善されたポリエチレンイミンポリエチレングリコールベクター |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461993110P | 2014-05-14 | 2014-05-14 | |
| US61/993,110 | 2014-05-14 | ||
| PCT/IL2015/050514 WO2015173824A1 (en) | 2014-05-14 | 2015-05-14 | Improved polyethyleneimine polyethyleneglycol vectors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020139643A Division JP7406475B2 (ja) | 2014-05-14 | 2020-08-20 | 改善されたポリエチレンイミンポリエチレングリコールベクター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017521090A JP2017521090A (ja) | 2017-08-03 |
| JP2017521090A5 true JP2017521090A5 (enExample) | 2018-06-21 |
| JP6753843B2 JP6753843B2 (ja) | 2020-09-16 |
Family
ID=54479412
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512466A Active JP6753843B2 (ja) | 2014-05-14 | 2015-05-14 | 改善されたポリエチレンイミンポリエチレングリコールベクター |
| JP2020139643A Active JP7406475B2 (ja) | 2014-05-14 | 2020-08-20 | 改善されたポリエチレンイミンポリエチレングリコールベクター |
| JP2023211790A Pending JP2024028995A (ja) | 2014-05-14 | 2023-12-15 | 改善されたポリエチレンイミンポリエチレングリコールベクター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020139643A Active JP7406475B2 (ja) | 2014-05-14 | 2020-08-20 | 改善されたポリエチレンイミンポリエチレングリコールベクター |
| JP2023211790A Pending JP2024028995A (ja) | 2014-05-14 | 2023-12-15 | 改善されたポリエチレンイミンポリエチレングリコールベクター |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US10278991B2 (enExample) |
| EP (1) | EP3142673A4 (enExample) |
| JP (3) | JP6753843B2 (enExample) |
| KR (2) | KR102589295B1 (enExample) |
| CN (3) | CN116966310A (enExample) |
| AU (2) | AU2015260725B2 (enExample) |
| CA (1) | CA2949017A1 (enExample) |
| IL (2) | IL287206B2 (enExample) |
| MA (1) | MA39970A (enExample) |
| MX (2) | MX377654B (enExample) |
| NZ (1) | NZ727092A (enExample) |
| PH (1) | PH12016502258B1 (enExample) |
| RU (1) | RU2771104C2 (enExample) |
| SG (2) | SG10201911695SA (enExample) |
| WO (1) | WO2015173824A1 (enExample) |
| ZA (1) | ZA201608042B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2771104C2 (ru) | 2014-05-14 | 2022-04-26 | Таргиммьюн Терапьютикс Аг | Улучшенные полиэтилениминовые полиэтиленгликолевые векторы |
| ES2755418T3 (es) | 2015-11-17 | 2020-04-22 | Bioncotech Therapeutics S L | Novedosa composición farmacéutica que comprende partículas que comprenden un complejo de un polirribonucleótido de doble cadena y una polialquilenimina |
| AR107823A1 (es) * | 2016-03-07 | 2018-06-06 | Hanmi Pharm Ind Co Ltd | Derivados de polietilenglicol y uso de los mismos |
| BR112019004017A2 (pt) | 2016-09-04 | 2019-06-25 | Targimmune Therapeutics Ag | proteínas quiméricas para direcionar dsrna |
| ES2924138T3 (es) | 2017-05-17 | 2022-10-04 | Highlight Therapeutics S L | Nueva composición farmacéutica que comprende partículas que comprenden un complejo de un polirribonucleótido de doble cadena y una polialquilenimina |
| CN111164093A (zh) * | 2017-09-27 | 2020-05-15 | 塔尔格免疫治疗有限公司 | 去势抵抗性前列腺癌 |
| JP2021516056A (ja) * | 2018-03-08 | 2021-07-01 | ターグイミューン セラピューティクス アーゲー | 二本鎖ｒｎａ結合ドメインを含む組換えタンパク質 |
| CN109893657B (zh) * | 2019-02-28 | 2022-04-29 | 中国人民解放军军事科学院军事医学研究院 | 基因递送载体、药物复合物、抗肺纤维化药物及应用 |
| MX2021011654A (es) * | 2019-04-03 | 2022-02-21 | Targimmune Therapeutics Ag | Inmunoterapia para el tratamiento del cancer. |
| WO2020263782A1 (en) * | 2019-06-24 | 2020-12-30 | North Carolina State University | Methods and compositions for modifying nucleic acids and for killing cells |
| WO2021001023A1 (en) * | 2019-07-02 | 2021-01-07 | Biontech Rna Pharmaceuticals Gmbh | Rna formulations suitable for therapy |
| AU2021357354A1 (en) * | 2020-10-08 | 2023-04-20 | Targimmune Therapeutics Ag | Immunotherapy for the treatment of cancer |
| WO2023079142A2 (en) | 2021-11-05 | 2023-05-11 | Targimmune Therapeutics Ag | Targeted linear conjugates comprising polyethyleneimine and polyethylene glycol and polyplexes comprising the same |
| US20240091348A1 (en) * | 2022-09-20 | 2024-03-21 | Highlight Therapeutics, S.L. | Novel compositions based on polyinosinic-polycytidylic acid |
| IL320618A (en) | 2022-11-07 | 2025-07-01 | Targimmune Therapeutics Ag | Polyplexes of nucleic acids and targeted pairs containing polyethyleneimine and polyethylene glycol |
| KR20250106292A (ko) | 2022-11-07 | 2025-07-09 | 타르그이뮨 테라퓨틱스 아게 | 폴리에틸렌이민 및 폴리에틸렌 글리콜을 포함하는 psma 표적화 선형 컨쥬게이트 및 이들을 포함하는 다중복합체 |
| WO2024100046A1 (en) * | 2022-11-07 | 2024-05-16 | Targimmune Therapeutics Ag | Targeted linear conjugates comprising polyethyleneimine and polyethylene glycol and polyplexes comprising the same |
| WO2025238236A1 (en) | 2024-05-16 | 2025-11-20 | Targimmune Therapeutics Ag | Polyplexes of nucleic acids and targeted conjugates comprising polyethyleneimine and polyethylene glycol |
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| KR102285326B1 (ko) | 2013-06-28 | 2021-08-04 | 에트리스 게엠베하 | Rna를 세포에 도입하기 위한 조성물 |
| CN104341488A (zh) | 2013-08-02 | 2015-02-11 | 复旦大学 | c(LyP-1)多肽及其构建的纳米递药系统和应用 |
| US20160312218A1 (en) | 2013-11-04 | 2016-10-27 | Northeastern University | System for co-delivery of polynucleotides and drugs into protease-expressing cells |
| CN105705143A (zh) | 2013-11-08 | 2016-06-22 | 达娜-法勃肿瘤研究所公司 | 用于体内试剂递送的核酸纳米结构 |
| MX378984B (es) | 2014-03-14 | 2025-03-11 | Pfizer | Nanoparticulas terapeuticas que comprenden un agente terapeutico, y metodos para su elaboracion y uso. |
| EP3126501A1 (en) | 2014-03-24 | 2017-02-08 | RiboxX GmbH | Double-stranded rna conjugates and their use |
| US10682400B2 (en) | 2014-04-30 | 2020-06-16 | President And Fellows Of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| RU2771104C2 (ru) | 2014-05-14 | 2022-04-26 | Таргиммьюн Терапьютикс Аг | Улучшенные полиэтилениминовые полиэтиленгликолевые векторы |
| EP3253414A4 (en) | 2015-02-05 | 2018-07-11 | The University Of Queensland | Targeting constructs for delivery of payloads |
| WO2016183447A1 (en) | 2015-05-14 | 2016-11-17 | The Johns Hopkins University | Compositions of nucleic acid-containing nanoparticles for in vivo delivery |
| ES2755418T3 (es) | 2015-11-17 | 2020-04-22 | Bioncotech Therapeutics S L | Novedosa composición farmacéutica que comprende partículas que comprenden un complejo de un polirribonucleótido de doble cadena y una polialquilenimina |
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