JP2016512426A5 - - Google Patents

Download PDF

Info

Publication number
JP2016512426A5
JP2016512426A5 JP2016501047A JP2016501047A JP2016512426A5 JP 2016512426 A5 JP2016512426 A5 JP 2016512426A5 JP 2016501047 A JP2016501047 A JP 2016501047A JP 2016501047 A JP2016501047 A JP 2016501047A JP 2016512426 A5 JP2016512426 A5 JP 2016512426A5
Authority
JP
Japan
Prior art keywords
binding polypeptide
optionally
glycan
moiety
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016501047A
Other languages
English (en)
Japanese (ja)
Other versions
JP6588422B2 (ja
JP2016512426A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/022728 external-priority patent/WO2014164534A2/en
Publication of JP2016512426A publication Critical patent/JP2016512426A/ja
Publication of JP2016512426A5 publication Critical patent/JP2016512426A5/ja
Application granted granted Critical
Publication of JP6588422B2 publication Critical patent/JP6588422B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016501047A 2013-03-11 2014-03-10 糖類工学による部位特異的抗体−薬物コンジュゲーション Active JP6588422B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361776715P 2013-03-11 2013-03-11
US201361776710P 2013-03-11 2013-03-11
US201361776724P 2013-03-11 2013-03-11
US61/776,724 2013-03-11
US61/776,715 2013-03-11
US61/776,710 2013-03-11
PCT/US2014/022728 WO2014164534A2 (en) 2013-03-11 2014-03-10 Site-specific antibody-drug conjugation through glycoengineering

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019165052A Division JP7021159B2 (ja) 2013-03-11 2019-09-11 糖類工学による部位特異的抗体－薬物コンジュゲーション

Publications (3)

Publication Number Publication Date
JP2016512426A JP2016512426A (ja) 2016-04-28
JP2016512426A5 true JP2016512426A5 (enExample) 2017-03-30
JP6588422B2 JP6588422B2 (ja) 2019-10-09

Family

ID=50543307

Family Applications (9)

Application Number Title Priority Date Filing Date
JP2016501017A Active JP6739330B2 (ja) 2013-03-11 2014-03-10 高グリコシル化結合性ポリペプチド
JP2016501047A Active JP6588422B2 (ja) 2013-03-11 2014-03-10 糖類工学による部位特異的抗体−薬物コンジュゲーション
JP2019040108A Active JP7121675B2 (ja) 2013-03-11 2019-03-06 高グリコシル化結合性ポリペプチド
JP2019165052A Active JP7021159B2 (ja) 2013-03-11 2019-09-11 糖類工学による部位特異的抗体－薬物コンジュゲーション
JP2021068088A Active JP7321206B2 (ja) 2013-03-11 2021-04-14 高グリコシル化結合性ポリペプチド
JP2022014608A Active JP7390414B2 (ja) 2013-03-11 2022-02-02 糖類工学による部位特異的抗体－薬物コンジュゲーション
JP2023075428A Pending JP2023099146A (ja) 2013-03-11 2023-05-01 高グリコシル化結合性ポリペプチド
JP2023195664A Active JP7650943B2 (ja) 2013-03-11 2023-11-17 糖類工学による部位特異的抗体－薬物コンジュゲーション
JP2025037867A Pending JP2025090711A (ja) 2013-03-11 2025-03-11 糖類工学による部位特異的抗体－薬物コンジュゲーション

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2016501017A Active JP6739330B2 (ja) 2013-03-11 2014-03-10 高グリコシル化結合性ポリペプチド

Family Applications After (7)

Application Number Title Priority Date Filing Date
JP2019040108A Active JP7121675B2 (ja) 2013-03-11 2019-03-06 高グリコシル化結合性ポリペプチド
JP2019165052A Active JP7021159B2 (ja) 2013-03-11 2019-09-11 糖類工学による部位特異的抗体－薬物コンジュゲーション
JP2021068088A Active JP7321206B2 (ja) 2013-03-11 2021-04-14 高グリコシル化結合性ポリペプチド
JP2022014608A Active JP7390414B2 (ja) 2013-03-11 2022-02-02 糖類工学による部位特異的抗体－薬物コンジュゲーション
JP2023075428A Pending JP2023099146A (ja) 2013-03-11 2023-05-01 高グリコシル化結合性ポリペプチド
JP2023195664A Active JP7650943B2 (ja) 2013-03-11 2023-11-17 糖類工学による部位特異的抗体－薬物コンジュゲーション
JP2025037867A Pending JP2025090711A (ja) 2013-03-11 2025-03-11 糖類工学による部位特異的抗体－薬物コンジュゲーション

Country Status (14)

Country Link
US (9) US9701753B2 (enExample)
EP (5) EP4098663A1 (enExample)
JP (9) JP6739330B2 (enExample)
KR (6) KR102494631B1 (enExample)
CN (4) CN105189555B (enExample)
AU (5) AU2014249290B2 (enExample)
BR (2) BR112015020315A2 (enExample)
CA (2) CA2902530C (enExample)
HK (1) HK1214501A1 (enExample)
IL (7) IL318672A (enExample)
MX (3) MX370356B (enExample)
RU (2) RU2711935C2 (enExample)
SG (3) SG10201809779RA (enExample)
WO (2) WO2014164534A2 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8528728B2 (en) 2010-05-19 2013-09-10 Johnson & Johnson Vision Care, Inc. Ophthalmic lens disinfecting storage case
UY34317A (es) 2011-09-12 2013-02-28 Genzyme Corp Anticuerpo antireceptor de célula T (alfa)/ß
US9790268B2 (en) 2012-09-12 2017-10-17 Genzyme Corporation Fc containing polypeptides with altered glycosylation and reduced effector function
US9701753B2 (en) 2013-03-11 2017-07-11 Genzyme Corporation Hyperglycosylated binding polypeptides
AU2015231307B2 (en) * 2014-03-19 2021-01-28 Genzyme Corporation Site-specific glycoengineering of targeting moieties
CN108025083B (zh) * 2014-10-09 2021-09-03 建新公司 糖工程化的抗体药物缀合物
TN2017000275A1 (en) * 2015-01-23 2018-10-19 Sanofi Sa Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123
AU2015242213A1 (en) 2015-07-12 2018-03-08 Hangzhou Dac Biotech Co., Ltd Bridge linkers for conjugation of cell-binding molecules
US11091498B2 (en) 2016-04-04 2021-08-17 Rutgers, The State University Of New Jersey Topoisomerase poisons
CN106248971B (zh) * 2016-08-19 2017-10-03 合肥瀚科迈博生物技术有限公司 用于检测人血清中her2含量的elisa试剂盒、使用方法及用途
MX2019005583A (es) 2016-11-14 2019-10-21 Hangzhou Dac Biotech Co Ltd Vinculantes de conjugacion, conjugados de molecula de union a celulas que contienen los vinculantes, metodos de creacion y usos de dichos conjugados con los vinculantes.
US10583191B2 (en) 2016-12-19 2020-03-10 Mosaic Biomedicals Slu Antibodies against LIF and uses thereof
IL267450B (en) 2016-12-19 2022-07-01 Mosaic Biomedicals S L U Antibodies against lif and their uses
WO2018126092A1 (en) 2016-12-29 2018-07-05 Development Center For Biotechnology Processes for preparing glycoprotein-drug conjugates
WO2018178277A1 (en) 2017-03-29 2018-10-04 Avicenna Oncology Gmbh New targeted cytotoxic isocombretaquinoline derivatives and conjugates thereof
CN119708265A (zh) * 2017-08-31 2025-03-28 辛格隆股份公司 用于制备细菌素和抗微生物肽的方法和组合物
KR102110182B1 (ko) * 2017-09-20 2020-05-14 한양대학교 에리카산학협력단 신규한 옥심 유도체 화합물 및 이를 포함한 항체-약물 복합체
EP3707167A4 (en) * 2017-11-09 2021-08-04 National Research Council of Canada ANTIBODY GLYCOCONJUGATES, PRODUCTION AND USE PROCESSES
FR3085952B1 (fr) 2018-09-17 2020-10-30 Centre Nat Rech Scient Conjugue anticorps-medicament comprenant des derives de quinoline
CN120192414A (zh) 2019-04-03 2025-06-24 建新公司 具有降低的断裂的抗αβTCR结合多肽
US20230025327A1 (en) 2019-06-29 2023-01-26 Hangzhou Dac Biotech Co., Ltd. Conjugates of tubulysin derivatives and cell binding molecules and methods of making
EP3865155B1 (en) * 2020-02-13 2022-11-30 Orano Med Process for site-specific modification of an antibody
CA3217739A1 (en) 2021-05-05 2022-11-10 Sebastian Bunk Bma031 antigen binding polypeptides
KR102341642B1 (ko) 2021-06-24 2021-12-21 주식회사 글로브 플로어용 영상 표출 시스템
CN117980327A (zh) 2021-11-03 2024-05-03 杭州多禧生物科技有限公司 抗体的特异性偶联
KR20240133715A (ko) * 2021-12-17 2024-09-04 포트비타 바이오로직스 (싱가포르) 피티이. 리미티드 Claudin18.2를 표적으로 하는 항체-약물 접합체
WO2025088546A1 (en) 2023-10-25 2025-05-01 Ablynx N.V. Fc domain variants with enhanced fc receptor binding

Family Cites Families (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
DE68928427T2 (de) 1988-09-15 1998-06-04 Univ Columbia Antikörper mit modifiziertem Kohlenhydratgehalt und Verfahren zur Herstellung und Verwendung
JP2650358B2 (ja) 1988-10-06 1997-09-03 株式会社ニコン 半透過部材を有する光学装置
US6780613B1 (en) 1988-10-28 2004-08-24 Genentech, Inc. Growth hormone variants
CA2018248A1 (en) 1989-06-07 1990-12-07 Clyde W. Shearman Monoclonal antibodies against the human alpha/beta t-cell receptor, their production and use
US5622929A (en) * 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
US5837821A (en) 1992-11-04 1998-11-17 City Of Hope Antibody construct
US5792456A (en) * 1994-08-04 1998-08-11 Bristol-Myers Squibb Company Mutant BR96 antibodies reactive with human carcinomas
DK0706799T3 (da) 1994-09-16 2002-02-25 Merck Patent Gmbh Immunkonjugater II
GB9422383D0 (en) 1994-11-05 1995-01-04 Wellcome Found Antibodies
US5739277A (en) 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
WO1996040662A2 (en) * 1995-06-07 1996-12-19 Cellpro, Incorporated Aminooxy-containing linker compounds and their application in conjugates
AU6873396A (en) 1995-10-16 1997-05-07 Unilever N.V. A bifunctional or bivalent antibody fragment analogue
GB9524973D0 (en) 1995-12-06 1996-02-07 Lynxvale Ltd Viral vectors
SE9601245D0 (sv) 1996-03-29 1996-03-29 Pharmacia Ab Chimeric superantigens and their use
CA2249320C (en) * 1996-03-20 2008-12-23 Immunomedics, Inc. Glycosylated humanized b-cell specific antibodies
ATE386809T1 (de) 1996-08-02 2008-03-15 Bristol Myers Squibb Co Ein verfahren zur inhibierung immunglobulininduzierter toxizität aufgrund von der verwendung von immunoglobinen in therapie und in vivo diagnostik
WO1998023289A1 (en) 1996-11-27 1998-06-04 The General Hospital Corporation MODULATION OF IgG BINDING TO FcRn
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
WO1999022764A1 (en) 1997-10-31 1999-05-14 Genentech, Inc. Methods and compositions comprising glycoprotein glycoforms
US6953675B2 (en) 1997-11-06 2005-10-11 Immunomedics, Inc. Landscaped antibodies and antibody fragments for clinical use
US6001817A (en) * 1998-01-12 1999-12-14 Unitech Pharmaceuticals, Inc. Pharmaceutical composition comprised of cisplatin, and processes for making and using same
US6242195B1 (en) 1998-04-02 2001-06-05 Genentech, Inc. Methods for determining binding of an analyte to a receptor
ES2292236T3 (es) 1998-04-02 2008-03-01 Genentech, Inc. Variantes de anticuerpos y sus fragmentos.
US6528624B1 (en) 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
AU770555B2 (en) 1998-08-17 2004-02-26 Abgenix, Inc. Generation of modified molecules with increased serum half-lives
US6465612B1 (en) * 1998-09-23 2002-10-15 The Regents Of The University Of California Synthetic peptides, conjugation reagents and methods
EP1006183A1 (en) 1998-12-03 2000-06-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Recombinant soluble Fc receptors
CN1763097B (zh) 1999-01-15 2011-04-13 杰南技术公司 具有改变的效应功能的多肽变体
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US7183387B1 (en) 1999-01-15 2007-02-27 Genentech, Inc. Polypeptide variants with altered effector function
US20020102208A1 (en) 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
CN1110322C (zh) * 1999-07-21 2003-06-04 中国医学科学院医药生物技术研究所 单克隆抗体Fab'－平阳霉素偶联物及其抗肿瘤作用
WO2002002781A1 (en) 2000-06-30 2002-01-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Heterodimeric fusion proteins
GB0029407D0 (en) 2000-12-01 2001-01-17 Affitech As Product
WO2002060919A2 (en) 2000-12-12 2002-08-08 Medimmune, Inc. Molecules with extended half-lives, compositions and uses thereof
US20050107595A1 (en) * 2001-06-20 2005-05-19 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
CN1671416B (zh) 2001-07-12 2013-01-02 杰斐逊·富特 超人源化抗体
US6900292B2 (en) 2001-08-17 2005-05-31 Lee-Hwei K. Sun Fc fusion proteins of human erythropoietin with increased biological activities
US7265084B2 (en) * 2001-10-10 2007-09-04 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
HK1080090B (zh) * 2001-10-10 2012-12-14 诺和诺德公司 肽的重构和糖缀合的方法
US7214660B2 (en) * 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) * 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7226903B2 (en) * 2001-10-10 2007-06-05 Neose Technologies, Inc. Interferon beta: remodeling and glycoconjugation of interferon beta
US7696163B2 (en) * 2001-10-10 2010-04-13 Novo Nordisk A/S Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7795210B2 (en) * 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
AU2002335585B2 (en) 2001-10-29 2007-08-16 Crucell Holland B.V. Methods and means for producing proteins with predetermined post-translational modifications
US20040002587A1 (en) 2002-02-20 2004-01-01 Watkins Jeffry D. Fc region variants
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
CA2478011C (en) 2002-03-01 2013-05-21 Immunomedics, Inc. Bispecific antibody point mutations for enhancing rate of clearance
US20070207142A1 (en) * 2002-05-08 2007-09-06 Genentech, Inc. Compositions and methods for the treatment of tumor of hematopoietic origin
CA2495251C (en) 2002-08-14 2018-03-06 Macrogenics, Inc. Fc.gamma.riib-specific antibodies and methods of use thereof
EP1553975B8 (en) 2002-09-27 2023-04-12 Xencor, Inc. Optimized fc variants and methods for their generation
DE60334141D1 (de) 2002-10-15 2010-10-21 Facet Biotech Corp VERÄNDERUNG VON FcRn-BINDUNGSAFFINITÄTEN ODER VON SERUMHALBWERTSZEITEN VON ANTIKÖRPERN MITTELS MUTAGENESE
AU2004204494B2 (en) 2003-01-09 2011-09-29 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
EP2055189A1 (en) * 2003-04-09 2009-05-06 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
KR100758755B1 (ko) 2003-06-12 2007-09-14 일라이 릴리 앤드 캄파니 Ｇｌｐ-1 유사체 융합 단백질
EP1664116A4 (en) 2003-08-22 2009-06-03 Biogen Idec Inc IMPROVED ANTIBODIES WITH CHANGED EFFECTOR FUNCTION AND MANUFACTURING METHOD THEREFOR
RU2392324C2 (ru) 2003-09-18 2010-06-20 Симфоген А/С Способ связывания интересующих последовательностей
GB0324368D0 (en) 2003-10-17 2003-11-19 Univ Cambridge Tech Polypeptides including modified constant regions
CN103394083B (zh) * 2003-11-06 2017-07-18 西雅图基因公司 能够与配体偶联的单甲基缬氨酸化合物
EP2385069A3 (en) 2003-11-12 2012-05-30 Biogen Idec MA Inc. Neonatal Fc rReceptor (FcRn)- binding polypeptide variants, dimeric Fc binding proteins and methods related thereto
US7001978B2 (en) 2003-11-19 2006-02-21 Xerox Corporation Unsaturated ester substituted polymers with reduced halogen content
WO2005056759A2 (en) 2003-12-04 2005-06-23 Xencor, Inc. Methods of generating variant proteins with increased host string content and compositions thereof
EP1697520A2 (en) 2003-12-22 2006-09-06 Xencor, Inc. Fc polypeptides with novel fc ligand binding sites
JP5743368B2 (ja) * 2004-01-08 2015-07-01 ラショファーム ゲーエムベーハー ペプチドのｏ結合型グリコシル化
US20080089892A1 (en) 2004-01-12 2008-04-17 Eli Lilly And Co. Fc Region Variants
WO2005092925A2 (en) 2004-03-24 2005-10-06 Xencor, Inc. Immunoglobulin variants outside the fc region
WO2005123780A2 (en) 2004-04-09 2005-12-29 Protein Design Labs, Inc. Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
BRPI0510295A (pt) * 2004-05-04 2007-11-06 Novo Nordisk Healthcare Ag preparação de uma glicoproteìna, e, método para produzir a mesma
WO2006085967A2 (en) 2004-07-09 2006-08-17 Xencor, Inc. OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
KR100863776B1 (ko) 2004-07-15 2008-10-16 젠코어 인코포레이티드 최적화된 Ｆｃ 변이체
SI1791565T1 (sl) * 2004-09-23 2016-08-31 Genentech, Inc. Cisteinsko konstruirana protitelesa in konjugati
AU2005289594B2 (en) 2004-09-27 2012-02-02 Centocor, Inc. Srage mimetibody, compositions, methods and uses
WO2006047350A2 (en) 2004-10-21 2006-05-04 Xencor, Inc. IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
JP4829609B2 (ja) 2004-12-22 2011-12-07 独立行政法人科学技術振興機構 ヒト抗体酵素およびその生産方法
US8217154B2 (en) 2005-02-23 2012-07-10 Lipoxen Technologies Limited Activated sialic acid derivatives for protein derivatisation and conjugation
US7812135B2 (en) 2005-03-25 2010-10-12 Tolerrx, Inc. GITR-binding antibodies
JP2008537941A (ja) * 2005-03-31 2008-10-02 ゼンコー・インコーポレイテッド 最適化特性を有するＦｃ変異体
CA2602663A1 (en) 2005-03-31 2006-10-05 Xencor, Inc. Fc variants with optimized properties
WO2006130834A2 (en) 2005-05-31 2006-12-07 Board Of Regents, The University Of Texas System IGGl ANTIBODIES WITH MUTATED FC PORTION FOR INCREASED BINDING TO FCRN RECEPTOR AND USES THEREOF
AU2006261127B2 (en) 2005-06-17 2012-03-15 Merck Sharp & Dohme Corp. ILT3 binding molecules and uses therefor
EP1896071B1 (en) 2005-06-30 2015-04-29 Janssen Biotech, Inc. Methods and compositions with enhanced therapeutic activity
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
US7846724B2 (en) 2006-04-11 2010-12-07 Hoffmann-La Roche Inc. Method for selecting CHO cell for production of glycosylated antibodies
TW200815467A (en) * 2006-06-06 2008-04-01 Genentech Inc Anti-DLL4 antibodies and methods using same
WO2008094176A2 (en) 2006-06-19 2008-08-07 Tolerx, Inc. Ilt3 binding molecules and uses therefor
US8580511B2 (en) * 2006-06-19 2013-11-12 The Regents Of The University Of California Two-color fluorescent reporter for alternative pre-mRNA splicing
US8460362B2 (en) 2006-07-20 2013-06-11 Orbusneich Medical, Inc. Bioabsorbable polymeric medical device
CN101516388B (zh) * 2006-07-21 2012-10-31 诺和诺德公司 通过o-联糖基化序列的肽的糖基化
MX2009003470A (es) 2006-10-04 2009-04-14 Novo Nordisk As Azucares y glicopeptidos pegilados enlazados a glicerol.
FI20060946A0 (fi) 2006-10-26 2006-10-26 Glykos Finland Oy Influenssaviruksen nukleiinihappoja ja peptidejä
CA2666308C (en) * 2006-10-26 2014-09-23 The Rockefeller University Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods
AR063975A1 (es) 2006-11-28 2009-03-04 Centelion Fusiones fc con receptor para fgf soluble modificadas con actividad biologica mejorada
ES2464815T3 (es) 2007-01-09 2014-06-04 Biogen Idec Ma Inc. Anticuerpos SP35 y usos de éstos
JP5357778B2 (ja) 2007-01-23 2013-12-04 ゼンコー・インコーポレイテッド 最適化ｃｄ４０抗体および前記を使用する方法
US7723485B2 (en) 2007-05-08 2010-05-25 Genentech, Inc. Cysteine engineered anti-MUC16 antibodies and antibody drug conjugates
ES2637918T3 (es) * 2007-09-28 2017-10-17 Janssen Biotech, Inc. Métodos y conformaciones estructurales de preparaciones de anticuerpos con aumento de la resistencia a las proteasas
EP2050764A1 (en) 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
ES2450755T3 (es) 2007-10-19 2014-03-25 Genentech, Inc. Anticuerpos anti-TENB2 modificados por ingeniería genética con cisteína, y conjugados de anticuerpo y fármaco
JP5647899B2 (ja) * 2008-01-08 2015-01-07 ラツィオファルム ゲーエムベーハーｒａｔｉｏｐｈａｒｍ ＧｍｂＨ オリゴサッカリルトランスフェラーゼを使用するポリペプチドの複合糖質化
EP3269737B1 (en) * 2008-01-31 2024-06-19 Genentech, Inc. Anti-cd79b antibodies and immunoconjugates and methods of use
EP2268807A2 (en) 2008-04-21 2011-01-05 Novo Nordisk A/S Hyperglycosylated human coagulation factor ix
UA40611U (ru) 2008-05-26 2009-04-27 Владимир Семенович Живченко Способ десульфурации железоуглеродистого расплава в тигельной печи
JP2012501178A (ja) 2008-08-26 2012-01-19 マクロジェニクス，インコーポレーテッド Ｔ細胞受容体抗体およびその使用方法
EP2233499A1 (en) 2009-03-26 2010-09-29 CSL Behring AG Antibody composition with altered Fab sialylation
US10087236B2 (en) * 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
WO2011101277A1 (en) 2010-02-16 2011-08-25 Novo Nordisk A/S Conjugated proteins
BR112012022210B1 (pt) 2010-03-04 2021-08-17 Macrogenics, Inc Anticorpo isolado ou seu fragmento imunorreativo, molécula de ácido nucleico, composição farmacêutica, e, uso do anticorpo isolado
AU2011288464B2 (en) * 2010-08-10 2015-10-29 Glycotope Gmbh Fab-glycosylated antibodies
AR085302A1 (es) * 2011-02-24 2013-09-18 Sanofi Sa Metodo de produccion de anticuerpos sialilados
SG10201604757RA (en) 2011-03-11 2016-08-30 Amicus Therapeutics Inc Dosing regimens for the treatment of fabry disease
TWI622597B (zh) 2011-03-28 2018-05-01 賽諾菲公司 具有交叉結合區定向之雙重可變區類抗體結合蛋白
UY34317A (es) 2011-09-12 2013-02-28 Genzyme Corp Anticuerpo antireceptor de célula T (alfa)/ß
US9790268B2 (en) * 2012-09-12 2017-10-17 Genzyme Corporation Fc containing polypeptides with altered glycosylation and reduced effector function
EA202091166A1 (ru) 2013-03-11 2021-04-30 Джензим Корпорейшн ПОЛИПЕПТИДЫ, СОДЕРЖАЩИЕ Fc С ИЗМЕНЕННЫМ ГЛИКОЗИЛИРОВАНИЕМ И СНИЖЕННОЙ ЭФФЕКТОРНОЙ ФУНКЦИЕЙ
US9701753B2 (en) 2013-03-11 2017-07-11 Genzyme Corporation Hyperglycosylated binding polypeptides
AU2015231307B2 (en) 2014-03-19 2021-01-28 Genzyme Corporation Site-specific glycoengineering of targeting moieties
AU2015243512B2 (en) 2014-04-08 2020-06-04 University Of Georgia Research Foundation Inc. Site-specific antibody-drug glycoconjugates and methods
CN108025083B (zh) 2014-10-09 2021-09-03 建新公司 糖工程化的抗体药物缀合物
CN120192414A (zh) 2019-04-03 2025-06-24 建新公司 具有降低的断裂的抗αβTCR结合多肽

Similar Documents

Publication Publication Date Title
JP2016512426A5 (enExample)
RU2015142992A (ru) Сайт-специфическая конъюгация антитело-лекарственное средство посредством гликоинженерии
JP2020000252A5 (enExample)
JP2015533490A5 (enExample)
HRP20230260T1 (hr) Glikoinženjering ciljajućih dijelova specifičan za mjesto
JP2016512425A5 (enExample)
CN105829543B (zh) 糖基改造的抗体、抗体-缀合物及其制备方法
JP2022062157A5 (enExample)
NO20074025L (no) Konjugater for dobbel billeddannelse og radiokjemoterapi:sammensetninger, fremstilling og anvendelse
US9987373B2 (en) Modified glycoprotein, protein-conjugate and process for the preparation thereof
TWI853822B (zh) 用於糖蛋白工程的糖苷合成酶變體及其使用方法
JP2020500016A5 (enExample)
CA2637765A1 (en) Benzamide and heteroarene derivatives
AU2021285747A8 (en) LPA receptor antagonists and uses thereof
FI3626825T3 (fi) Anti-cdh6-vasta-aine ja anti-cdh6-vasta-aine-lääke-konjugaatti
UA103198C2 (en) Squaramide derivatives as cxcr2 antagonists
MX2009003145A (es) Dextrano funcionalizado con aminoacidos hidrofobicos.
WO2013115926A3 (en) Aspartyl-trna synthetase-fc conjugates
UA99836C2 (en) Azacytidine analogue and using thereof
IL198930A0 (en) Non-standard amino acid conjugates of amphetamine and processes for making and using the same
NZ594480A (en) Methods and compositions for diagnosis and treatment of cancer
JP2013520986A5 (enExample)
MX2018004938A (es) Vacunas de antigeno ligado a pcrv de p. aeruginosa.
MX2020006328A (es) Composición inmunogénica.
MX2023007630A (es) Composiciones de trem modificadas y usos de las mismas.