|
AU600575B2
(en)
|
1987-03-18 |
1990-08-16 |
Sb2, Inc. |
Altered antibodies
|
|
DE68928427T2
(de)
|
1988-09-15 |
1998-06-04 |
Univ Columbia |
Antikörper mit modifiziertem Kohlenhydratgehalt und Verfahren zur Herstellung und Verwendung
|
|
JP2650358B2
(ja)
|
1988-10-06 |
1997-09-03 |
株式会社ニコン |
半透過部材を有する光学装置
|
|
US6780613B1
(en)
|
1988-10-28 |
2004-08-24 |
Genentech, Inc. |
Growth hormone variants
|
|
CA2018248A1
(en)
|
1989-06-07 |
1990-12-07 |
Clyde W. Shearman |
Monoclonal antibodies against the human alpha/beta t-cell receptor, their production and use
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
US5837821A
(en)
|
1992-11-04 |
1998-11-17 |
City Of Hope |
Antibody construct
|
|
US5792456A
(en)
*
|
1994-08-04 |
1998-08-11 |
Bristol-Myers Squibb Company |
Mutant BR96 antibodies reactive with human carcinomas
|
|
ATE208633T1
(de)
*
|
1994-09-16 |
2001-11-15 |
Merck Patent Gmbh |
Immunokonjugate
|
|
GB9422383D0
(en)
|
1994-11-05 |
1995-01-04 |
Wellcome Found |
Antibodies
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
WO1996040662A2
(en)
|
1995-06-07 |
1996-12-19 |
Cellpro, Incorporated |
Aminooxy-containing linker compounds and their application in conjugates
|
|
US5989830A
(en)
|
1995-10-16 |
1999-11-23 |
Unilever Patent Holdings Bv |
Bifunctional or bivalent antibody fragment analogue
|
|
GB9524973D0
(en)
|
1995-12-06 |
1996-02-07 |
Lynxvale Ltd |
Viral vectors
|
|
SE9601245D0
(sv)
|
1996-03-29 |
1996-03-29 |
Pharmacia Ab |
Chimeric superantigens and their use
|
|
EP0888125B1
(en)
*
|
1996-03-20 |
2004-05-26 |
Immunomedics, Inc. |
GLYCOSYLATED IgG ANTIBODIES
|
|
WO1998005787A1
(en)
|
1996-08-02 |
1998-02-12 |
Bristol-Myers Squibb Company |
A method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
|
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
EP1028751B1
(en)
|
1997-10-31 |
2008-12-31 |
Genentech, Inc. |
Methods and compositions comprising glycoprotein glycoforms
|
|
US6953675B2
(en)
*
|
1997-11-06 |
2005-10-11 |
Immunomedics, Inc. |
Landscaped antibodies and antibody fragments for clinical use
|
|
US6001817A
(en)
*
|
1998-01-12 |
1999-12-14 |
Unitech Pharmaceuticals, Inc. |
Pharmaceutical composition comprised of cisplatin, and processes for making and using same
|
|
US6242195B1
(en)
|
1998-04-02 |
2001-06-05 |
Genentech, Inc. |
Methods for determining binding of an analyte to a receptor
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
DE69937291T2
(de)
|
1998-04-02 |
2008-07-10 |
Genentech, Inc., South San Francisco |
Antikörpervarianten und fragmente davon
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
US20020142374A1
(en)
|
1998-08-17 |
2002-10-03 |
Michael Gallo |
Generation of modified molecules with increased serum half-lives
|
|
AU6059699A
(en)
|
1998-09-23 |
2000-04-10 |
Regents Of The University Of California, The |
Synthetic peptides, conjugation reagents and methods
|
|
EP1006183A1
(en)
|
1998-12-03 |
2000-06-07 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Recombinant soluble Fc receptors
|
|
KR101077001B1
(ko)
|
1999-01-15 |
2011-10-26 |
제넨테크, 인크. |
효과기 기능이 변화된 폴리펩티드 변이체
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US20020102208A1
(en)
|
1999-03-01 |
2002-08-01 |
Paul Chinn |
Radiolabeling kit and binding assay
|
|
CN1110322C
(zh)
*
|
1999-07-21 |
2003-06-04 |
中国医学科学院医药生物技术研究所 |
单克隆抗体Fab'-平阳霉素偶联物及其抗肿瘤作用
|
|
AU2001270609A1
(en)
|
2000-06-30 |
2002-01-14 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
Heterodimeric fusion proteins
|
|
GB0029407D0
(en)
|
2000-12-01 |
2001-01-17 |
Affitech As |
Product
|
|
PT1355919E
(pt)
|
2000-12-12 |
2011-03-02 |
Medimmune Llc |
Moléculas com semivida longa, composições que as contêm e suas utilizações
|
|
US20050107595A1
(en)
|
2001-06-20 |
2005-05-19 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
IL166244A0
(en)
|
2001-07-12 |
2006-01-15 |
Jefferson Foote |
Super humanized antibodies
|
|
US6900292B2
(en)
|
2001-08-17 |
2005-05-31 |
Lee-Hwei K. Sun |
Fc fusion proteins of human erythropoietin with increased biological activities
|
|
US7696163B2
(en)
*
|
2001-10-10 |
2010-04-13 |
Novo Nordisk A/S |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
EP2305312B1
(en)
*
|
2001-10-10 |
2015-03-04 |
ratiopharm GmbH |
Remodelling and glycoconjugation of follicle-stimulating hormone (FSH)
|
|
US7173003B2
(en)
*
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
|
US7265084B2
(en)
*
|
2001-10-10 |
2007-09-04 |
Neose Technologies, Inc. |
Glycopegylation methods and proteins/peptides produced by the methods
|
|
US7214660B2
(en)
*
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US7795210B2
(en)
*
|
2001-10-10 |
2010-09-14 |
Novo Nordisk A/S |
Protein remodeling methods and proteins/peptides produced by the methods
|
|
US7226903B2
(en)
*
|
2001-10-10 |
2007-06-05 |
Neose Technologies, Inc. |
Interferon beta: remodeling and glycoconjugation of interferon beta
|
|
EA008220B1
(ru)
|
2001-10-29 |
2007-04-27 |
Круселл Холланд Б.В. |
Композиция, включающая эритропоэтинподобные молекулы, и способы ее применения
|
|
US20040002587A1
(en)
|
2002-02-20 |
2004-01-01 |
Watkins Jeffry D. |
Fc region variants
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
CA2478011C
(en)
|
2002-03-01 |
2013-05-21 |
Immunomedics, Inc. |
Bispecific antibody point mutations for enhancing rate of clearance
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US20070207142A1
(en)
*
|
2002-05-08 |
2007-09-06 |
Genentech, Inc. |
Compositions and methods for the treatment of tumor of hematopoietic origin
|
|
US7425620B2
(en)
|
2002-08-14 |
2008-09-16 |
Scott Koenig |
FcγRIIB-specific antibodies and methods of use thereof
|
|
WO2004029207A2
(en)
|
2002-09-27 |
2004-04-08 |
Xencor Inc. |
Optimized fc variants and methods for their generation
|
|
DK1562972T3
(da)
|
2002-10-15 |
2010-12-06 |
Facet Biotech Corp |
Modifikation af FcRn-bindingsaffiniteter eller serumhalveringstider for antistoffer ved mutagenese
|
|
EP2368578A1
(en)
|
2003-01-09 |
2011-09-28 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
|
EP1615945B1
(en)
|
2003-04-09 |
2011-09-28 |
BioGeneriX AG |
Glycopegylation methods and proteins/peptides produced by the methods
|
|
EA008831B1
(ru)
|
2003-06-12 |
2007-08-31 |
Эли Лилли Энд Компани |
Слитые белки аналогов glp-1
|
|
NZ545776A
(en)
|
2003-08-22 |
2009-05-31 |
Biogen Idec Inc |
Improved antibodies having altered effector function and methods for making the same
|
|
RU2392324C2
(ru)
|
2003-09-18 |
2010-06-20 |
Симфоген А/С |
Способ связывания интересующих последовательностей
|
|
GB0324368D0
(en)
|
2003-10-17 |
2003-11-19 |
Univ Cambridge Tech |
Polypeptides including modified constant regions
|
|
CN107213469A
(zh)
*
|
2003-11-06 |
2017-09-29 |
西雅图基因公司 |
能够与配体偶联的单甲基缬氨酸化合物
|
|
CA2545603A1
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
Neonatal fc receptor (fcrn)-binding polypeptide variants, dimeric fc binding proteins and methods related thereto
|
|
US7001978B2
(en)
|
2003-11-19 |
2006-02-21 |
Xerox Corporation |
Unsaturated ester substituted polymers with reduced halogen content
|
|
JP2007512846A
(ja)
|
2003-12-04 |
2007-05-24 |
ゼンコー・インコーポレイテッド |
増加した宿主ストリング含有量を有する変異体タンパク質の生成方法およびその組成物
|
|
WO2005077981A2
(en)
|
2003-12-22 |
2005-08-25 |
Xencor, Inc. |
Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES
|
|
US8361961B2
(en)
*
|
2004-01-08 |
2013-01-29 |
Biogenerix Ag |
O-linked glycosylation of peptides
|
|
EP1706424B1
(en)
|
2004-01-12 |
2009-07-22 |
Applied Molecular Evolution, Inc. |
Fc region variants
|
|
US7276585B2
(en)
|
2004-03-24 |
2007-10-02 |
Xencor, Inc. |
Immunoglobulin variants outside the Fc region
|
|
WO2005123780A2
(en)
|
2004-04-09 |
2005-12-29 |
Protein Design Labs, Inc. |
Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
EP1745141B2
(en)
*
|
2004-05-04 |
2019-09-25 |
Novo Nordisk Health Care AG |
O-linked glycoforms of faktor vii and method to manufacture them
|
|
WO2006085967A2
(en)
|
2004-07-09 |
2006-08-17 |
Xencor, Inc. |
OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
|
|
CN103172731A
(zh)
|
2004-07-15 |
2013-06-26 |
赞科股份有限公司 |
优化的Fc变体
|
|
KR101270829B1
(ko)
*
|
2004-09-23 |
2013-06-07 |
제넨테크, 인크. |
시스테인 유전자조작 항체 및 접합체
|
|
CA2581505A1
(en)
|
2004-09-27 |
2006-04-06 |
Centocor, Inc. |
Srage mimetibody, compositions, methods and uses
|
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
|
JP4829609B2
(ja)
|
2004-12-22 |
2011-12-07 |
独立行政法人科学技術振興機構 |
ヒト抗体酵素およびその生産方法
|
|
EP1853634B1
(en)
|
2005-02-23 |
2016-08-10 |
Lipoxen Technologies Limited |
Activated sialic acid derivatives for protein derivatisation and conjugation
|
|
WO2006105021A2
(en)
|
2005-03-25 |
2006-10-05 |
Tolerrx, Inc. |
Gitr binding molecules and uses therefor
|
|
EP1871808A2
(en)
|
2005-03-31 |
2008-01-02 |
Xencor, Inc. |
Fc VARIANTS WITH OPTIMIZED PROPERTIES
|
|
JP2008537941A
(ja)
*
|
2005-03-31 |
2008-10-02 |
ゼンコー・インコーポレイテッド |
最適化特性を有するFc変異体
|
|
US8163881B2
(en)
|
2005-05-31 |
2012-04-24 |
The Board Of Regents Of The University Of Texas System |
Immunoglobulin molecules with improved characteristics
|
|
EP1907001B1
(en)
|
2005-06-17 |
2015-07-15 |
Merck Sharp & Dohme Corp. |
Ilt3 binding molecules and uses therefor
|
|
JP2009504569A
(ja)
|
2005-06-30 |
2009-02-05 |
セントカー・インコーポレーテツド |
向上した治療活性をもつ方法および組成物
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
US7846724B2
(en)
|
2006-04-11 |
2010-12-07 |
Hoffmann-La Roche Inc. |
Method for selecting CHO cell for production of glycosylated antibodies
|
|
CA2654000A1
(en)
*
|
2006-06-06 |
2008-05-22 |
Genentech, Inc. |
Anti-dll4 antibodies and methods using same
|
|
US8580511B2
(en)
*
|
2006-06-19 |
2013-11-12 |
The Regents Of The University Of California |
Two-color fluorescent reporter for alternative pre-mRNA splicing
|
|
CA2655903A1
(en)
|
2006-06-19 |
2008-08-07 |
Tolerx, Inc. |
Ilt3 binding molecules and uses therefor
|
|
US8460362B2
(en)
|
2006-07-20 |
2013-06-11 |
Orbusneich Medical, Inc. |
Bioabsorbable polymeric medical device
|
|
US9187532B2
(en)
*
|
2006-07-21 |
2015-11-17 |
Novo Nordisk A/S |
Glycosylation of peptides via O-linked glycosylation sequences
|
|
CA2665480C
(en)
|
2006-10-04 |
2019-11-12 |
Novo Nordisk A/S |
Glycerol linked pegylated sugars and glycopeptides
|
|
CA2666308C
(en)
*
|
2006-10-26 |
2014-09-23 |
The Rockefeller University |
Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods
|
|
FI20060946A0
(fi)
|
2006-10-26 |
2006-10-26 |
Glykos Finland Oy |
Influenssaviruksen nukleiinihappoja ja peptidejä
|
|
PE20081250A1
(es)
*
|
2006-11-28 |
2008-10-07 |
Centelion |
FUSIONES Fc CON RECEPTOR PARA FGF SOLUBLE MODIFICADAS, CON ACTIVIDAD BIOLOGICA MEJORADA
|
|
ES2464815T3
(es)
|
2007-01-09 |
2014-06-04 |
Biogen Idec Ma Inc. |
Anticuerpos SP35 y usos de éstos
|
|
WO2008091954A2
(en)
|
2007-01-23 |
2008-07-31 |
Xencor, Inc. |
Optimized cd40 antibodies and methods of using the same
|
|
AR066476A1
(es)
|
2007-05-08 |
2009-08-19 |
Genentech Inc |
Anticuerpos anti-muc16 disenados con cisteina y conjugaods de anticuerpos y farmacos
|
|
WO2009045894A1
(en)
*
|
2007-09-28 |
2009-04-09 |
Centocor, Inc. |
Methods and structural conformations of antibody preparations with increased resistance to proteases
|
|
EP2050764A1
(en)
|
2007-10-15 |
2009-04-22 |
sanofi-aventis |
Novel polyvalent bispecific antibody format and uses thereof
|
|
CA2698541C
(en)
|
2007-10-19 |
2018-01-09 |
Genentech, Inc. |
Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates
|
|
WO2009089396A2
(en)
*
|
2008-01-08 |
2009-07-16 |
Neose Technologies, Inc. |
Glycoconjugation of polypeptides using oligosaccharyltransferases
|
|
ES2643239T3
(es)
*
|
2008-01-31 |
2017-11-21 |
Genentech, Inc. |
Anticuerpos anti-CD79b e inmunoconjugados y métodos de uso
|
|
EP2811017A2
(en)
|
2008-04-21 |
2014-12-10 |
Novo Nordisk Health Care AG |
Hyperglycosylated human coagulation factor IX
|
|
UA40611U
(ru)
|
2008-05-26 |
2009-04-27 |
Владимир Семенович Живченко |
Способ десульфурации железоуглеродистого расплава в тигельной печи
|
|
WO2010027797A1
(en)
|
2008-08-26 |
2010-03-11 |
Macrogenics Inc. |
T-cell receptor antibodies and methods of use thereof
|
|
EP2233499A1
(en)
*
|
2009-03-26 |
2010-09-29 |
CSL Behring AG |
Antibody composition with altered Fab sialylation
|
|
US10087236B2
(en)
*
|
2009-12-02 |
2018-10-02 |
Academia Sinica |
Methods for modifying human antibodies by glycan engineering
|
|
JP5826772B2
(ja)
|
2010-02-16 |
2015-12-02 |
ノヴォ ノルディスク アー/エス |
コンジュゲートタンパク質
|
|
DK2542256T3
(da)
|
2010-03-04 |
2019-08-26 |
Macrogenics Inc |
Antistoffer reagerende med b7-h3, immunologisk aktive fragmenter deraf og anvendelser deraf
|
|
BR112013003095B1
(pt)
*
|
2010-08-10 |
2023-03-28 |
Glycotope Gmbh |
Método para controle da meia-vida em circulação de um anticorpo ou um fragmento ou derivado funcional do mesmo, composições de anticorpo, seu usos e seus métodos de produção
|
|
AR085302A1
(es)
*
|
2011-02-24 |
2013-09-18 |
Sanofi Sa |
Metodo de produccion de anticuerpos sialilados
|
|
CN107088225A
(zh)
|
2011-03-11 |
2017-08-25 |
阿米库斯治疗学公司 |
治疗法布里病的给药方案
|
|
TWI588156B
(zh)
|
2011-03-28 |
2017-06-21 |
賽諾菲公司 |
具有交叉結合區定向之雙重可變區類抗體結合蛋白
|
|
UY34317A
(es)
|
2011-09-12 |
2013-02-28 |
Genzyme Corp |
Anticuerpo antireceptor de célula T (alfa)/ß
|
|
US9790268B2
(en)
|
2012-09-12 |
2017-10-17 |
Genzyme Corporation |
Fc containing polypeptides with altered glycosylation and reduced effector function
|
|
SI2895513T1
(sl)
|
2012-09-12 |
2018-11-30 |
Genzyme Corporation |
Polipeptidi, ki vsebujejo FC, s spremenjeno glikozilacijo in zmanjšano efektorsko funkcijo
|
|
IL289918B2
(en)
|
2013-03-11 |
2025-07-01 |
Genzyme Corp |
Site-specific antibody-drug conjugation through glycoengineering
|
|
US10995148B2
(en)
|
2014-03-19 |
2021-05-04 |
Genzyme Corporation |
Site-specific glycoengineering of targeting moieties
|
|
WO2015157446A1
(en)
|
2014-04-08 |
2015-10-15 |
University Of Georgia Research Foundation Inc. |
Site-specific antibody-drug glycoconjugates and methods
|
|
PT3204425T
(pt)
|
2014-10-09 |
2020-12-18 |
Genzyme Corp |
Conjugados anticorpo fármaco glicomanipulados
|
|
WO2020206063A1
(en)
|
2019-04-03 |
2020-10-08 |
Genzyme Corporation |
Anti-alpha beta tcr binding polypeptides with reduced fragmentation
|