WO2008001392A3 - An improved process for the preparation of pantoprazole and its pharmaceutically acceptable salts - Google Patents

An improved process for the preparation of pantoprazole and its pharmaceutically acceptable salts Download PDF

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Publication number
WO2008001392A3
WO2008001392A3 PCT/IN2007/000265 IN2007000265W WO2008001392A3 WO 2008001392 A3 WO2008001392 A3 WO 2008001392A3 IN 2007000265 W IN2007000265 W IN 2007000265W WO 2008001392 A3 WO2008001392 A3 WO 2008001392A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
pantoprazole
improved process
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
PCT/IN2007/000265
Other languages
French (fr)
Other versions
WO2008001392A2 (en
Inventor
Manne Satyanarayna Reddy
Muppa Kishore Kumar
Srinivasan Thirumalai Rajan
Karamala Rama Subba Reddy
Manne Satyanarayana Reddy
Original Assignee
Msn Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Limited filed Critical Msn Laboratories Limited
Publication of WO2008001392A2 publication Critical patent/WO2008001392A2/en
Publication of WO2008001392A3 publication Critical patent/WO2008001392A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention related to an improved process for the preparation of Pantoprazole sodium sesquihydrate comprising the reaction of 5-difluoromethoxy-2-mercapto benzimidazole with 2-chloromethyl-3,4-dimethoxy pyridine hydrochloride in an aqueous alkali, which upon oxidation with sodium hypochlorite having pH of about 8.5-9.0 and assay of about 3.0-3.5 in chloro solvent followed by reaction with sodium hydroxide in acetone. The invention also relates to the process for the preparation of pantoprazole sodium sesquihydrate form-I.
PCT/IN2007/000265 2006-06-30 2007-06-29 An improved process for the preparation of pantoprazole and its pharmaceutically acceptable salts WO2008001392A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1121/CHE/2006 2006-06-30
IN1121CH2006 2006-06-30

Publications (2)

Publication Number Publication Date
WO2008001392A2 WO2008001392A2 (en) 2008-01-03
WO2008001392A3 true WO2008001392A3 (en) 2009-09-24

Family

ID=38846112

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000265 WO2008001392A2 (en) 2006-06-30 2007-06-29 An improved process for the preparation of pantoprazole and its pharmaceutically acceptable salts

Country Status (1)

Country Link
WO (1) WO2008001392A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05013316A (en) 2003-06-10 2006-03-17 Teva Pharma Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole.
US7682828B2 (en) 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
US20100210847A1 (en) * 2007-07-17 2010-08-19 Ranbaxy Laboratories Limited Process for the preparation of pantoprazole sodium and pantoprazole sodium sesquihydrate
WO2010012063A1 (en) 2008-07-31 2010-02-04 Labbell Inc. Method of detecting bioactive molecules in a fluid sample
CN102584790B (en) * 2011-12-31 2014-04-02 江苏奥赛康药业股份有限公司 S-pantoprazole sodium trihydrate, and preparation method and application thereof
CN103214459B (en) * 2013-03-22 2014-11-12 海南中化联合制药工业股份有限公司 Pantoprazole sodium crystalline compound, pharmaceutical composition and preparation method thereof
CN114853678A (en) * 2022-03-31 2022-08-05 山东科源制药股份有限公司 Synthesis method of lansoprazole bulk drug intermediate H-benzimidazole

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1411053A1 (en) * 2000-04-14 2004-04-21 Esteve Quimica, S.A. Method for obtaining derivatives of (pyridil substituted)methyl]thio]benzimidazol
WO2004063188A1 (en) * 2003-01-15 2004-07-29 Cipla Limited Paharmaceutical process and compounds prepared thereby
US20040186139A1 (en) * 2002-09-02 2004-09-23 Dr. Reddy's Laboratories Limited Process for preparation of crystalline form-1 of pantoprazole sodium sesquihydrate
WO2004111029A2 (en) * 2003-06-10 2004-12-23 Teva Pharmaceutical Industries Ltd. Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
WO2006040778A1 (en) * 2004-10-15 2006-04-20 Matrix Laboratories Ltd Process for preparations and purification of pantoprazole sesquihydrate

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1411053A1 (en) * 2000-04-14 2004-04-21 Esteve Quimica, S.A. Method for obtaining derivatives of (pyridil substituted)methyl]thio]benzimidazol
US20040186139A1 (en) * 2002-09-02 2004-09-23 Dr. Reddy's Laboratories Limited Process for preparation of crystalline form-1 of pantoprazole sodium sesquihydrate
WO2004063188A1 (en) * 2003-01-15 2004-07-29 Cipla Limited Paharmaceutical process and compounds prepared thereby
WO2004111029A2 (en) * 2003-06-10 2004-12-23 Teva Pharmaceutical Industries Ltd. Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
WO2006040778A1 (en) * 2004-10-15 2006-04-20 Matrix Laboratories Ltd Process for preparations and purification of pantoprazole sesquihydrate

Also Published As

Publication number Publication date
WO2008001392A2 (en) 2008-01-03

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