JP2010221042A - 検体の監視および薬物送達のための医療デバイス - Google Patents
検体の監視および薬物送達のための医療デバイス Download PDFInfo
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Abstract
【解決手段】外部表面および内部表面を有する摂取可能な医療デバイスである。医療デバイスは、以下を含む。a)疾患マーカである生物学的検体と相互作用することができるポリペプチド生物活性因子を含むマイクロアレイと、b)治療薬を含むリザーバと、c)マイクロチップと、d)摂取可能な医療デバイスの外部表面に被覆された生体適合性ポリマー被覆と、を備える。
【選択図】図1
Description
(1.発明の分野)
本発明は、診断および薬物送達の分野に関する。より詳細には、本発明は、体液検体のレベルを監視し、状況に応じて適切な治療薬を放出することのできる医療デバイスおよび方法に関する。
生体高分子の活性または薬物の濃度レベルを検出することのできる「ポイントオブケア」デバイスは、それらが患者の検査室訪問の必要性を排除し、従って時間と費用の両方を節約することができるため、需要が高い。現代のマイクロアレイ技術の最も価値ある側面の1つは、疾患を招く生体高分子の機能不全、奇形または突然変異を検出する能力である。しかしながら、そのようなアレイが摂取可能、埋め込み可能または装着可能なポイントオブケアデバイス内に組み込まれていないために、この能力は、十分に生かされていない。現代のマイクロアレイ技術は、機械の内部に挿入されることになるスライド上に安定化された固定化検体の分析によるか、または生体の外部で手作業で分析した生体高分子およびそれらの代謝産物の特性付けに限定されている。
全血は細胞、血小板、無数の蛋白質および他の高分子を含んでいるため、血液を含むアッセイは一般に、これらの成分を除去するための試料の前処理を必要とする。前処理ステップをポイントオブケアデバイス内に統合することは、デバイス自体にかかるコストを押し上げ、従って、デバイスの使用を財政的に実行不可能とする。例えば、現在市販されている一部のデバイスは、それらのアッセイに全血を使用しており、それらの中には、血液によって運ばれる検体(コレステロールがその代表である)を測定するためのBoehringer MannheimのReflotron(商標)システム、および電解質、一般的化学反応、血液ガスおよび血液学を含むいくつかの集中治療用アッセイを行うiStat(商標)(iStat Inc.)がある。Reflotron(商標)は、酵素または他の反応性要素がテストストリップの表面上に固定化されるドライケミストリー技術に依存している。そのアッセイは、反応が変色を引き起こし、従って存在する検体の量を示す、熱量計による活性度アッセイである。iStat(商標)は、電気化学検出に依存して、信号を生成する。どちらの場合にも、血液試料が別個に取られ(一般に指を刺すことによって)、ついでチップ(またはiStatの場合はカートリッジ)上に配置され、そこで反応が生じ、外部の検出装置で分析される。これらの既存の監視システムは、それらが通常、使用者が自身に針を刺し、かつ1つの結果を得るのに多くのステップを必要とするので、不十分かつ不都合である。従って、血液などの体液を、繰り返し、自動的かつ正確に監視することのできる装着可能なデバイスに対する必要性が存在する。
本発明の一態様は、疾患マーカである生物学的検体と相互に作用することのできる生物活性因子を含むマイクロアレイと、少なくとも1つの治療薬を含み、かつ該治療薬を医療デバイスから放出することのできるリザーバと、疾患マーカである生物学的検体と生物活性因子との間の相互作用の物理的パラメータデータを取得することのできるマイクロアレイ走査デバイスを含む複数のマイクロチップと、物理的パラメータデータを検体の相互作用プロファイルと比較することのできる生体測定認識デバイスと、リザーバからの治療薬の放出を制御することのできる治療薬放出デバイスと、マイクロアレイ走査デバイス、生体測定認識デバイスおよび治療薬放出デバイス間の連絡を促進することのできるインターフェースデバイスと、医療デバイスに動力を供給するためのエネルギー源とを備える医療デバイスに関する。
本方法の追加の実施形態では、インターフェースデバイスは、パーソナルエリアネットワークを備える。
すなわち、本発明は以下を特徴とする。
(項目1)
医療デバイスであって、
a) 疾患マーカである生物学的検体と相互作用することができる生物活性因子を含むマイクロアレイと、
b) 少なくとも1つの治療薬を含み、かつ該医療デバイスから該少なくとも1つの治療薬を放出することができる少なくとも1つのリザーバと、
c) 複数のマイクロチップであって、
i) 該疾患マーカである生物学的検体と該生物活性因子との間の相互作用の物理的パラメータデータを取得することができるマイクロアレイ走査デバイスと、
ii) 該物理的パラメータデータを検体の相互作用プロファイルと比較することができる生体測定認識デバイスと、
iii) 該リザーバからの該治療薬の放出を制御することができる治療薬放出デバイスと、
iv) 該マイクロアレイ走査デバイス、該生体測定認識デバイスおよび該治療薬放出デバイス間の連絡を促進することができるインターフェースデバイスと、
を備える複数のマイクロチップと、
d) 前記医療デバイスに動力を供給するためのエネルギー源と、
を備える、医療デバイス。
(項目2)
前記デバイスは、生体適合性ポリマーで被覆されている、項目1に記載の医療デバイス。
(項目3)
前記ポリマーは、チャネルを有する、項目1に記載の医療デバイス。
(項目4)
前記ポリマーは、多孔質である、項目1に記載の医療デバイス。
(項目5)
前記マイクロアレイは、マイクロビーズを備える、項目1に記載の医療デバイス。
(項目6)
前記生物活性因子は、核酸である、項目1に記載の医療デバイス。
(項目7)
前記生物活性因子は、ポリペプチドである、項目1に記載の医療デバイス。
(項目8)
前記生物活性因子は、免疫グロブリンである、項目7に記載の医療デバイス。
(項目9)
前記生物活性因子は、蛍光標識されている、項目1に記載の医療デバイス。
(項目10)
前記生物活性因子は、ナノ結晶で蛍光標識されている、項目1に記載の医療デバイス。
(項目11)
前記疾患マーカである生物学的検体は、核酸である、項目1に記載の医療デバイス。
(項目12)
前記疾患マーカである生物学的検体は、ポリペプチドである、項目1に記載の医療デバイス。
(項目13)
前記疾患マーカである生物学的検体は、免疫グロブリンである、項目12に記載の医療デバイス。
(項目14)
前記複数のマイクロチップは、シリコンゲルマニウムを含む、項目1に記載の医療デバイス。
(項目15)
前記マイクロアレイ走査デバイスは、光ファイバ素子を備える、項目1に記載の医療デバイス。
(項目16)
前記検体の相互作用プロファイルは、前記生体測定認識デバイス内に格納される、項目1に記載の医療デバイス。
(項目17)
前記検体の相互作用プロファイルは、前記医療デバイスの外部に格納される、項目1に記載の医療デバイス。
(項目18)
複数のリザーバを有する、項目1に記載の医療デバイス。
(項目19)
前記インターフェースデバイスは、パーソナルエリアネットワークを備える、項目1に記載の医療デバイス。
(項目20)
エネルギー源は、電池である、項目1に記載の医療デバイス。
(項目21)
エネルギー源は、パーソナルエリアネットワークによって提供される、項目1に記載の医療デバイス。
(項目22)
患者における疾患を検出および治療する方法であって、
A) 該患者に医療デバイスを投与する工程であって、
a) 疾患マーカである生物学的検体と相互作用することができる生物活性因子を含むマイクロアレイと、
b) 少なくとも1つの治療薬を含み、かつ該医療デバイスから該少なくとも1つの治療薬を放出することができる少なくとも1つのリザーバと、
c) 複数のマイクロチップであって、
i) 該疾患マーカである生物学的検体と該生物活性因子との間の相互作用の物理的パラメータデータを取得することができるマイクロアレイ走査デバイスと、
ii) 該物理的パラメータデータを検体の相互作用プロファイルと比較することができる生体測定認識デバイスと、
iii) 該リザーバからの該治療薬の放出を制御することができる治療薬放出デバイスと、
iv) 該マイクロアレイ走査デバイス、該生体測定認識デバイスおよび該治療薬放出デバイス間の連絡を促進することができるインターフェースデバイスと、
を含む複数のマイクロチップと、
d) 該医療デバイスに動力を供給するためのエネルギー源と、
を備える医療デバイスを投与する工程、ならびに
B) 該医療デバイスを該患者から除去する工程か、または該医療デバイスが該患者を通過することを可能にする工程、
を包含する、方法。
(項目23)
前記デバイスは、該デバイスが腸管を通過することを可能にする生体適合性のポリマーで被覆されている。項目22に記載の方法。
(項目24)
前記ポリマーは、チャネルを有する、項目22に記載の方法。
(項目25)
前記ポリマーは、多孔質である、項目22に記載の方法。
(項目26)
前記マイクロアレイは、マイクロビーズを備える、項目22に記載の方法。
(項目27)
前記生物活性因子は、核酸である、項目22に記載の方法。
(項目28)
前記生物活性因子は、ポリペプチドである、項目22に記載の方法。
(項目29)
前記生物活性因子は、免疫グロブリンである、項目28に記載の方法。
(項目30)
前記生物活性因子は、蛍光標識されている、項目22に記載の方法。
(項目31)
前記生物活性因子は、ナノ結晶で蛍光標識されている、項目22に記載の方法。
(項目32)
前記疾患マーカ生物学的検体は、核酸である、項目22に記載の方法。
(項目33)
前記疾患マーカ生物学的検体は、ポリペプチドである、項目22に記載の方法。
(項目34)
前記疾患マーカ生物学的検体は、免疫グロブリンである、項目33に記載の方法。
(項目35)
前記複数のマイクロチップは、シリコンゲルマニウムを含む、項目22に記載の方法。
(項目36)
前記マイクロアレイ走査デバイスは、光ファイバ素子を備える、項目22に記載の方法。
(項目37)
前記検体の相互作用プロファイルは、前記生体測定認識デバイス内に格納される、項目22に記載の方法。
(項目38)
前記検体の相互作用プロファイルは、前記医療デバイスの外部に格納される、項目22に記載の方法。
(項目39)
複数のリザーバを有する、項目22に記載の方法。
(項目40)
前記インターフェースデバイスは、パーソナルエリアネットワークを備える、項目22に記載の方法。
(項目41)
エネルギー源は、電池である、項目22に記載の方法。
(項目42)
エネルギー源は、パーソナルエリアネットワークによって提供される、項目22に記載の方法。
(項目43)
前記連絡は、外部コンピュータによって監視される、項目22に記載の方法。
(項目44)
前記外部コンピュータは、前記治療薬の放出を指示する、項目43に記載の方法。
(項目45)
浸透圧ポンプをさらに備える、項目1に記載の医療デバイス。
(項目46)
加圧マイクロ流体チャネルをさらに備える、項目に記載の医療デバイス。
(項目47)
体液の流れを方向付けるパーソナルエリアネットワーク送信機をさらに備える、項目1に記載の医療デバイス。
(項目48)
体液中の検体を検出することができる医療デバイスであって、
A) 体液の試料を採取することができる少なくとも1本のマイクロニードルと、
B) 該少なくとも1本のマイクロニードルと流体連絡する、該試料が貫流する第1のマイクロチャネルと、
C) 該第1のマイクロチャネルと流体連絡し、緩衝剤が通って流れる第2のマイクロチャネルであって、少なくとも1つの生物活性因子を有するマイクロアレイをさらに備える、第2のマイクロチャネルと、
D) 生物活性因子と該体液中の検体との間の相互作用を検出するためのマイクロアレイ走査デバイスと、
E) 該マイクロアレイ走査デバイスと生体測定認識デバイスとの間の連絡を促進することができるインターフェースデバイスと、
を備える医療デバイス。
(項目49)
前記体液は、血液である、項目48に記載の医療デバイス。
(項目50)
前記少なくとも1本のマイクロニードルは、複数のマイクロニードルである、項目48に記載の医療デバイス。
(項目51)
前記マイクロニードルは、直径が約10ミクロンと約200ミクロンとの間である、項目48に記載の医療デバイス。
(項目52)
前記マイクロニードルは、約100マイクロリットルの血液を引くことができる、項目48に記載の医療デバイス。
(項目53)
前記第1のマイクロチャネルは、直径が約100マイクロメートルである、項目48に記載の医療デバイス。
(項目54)
前記第2のマイクロチャネルは、直径が約100マイクロメートルである、項目48に記載の医療デバイス。
(項目55)
前記第1のマイクロチャネルを通って流れる前記体液中の前記検体が、前記第2のマイクロチャネル内に拡散し、かつ前記生物活性因子と相互に作用する、項目48に記載の医療デバイス。
(項目56)
前記第1のマイクロチャネルを通って流れる前記体液中の前記検体は、前記第2のマイクロチャネル内に拡散し、標識検体を、前記生物活性因子に結合している状態から競合的に置き換える、項目55に記載の医療デバイス。
(項目57)
前記標識検体は、所定量で提供される、項目56に記載の医療デバイス。
(項目58)
前記標識検体は、蛍光部分で標識されている、項目56に記載の医療デバイス。
(項目59)
前記マイクロアレイは、前記体液中の前記検体を特異的に結合する抗体の被覆を有する第2のマイクロチャネルの一部分である、項目48に記載の医療デバイス。
(項目60)
前記マイクロアレイ走査デバイスは、全内部反射蛍光(TIRF)分光計を備える、項目48に記載の医療デバイス。
(項目61)
前記生体測定認識デバイスは、前記デバイスの外部に配置され、かつ前記連絡は、無線伝送による、項目48に記載の医療デバイス。
(項目62)
前記検体は、インスリンであり、かつ前記生物活性因子は、インスリンに対して特異的な抗体である、項目48に記載の医療デバイス。
(項目63)
前記検体は、グルコースであり、かつ前記生物活性因子は、グルコースに対して特異的な抗体である、項目48に記載の医療デバイス。
(項目64)
前記デバイスは、パッチとして皮膚上に装着される、項目48に記載の医療デバイス。
(項目65)
前記検体は、疾患を示す、項目48に記載の医療デバイス。
(項目66)
項目48に記載の医療デバイスであって、さらに、
F) 中に治療薬を有するリザーバと、
G) 前記生体測定認識デバイスからの指示に応答して、リザーバからの治療薬の放出を制御することができる治療薬放出デバイス
とを備える、医療デバイス。
(項目67)
前記検体は、グルコースであり、かつ前記治療薬は、インスリンである、項目66に記載の医療デバイス。
(項目68)
前記検体は、前記治療薬と同一である、項目66に記載の医療デバイス。
(項目69)
前記検体は、前記治療薬の代謝産物である、項目66に記載の医療デバイス。
(項目70)
項目48に記載の医療デバイスであって、ここで、少なくとも1つの使い捨てアッセイデバイスは、前記少なくとも1本のマイクロニードルと、前記第1のマイクロチャネルと、前記第2のマイクロチャネルとを備え、かつ非使い捨てアッセイ読み取りデバイスは、前記マイクロアレイ走査デバイス、前記インターフェースデバイスを備える、医療デバイス。
(項目71)
前記アッセイデバイスとアッセイ読み取りデバイスとは、互いに光連絡している、項目70に記載の医療デバイス。
(項目72)
単一のアッセイ読み取りデバイス内にはめ込まれた複数の使い捨てアッセイデバイスが存在する、項目70に記載の医療デバイス。
(項目73)
前記マイクロアレイは、前記生物活性因子で機能化された単一のガラス光ファイバの、1つのクラッディングされていない部分を含み、該単一のガラス光ファイバのクラッディングされていない部分は、前記第2のマイクロチャネルと流体接触している、項目48に記載の医療デバイス。
(項目74)
前記マイクロアレイは、前記生物活性因子で機能化された単一のガラス光ファイバの、複数のクラッディングされていない部分を含み、該単一のガラス光ファイバのクラッディングされていない部分は、前記第2のマイクロチャネルと流体接触している、項目48に記載の医療デバイス。
その最も基本的な形態において、本発明は、体液中の検体を定性的かつ/または定量的に検出するためのセンサとして機能する医療デバイスに関する。そのような検体は、疾患を示す可能性を秘めているものであっても、薬物または薬物代謝産物であってもよい。さらに、本デバイスは、感覚の入力に応答して治療薬を放出することを可能とすることができる。従って、これはさらに、持続的な診断および投薬を提供することができる。本発明の装置は、埋め込み可能としても、摂取可能としても、パッチとして皮膚上に装着してもよい。
Publishing Co.,マサチューセッツ州レディング所在、1988年)、Runyan他、Semiconductor Integrated Circuit
Processing Technology(Addison−Wesley Publishing Co.,マサチューセッツ州レディング所在、1990年)、Processing of the IEEE Micro Electro Mechanical Systems Conference 1987年−1998年、Rai−Choudhury編集、Handbook of Microlithography,Micromachining & Microfabrication (SPIE
Optical Engineering Press、ワシントン州ベリンガム所在、1997年)を参照されたい。代替的に、針は、シリコンウエハ内に成形し、次いで、従来のワイヤ切断技法を用いて、ニッケル、金、チタンまたは種々の他の生体適合性を有する金属で被覆することができる。別の実施形態では、針は、生体高分子で作製することができる。マイクロニードルは、その全体が引用により本明細書に組み込まれる、Mukerjee他、Sensors and Actuators A:Physical、第114巻、第2号−第3号、2004年9月1日、第267頁−第275頁に記載の方法に従って、特許請求の範囲のデバイス用に作製し、使用することができる。
Guide」は、参考になる手引書であり、その全体が引用により組み込まれる。ビーズは、球状である必要はなく、不ぞろいの微粒子を用いてもよい。さらに、ビーズは多孔質とすることができ、そうすることにより、生物活性因子の付着またはタグの取り付けに利用可能な表面積を増大させる。ビーズの大きさは、ナノメートル、例えば100nmからミリメートル、例えば1mmの範囲にわたり、約0.2ミクロン〜約約200ミクロンのビーズが好ましく、約0.5ミクロン〜約5ミクロンのビーズが特に好ましいが、一部の実施形態では、より小さいかまたはより大きいビーズを用いることができる。各マイクロ球体が生物活性因子を含むのが好ましい。
マイクロチャネルシステムは、拡散制御結合事象が、機能化されたチャネルの表面上または光学的表面積の最適化のためにチャネルの中央に通された機能化されたファイバ上で発生することを可能にする。これにより、表面内にわずか約1000オングストローム貫入することによって、エバネッセント波に基づくセンサが全血などの流体から検体を検出することが可能となる。代替的に、流れの中央に埋め込まれたファイバの場合、拡散および分離は、ファイバの両側で測定を行うことができるさらにより簡素なシステムによって可能となる。
光ファイバ全内部反射蛍光(TIRF)バイオセンサが構築され、本明細書に定義するマイクロアレイおよびマイクロアレイ走査デバイスを構成する。Preininger他(Analytica Chimica Acta、2000年、403、67−76)を参照されたい。レーザ光は、レーザ光源から、すべてが一連の光ファイバを経由して、フローセル型検出器へ誘導される。この光ファイバをベースとする装置の概略図を、図12に示す。本センサでは、入射レーザ光は、50:50の光ファイバスプリッタの出力区間を経由して、機能化されたファイバへ誘導される。放射蛍光は、ファイバ内に再帰結合し、レーザ光からの干渉をほとんど受けることなく、検出器に向かって伝播する。この設計は、いくつかの利点を有する。開始から終了までのファイバ使用により、自由空間結合による損失が排除される。ファイバが堅牢な光の輸送手段となり、従って、振動に敏感でなく、かつ市販の光ファイバコネクタで複数本のファイバを容易に結合することができる。従って、マイクロアレイは、1本のファイバの機能化された表面であっても、複数本のファイバの機能化された表面であってもよい。
・ スペクトル特性QY=0.3ε=110、000を有するフルオロフォア Atto 655(Sigma Aldrich)
(表1:レーザパワーとファイバ特性の関数としての蛍光出力)
例示的なパッチデバイスは、バンコマイシンに対して0.1mlの血液を自動的に採取およびサンプリングする無痛の方法を代表している。各パッチは、2つの部分、すなわち、単回使用マイクロニードルおよびマイクロチャネルを含む使い捨て部分(アッセイデバイス)と、残りの光学部品、電子機器ならびに機構(アッセイ読み取りデバイス)を含む再使用可能部分とからなる。図5、図7。
5,6 パーソナルエリアネットワーク用送信機
7 マイクロアレイ走査デバイス
8 インターフェースデバイス
9 生体測定認識デバイス
10 治療薬放出デバイス
13,14 リザーバ
15 エネルギー源
16 外部コンピュータネットワーク
29 生体測定認識デバイス
Claims (46)
- 外部表面および内部表面を有する摂取可能な医療デバイスであって、
a) 疾患マーカである生物学的検体と相互作用することができるポリペプチド生物活性因子を含むマイクロアレイと、
b) 治療薬を含むリザーバと、
c) マイクロチップであって、
i) 該疾患マーカである生物学的検体と該ポリペプチド生物活性因子との間の相互作用を表す物理的パラメータの信号表示を光学的に検出するように構成された光学マイクロアレイ走査デバイスと、
ii) 該物理的パラメータのデータを検体の相互作用プロファイルと比較するように構成された生体測定認識デバイスと、
iii) 該リザーバからの該治療薬の放出を制御するように構成された治療薬放出デバイスと、
iv) 該マイクロアレイ走査デバイス、および該生体測定認識デバイス間の連絡を促進するように構成されたインターフェースデバイスと、
を備えるマイクロチップと、
d) 該摂取可能な医療デバイスの外部表面に被覆された生体適合性ポリマー被覆と、
を備える、医療デバイス。 - 前記生体適合性ポリマー被覆は、チャネルを有する、請求項1に記載の医療デバイス。
- 前記生体適合性ポリマー被覆は、多孔質である、請求項1に記載の医療デバイス。
- 前記マイクロアレイは、マイクロビーズを備える、請求項1に記載の医療デバイス。
- 前記生物活性因子は、免疫グロブリンである、請求項1に記載の医療デバイス。
- 前記生物活性因子は、蛍光標識されている、請求項1に記載の医療デバイス。
- 前記生物活性因子は、ナノ結晶で蛍光標識されている、請求項1に記載の医療デバイス。
- 前記疾患マーカである生物学的検体は、ポリペプチドである、請求項1に記載の医療デバイス。
- 前記疾患マーカである生物学的検体は、免疫グロブリンである、請求項8に記載の医療デバイス。
- 前記マイクロチップは、シリコンゲルマニウムを含む、請求項1に記載の医療デバイス。
- 前記マイクロアレイ走査デバイスは、光ファイバ素子を備える、請求項1に記載の医療デバイス。
- 前記検体の相互作用プロファイルは、前記医療デバイスから離れた外部装置に格納される、請求項1に記載の医療デバイス。
- 複数のリザーバを有する、請求項1に記載の医療デバイス。
- 前記インターフェースデバイスは、パーソナルエリアネットワークを備える、請求項1に記載の医療デバイス。
- 前記医療デバイスに電力を供給するエネルギー源をさらに有する、請求項1に記載のシステム。
- 前記エネルギー源は、パーソナルエリアネットワークによって提供される、請求項1に記載の医療デバイス。
- 患者における疾患を検出および/または治療するためのシステムであって、該システムは、
A)該デバイスを患者に投与することにより、摂取可能な医療デバイスを体液と接触させること、該デバイスは外部表面および内部表面を有し、
a) 患者の体液と流体的に連絡するように構成された
小型の試験部位のマイクロアレイであって、
該マイクロアレイは、体液中に存在すると疑われる疾患マーカとの相互作用に影響するために、そこに固定された複数のポリペプチド生物活性因子を含むマイクロアレイと、
b) 治療薬を含むリザーバと、
c) 該疾患マーカと該ポリペプチド生物活性因子との間の相互作用に基づいた疾患マーカーを示す物理的パラメータの信号表示を光学的に検出するように構成された光学マイクロアレイ走査デバイスと、
d) 該物理的パラメータデータを検体の相互作用プロファイルと比較するように構成された生体測定認識デバイスと、
e) 該リザーバからの該少なくとも1つの治療薬の放出を制御するように構成された治療薬放出デバイスと、
f) 該マイクロアレイ走査デバイス、および該生体測定認識デバイス間の連絡を促進するように構成されたインターフェースデバイスと、
g) 摂取可能な医療デバイスの外部表面に被覆された生体適合性ポリマー被覆であって、腸管の道を通過して該装置を促進する、生体適合性ポリマー被覆と、
B) 該摂取可能な医療デバイスを操作して該疾患の存在の物理的パラメータ表示を取得する手段と、任意に
C)該患者に該治療薬を放出する手段と、
を備える、システム。 - 前記生体適合性ポリマー被覆は、チャネルを有する、請求項17に記載のシステム。
- 前記生体適合性ポリマー被覆は、多孔質である、請求項17に記載のシステム。
- 前記マイクロアレイは、マイクロビーズを備える、請求項17に記載のシステム。
- 前記複数の生物活性因子は、モノクローナル抗体である、請求項17に記載のシステム。
- 前記複数の生物活性因子は、免疫グロブリンである、請求項17に記載のシステム。
- 前記複数の生物活性因子は、蛍光標識されている、請求項17に記載のシステム。
- 前記複数の生物活性因子は、ナノ結晶で蛍光標識されている、請求項17に記載のシステム。
- 前記疾患マーカは、核酸である、請求項17に記載のシステム。
- 前記疾患マーカは、ポリペプチドである、請求項17に記載のシステム。
- 前記疾患マーカは、免疫グロブリンである、請求項17に記載のシステム。
- 前記マイクロアレイ走査デバイス、該生体測定認識デバイス、治療装置およびイーターフェースデバイスの1つ以上は、シリコンゲルマニウムを含む、請求項17に記載のシステム。
- 前記マイクロアレイ走査デバイスは、光ファイバ素子を備える、請求項17に記載のシステム。
- 前記検体の相互作用プロファイルは、前記生体測定認識デバイス内に格納される、請求項17に記載のシステム。
- 前記検体の相互作用プロファイルは、前記医療デバイスから離れた外部装置に格納される、請求項17に記載のシステム。
- 前記リザーバは、前記医療デバイスから前記少なくとも1つの治療薬を開放するように構成されている、請求項17に記載のシステム。
- 前記インターフェースデバイスは、パーソナルエリアネットワークを備える、請求項17に記載のシステム。
- 前記医療デバイスに電力を供給するエネルギー源をさらに有する、請求項17に記載のシステム。
- エネルギー源は、パーソナルエリアネットワークによって提供される、請求項34に記載のシステム。
- 前記連絡は、外部コンピュータによって監視される、請求項17に記載のシステム。
- 前記外部コンピュータは、前記治療薬の放出を指示する、請求項36に記載のシステム。
- 前記医療デバイスは、1つ以上の使い捨て要素を有する、請求項1に記載の医療デバイス。
- 前記生体測定認識デバイスは、前記治療薬開放デバイスを制御する、請求項1に記載の医療デバイス。
- 前記生体測定認識デバイスは、前記物理的パラメータデータを格納するように構成され、かつ該格納した物理的パラメータのデータからアクセス可能な検体相互作用プロファイルの薬物動力学データベースを構築するように構成されている、請求項1に記載の医療デバイス。
- 浸透圧ポンプをさらに備える、請求項1に記載の医療デバイス。
- 加圧マイクロ流体チャネルをさらに備える、請求項1に記載の医療デバイス。
- 前記物理的パラメータを検体の相互作用プロファイルと比較して疾患の検出を促進する手段をさらに備える、請求項17に記載のシステム。
- 前記疾患マーカが生物学的検体である、請求項17に記載のシステム。
- 前記複数の生物活性因子は、同じ生物活性因子を含む、請求項17に記載のシステム。
- 前記複数の生物活性因子は、異なる生物活性因子を含む、請求項17に記載のシステム。
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JP2003525432A (ja) * | 2000-03-02 | 2003-08-26 | マイクロチップス・インコーポレーテッド | 化学物質およびデバイスを格納し、選択的に露出させるための微細加工されたデバイス |
WO2003066128A2 (en) * | 2002-02-08 | 2003-08-14 | Rosedale Medical, Inc. | Autonomous, ambulatory analyte monitor or drug delivery device |
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JP2017529895A (ja) * | 2014-08-11 | 2017-10-12 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ | 生物流体の表皮特性評価のためのデバイス及び関連する方法 |
US11064946B2 (en) | 2014-08-11 | 2021-07-20 | The Board Of Trustees Of The University Of Illinois | Devices and related methods for epidermal characterization of biofluids |
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