JP2010187677A5 - - Google Patents
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- JP2010187677A5 JP2010187677A5 JP2010058499A JP2010058499A JP2010187677A5 JP 2010187677 A5 JP2010187677 A5 JP 2010187677A5 JP 2010058499 A JP2010058499 A JP 2010058499A JP 2010058499 A JP2010058499 A JP 2010058499A JP 2010187677 A5 JP2010187677 A5 JP 2010187677A5
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- disease
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- immune
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- 241000124008 Mammalia Species 0.000 claims 12
- 210000001519 tissues Anatomy 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 7
- 230000002757 inflammatory Effects 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 102000004965 antibodies Human genes 0.000 claims 4
- 108090001123 antibodies Proteins 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 3
- 201000005794 allergic hypersensitivity disease Diseases 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 238000005755 formation reaction Methods 0.000 claims 2
- 230000001404 mediated Effects 0.000 claims 2
- 208000009094 Anemia, Hemolytic, Autoimmune Diseases 0.000 claims 1
- 208000006673 Asthma Diseases 0.000 claims 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 206010050245 Autoimmune thrombocytopenia Diseases 0.000 claims 1
- 206010004661 Biliary cirrhosis primary Diseases 0.000 claims 1
- 210000003169 Central Nervous System Anatomy 0.000 claims 1
- 206010008609 Cholangitis sclerosing Diseases 0.000 claims 1
- 208000010247 Contact Dermatitis Diseases 0.000 claims 1
- 208000004275 Demyelinating Disease Diseases 0.000 claims 1
- 206010061811 Demyelinating polyneuropathy Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 206010015218 Erythema multiforme Diseases 0.000 claims 1
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
- 206010016946 Food allergy Diseases 0.000 claims 1
- 108010068370 Glutens Proteins 0.000 claims 1
- 206010018651 Graft versus host disease Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 208000002183 Guillain-Barre Syndrome Diseases 0.000 claims 1
- 208000005252 Hepatitis A Diseases 0.000 claims 1
- 206010019780 Hepatitis infectious Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010021425 Immune system disease Diseases 0.000 claims 1
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010029151 Nephropathy Diseases 0.000 claims 1
- 210000001428 Peripheral Nervous System Anatomy 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 206010036105 Polyneuropathy Diseases 0.000 claims 1
- 208000004358 Polyneuropathy Diseases 0.000 claims 1
- 208000002098 Purpura, Thrombocytopenic, Idiopathic Diseases 0.000 claims 1
- 206010038428 Renal disease Diseases 0.000 claims 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 208000010157 Sclerosing Cholangitis Diseases 0.000 claims 1
- 206010040767 Sjogren's syndrome Diseases 0.000 claims 1
- 208000006641 Skin Disease Diseases 0.000 claims 1
- 208000006045 Spondylarthropathy Diseases 0.000 claims 1
- 206010052775 Spondyloarthropathy Diseases 0.000 claims 1
- 208000004732 Systemic Vasculitis Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 206010043778 Thyroiditis Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 206010046736 Urticarias Diseases 0.000 claims 1
- 206010047931 Whipple's disease Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 claims 1
- 201000006322 bullous skin disease Diseases 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000001684 chronic Effects 0.000 claims 1
- 231100000080 dermatitis contact Toxicity 0.000 claims 1
- 201000009580 eosinophilic pneumonia Diseases 0.000 claims 1
- 235000021312 gluten Nutrition 0.000 claims 1
- 201000007192 granulomatous hepatitis Diseases 0.000 claims 1
- 201000010229 hepatobiliary disease Diseases 0.000 claims 1
- 230000009610 hypersensitivity Effects 0.000 claims 1
- 201000009794 idiopathic pulmonary fibrosis Diseases 0.000 claims 1
- 201000002481 myositis Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000002728 primary biliary cirrhosis Diseases 0.000 claims 1
- 201000004681 psoriasis Diseases 0.000 claims 1
- 230000002685 pulmonary Effects 0.000 claims 1
- 230000036647 reaction Effects 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 201000005671 spondyloarthropathy Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 201000009594 systemic scleroderma Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Claims (5)
- 哺乳動物における炎症性免疫反応の存在の検出方法において、（ａ）哺乳動物から採取した組織細胞の試験試料中、及び（ｂ）同じ細胞型の既知の正常組織細胞のコントロール試料中における、配列番号：２に示すアミノ酸配列のポリペプチドをコードする遺伝子の発現レベルを検出することを含んでなり、コントロール試料と比較して試験試料中における前記遺伝子の発現レベルが高い場合に、試験組織細胞が採取された哺乳動物における炎症性免疫反応の存在が示される方法。
- 哺乳動物における炎症性免疫反応の存在の検出方法において、（ａ）哺乳動物から採取した組織細胞の試験試料と、配列番号：２に示すアミノ酸配列に結合する抗体とを接触させ、（ｂ）抗体と試験試料中のポリペプチドの間の複合体の生成を検出することを含んでなり、試験試料中に大量の複合体が形成された場合に、試験組織細胞が採取された哺乳動物における炎症性免疫反応の存在が示される方法。
- 哺乳動物における免疫関連疾患の存在の検出方法において、（ａ）哺乳動物から採取した組織細胞の試験試料中、及び（ｂ）同じ細胞型の既知の正常組織細胞のコントロール試料中における、配列番号：２に示すアミノ酸配列のポリペプチドをコードする遺伝子の発現レベルを検出することを含んでなり、コントロール試料と比較して試験試料中における前記遺伝子の発現レベルが高い場合に、試験組織細胞が採取された哺乳動物における免疫関連疾患の存在が示される方法。
- 哺乳動物における免疫関連疾患の存在の検出方法において、（ａ）前記哺乳動物から採取した組織細胞の試験試料と、配列番号：２に示すアミノ酸配列に結合する抗体とを接触させ、（ｂ）抗体と試験試料中のポリペプチドの間の複合体の生成を検出することを含んでなり、試験試料中に大量の複合体が形成された場合に、試験組織細胞が採取された哺乳動物における免疫関連疾患の存在が示される方法。
- 免疫関連疾患が、乾癬、炎症性腸疾患、全身性紅斑性狼瘡、リウマチ様関節炎、骨関節症、若年性慢性関節炎、脊椎関節症、全身性硬化症、特発性炎症ミオパシー、シェーグレン症候群、全身性血管炎、サルコイドーシス、自己免疫性溶血性貧血、自己免疫性血小板減少症、甲状腺炎、真性糖尿病、免疫仲介腎疾患、中枢又は末梢神経系の脱髄疾患、特発性脱髄性多発神経障害、ギラン-バレー症候群、慢性炎症性脱随性多発神経障害、肝胆道疾患、感染性又は自己免疫性慢性活動性肝炎、原発性胆汁性肝硬変症、肉芽腫性肝炎、硬化性胆管炎、グルテン過敏性腸疾患、ウィップル病、自己免疫又は免疫媒介皮膚疾患、水疱性皮膚疾患、多形性紅斑、接触性皮膚炎、アレルギー性疾患、喘息、アレルギー性鼻炎、アトピー性皮膚炎、食物過敏症、蕁麻疹、肺の免疫疾患、好球性肺炎、特発性肺線維症、過敏性肺炎、移植関連疾患、移植片拒絶反応、又は移植片対宿主疾患である、請求項３又は４に記載の方法。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41006202P | 2002-09-11 | 2002-09-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004536371A Division JP5401001B2 (ja) | 2002-09-11 | 2003-09-09 | 免疫関連疾患の治療のための新規組成物と方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010187677A JP2010187677A (ja) | 2010-09-02 |
| JP2010187677A5 true JP2010187677A5 (ja) | 2011-06-02 |
Family
ID=31994051
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004536371A Expired - Lifetime JP5401001B2 (ja) | 2002-09-11 | 2003-09-09 | 免疫関連疾患の治療のための新規組成物と方法 |
| JP2010058499A Pending JP2010187677A (ja) | 2002-09-11 | 2010-03-15 | 免疫関連疾患の治療のための新規組成物と方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004536371A Expired - Lifetime JP5401001B2 (ja) | 2002-09-11 | 2003-09-09 | 免疫関連疾患の治療のための新規組成物と方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US20040121370A1 (ja) |
| EP (3) | EP2085096A3 (ja) |
| JP (2) | JP5401001B2 (ja) |
| AT (1) | ATE493433T1 (ja) |
| AU (2) | AU2003270439B2 (ja) |
| CA (1) | CA2498008C (ja) |
| DE (1) | DE60335552D1 (ja) |
| ES (1) | ES2357505T3 (ja) |
| WO (1) | WO2004024068A2 (ja) |
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-
2003
- 2003-09-09 AT AT03752132T patent/ATE493433T1/de active
- 2003-09-09 DE DE60335552T patent/DE60335552D1/de not_active Expired - Lifetime
- 2003-09-09 AU AU2003270439A patent/AU2003270439B2/en not_active Expired
- 2003-09-09 WO PCT/US2003/028202 patent/WO2004024068A2/en active Application Filing
- 2003-09-09 CA CA2498008A patent/CA2498008C/en not_active Expired - Lifetime
- 2003-09-09 US US10/658,482 patent/US20040121370A1/en not_active Abandoned
- 2003-09-09 ES ES03752132T patent/ES2357505T3/es not_active Expired - Lifetime
- 2003-09-09 EP EP09004342A patent/EP2085096A3/en not_active Ceased
- 2003-09-09 JP JP2004536371A patent/JP5401001B2/ja not_active Expired - Lifetime
- 2003-09-09 EP EP10177178A patent/EP2277532A1/en not_active Withdrawn
- 2003-09-09 EP EP03752132A patent/EP1539228B1/en not_active Expired - Lifetime
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2006
- 2006-09-29 US US11/537,270 patent/US20090181024A1/en not_active Abandoned
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2009
- 2009-12-16 AU AU2009250980A patent/AU2009250980A1/en not_active Withdrawn
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2010
- 2010-03-15 JP JP2010058499A patent/JP2010187677A/ja active Pending
- 2010-12-14 US US12/967,886 patent/US8431350B2/en not_active Ceased
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2014
- 2014-03-27 US US14/228,172 patent/USRE46805E1/en not_active Expired - Lifetime
- 2014-03-27 US US14/228,173 patent/USRE46816E1/en not_active Expired - Lifetime
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