JP2009526084A5 - - Google Patents
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- JP2009526084A5 JP2009526084A5 JP2008554516A JP2008554516A JP2009526084A5 JP 2009526084 A5 JP2009526084 A5 JP 2009526084A5 JP 2008554516 A JP2008554516 A JP 2008554516A JP 2008554516 A JP2008554516 A JP 2008554516A JP 2009526084 A5 JP2009526084 A5 JP 2009526084A5
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- Prior art keywords
- disease
- pharmaceutical composition
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- inflammatory
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- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 200000000018 inflammatory disease Diseases 0.000 claims 10
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 230000001684 chronic Effects 0.000 claims 4
- 206010003246 Arthritis Diseases 0.000 claims 2
- 206010003816 Autoimmune disease Diseases 0.000 claims 2
- 206010018651 Graft versus host disease Diseases 0.000 claims 2
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 2
- 102100008982 IL17A Human genes 0.000 claims 2
- 101710003110 IL17A Proteins 0.000 claims 2
- 102100015975 IL17F Human genes 0.000 claims 2
- 101700007032 IL17F Proteins 0.000 claims 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 2
- 230000001154 acute Effects 0.000 claims 2
- 201000009596 autoimmune hypersensitivity disease Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 230000002757 inflammatory Effects 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 208000006673 Asthma Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010011401 Crohn's disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 206010067410 Endotoxaemia Diseases 0.000 claims 1
- 206010028417 Myasthenia gravis Diseases 0.000 claims 1
- 206010037162 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010044248 Toxic shock syndrome Diseases 0.000 claims 1
- 231100000650 Toxic shock syndrome Toxicity 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 201000003883 cystic fibrosis Diseases 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 102000037240 fusion proteins Human genes 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 201000004681 psoriasis Diseases 0.000 claims 1
- 201000001263 psoriatic arthritis Diseases 0.000 claims 1
- 201000006704 ulcerative colitis Diseases 0.000 claims 1
Claims (16)
- SEQ ID NO：68の残基21番〜467番のアミノ酸配列を含む、単離された可溶性受容体ポリペプチド。
- 可溶性受容体が、免疫グロブリン重鎖定常領域をさらに含む可溶性融合タンパク質である、請求項1記載の可溶性受容体ポリペプチド。
- 免疫グロブリン重鎖定常領域がFc断片である、請求項2記載の可溶性受容体ポリペプチド。
- 哺乳動物においてIL-17Aによって誘発される炎症および／またはIL-17Fによって誘発される炎症を軽減させるための、請求項1〜3のいずれか一項記載の単離可溶性受容体ポリペプチドを含む薬学的組成物。
- IL-17Aおよび／またはIL-17Fが役割を果たしている炎症性疾患に苦しむ哺乳動物を治療するための、請求項1〜3のいずれか一項記載の単離可溶性受容体ポリペプチドを含む、薬学的組成物。
- 炎症性疾患が慢性炎症性疾患である、請求項5記載の薬学的組成物。
- 慢性炎症性疾患が、炎症性腸疾患(IBD)、関節炎、アトピー性皮膚炎、および乾癬からなる群より選択される、請求項6記載の薬学的組成物。
- 炎症性腸疾患が、潰瘍性大腸炎およびクローン病からなる群より選択される、請求項7記載の薬学的組成物。
- 関節炎が、関節リウマチおよび乾癬性関節炎からなる群より選択される、請求項7記載の薬学的組成物。
- 炎症性疾患が急性炎症性疾患である、請求項5記載の薬学的組成物。
- 急性炎症性疾患が、内毒素血症、敗血症、トキシックショック症候群、および感染症からなる群より選択される、請求項10記載の薬学的組成物。
- 炎症性疾患が自己免疫疾患である、請求項5記載の薬学的組成物。
- 自己免疫疾患が、I型糖尿病(IDDM)、多発性硬化症(MS)、全身性エリテマトーデス(SLE)、重症筋無力症、関節リウマチ、および炎症性腸疾患（IBD）からなる群より選択される、請求項12記載の薬学的組成物。
- 炎症性疾患が慢性炎症性気道疾患である、請求項5記載の薬学的組成物。
- 慢性炎症性気道疾患が喘息、慢性閉塞性肺疾患(COPD)、および嚢胞性線維症からなる群より選択される、請求項14記載の薬学的組成物。
- 炎症性疾患が移植拒絶および移植片対宿主疾患(GVHD)からなる群より選択される、請求項5記載の薬学的組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77217706P | 2006-02-10 | 2006-02-10 | |
| US78107806P | 2006-03-10 | 2006-03-10 | |
| PCT/US2007/061909 WO2008039553A1 (en) | 2006-02-10 | 2007-02-09 | Soluble il-17rcx4 and methods of using in inflammation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009526084A JP2009526084A (ja) | 2009-07-16 |
| JP2009526084A5 true JP2009526084A5 (ja) | 2010-03-18 |
Family
ID=38895865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554516A Pending JP2009526084A (ja) | 2006-02-10 | 2007-02-09 | 可溶性ＩＬ−１７ＲＣｘ４および炎症における使用法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7622116B2 (ja) |
| EP (1) | EP1987058B1 (ja) |
| JP (1) | JP2009526084A (ja) |
| AT (1) | ATE467640T1 (ja) |
| AU (1) | AU2007300393B2 (ja) |
| CA (1) | CA2638819A1 (ja) |
| DE (1) | DE602007006429D1 (ja) |
| ES (1) | ES2347840T3 (ja) |
| IL (1) | IL192950A0 (ja) |
| WO (1) | WO2008039553A1 (ja) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2569867A1 (en) * | 2004-06-10 | 2005-12-29 | Zymogenetics, Inc. | Soluble zcytor14, anti-zcytor14 antibodies and binding partners and methods of using in inflammation |
| JP2010522564A (ja) | 2007-03-26 | 2010-07-08 | ザイモジェネティクス， インコーポレイテッド | 可溶性ｉｌ−１７ｒａ／ｒｃ融合タンパク質および関連する方法 |
| US20100239590A1 (en) * | 2007-06-20 | 2010-09-23 | Schering Corporation | Joint destruction biomarkers for anti-il-17a therapy of inflammatory joint disease |
| GB2464183A (en) * | 2008-09-19 | 2010-04-14 | Singulex Inc | Sandwich assay |
| WO2010096394A2 (en) | 2009-02-17 | 2010-08-26 | Redwood Biosciences, Inc. | Aldehyde-tagged protein-based drug carriers and methods of use |
| EP2403531A4 (en) | 2009-03-05 | 2013-02-27 | Abbott Lab | IL-17 BINDING PROTEINS |
| AU2010259022B2 (en) | 2009-06-08 | 2016-05-12 | Singulex, Inc. | Highly sensitive biomarker panels |
| JP2011032170A (ja) * | 2009-07-29 | 2011-02-17 | Morinaga Milk Ind Co Ltd | ヒト細胞ｉｌ−１７産生抑制剤 |
| US20130011413A1 (en) * | 2010-02-03 | 2013-01-10 | The University Of Tokyo | Method and Pharmaceutical Composition for Treatment of Intestinal Disease |
| US20110301053A1 (en) | 2010-05-06 | 2011-12-08 | Singulex, Inc. | Methods for Diagnosing, Staging, Predicting Risk for Developing and Identifying Treatment Responders for Rheumatoid Arthritis |
| RU2535033C2 (ru) * | 2010-08-06 | 2014-12-10 | Олег Ильич Эпштейн | Лекарственное средство и способ профилактики инфицирования вич, профилактики и лечения заболеваний, вызываемых вич или ассоциированных с вич, в том числе спида |
| RU2606016C2 (ru) | 2011-01-14 | 2017-01-10 | Редвуд Байосайнс, Инк. | Меченые альдегидом полипептиды иммуноглобулина и способы их применения |
| EP2809660B1 (en) | 2012-02-02 | 2016-01-20 | Ensemble Therapeutics Corporation | Macrocyclic compounds for modulating il-17 |
| MX2018005031A (es) | 2015-10-27 | 2018-06-13 | Ucb Biopharma Sprl | Metodos de tratamiento con anticuerpos anti interleucina 17a/17f (il-17a/f). |
| CN109071634A (zh) | 2016-04-26 | 2018-12-21 | R.P.谢勒技术有限责任公司 | 抗体偶联物及其制备和使用方法 |
| CN114107385A (zh) * | 2019-01-17 | 2022-03-01 | 百奥赛图(北京)医药科技股份有限公司 | 人源化转基因动物 |
| WO2021034727A1 (en) | 2019-08-16 | 2021-02-25 | Applied Molecular Transport Inc. | Compositions, formulations, and interleukin production and purification |
| CN112250764B (zh) * | 2020-10-22 | 2022-07-29 | 深圳市康瑞克生物科技有限责任公司 | 一种抗白细胞介素17a的单克隆抗体、其编码基因及应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5684032A (en) * | 1994-12-13 | 1997-11-04 | Smithkline Beecham Corporation | Compounds |
| US5869286A (en) | 1995-03-23 | 1999-02-09 | Immunex Corporation | Receptor that binds IL-17 |
| US5945511A (en) | 1997-02-20 | 1999-08-31 | Zymogenetics, Inc. | Class II cytokine receptor |
| US20020177188A1 (en) * | 1998-05-15 | 2002-11-28 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
| US6569645B2 (en) * | 1999-05-14 | 2003-05-27 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
| US6579520B2 (en) * | 1998-05-15 | 2003-06-17 | Genentech, Inc. | IL-17 related mammalian cytokine polypeptides (IL-17E) |
| WO1998049307A1 (en) | 1997-05-01 | 1998-11-05 | Zymogenetics, Inc. | Mammalian cytokine-like receptor |
| US5965704A (en) | 1997-08-05 | 1999-10-12 | Zymogenetics, Inc. | Class two cytokine receptor-11 |
| US6635443B1 (en) | 1997-09-17 | 2003-10-21 | Human Genome Sciences, Inc. | Polynucleotides encoding a novel interleukin receptor termed interleukin-17 receptor-like protein |
| EP1078046A4 (en) | 1998-05-12 | 2005-05-11 | Human Genome Sciences Inc | 97 HUMAN SECRETED PROTEINS |
| US20030199041A1 (en) * | 1999-07-07 | 2003-10-23 | Presnell Scott R. | Interleukin-17 receptor homologue |
| AU6069800A (en) | 1999-07-07 | 2001-01-30 | Zymogenetics Inc. | Human cytokine receptor |
| ATE444361T1 (de) | 1999-12-23 | 2009-10-15 | Genentech Inc | Il-17 und il-17r homologe polypeptide und deren therapeutische verwendungen |
| CA2410083A1 (en) * | 2000-05-24 | 2001-11-29 | Schering Corporation | Mammalian receptor proteins; related reagents and methods |
| AU2001260847A1 (en) | 2000-05-24 | 2001-12-03 | Genesis Research And Development Corporation Limited | Compositions isolated from skin cells and methods for their use |
| WO2002058717A2 (en) * | 2000-10-18 | 2002-08-01 | Immunex Corporation | Methods for treating rheumatoid arthritis using il-17 antagonists |
| AU2002225714A1 (en) * | 2000-11-10 | 2002-05-21 | The Regents Of The University Of California | Il-17 receptor-like protein, uses thereof, and modulation of catabolic activity of il-17 cytokines on bone and cartilage |
| US20040097447A1 (en) * | 2002-11-16 | 2004-05-20 | Isis Pharmaceuticals Inc. | Modulation of interleukin 22 receptor expression |
| CA2569867A1 (en) * | 2004-06-10 | 2005-12-29 | Zymogenetics, Inc. | Soluble zcytor14, anti-zcytor14 antibodies and binding partners and methods of using in inflammation |
| JP2008532936A (ja) * | 2005-02-14 | 2008-08-21 | ワイス | インターロイキン−１７ｆ抗体及び他のｉｌ−１７ｆシグナル伝達拮抗物質並びにそれらの使用 |
| PL1931697T3 (pl) * | 2005-09-28 | 2011-03-31 | Zymogenetics Inc | Antagoniści interleukiny IL-17A i IL-17F oraz sposoby ich zastosowania |
| US20070249533A1 (en) * | 2005-09-28 | 2007-10-25 | Levin Steven D | Il-17a and il-17f antagonists and methods of using the same |
-
2007
- 2007-02-09 JP JP2008554516A patent/JP2009526084A/ja active Pending
- 2007-02-09 CA CA002638819A patent/CA2638819A1/en not_active Abandoned
- 2007-02-09 DE DE602007006429T patent/DE602007006429D1/de active Active
- 2007-02-09 WO PCT/US2007/061909 patent/WO2008039553A1/en active Application Filing
- 2007-02-09 US US11/673,094 patent/US7622116B2/en active Active
- 2007-02-09 AT AT07863316T patent/ATE467640T1/de active
- 2007-02-09 ES ES07863316T patent/ES2347840T3/es active Active
- 2007-02-09 EP EP07863316A patent/EP1987058B1/en not_active Not-in-force
- 2007-02-09 AU AU2007300393A patent/AU2007300393B2/en not_active Expired - Fee Related
-
2008
- 2008-07-22 IL IL192950A patent/IL192950A0/en unknown
-
2009
- 2009-10-15 US US12/580,112 patent/US8093355B2/en active Active
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