BR112012031329A2 - proteínas de fusão diméricas vstm3 e composições e métodos relacionados - Google Patents

proteínas de fusão diméricas vstm3 e composições e métodos relacionados

Info

Publication number
BR112012031329A2
BR112012031329A2 BR112012031329A BR112012031329A BR112012031329A2 BR 112012031329 A2 BR112012031329 A2 BR 112012031329A2 BR 112012031329 A BR112012031329 A BR 112012031329A BR 112012031329 A BR112012031329 A BR 112012031329A BR 112012031329 A2 BR112012031329 A2 BR 112012031329A2
Authority
BR
Brazil
Prior art keywords
methods
vstm3
dimeric
related compositions
fusion proteins
Prior art date
Application number
BR112012031329A
Other languages
English (en)
Inventor
Anitra Wolf
Craig D Ostrander
David W Taft
Katherine E Lewis
Margaret D Moore
Megan M Lantry
Robert J Rosler
Steven D Levin
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of BR112012031329A2 publication Critical patent/BR112012031329A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

proteínas de fusão diméricas vstm3 e composições e métodos relacionados. composições e métodos que se referem a proteínas diméricas solúveis são descritos. proteínas diméricas compreendem a primeira e a segunda fusão de polipeptídeo ligadas através de um domínio dimerizante, cada fusão de polipeptídeo compreenedendo o primeiro e o segundo domínio de monômero correspondentes a uma citocina ou um domínio extracelular de um receptor de superfície celular. os domínios de monômero podem ser posicionados no amino terminal e carboxila terminal em relação ao domínio dimerizante. alternativamente, os domínios de monômero podem ser posicionados no tandem, ou carboxila terminal ou amino terminal em relação ao domínio dimerizante. as proteínas diméricas são úteis em métodos para terapia, diagnóstico e pesquisa.
BR112012031329A 2010-06-09 2011-06-07 proteínas de fusão diméricas vstm3 e composições e métodos relacionados BR112012031329A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35287310P 2010-06-09 2010-06-09
PCT/US2011/039422 WO2011156356A1 (en) 2010-06-09 2011-06-07 Dimeric vstm3 fusion proteins and related compositions and methods

Publications (1)

Publication Number Publication Date
BR112012031329A2 true BR112012031329A2 (pt) 2016-10-11

Family

ID=44281053

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012031329A BR112012031329A2 (pt) 2010-06-09 2011-06-07 proteínas de fusão diméricas vstm3 e composições e métodos relacionados

Country Status (9)

Country Link
US (1) US8822642B2 (pt)
EP (1) EP2580238A1 (pt)
JP (1) JP2013531982A (pt)
CN (1) CN103168048B (pt)
BR (1) BR112012031329A2 (pt)
CA (1) CA2802017A1 (pt)
EA (1) EA022932B1 (pt)
MX (1) MX2012013899A (pt)
WO (1) WO2011156356A1 (pt)

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Also Published As

Publication number Publication date
CA2802017A1 (en) 2011-12-15
EP2580238A1 (en) 2013-04-17
MX2012013899A (es) 2013-03-20
US20130095102A1 (en) 2013-04-18
CN103168048B (zh) 2017-02-15
CN103168048A (zh) 2013-06-19
EA201270802A1 (ru) 2013-04-30
WO2011156356A1 (en) 2011-12-15
US8822642B2 (en) 2014-09-02
JP2013531982A (ja) 2013-08-15
EA022932B1 (ru) 2016-03-31

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]