BR112012031329A2 - proteínas de fusão diméricas vstm3 e composições e métodos relacionados - Google Patents
proteínas de fusão diméricas vstm3 e composições e métodos relacionadosInfo
- Publication number
- BR112012031329A2 BR112012031329A2 BR112012031329A BR112012031329A BR112012031329A2 BR 112012031329 A2 BR112012031329 A2 BR 112012031329A2 BR 112012031329 A BR112012031329 A BR 112012031329A BR 112012031329 A BR112012031329 A BR 112012031329A BR 112012031329 A2 BR112012031329 A2 BR 112012031329A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- vstm3
- dimeric
- related compositions
- fusion proteins
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 102000037865 fusion proteins Human genes 0.000 title abstract 2
- 108020001507 fusion proteins Proteins 0.000 title abstract 2
- 230000000447 dimerizing effect Effects 0.000 abstract 3
- 239000000178 monomer Substances 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 230000004927 fusion Effects 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 108010001857 Cell Surface Receptors Proteins 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 102000006240 membrane receptors Human genes 0.000 abstract 1
- 238000011160 research Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
proteínas de fusão diméricas vstm3 e composições e métodos relacionados. composições e métodos que se referem a proteínas diméricas solúveis são descritos. proteínas diméricas compreendem a primeira e a segunda fusão de polipeptídeo ligadas através de um domínio dimerizante, cada fusão de polipeptídeo compreenedendo o primeiro e o segundo domínio de monômero correspondentes a uma citocina ou um domínio extracelular de um receptor de superfície celular. os domínios de monômero podem ser posicionados no amino terminal e carboxila terminal em relação ao domínio dimerizante. alternativamente, os domínios de monômero podem ser posicionados no tandem, ou carboxila terminal ou amino terminal em relação ao domínio dimerizante. as proteínas diméricas são úteis em métodos para terapia, diagnóstico e pesquisa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35287310P | 2010-06-09 | 2010-06-09 | |
PCT/US2011/039422 WO2011156356A1 (en) | 2010-06-09 | 2011-06-07 | Dimeric vstm3 fusion proteins and related compositions and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012031329A2 true BR112012031329A2 (pt) | 2016-10-11 |
Family
ID=44281053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012031329A BR112012031329A2 (pt) | 2010-06-09 | 2011-06-07 | proteínas de fusão diméricas vstm3 e composições e métodos relacionados |
Country Status (9)
Country | Link |
---|---|
US (1) | US8822642B2 (pt) |
EP (1) | EP2580238A1 (pt) |
JP (1) | JP2013531982A (pt) |
CN (1) | CN103168048B (pt) |
BR (1) | BR112012031329A2 (pt) |
CA (1) | CA2802017A1 (pt) |
EA (1) | EA022932B1 (pt) |
MX (1) | MX2012013899A (pt) |
WO (1) | WO2011156356A1 (pt) |
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CA3179151A1 (en) | 2008-04-09 | 2009-10-15 | Genentech, Inc. | Novel compositions and methods for the treatment of immune related diseases |
WO2015089217A2 (en) | 2013-12-10 | 2015-06-18 | Bionz, Llc | Methods of developing selective peptide antagonists |
EP3636274A1 (en) * | 2011-01-18 | 2020-04-15 | Bioniz, LLC | Compositions and methods for modulating gamma-c-cytokine activity |
CN103965362B (zh) * | 2013-02-06 | 2019-02-01 | 上海细胞治疗集团有限公司 | 一种可使t细胞趋向肿瘤部位的嵌合趋化因子受体 |
AU2014290069B2 (en) | 2013-07-16 | 2019-01-03 | Genentech, Inc. | Methods of treating cancer using PD-1 axis binding antagonists and TIGIT inhibitors |
MA40475A (fr) | 2014-08-19 | 2017-06-28 | Fayadat Dilman Laurence | Anticorps anti-tigit |
US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
UY36471A (es) | 2014-12-23 | 2016-06-30 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Anticuerpos contra el inmunorreceptor (tigit) de linfocitos t con dominios ig y motivos de inhibición del inmunorreceptor basados en tirosina (itim) |
WO2017030823A2 (en) | 2015-08-14 | 2017-02-23 | Merck Sharp & Dohme Corp. | Anti-tigit antibodies |
JP6764474B2 (ja) | 2015-09-25 | 2020-09-30 | ジェネンテック, インコーポレイテッド | 抗tigit抗体及び使用方法 |
RU2020124191A (ru) | 2015-10-01 | 2020-08-27 | Потенза Терапевтикс, Инк. | Анти-tigit антиген-связывающие белки и способы их применения |
PL3359556T3 (pl) | 2015-10-09 | 2021-11-22 | Bioniz, Llc | Modulowanie aktywności gamma-c-cytokin |
CA3009393C (en) * | 2015-12-23 | 2023-08-22 | Greenovation Biotech Gmbh | Polypeptides for inhibiting complement activation |
EP3423089A4 (en) | 2016-03-04 | 2019-10-23 | JN Biosciences, LLC | ANTI-Tigit ANTIBODY |
AU2017253320B2 (en) | 2016-04-20 | 2020-10-22 | University Of Tsukuba | Regulatory T cell activator, and use thereof |
US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
US11753438B2 (en) | 2016-05-11 | 2023-09-12 | Cytiva Bioprocess R&D Ab | Method of cleaning and/or sanitizing a separation matrix |
JP7106187B2 (ja) | 2016-05-11 | 2022-07-26 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックスを保存する方法 |
US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
CN109071613A (zh) | 2016-05-11 | 2018-12-21 | 通用电气医疗集团生物工艺研发股份公司 | 分离基质 |
US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
JOP20190203A1 (ar) | 2017-03-30 | 2019-09-03 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها |
CN110997720A (zh) | 2017-07-27 | 2020-04-10 | Iteos治疗公司 | 抗tigit抗体 |
CN108558997B (zh) * | 2017-10-20 | 2021-10-08 | 中国人民解放军第四军医大学 | 一种重组融合蛋白TIGIT-Fc及其抗移植排斥反应的应用 |
CA3106279A1 (en) * | 2018-07-19 | 2020-01-23 | University Of Washington | De novo design of protein switches |
CN112638944A (zh) | 2018-08-23 | 2021-04-09 | 西进公司 | 抗tigit抗体 |
US11312963B2 (en) | 2018-10-18 | 2022-04-26 | Synerk Inc. | Compositions and methods for inhibiting TIGIT gene expression |
CN110669139A (zh) * | 2019-09-18 | 2020-01-10 | 沣潮医药科技(上海)有限公司 | 二聚体免疫粘附素、药物组合物和用途 |
CN111018999B (zh) * | 2019-12-05 | 2022-07-12 | 沣潮医药科技(上海)有限公司 | 二聚体免疫融合蛋白、药物组合物和用途 |
PE20231078A1 (es) | 2020-06-02 | 2023-07-17 | Arcus Biosciences Inc | Anticuerpos anti-tigit |
CN112190689B (zh) * | 2020-08-25 | 2022-12-09 | 沣潮医药科技(上海)有限公司 | Tigit免疫粘附素在调控肿瘤免疫及调节血管生成产品中的应用 |
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-
2011
- 2011-06-07 EA EA201270802A patent/EA022932B1/ru not_active IP Right Cessation
- 2011-06-07 EP EP11726021.6A patent/EP2580238A1/en not_active Withdrawn
- 2011-06-07 BR BR112012031329A patent/BR112012031329A2/pt not_active Application Discontinuation
- 2011-06-07 WO PCT/US2011/039422 patent/WO2011156356A1/en active Application Filing
- 2011-06-07 CA CA2802017A patent/CA2802017A1/en not_active Abandoned
- 2011-06-07 JP JP2013514296A patent/JP2013531982A/ja active Pending
- 2011-06-07 CN CN201180039006.4A patent/CN103168048B/zh active Active
- 2011-06-07 MX MX2012013899A patent/MX2012013899A/es active IP Right Grant
- 2011-06-07 US US13/701,234 patent/US8822642B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2011156356A1 (en) | 2011-12-15 |
US8822642B2 (en) | 2014-09-02 |
US20130095102A1 (en) | 2013-04-18 |
JP2013531982A (ja) | 2013-08-15 |
CN103168048B (zh) | 2017-02-15 |
EA022932B1 (ru) | 2016-03-31 |
CN103168048A (zh) | 2013-06-19 |
EA201270802A1 (ru) | 2013-04-30 |
MX2012013899A (es) | 2013-03-20 |
CA2802017A1 (en) | 2011-12-15 |
EP2580238A1 (en) | 2013-04-17 |
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