JP2010138205A5 - - Google Patents
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- JP2010138205A5 JP2010138205A5 JP2010058365A JP2010058365A JP2010138205A5 JP 2010138205 A5 JP2010138205 A5 JP 2010138205A5 JP 2010058365 A JP2010058365 A JP 2010058365A JP 2010058365 A JP2010058365 A JP 2010058365A JP 2010138205 A5 JP2010138205 A5 JP 2010138205A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- adenovirus
- protein
- culture
- mdck
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10144906.2 | 2001-09-12 | ||
| DE10144906A DE10144906B4 (de) | 2001-09-12 | 2001-09-12 | Verfahren zur großtechnischen Herstellung von Impfstoffen |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008204890A Division JP2008289499A (ja) | 2001-09-12 | 2008-08-07 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010138205A JP2010138205A (ja) | 2010-06-24 |
| JP2010138205A5 true JP2010138205A5 (https=) | 2011-09-08 |
| JP5264812B2 JP5264812B2 (ja) | 2013-08-14 |
Family
ID=7698764
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003527086A Pending JP2005532779A (ja) | 2001-09-12 | 2002-09-11 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
| JP2008204890A Pending JP2008289499A (ja) | 2001-09-12 | 2008-08-07 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
| JP2010058365A Expired - Fee Related JP5264812B2 (ja) | 2001-09-12 | 2010-03-15 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
| JP2011158481A Withdrawn JP2011212021A (ja) | 2001-09-12 | 2011-07-19 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003527086A Pending JP2005532779A (ja) | 2001-09-12 | 2002-09-11 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
| JP2008204890A Pending JP2008289499A (ja) | 2001-09-12 | 2008-08-07 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011158481A Withdrawn JP2011212021A (ja) | 2001-09-12 | 2011-07-19 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10329536B2 (https=) |
| EP (3) | EP1427815B1 (https=) |
| JP (4) | JP2005532779A (https=) |
| KR (1) | KR100999345B1 (https=) |
| AT (2) | ATE479742T1 (https=) |
| AU (2) | AU2002338667B2 (https=) |
| BR (1) | BR0212470A (https=) |
| CA (1) | CA2455189C (https=) |
| CY (2) | CY1110964T1 (https=) |
| DE (3) | DE10144906B4 (https=) |
| DK (2) | DK1427815T3 (https=) |
| ES (2) | ES2351300T3 (https=) |
| NZ (1) | NZ532202A (https=) |
| PT (2) | PT2011862E (https=) |
| SI (1) | SI1427815T1 (https=) |
| WO (1) | WO2003023021A2 (https=) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007537760A (ja) * | 2004-05-20 | 2007-12-27 | アイディー バイオメディカル コーポレイション | インフルエンザワクチンを製造するためのプロセス |
| ATE489965T1 (de) | 2004-09-09 | 2010-12-15 | Novartis Vaccines & Diagnostic | Verminderung von potentiellen iatrogenen risiken in verbindung mit influenza impfstoffen |
| FR2884255B1 (fr) | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
| ES2525518T3 (es) | 2005-11-01 | 2014-12-26 | Novartis Vaccines And Diagnostics Gmbh | Vacunas virales derivadas de células con niveles reducidos de ADN celular residual |
| NZ568211A (en) | 2005-11-04 | 2011-11-25 | Novartis Vaccines & Diagnostic | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
| NZ594482A (en) | 2005-11-04 | 2012-11-30 | Novartis Vaccines & Diagnostic | Influenza vaccines with reduced amount of oil-in-water emulsion as adjuvant |
| JP2009514844A (ja) | 2005-11-04 | 2009-04-09 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | スプリットインフルエンザワクチン用のアジュバントとしての遊離水相界面活性剤を含むエマルション |
| CN102755645A (zh) | 2005-11-04 | 2012-10-31 | 诺华疫苗和诊断有限公司 | 佐剂配制的包含细胞因子诱导剂的流感疫苗 |
| CA2628152C (en) | 2005-11-04 | 2016-02-02 | Novartis Vaccines And Diagnostics S.R.L. | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| CN101448523A (zh) | 2006-03-24 | 2009-06-03 | 诺华疫苗和诊断有限两合公司 | 无需冷藏储存流感疫苗 |
| CA2647985C (en) | 2006-03-31 | 2014-12-30 | Warf-Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| EP4585610A3 (en) | 2006-09-11 | 2025-09-24 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
| EP2615167A1 (en) | 2006-09-15 | 2013-07-17 | MedImmune, LLC | Method for eliminating DNA contaminants from viral preparations |
| US9474798B2 (en) | 2007-06-18 | 2016-10-25 | Wisconsin Alumni Research Foundation | Influenza M2 protein mutant viruses as live influenza attenuated vaccines |
| KR20100045437A (ko) | 2007-06-27 | 2010-05-03 | 노파르티스 아게 | 첨가물이 적은 인플루엔자 백신 |
| US9439960B2 (en) * | 2007-10-10 | 2016-09-13 | The Trustees Of Princeton University | Cytomegalovirus vaccines and methods of production |
| GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| US8785173B2 (en) | 2008-09-24 | 2014-07-22 | Medimmune, Llc | Methods for purification of viruses |
| USH2283H1 (en) | 2009-04-27 | 2013-09-03 | Novartis Ag | Vaccines for protecting against influenza |
| EP2456855B1 (en) | 2009-07-23 | 2017-03-29 | GE Healthcare Bio-Sciences Corp. | Drain down and re-feed of microcarrier bioreactor |
| EP2493912B1 (en) | 2009-10-26 | 2020-07-29 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in vero cells |
| US20110142863A1 (en) * | 2009-12-16 | 2011-06-16 | Millipore Corporation | Flow through purification processes for large biomolecules |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| CA2797059A1 (en) * | 2010-05-03 | 2011-11-10 | Glaxosmithkline Biologicals S.A. | Novel method |
| US9426989B2 (en) | 2010-05-06 | 2016-08-30 | Novartis Ag | Organic peroxide compounds for microorganism inactivation |
| CN103025350A (zh) | 2010-05-21 | 2013-04-03 | 诺华有限公司 | 流感病毒的重配方法 |
| CA2801151A1 (en) | 2010-06-01 | 2011-12-08 | Novartis Ag | Concentration of vaccine antigens with lyophilization |
| WO2011151723A2 (en) | 2010-06-01 | 2011-12-08 | Novartis Ag | Concentration of vaccine antigens without lyophilization |
| WO2012023044A1 (en) | 2010-08-20 | 2012-02-23 | Novartis Ag | Soluble needle arrays for delivery of influenza vaccines |
| WO2012033236A1 (ko) * | 2010-09-06 | 2012-03-15 | 에스케이케미칼 주식회사 | 무혈청 배양 및 부유 배양에 적응된 ｍｄｃｋ 세포주 및 상기 세포를 사용하여 백신용 바이러스를 제조하는 방법 |
| US20120156757A1 (en) | 2010-12-15 | 2012-06-21 | Millipore Corporation | Purification of immunogens using a non-polysaccharide matrix |
| JP2014527799A (ja) | 2011-08-26 | 2014-10-23 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス |
| GB201216121D0 (en) | 2012-09-10 | 2012-10-24 | Novartis Ag | Sample quantification by disc centrifugation |
| EP2822585B1 (en) | 2012-03-06 | 2017-05-17 | Janssen Vaccines & Prevention B.V. | Improved vaccination against influenza |
| KR101370512B1 (ko) * | 2013-06-07 | 2014-03-06 | 재단법인 목암생명공학연구소 | 무단백 배지에서 부유 배양되는 mdck 유래 세포주 및 상기 세포주를 이용하여 바이러스를 증식시키는 방법 |
| WO2015009743A1 (en) | 2013-07-15 | 2015-01-22 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| US11013795B2 (en) | 2015-06-26 | 2021-05-25 | Seqirus UK Limited | Antigenically matched influenza vaccines |
| US9890363B2 (en) | 2015-07-06 | 2018-02-13 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| KR102790570B1 (ko) | 2015-07-07 | 2025-04-04 | 세퀴러스 유케이 리미티드 | 인플루엔자 효능 검정 |
| TWI830290B (zh) * | 2015-10-30 | 2024-01-21 | 財團法人國家衛生研究院 | 用於疫苗製備之於無血清、化學性界定培養基中之mdck懸浮細胞株 |
| CN105561317B (zh) * | 2015-12-22 | 2018-03-20 | 肇庆大华农生物药品有限公司 | 重组伪狂犬病病毒疫苗耐热冻干保护剂及其制备方法 |
| US11197925B2 (en) | 2016-02-19 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Influenza B virus replication for vaccine development |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| EP3914295A2 (en) | 2019-01-23 | 2021-12-01 | Yoshihiro Kawaoka | Mutations that confer genetic stability to additional genes in influenza viruses |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| CN114929269A (zh) | 2019-05-01 | 2022-08-19 | 威斯康星校友研究基金会(Warf) | 用于疫苗开发的改进的流感病毒复制 |
| CN110237246B (zh) * | 2019-07-25 | 2022-11-15 | 北京鼎持生物技术有限公司 | 一种全悬浮细胞培养禽流感（h9）灭活疫苗的方法 |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| EP4061930A1 (en) | 2019-11-18 | 2022-09-28 | Seqirus Pty Ltd | Method for producing reassortant influenza viruses |
| JP2023511444A (ja) | 2020-01-24 | 2023-03-17 | ウィスコンシン アルムニ リサーチ ファンデイション | 安定化されたｎａを有する組換えインフルエンザウイルス |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| WO2021261892A1 (ko) * | 2020-06-22 | 2021-12-30 | 코오롱생명과학 주식회사 | 부유세포를 이용한 백시니아 바이러스의 대량생산방법 |
| US12577540B2 (en) | 2020-12-10 | 2026-03-17 | Sarepta Therapeutics, Inc. | Suspension mode seed train development for adherent cells |
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|---|---|---|---|---|
| DE1278075B (de) | 1964-06-22 | 1968-09-19 | Norden Lab Inc | Verwendung von Gewebekulturen zur Zuechtung von Viren fuer die Gewinnung von Impfstoffen |
| US4064232A (en) * | 1974-01-14 | 1977-12-20 | Sandoz Ltd. | Process for isolating the immunogenic components of influenza viruses |
| US4500513A (en) * | 1979-05-15 | 1985-02-19 | Miles Laboratories, Inc. | Influenza vaccine production in liquid cell culture |
| CA1122527A (en) * | 1979-05-15 | 1982-04-27 | Karen K. Brown | Influenza vaccine production in liquid cell culture |
| USRE33164E (en) * | 1979-05-15 | 1990-02-13 | Mobay Corporation | Influenza vaccine production in liquid cell culture |
| US4525349A (en) | 1981-12-29 | 1985-06-25 | Societe Anonyme Dite: Institut Merueux | Process for the large-scale production of a vaccine against poliomyelitis and the resulting vaccine |
| US5013663A (en) * | 1983-06-15 | 1991-05-07 | American Home Products Corporation | Canine corona virus vaccine |
| US4783411A (en) * | 1984-10-22 | 1988-11-08 | Janis Gabliks | Influenza-A virus vaccine from fish cell cultures |
| DE69024392T2 (de) | 1989-03-29 | 1996-07-25 | Univ New York | Verfahren zur Reinigungbvon Aussenmembran-Protein von Haemophilus influenzae |
| AT393277B (de) | 1990-01-04 | 1991-09-25 | Immuno Ag | Verfahren zur herstellung von fruehsommer- meningoenzephalitis-virus (fsme-virus)-antigen |
| MY107664A (en) * | 1991-01-17 | 1996-05-30 | Kao Corp | Novel alkaline proteinase and process for producing the same |
| GB9110808D0 (en) * | 1991-05-17 | 1991-07-10 | Retroscreen Ltd | Aids vaccine and method for its production |
| JPH08508875A (ja) * | 1992-05-01 | 1996-09-24 | 帝人株式会社 | 蛋白分泌細胞の流加回分培養法 |
| US5762939A (en) | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
| US5824536A (en) | 1994-08-23 | 1998-10-20 | St. Jude Children's Research Hospital | Influenza virus replicated in mammalian cell culture and vaccine production |
| US5756341A (en) * | 1994-11-10 | 1998-05-26 | Immuno Ag | Method for controlling the infectivity of viruses |
| US5753489A (en) * | 1994-11-10 | 1998-05-19 | Immuno Ag | Method for producing viruses and vaccines in serum-free culture |
| CA2205015C (en) | 1994-11-10 | 2003-04-08 | Otfried Kistner | Method for producing biologicals in protein-free culture |
| EP0808361A4 (en) | 1994-11-16 | 2001-07-18 | St Jude Childrens Res Hospital | Novel replication process |
| US5646033A (en) * | 1994-11-30 | 1997-07-08 | Dyncorp | African green monkey kidney cell lines useful for maintaining viruses and for preparation of viral vaccines |
| US6165774A (en) | 1995-09-22 | 2000-12-26 | Connaught Laboratories Limited | Parainfluenza virus glycoproteins and vaccines |
| DE19612967A1 (de) | 1996-04-01 | 1997-10-02 | Behringwerke Ag | Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren |
| DE19612966B4 (de) * | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| KR20010032699A (ko) * | 1998-10-05 | 2001-04-25 | 무따이 마사히꼬 | 일본 뇌염 바이러스 감염에 대한 불활성 백신을 위한증강된 면역원 및 그 제조방법 |
| US6514502B1 (en) * | 1999-01-26 | 2003-02-04 | Schering-Plough Veterinary Corporation | Propagation of bovine cononavirus in chinese hamster ovary cells |
| EP1229125A4 (en) * | 1999-10-19 | 2005-06-01 | Kyowa Hakko Kogyo Kk | PROCESS FOR PREPARING A POLYPEPTIDE |
| US7521220B2 (en) | 1999-11-26 | 2009-04-21 | Crucell Holland B.V. | Production of vaccines |
| KR100797547B1 (ko) * | 2000-03-03 | 2008-01-24 | 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 | 무혈청 배양 및 부유 배양에서 사용할 수 있는 세포 및상기 세포를 사용하여 백신용 바이러스를 제조하는 방법 |
| KR20050010040A (ko) | 2002-06-11 | 2005-01-26 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 면역원성 조성물 |
| KR20050114225A (ko) | 2003-03-07 | 2005-12-05 | 머크 앤드 캄파니 인코포레이티드 | 인플루엔자 바이러스 백신 |
| EP1608402B1 (en) | 2003-03-24 | 2010-10-20 | Intercell AG | Improved vaccines |
| AR054020A1 (es) | 2005-03-23 | 2007-05-30 | Glaxosmithkline Biolog Sa | Nuevo uso |
| EP4585610A3 (en) | 2006-09-11 | 2025-09-24 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
| EA015817B1 (ru) | 2006-10-12 | 2011-12-30 | Глаксосмитклайн Байолоджикалс С.А. | Иммуногенная композиция, содержащая адъювант в виде эмульсии "масло в воде" |
| PT2121011E (pt) | 2006-12-06 | 2014-07-31 | Novartis Ag | Vacinas compreendendo um antigénio a partir de quatro estirpes do vírus da gripe |
| PE20090146A1 (es) | 2007-04-20 | 2009-03-23 | Glaxosmithkline Biolog Sa | Composicion inmunogenica contra el virus influenza |
| US8506966B2 (en) | 2008-02-22 | 2013-08-13 | Novartis Ag | Adjuvanted influenza vaccines for pediatric use |
| US9494571B2 (en) | 2010-03-08 | 2016-11-15 | Novartis Ag | Methods of testing for intracellular pathogens |
-
2001
- 2001-09-12 DE DE10144906A patent/DE10144906B4/de not_active Expired - Lifetime
-
2002
- 2002-09-11 PT PT08018057T patent/PT2011862E/pt unknown
- 2002-09-11 WO PCT/EP2002/010208 patent/WO2003023021A2/de not_active Ceased
- 2002-09-11 JP JP2003527086A patent/JP2005532779A/ja active Pending
- 2002-09-11 KR KR1020047003712A patent/KR100999345B1/ko not_active Expired - Lifetime
- 2002-09-11 EP EP02777069A patent/EP1427815B1/de not_active Expired - Lifetime
- 2002-09-11 NZ NZ532202A patent/NZ532202A/en not_active IP Right Cessation
- 2002-09-11 EP EP10004227A patent/EP2216400A1/de not_active Withdrawn
- 2002-09-11 AT AT02777069T patent/ATE479742T1/de active
- 2002-09-11 EP EP08018057A patent/EP2011862B1/de not_active Expired - Lifetime
- 2002-09-11 PT PT02777069T patent/PT1427815E/pt unknown
- 2002-09-11 DE DE122011000005C patent/DE122011000005I1/de active Pending
- 2002-09-11 AT AT08018057T patent/ATE512213T1/de active
- 2002-09-11 SI SI200230924T patent/SI1427815T1/sl unknown
- 2002-09-11 BR BR0212470-0A patent/BR0212470A/pt active Search and Examination
- 2002-09-11 ES ES02777069T patent/ES2351300T3/es not_active Expired - Lifetime
- 2002-09-11 AU AU2002338667A patent/AU2002338667B2/en not_active Expired
- 2002-09-11 DE DE50214630T patent/DE50214630D1/de not_active Expired - Lifetime
- 2002-09-11 CA CA2455189A patent/CA2455189C/en not_active Expired - Lifetime
- 2002-09-11 DK DK02777069.2T patent/DK1427815T3/da active
- 2002-09-11 DK DK08018057.3T patent/DK2011862T3/da active
- 2002-09-11 ES ES08018057T patent/ES2367833T3/es not_active Expired - Lifetime
- 2002-09-11 US US10/487,707 patent/US10329536B2/en not_active Expired - Fee Related
-
2008
- 2008-08-07 JP JP2008204890A patent/JP2008289499A/ja active Pending
- 2008-08-28 AU AU2008207588A patent/AU2008207588B2/en not_active Expired
-
2010
- 2010-03-15 JP JP2010058365A patent/JP5264812B2/ja not_active Expired - Fee Related
- 2010-11-30 CY CY20101101097T patent/CY1110964T1/el unknown
-
2011
- 2011-07-19 JP JP2011158481A patent/JP2011212021A/ja not_active Withdrawn
- 2011-08-26 CY CY20111100819T patent/CY1113241T1/el unknown
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