JP2009545637A5 - - Google Patents

Info

Publication number

JP2009545637A5

JP2009545637A5 JP2009522088A JP2009522088A JP2009545637A5 JP 2009545637 A5 JP2009545637 A5 JP 2009545637A5 JP 2009522088 A JP2009522088 A JP 2009522088A JP 2009522088 A JP2009522088 A JP 2009522088A JP 2009545637 A5 JP2009545637 A5 JP 2009545637A5

Authority

JP

Japan

Prior art keywords

hyaluronic acid

branched

less

glucosamine

deacetylated

Prior art date

2007-07-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 22
• 229920002674 hyaluronan Polymers 0.000 claims 16
• 229960003160 hyaluronic acid Drugs 0.000 claims 16
• MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 7
• MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 7
• 229960002442 glucosamine Drugs 0.000 claims 7
• OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims 4
• OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 4
• MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• 229950006780 n-acetylglucosamine Drugs 0.000 claims 4
• 239000013543 active substance Substances 0.000 claims 3
• 229920000249 biocompatible polymer Polymers 0.000 claims 3
• OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical class CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 claims 2
• 206010052428 Wound Diseases 0.000 claims 2
• 208000027418 Wounds and injury Diseases 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 150000003141 primary amines Chemical class 0.000 claims 2
• 238000007126 N-alkylation reaction Methods 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 125000003172 aldehyde group Chemical group 0.000 claims 1
• 230000033115 angiogenesis Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 239000002775 capsule Substances 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 150000002302 glucosamines Chemical class 0.000 claims 1
• 239000003094 microcapsule Substances 0.000 claims 1
• 201000008482 osteoarthritis Diseases 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 230000002829 reductive effect Effects 0.000 claims 1
• 150000003335 secondary amines Chemical class 0.000 claims 1
• 239000003981 vehicle Substances 0.000 claims 1
• 230000029663 wound healing Effects 0.000 claims 1