BR9909346A - Segmento de ácido nucleico, vetor recombinante, célula hospedeira, composição, processos para detectar uma espécie de dna, uma célula bacteriana e infecção, para produzir ácido hialurÈnico e para criar uma vacina, sequência de ácido nucleico e de cdna, vacina e teste diagnóstico - Google Patents
Segmento de ácido nucleico, vetor recombinante, célula hospedeira, composição, processos para detectar uma espécie de dna, uma célula bacteriana e infecção, para produzir ácido hialurÈnico e para criar uma vacina, sequência de ácido nucleico e de cdna, vacina e teste diagnósticoInfo
- Publication number
- BR9909346A BR9909346A BR9909346-4A BR9909346A BR9909346A BR 9909346 A BR9909346 A BR 9909346A BR 9909346 A BR9909346 A BR 9909346A BR 9909346 A BR9909346 A BR 9909346A
- Authority
- BR
- Brazil
- Prior art keywords
- nucleic acid
- vaccine
- infection
- dna
- species
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
"SEGMENTO DE áCIDO NUCLEICO, VETOR RECOMBINANTE, CéLULA HOSPEDEIRA, COMPOSIçãO, PROCESSOS PARA DETECTAR UMA ESPéCIE DE DNA, UMA CéLULA BACTERIANA E INFECçãO, PARA PRODUZIR áCIDO HIALURÈNICO E PARA CRIAR UMA VACINA, SEQUêNCIA DE áCIDO NUCLEICO E DE CDNA, VACINA E TESTE DIAGNóSTICO". A presente invenção refere-se a segmento de ácido nucleico tendo um segmento de região de codificação codificando hialuronato sintase bacteriana multocida enzimaticamente ativa (PmHAS), e ao uso deste segmento de ácido nucleico na preparação de células recombinantes que produzem hialuronato sintase e seu produto de ácido hialurónico. Hialurónico é também conhecido como ácido hialurónico ou hialuronano. A presente invenção também se refere ao uso de PmHas na construção de cepas mutantes "de abate" de P. multocida para uso em vacinações. A presente invenção ainda se refere ao uso de PmHAS em testes diagnósticos nas determinações de campo de infecção de P. multocida de animais de criação.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8041498P | 1998-04-02 | 1998-04-02 | |
| US17885198A | 1998-10-26 | 1998-10-26 | |
| PCT/US1999/007289 WO1999051265A1 (en) | 1998-04-02 | 1999-04-01 | Nucleic acid encoding hyaluronan synthase and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9909346A true BR9909346A (pt) | 2001-09-11 |
Family
ID=26763480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9909346-4A BR9909346A (pt) | 1998-04-02 | 1999-04-01 | Segmento de ácido nucleico, vetor recombinante, célula hospedeira, composição, processos para detectar uma espécie de dna, uma célula bacteriana e infecção, para produzir ácido hialurÈnico e para criar uma vacina, sequência de ácido nucleico e de cdna, vacina e teste diagnóstico |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP1832662B1 (pt) |
| JP (2) | JP4490581B2 (pt) |
| CN (2) | CN1327894C (pt) |
| AT (1) | ATE501275T1 (pt) |
| AU (1) | AU770903B2 (pt) |
| BR (1) | BR9909346A (pt) |
| CA (1) | CA2326821C (pt) |
| CZ (1) | CZ20003576A3 (pt) |
| DE (1) | DE69943276D1 (pt) |
| IL (1) | IL138803A0 (pt) |
| WO (1) | WO1999051265A1 (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7060469B2 (en) | 1998-04-02 | 2006-06-13 | The Board Of Regents Of The University Of Oklahoma | Polymer grafting by polysaccharide synthases |
| DE69940353D1 (en) * | 1998-11-11 | 2009-03-12 | Univ Oklahoma | Polymerpfropfung mittels polysaccharide-synthase |
| US7534589B2 (en) | 1999-11-10 | 2009-05-19 | The Board Of Regents Of The University Of Oklahoma | Polymer grafting by polysaccharide synthases |
| JP2003524018A (ja) | 2000-02-24 | 2003-08-12 | アイトゲネーシシェ テクニシェ ホッホシューレ チューリッヒ | フィブロネクチンのｅｄ‐ｂドメインに特異的な抗体、前記抗体を含む複合体、および血管形成を検出および治療するためのその使用 |
| EP1282684B1 (en) * | 2000-04-25 | 2009-09-23 | The Board Of Rengents Of The University Of Oklahoma | Chondroitin synthase gene and methods of making and using same |
| CN101709285B (zh) * | 2001-06-13 | 2014-03-26 | 俄克拉何马大学董事会 | 透明质素合成酶基因及其表达 |
| JP2005525091A (ja) | 2001-12-21 | 2005-08-25 | ノボザイムス バイオポリマー アクティーゼルスカブ | 組換え宿主細胞におけるヒアルロナンの生成方法 |
| JP2009545637A (ja) | 2006-08-04 | 2009-12-24 | ノボザイムス バイオファーマ デーコー アクティーゼルスカブ | 分岐ヒアルロン酸及びその製造方法 |
| WO2009026635A1 (en) * | 2007-08-31 | 2009-03-05 | The University Of Queensland | Production of hyaluronic acid |
| JP5523338B2 (ja) | 2007-12-19 | 2014-06-18 | エヴォニク ゴールドシュミット ゲーエムベーハー | エマルジョン中の架橋ヒアルロン酸 |
| CA2732092C (en) * | 2008-07-25 | 2015-02-24 | Denki Kagaku Kogyo Kabushiki Kaisha | Method for producing hyaluronic acid |
| JP2014515426A (ja) | 2011-05-30 | 2014-06-30 | ノボザイムス バイオファーマ デーコー アクティーゼルスカブ | 高分子量ヒアルロン酸の噴霧乾燥 |
| CA2847328A1 (en) | 2011-09-02 | 2013-03-07 | Novozymes Biopharma Dk A/S | Oral formulations containing hyaluronic acid for sustained drug release |
| US9493755B2 (en) | 2012-02-21 | 2016-11-15 | Bloomage Freda Biopharm Co., Ltd. | Bacillus, hyaluronidase, and uses thereof |
| ITMI20120896A1 (it) | 2012-05-23 | 2013-11-24 | Bongulielmi Reto | Condroitina per uso in medicina |
| ITMI20121316A1 (it) | 2012-07-27 | 2014-01-28 | Altergon Sa | Complessi di condroitina ad assorbimento transcutaneo |
| WO2014100837A1 (en) | 2012-12-17 | 2014-06-26 | Bui The Duy | Computer aided implantation of body implants |
| ES2824402T3 (es) | 2013-11-01 | 2021-05-12 | Boehringer Ingelheim Animal Health Usa Inc | Vacunas atenuadas contra Pasteurella multocida y procedimientos de fabricación y uso de las mismas |
| RU2719140C1 (ru) | 2019-07-26 | 2020-04-17 | Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех" | Бактерия рода bacillus, продуцирующая гиалуроновую кислоту, и способ получения гиалуроновой кислоты с использованием указанной бактерии |
| RU2723722C1 (ru) | 2019-07-26 | 2020-06-17 | Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех" | ТАНДЕМНЫЙ ПРОМОТОР, ФУНКЦИОНИРУЮЩИЙ В БАКТЕРИИ РОДА Bacillus, ТРАНСФОРМИРОВАННАЯ БАКТЕРИЯ РОДА Bacillus - ПРОДУЦЕНТ ЦЕЛЕВОГО ПРОДУКТА, СОДЕРЖАЩАЯ УКАЗАННЫЙ ПРОМОТОР, И СПОСОБ ПОЛУЧЕНИЯ ЦЕЛЕВОГО ПРОДУКТА С ИСПОЛЬЗОВАНИЕМ УКАЗАННОЙ БАКТЕРИИ |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6163294A (ja) * | 1984-09-05 | 1986-04-01 | Chisso Corp | 発酵法によるヒアルロン酸の製造法 |
| US4784990A (en) * | 1985-01-18 | 1988-11-15 | Bio-Technology General Corporation | High molecular weight sodium hyaluronate |
| US5015577A (en) * | 1989-08-29 | 1991-05-14 | Board Of Regents, The University Of Texas System | DNA encoding hyaluronate synthase |
| CA2061703C (en) * | 1992-02-20 | 2002-07-02 | Rudolf E. Falk | Formulations containing hyaluronic acid |
| IT1260153B (it) * | 1992-06-19 | 1996-03-28 | Michael O'regan | Individuazione di un frammento di dna codificante l'enzima acido ialuronico sintetasi (has) e della sua sequenza nucleotidica |
| US5496726A (en) * | 1993-04-16 | 1996-03-05 | Lucky Limited | Streptococcus zooepidemicus medium and process for preparing hyaluronic acid |
| CN1161060A (zh) * | 1994-09-12 | 1997-10-01 | M·G·伯杰龙 | 用于微生物学实验室日常诊断中迅速检测和鉴别临床样品中普通细菌病原体和抗生素抗性基因之特异性和通用性探针及扩增引物 |
| US6114161A (en) * | 1995-01-30 | 2000-09-05 | Lunamed Ag | Antitumor preparations |
| WO1997020061A1 (en) * | 1995-11-30 | 1997-06-05 | The Scripps Research Institute | Synthesis of hyaluronic acid |
| US6086894A (en) * | 1996-06-27 | 2000-07-11 | Virginia Tech Intellectual Properties, Inc. | Recombinant vaccine for diseases caused by encapsulated organisms |
| KR20010031682A (ko) * | 1997-10-31 | 2001-04-16 | 존 팔머 | 히알우로난 합성효소 유전자 및 그의 용도 |
| DE69940353D1 (en) * | 1998-11-11 | 2009-03-12 | Univ Oklahoma | Polymerpfropfung mittels polysaccharide-synthase |
-
1999
- 1999-04-01 AU AU35485/99A patent/AU770903B2/en not_active Ceased
- 1999-04-01 CN CNB998069426A patent/CN1327894C/zh not_active Expired - Fee Related
- 1999-04-01 CN CNA2007101098632A patent/CN101275143A/zh active Pending
- 1999-04-01 IL IL13880399A patent/IL138803A0/xx unknown
- 1999-04-01 AT AT07007453T patent/ATE501275T1/de not_active IP Right Cessation
- 1999-04-01 BR BR9909346-4A patent/BR9909346A/pt not_active IP Right Cessation
- 1999-04-01 EP EP07007453A patent/EP1832662B1/en not_active Expired - Lifetime
- 1999-04-01 WO PCT/US1999/007289 patent/WO1999051265A1/en active IP Right Grant
- 1999-04-01 CA CA2326821A patent/CA2326821C/en not_active Expired - Fee Related
- 1999-04-01 EP EP99917339A patent/EP1073460A4/en not_active Ceased
- 1999-04-01 DE DE69943276T patent/DE69943276D1/de not_active Expired - Lifetime
- 1999-04-01 CZ CZ20003576A patent/CZ20003576A3/cs unknown
- 1999-04-01 JP JP2000542035A patent/JP4490581B2/ja not_active Expired - Fee Related
-
2008
- 2008-06-03 JP JP2008146037A patent/JP4887333B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4490581B2 (ja) | 2010-06-30 |
| DE69943276D1 (de) | 2011-04-21 |
| CZ20003576A3 (cs) | 2001-09-12 |
| CA2326821C (en) | 2010-09-28 |
| IL138803A0 (en) | 2001-10-31 |
| EP1073460A1 (en) | 2001-02-07 |
| ATE501275T1 (de) | 2011-03-15 |
| WO1999051265A1 (en) | 1999-10-14 |
| CN1304317A (zh) | 2001-07-18 |
| EP1832662A3 (en) | 2007-11-07 |
| CA2326821A1 (en) | 1999-10-14 |
| EP1073460A4 (en) | 2001-05-23 |
| EP1832662A2 (en) | 2007-09-12 |
| EP1832662B1 (en) | 2011-03-09 |
| JP2008283974A (ja) | 2008-11-27 |
| AU3548599A (en) | 1999-10-25 |
| JP2002510648A (ja) | 2002-04-09 |
| WO1999051265A9 (en) | 2000-04-13 |
| CN1327894C (zh) | 2007-07-25 |
| AU770903B2 (en) | 2004-03-04 |
| CN101275143A (zh) | 2008-10-01 |
| JP4887333B2 (ja) | 2012-02-29 |
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Legal Events
| Date | Code | Title | Description |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6O, 7O E 8O ANUIDADES |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007. |