DK1783225T3 - Strukturprotein fra AAV, dets fremstilling og anvendelse - Google Patents

Strukturprotein fra AAV, dets fremstilling og anvendelse

Info

Publication number
DK1783225T3
DK1783225T3 DK06018532.9T DK06018532T DK1783225T3 DK 1783225 T3 DK1783225 T3 DK 1783225T3 DK 06018532 T DK06018532 T DK 06018532T DK 1783225 T3 DK1783225 T3 DK 1783225T3
Authority
DK
Denmark
Prior art keywords
aav
proteins
preparation
cells
structural protein
Prior art date
Application number
DK06018532.9T
Other languages
English (en)
Inventor
Michael Hallek
Martin Ried
Gilbert Deleage
Anne Girod
Original Assignee
Medigene Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medigene Ag filed Critical Medigene Ag
Application granted granted Critical
Publication of DK1783225T3 publication Critical patent/DK1783225T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK06018532.9T 1998-06-19 1999-06-21 Strukturprotein fra AAV, dets fremstilling og anvendelse DK1783225T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19827457A DE19827457C1 (de) 1998-06-19 1998-06-19 Strukturprotein von AAV, seine Herstellung und Verwendung
EP99929292A EP1088075B1 (de) 1998-06-19 1999-06-21 Strukturprotein von aav, seine herstellung und verwendung

Publications (1)

Publication Number Publication Date
DK1783225T3 true DK1783225T3 (da) 2011-01-03

Family

ID=7871464

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06018532.9T DK1783225T3 (da) 1998-06-19 1999-06-21 Strukturprotein fra AAV, dets fremstilling og anvendelse

Country Status (10)

Country Link
US (2) US20070238684A1 (da)
EP (3) EP1783225B1 (da)
JP (1) JP4652570B2 (da)
AT (2) ATE481490T1 (da)
AU (1) AU765330B2 (da)
CA (1) CA2332115C (da)
DE (3) DE19827457C1 (da)
DK (1) DK1783225T3 (da)
ES (2) ES2273498T3 (da)
WO (1) WO1999067393A2 (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19827457C1 (de) * 1998-06-19 2000-03-02 Medigene Ag Strukturprotein von AAV, seine Herstellung und Verwendung
AU770802B2 (en) 1998-10-21 2004-03-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Virus-like particles for the induction of autoantibodies
DE19849643A1 (de) * 1998-10-29 2000-05-04 Deutsches Krebsforsch An das AAV-Kapsid bindender, den Zelltropismus verändernder Antikörper und Verfahren zum gerichteten Gentransfer
US6759237B1 (en) 1998-11-05 2004-07-06 The Trustees Of The University Of Pennsylvania Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
ES2340230T3 (es) 1998-11-10 2010-05-31 University Of North Carolina At Chapel Hill Vectores viricos y sus procedimientos de preparacion y administracion.
US7314912B1 (en) 1999-06-21 2008-01-01 Medigene Aktiengesellschaft AAv scleroprotein, production and use thereof
DE19933288A1 (de) * 1999-07-15 2001-01-18 Medigene Ag Strukturprotein von Adeno-assoziiertem Virus mit veränderter Antigenität, seine Herstellung und Verwendung
DE19933719A1 (de) 1999-07-19 2001-01-25 Medigene Ag Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung
US9441244B2 (en) * 2003-06-30 2016-09-13 The Regents Of The University Of California Mutant adeno-associated virus virions and methods of use thereof
US9233131B2 (en) 2003-06-30 2016-01-12 The Regents Of The University Of California Mutant adeno-associated virus virions and methods of use thereof
NZ555830A (en) 2004-12-15 2009-01-31 Univ North Carolina Chimeric vectors
EP2012122A1 (en) * 2007-07-06 2009-01-07 Medigene AG Mutated parvovirus structural proteins as vaccines
EP2396343B1 (en) 2009-02-11 2017-05-17 The University of North Carolina At Chapel Hill Modified virus vectors and methods of making and using the same
US8663624B2 (en) 2010-10-06 2014-03-04 The Regents Of The University Of California Adeno-associated virus virions with variant capsid and methods of use thereof
RS62795B1 (sr) 2011-04-22 2022-02-28 Univ California Adeno-povezani virioni virusa sa varijantama kapsida i postupci za njihovu primenu
US11136557B2 (en) 2013-05-31 2021-10-05 The Regents Of The University Of California Adeno-associated virus variants and methods of use thereof
SG10201810150UA (en) 2014-03-17 2018-12-28 Adverum Biotechnologies Inc Compositions and methods for enhanced gene expression in cone cells
CN107405507B (zh) 2015-03-02 2022-05-03 阿德夫拉姆生物技术股份有限公司 用于将多核苷酸玻璃体内递送到视网膜视锥的组合物和方法
JP6836999B2 (ja) 2015-03-24 2021-03-03 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ アデノ随伴ウイルス変異体及びその使用方法
EP3490531A4 (en) 2016-07-29 2020-06-03 The Regents of The University of California VIONS OF ADENO-ASSOCIATED VIRUS WITH CAPSIDE VARIANT AND METHODS OF USE THEREOF
EP3528785A4 (en) 2016-10-19 2020-12-02 Adverum Biotechnologies, Inc. MODIFIED AAV CASPIDS AND USES THEREOF
CN110709511A (zh) 2017-08-28 2020-01-17 加利福尼亚大学董事会 腺相关病毒衣壳变体及其使用方法
SG11202006298XA (en) * 2018-01-11 2020-07-29 Chameleon Biosciences Inc Immuno-evasive vectors and use for gene therapy
US11821009B2 (en) 2018-05-15 2023-11-21 Cornell University Genetic modification of the AAV capsid resulting in altered tropism and enhanced vector delivery
WO2020168145A1 (en) 2019-02-15 2020-08-20 Sangamo Therapeutics, Inc. Compositions and methods for producing recombinant aav
EP3960755A4 (en) * 2019-04-24 2023-11-22 Takara Bio Inc. AAV MUTANT WITH BRAIN TARGETING PROPERTIES
WO2021034418A2 (en) * 2019-07-02 2021-02-25 Trustees Of Tufts College Novel peptide, compositions and method for delivery of agents into cells and tissues
RU2751592C2 (ru) * 2019-08-22 2021-07-15 Общество С Ограниченной Ответственностью "Анабион" Выделенный модифицированный белок VP1 капсида аденоассоциированного вируса 5 серотипа (AAV5), капсид и вектор на его основе
AR126840A1 (es) * 2021-08-20 2023-11-22 Llc «Anabion» Proteína de la cápside vp1 modificada aislada del virus adeno-asociado de serotipo 5 (aav5), cápside y vector basado en esta
AR126839A1 (es) * 2021-08-20 2023-11-22 Llc «Anabion» Proteína de la cápside vp1 modificada aislada del virus adeno-asociado de serotipo 9 (aav9), cápside y vector basado en esta
CN118480095A (zh) * 2023-09-20 2024-08-13 广州派真生物技术有限公司 腺相关病毒突变体及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0567578A1 (en) * 1991-01-25 1993-11-03 The Regents Of The University Of Minnesota Laminin a chain domain vi polypeptides
FR2716893B1 (fr) 1994-03-03 1996-04-12 Rhone Poulenc Rorer Sa Virus recombinants, leur préparation et leur utilisation thérapeutique.
US6204059B1 (en) * 1994-06-30 2001-03-20 University Of Pittsburgh AAV capsid vehicles for molecular transfer
EP0927044A4 (en) * 1996-04-16 1999-09-08 Immusol Inc DEFINED TARGET VIRAL VECTORS
US20010031463A1 (en) * 1997-09-02 2001-10-18 Jurgen Kleinschmidt Method for purifying and concentrating AAV-2 and antigen portions thereof
DE19827457C1 (de) * 1998-06-19 2000-03-02 Medigene Ag Strukturprotein von AAV, seine Herstellung und Verwendung
ES2340230T3 (es) * 1998-11-10 2010-05-31 University Of North Carolina At Chapel Hill Vectores viricos y sus procedimientos de preparacion y administracion.
US7749492B2 (en) * 2001-01-05 2010-07-06 Nationwide Children's Hospital, Inc. AAV vectors and methods
US6962815B2 (en) * 2001-01-05 2005-11-08 Children's Hopital Inc. AAV2 vectors and methods
JP2005512569A (ja) * 2001-12-21 2005-05-12 メディジーン・アクチェンゲゼルシャフト 目的とする細胞指向性をもつウイルスクローンの同定に有用な修飾した構造遺伝子またはキャプシド修飾した粒子のライブラリー

Also Published As

Publication number Publication date
ATE481490T1 (de) 2010-10-15
AU765330B2 (en) 2003-09-18
JP2002518050A (ja) 2002-06-25
DE19827457C1 (de) 2000-03-02
ATE338821T1 (de) 2006-09-15
AU4614199A (en) 2000-01-10
EP1783225B1 (de) 2010-09-15
EP1783225A1 (de) 2007-05-09
US20110052617A1 (en) 2011-03-03
DE59913833D1 (de) 2006-10-19
ES2273498T3 (es) 2007-05-01
ES2352666T3 (es) 2011-02-22
WO1999067393A2 (de) 1999-12-29
US20070238684A1 (en) 2007-10-11
WO1999067393A3 (de) 2000-03-30
DE59915205D1 (de) 2010-10-28
EP1088075B1 (de) 2006-09-06
CA2332115C (en) 2011-08-09
JP4652570B2 (ja) 2011-03-16
EP1088075A2 (de) 2001-04-04
CA2332115A1 (en) 1999-12-29
EP1783226A1 (de) 2007-05-09

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