DK1783225T3 - Strukturprotein fra AAV, dets fremstilling og anvendelse - Google Patents
Strukturprotein fra AAV, dets fremstilling og anvendelseInfo
- Publication number
- DK1783225T3 DK1783225T3 DK06018532.9T DK06018532T DK1783225T3 DK 1783225 T3 DK1783225 T3 DK 1783225T3 DK 06018532 T DK06018532 T DK 06018532T DK 1783225 T3 DK1783225 T3 DK 1783225T3
- Authority
- DK
- Denmark
- Prior art keywords
- aav
- proteins
- preparation
- cells
- structural protein
- Prior art date
Links
- 101710172711 Structural protein Proteins 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 241000702421 Dependoparvovirus Species 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 230000010415 tropism Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19827457A DE19827457C1 (de) | 1998-06-19 | 1998-06-19 | Strukturprotein von AAV, seine Herstellung und Verwendung |
EP99929292A EP1088075B1 (de) | 1998-06-19 | 1999-06-21 | Strukturprotein von aav, seine herstellung und verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1783225T3 true DK1783225T3 (da) | 2011-01-03 |
Family
ID=7871464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06018532.9T DK1783225T3 (da) | 1998-06-19 | 1999-06-21 | Strukturprotein fra AAV, dets fremstilling og anvendelse |
Country Status (10)
Country | Link |
---|---|
US (2) | US20070238684A1 (da) |
EP (3) | EP1783225B1 (da) |
JP (1) | JP4652570B2 (da) |
AT (2) | ATE481490T1 (da) |
AU (1) | AU765330B2 (da) |
CA (1) | CA2332115C (da) |
DE (3) | DE19827457C1 (da) |
DK (1) | DK1783225T3 (da) |
ES (2) | ES2273498T3 (da) |
WO (1) | WO1999067393A2 (da) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19827457C1 (de) * | 1998-06-19 | 2000-03-02 | Medigene Ag | Strukturprotein von AAV, seine Herstellung und Verwendung |
AU770802B2 (en) | 1998-10-21 | 2004-03-04 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Virus-like particles for the induction of autoantibodies |
DE19849643A1 (de) * | 1998-10-29 | 2000-05-04 | Deutsches Krebsforsch | An das AAV-Kapsid bindender, den Zelltropismus verändernder Antikörper und Verfahren zum gerichteten Gentransfer |
US6759237B1 (en) | 1998-11-05 | 2004-07-06 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same |
ES2340230T3 (es) | 1998-11-10 | 2010-05-31 | University Of North Carolina At Chapel Hill | Vectores viricos y sus procedimientos de preparacion y administracion. |
US7314912B1 (en) | 1999-06-21 | 2008-01-01 | Medigene Aktiengesellschaft | AAv scleroprotein, production and use thereof |
DE19933288A1 (de) * | 1999-07-15 | 2001-01-18 | Medigene Ag | Strukturprotein von Adeno-assoziiertem Virus mit veränderter Antigenität, seine Herstellung und Verwendung |
DE19933719A1 (de) | 1999-07-19 | 2001-01-25 | Medigene Ag | Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung |
US9441244B2 (en) * | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
US9233131B2 (en) | 2003-06-30 | 2016-01-12 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
NZ555830A (en) | 2004-12-15 | 2009-01-31 | Univ North Carolina | Chimeric vectors |
EP2012122A1 (en) * | 2007-07-06 | 2009-01-07 | Medigene AG | Mutated parvovirus structural proteins as vaccines |
EP2396343B1 (en) | 2009-02-11 | 2017-05-17 | The University of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
RS62795B1 (sr) | 2011-04-22 | 2022-02-28 | Univ California | Adeno-povezani virioni virusa sa varijantama kapsida i postupci za njihovu primenu |
US11136557B2 (en) | 2013-05-31 | 2021-10-05 | The Regents Of The University Of California | Adeno-associated virus variants and methods of use thereof |
SG10201810150UA (en) | 2014-03-17 | 2018-12-28 | Adverum Biotechnologies Inc | Compositions and methods for enhanced gene expression in cone cells |
CN107405507B (zh) | 2015-03-02 | 2022-05-03 | 阿德夫拉姆生物技术股份有限公司 | 用于将多核苷酸玻璃体内递送到视网膜视锥的组合物和方法 |
JP6836999B2 (ja) | 2015-03-24 | 2021-03-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California | アデノ随伴ウイルス変異体及びその使用方法 |
EP3490531A4 (en) | 2016-07-29 | 2020-06-03 | The Regents of The University of California | VIONS OF ADENO-ASSOCIATED VIRUS WITH CAPSIDE VARIANT AND METHODS OF USE THEREOF |
EP3528785A4 (en) | 2016-10-19 | 2020-12-02 | Adverum Biotechnologies, Inc. | MODIFIED AAV CASPIDS AND USES THEREOF |
CN110709511A (zh) | 2017-08-28 | 2020-01-17 | 加利福尼亚大学董事会 | 腺相关病毒衣壳变体及其使用方法 |
SG11202006298XA (en) * | 2018-01-11 | 2020-07-29 | Chameleon Biosciences Inc | Immuno-evasive vectors and use for gene therapy |
US11821009B2 (en) | 2018-05-15 | 2023-11-21 | Cornell University | Genetic modification of the AAV capsid resulting in altered tropism and enhanced vector delivery |
WO2020168145A1 (en) | 2019-02-15 | 2020-08-20 | Sangamo Therapeutics, Inc. | Compositions and methods for producing recombinant aav |
EP3960755A4 (en) * | 2019-04-24 | 2023-11-22 | Takara Bio Inc. | AAV MUTANT WITH BRAIN TARGETING PROPERTIES |
WO2021034418A2 (en) * | 2019-07-02 | 2021-02-25 | Trustees Of Tufts College | Novel peptide, compositions and method for delivery of agents into cells and tissues |
RU2751592C2 (ru) * | 2019-08-22 | 2021-07-15 | Общество С Ограниченной Ответственностью "Анабион" | Выделенный модифицированный белок VP1 капсида аденоассоциированного вируса 5 серотипа (AAV5), капсид и вектор на его основе |
AR126840A1 (es) * | 2021-08-20 | 2023-11-22 | Llc «Anabion» | Proteína de la cápside vp1 modificada aislada del virus adeno-asociado de serotipo 5 (aav5), cápside y vector basado en esta |
AR126839A1 (es) * | 2021-08-20 | 2023-11-22 | Llc «Anabion» | Proteína de la cápside vp1 modificada aislada del virus adeno-asociado de serotipo 9 (aav9), cápside y vector basado en esta |
CN118480095A (zh) * | 2023-09-20 | 2024-08-13 | 广州派真生物技术有限公司 | 腺相关病毒突变体及其应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0567578A1 (en) * | 1991-01-25 | 1993-11-03 | The Regents Of The University Of Minnesota | Laminin a chain domain vi polypeptides |
FR2716893B1 (fr) | 1994-03-03 | 1996-04-12 | Rhone Poulenc Rorer Sa | Virus recombinants, leur préparation et leur utilisation thérapeutique. |
US6204059B1 (en) * | 1994-06-30 | 2001-03-20 | University Of Pittsburgh | AAV capsid vehicles for molecular transfer |
EP0927044A4 (en) * | 1996-04-16 | 1999-09-08 | Immusol Inc | DEFINED TARGET VIRAL VECTORS |
US20010031463A1 (en) * | 1997-09-02 | 2001-10-18 | Jurgen Kleinschmidt | Method for purifying and concentrating AAV-2 and antigen portions thereof |
DE19827457C1 (de) * | 1998-06-19 | 2000-03-02 | Medigene Ag | Strukturprotein von AAV, seine Herstellung und Verwendung |
ES2340230T3 (es) * | 1998-11-10 | 2010-05-31 | University Of North Carolina At Chapel Hill | Vectores viricos y sus procedimientos de preparacion y administracion. |
US7749492B2 (en) * | 2001-01-05 | 2010-07-06 | Nationwide Children's Hospital, Inc. | AAV vectors and methods |
US6962815B2 (en) * | 2001-01-05 | 2005-11-08 | Children's Hopital Inc. | AAV2 vectors and methods |
JP2005512569A (ja) * | 2001-12-21 | 2005-05-12 | メディジーン・アクチェンゲゼルシャフト | 目的とする細胞指向性をもつウイルスクローンの同定に有用な修飾した構造遺伝子またはキャプシド修飾した粒子のライブラリー |
-
1998
- 1998-06-19 DE DE19827457A patent/DE19827457C1/de not_active Expired - Fee Related
-
1999
- 1999-06-21 ES ES99929292T patent/ES2273498T3/es not_active Expired - Lifetime
- 1999-06-21 AT AT06018532T patent/ATE481490T1/de active
- 1999-06-21 JP JP2000556035A patent/JP4652570B2/ja not_active Expired - Fee Related
- 1999-06-21 EP EP06018532A patent/EP1783225B1/de not_active Expired - Lifetime
- 1999-06-21 ES ES06018532T patent/ES2352666T3/es not_active Expired - Lifetime
- 1999-06-21 DK DK06018532.9T patent/DK1783225T3/da active
- 1999-06-21 EP EP99929292A patent/EP1088075B1/de not_active Expired - Lifetime
- 1999-06-21 DE DE59913833T patent/DE59913833D1/de not_active Expired - Lifetime
- 1999-06-21 DE DE59915205T patent/DE59915205D1/de not_active Expired - Lifetime
- 1999-06-21 WO PCT/EP1999/004288 patent/WO1999067393A2/de active IP Right Grant
- 1999-06-21 CA CA2332115A patent/CA2332115C/en not_active Expired - Fee Related
- 1999-06-21 EP EP06018533A patent/EP1783226A1/de not_active Withdrawn
- 1999-06-21 AT AT99929292T patent/ATE338821T1/de not_active IP Right Cessation
- 1999-06-21 AU AU46141/99A patent/AU765330B2/en not_active Ceased
-
2006
- 2006-12-28 US US11/647,687 patent/US20070238684A1/en not_active Abandoned
-
2009
- 2009-12-01 US US12/628,867 patent/US20110052617A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE481490T1 (de) | 2010-10-15 |
AU765330B2 (en) | 2003-09-18 |
JP2002518050A (ja) | 2002-06-25 |
DE19827457C1 (de) | 2000-03-02 |
ATE338821T1 (de) | 2006-09-15 |
AU4614199A (en) | 2000-01-10 |
EP1783225B1 (de) | 2010-09-15 |
EP1783225A1 (de) | 2007-05-09 |
US20110052617A1 (en) | 2011-03-03 |
DE59913833D1 (de) | 2006-10-19 |
ES2273498T3 (es) | 2007-05-01 |
ES2352666T3 (es) | 2011-02-22 |
WO1999067393A2 (de) | 1999-12-29 |
US20070238684A1 (en) | 2007-10-11 |
WO1999067393A3 (de) | 2000-03-30 |
DE59915205D1 (de) | 2010-10-28 |
EP1088075B1 (de) | 2006-09-06 |
CA2332115C (en) | 2011-08-09 |
JP4652570B2 (ja) | 2011-03-16 |
EP1088075A2 (de) | 2001-04-04 |
CA2332115A1 (en) | 1999-12-29 |
EP1783226A1 (de) | 2007-05-09 |
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