JP2009545637A5 - - Google Patents
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- Publication number
- JP2009545637A5 JP2009545637A5 JP2009522088A JP2009522088A JP2009545637A5 JP 2009545637 A5 JP2009545637 A5 JP 2009545637A5 JP 2009522088 A JP2009522088 A JP 2009522088A JP 2009522088 A JP2009522088 A JP 2009522088A JP 2009545637 A5 JP2009545637 A5 JP 2009545637A5
- Authority
- JP
- Japan
- Prior art keywords
- hyaluronic acid
- branched
- less
- glucosamine
- deacetylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 claims 22
- 229920002674 hyaluronan Polymers 0.000 claims 16
- 229960003160 hyaluronic acid Drugs 0.000 claims 16
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 7
- 229960002442 Glucosamine Drugs 0.000 claims 7
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-Acetylglucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 4
- 229950006780 N-Acetylglucosamine Drugs 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229920000249 biocompatible polymer Polymers 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical class CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003141 primary amines Chemical class 0.000 claims 2
- 238000007126 N-alkylation reaction Methods 0.000 claims 1
- 210000002356 Skeleton Anatomy 0.000 claims 1
- 125000003172 aldehyde group Chemical group 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002302 glucosamines Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000003094 microcapsule Substances 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000002829 reduced Effects 0.000 claims 1
- 150000003335 secondary amines Chemical class 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Claims (14)
- 分岐ヒアルロン酸であって、その直鎖骨格が、１又は２以上のＮ−アセチル−グルコサミンがグルコサミンに脱アセチル化されたヒアルロン酸を含んでなり、前記脱アセチル化グルコサミンの第１級アミンに分岐側鎖が共有結合して第２級アミンを形成する、分岐ヒアルロン酸。
- 分岐側鎖が生物適合性ポリマーを含んでなる、請求項１記載の分岐ヒアルロン酸。
- 生物適合性ポリマーがヒアルロン酸を含んでなる、請求項２記載の分岐ヒアルロン酸。
- 直鎖ヒアルロン酸骨格中のＮ−アセチル−グルコサミンの５０％以下がグルコサミンに脱アセチル化され、好ましくは、直鎖ヒアルロン酸骨格中のＮ−アセチル−グルコサミンの４０％以下、より好ましくは３０％以下、さらに好ましくは２０％以下、１０％以下、最も好ましくは５％以下がグルコサミンに脱アセチル化された、請求項１〜３のいずれか１項に記載の分岐ヒアルロン酸。
- 分岐ヒアルロン酸を製造する方法であって、
（ａ）１又は２以上のＮ−アセチル−グルコサミンがグルコサミンに脱アセチル化された直鎖ヒアルロン酸骨格を供給する工程；及び
（ｂ）少なくとも１の遊離還元性アルデヒド基を含んでなる生物適合性ポリマーを、（ａ）の１又は２以上のグルコサミンの第１級アミンと、還元的Ｎ−アルキル化により反応させ、分岐ヒアルロン酸を形成する工程を含んでなる方法。 - 直鎖ヒアルロン酸骨格中のＮ−アセチル−グルコサミンの５０％以下がグルコサミンに脱アセチル化され、好ましくは、直鎖ヒアルロン酸骨格中のＮ−アセチル−グルコサミンの４０％以下、より好ましくは３０％以下、さらに好ましくは２０％以下、１０％以下、最も好ましくは５％以下がグルコサミンに脱アセチル化された、請求項５記載の方法。
- 直鎖ヒアルロン酸骨格の平均分子量が１０〜３，０００キロダルトン（ｋＤａ）、好ましくは２０〜２，０００ｋＤａ、最も好ましくは２０〜１，０００ｋＤａである、請求項５又は６に記載の方法。
- 生物適合性ポリマーがヒアルロン酸を含んでなる、請求項５〜７のいずれかに記載の方法。
- 請求項１〜４のいずれかに記載の分岐ヒアルロン酸と、活性物質、好ましくは薬理学的活性物質とを含んでなる組成物。
- 請求項１〜４のいずれかに記載の分岐ヒアルロン酸の有効量と、医薬的に許容し得る担体、賦形剤又は希釈剤とを含んでなる医薬組成物。
- 請求項１〜４のいずれかに記載の分岐ヒアルロン酸の有効量をビヒクルとして含んでなるとともに、薬理学的活性物質を含んでなる医薬組成物。
- 請求項１〜４のいずれかに記載の分岐ヒアルロン酸、又は請求項９〜１１のいずれかに記載の組成物を含んでなる衛生製品、医療又は手術製品であって、好ましくは、おむつ、生理用ナプキン、手術用スポンジ、創傷治癒スポンジ、又は、絆創膏若しくは他の創傷被覆材の部材である前記製品。
- 請求項１〜４のいずれかに記載の分岐ヒアルロン酸、又は請求項９〜１１のいずれかに記載の組成物を含んでなる医薬カプセル又はマイクロカプセル。
- 変形性関節炎治療、眼科的治療、癌治療、創傷治療又は血管形成に用いられる薬剤の製造のための、請求項１〜４のいずれかに記載の分岐ヒアルロン酸、又は請求項９〜１１のいずれかに記載の組成物の使用。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200601034 | 2006-08-04 | ||
| PCT/DK2007/000358 WO2008014787A1 (en) | 2006-08-04 | 2007-07-13 | Branched hyaluronic acid and method of manufacture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009545637A JP2009545637A (ja) | 2009-12-24 |
| JP2009545637A5 true JP2009545637A5 (ja) | 2010-09-02 |
Family
ID=38659373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009522088A Pending JP2009545637A (ja) | 2006-08-04 | 2007-07-13 | 分岐ヒアルロン酸及びその製造方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8202986B2 (ja) |
| EP (1) | EP2049572A1 (ja) |
| JP (1) | JP2009545637A (ja) |
| CN (1) | CN101501075B (ja) |
| AU (1) | AU2007280846B2 (ja) |
| CA (1) | CA2657823A1 (ja) |
| WO (1) | WO2008014787A1 (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI561535B (en) | 2011-10-06 | 2016-12-11 | Bvw Holding Ag | Copolymers of hydrophobic and hydrophilic segments that reduce protein adsorption |
| CZ2012842A3 (cs) | 2012-11-27 | 2014-08-20 | Contipro Biotech S.R.O. | Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití |
| CZ2014150A3 (cs) | 2014-03-11 | 2015-05-20 | Contipro Biotech S.R.O. | Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití |
| US10363595B2 (en) | 2014-06-09 | 2019-07-30 | Hyperion Materials & Technologies (Sweden) Ab | Cemented carbide necking tool |
| CZ2014451A3 (cs) | 2014-06-30 | 2016-01-13 | Contipro Pharma A.S. | Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití |
| CZ309295B6 (cs) | 2015-03-09 | 2022-08-10 | Contipro A.S. | Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití |
| CZ306479B6 (cs) | 2015-06-15 | 2017-02-08 | Contipro A.S. | Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin |
| CZ306662B6 (cs) | 2015-06-26 | 2017-04-26 | Contipro A.S. | Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití |
| CZ308106B6 (cs) | 2016-06-27 | 2020-01-08 | Contipro A.S. | Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití |
| KR101969446B1 (ko) * | 2017-06-30 | 2019-04-16 | 한양대학교 산학협력단 | 히알루론산 기반 보습 소재 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60251898A (ja) | 1984-05-25 | 1985-12-12 | Shiseido Co Ltd | 醗酵法によるヒアルロン酸の製造方法 |
| US5510418A (en) * | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
| JP2739232B2 (ja) * | 1989-04-14 | 1998-04-15 | チッソ株式会社 | 生物学的親和性を有するセルロースゲルの使用方法 |
| IT1271001B (it) | 1994-07-26 | 1997-05-26 | Poli Ind Chimica Spa | Procedimento di preparazione di acido ialuronico mediante fermentazione con streptococcus |
| IT1282219B1 (it) | 1995-12-20 | 1998-03-16 | Fidia Advanced Biopolymers Srl | Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa |
| DE69828193T2 (de) | 1997-10-31 | 2005-12-01 | The Board Of Regents Of The University Of Oklahoma, Norman | Hyaluronan synthase gen und seine verwendung |
| CN101275143A (zh) | 1998-04-02 | 2008-10-01 | 俄克拉何马大学董事会 | 编码透明质酸合酶的核酸及其应用方法 |
| IL143080A0 (en) | 1998-11-11 | 2002-04-21 | Univ Oklahoma | Polymer grafting by polysaccharide synthases |
| IT1303735B1 (it) * | 1998-11-11 | 2001-02-23 | Falorni Italia Farmaceutici S | Acidi ialuronici reticolati e loro usi medici. |
| GB9902652D0 (en) * | 1999-02-05 | 1999-03-31 | Fermentech Med Ltd | Process |
| JP2000248002A (ja) * | 1999-02-19 | 2000-09-12 | Denki Kagaku Kogyo Kk | 自己架橋ヒアルロン酸とその製造方法及びその用途 |
| GB2358637A (en) * | 2000-01-27 | 2001-08-01 | Btg Int Ltd | Chitosan condensation products with a bisulphite addition compound |
| IT1317358B1 (it) | 2000-08-31 | 2003-06-16 | Fidia Advanced Biopolymers Srl | Derivati cross-linkati dell'acido ialuronico. |
| KR100375299B1 (ko) * | 2000-10-10 | 2003-03-10 | 주식회사 엘지생명과학 | 히알루론산의 가교결합형 아마이드 유도체와 이의 제조방법 |
| ITTS20010013A1 (it) * | 2001-06-04 | 2002-12-04 | Ct Ricerche Poly Tec H A R L S | Nuovi derivati di ialuronano. |
| KR100879908B1 (ko) | 2001-12-21 | 2009-01-21 | 노보자임스 바이오폴리머 에이/에스 | 재조합체 숙주 세포에서 히알루로난의 제조 방법 |
| TW200307011A (en) * | 2002-04-18 | 2003-12-01 | Chugai Pharmaceutical Co Ltd | Hyaluronic acid modifier |
| KR100507545B1 (ko) * | 2002-09-03 | 2005-08-09 | 주식회사 엘지생명과학 | 히알루론산 유도체 및 그의 제조방법 |
| ITPD20020271A1 (it) * | 2002-10-18 | 2004-04-19 | Fidia Farmaceutici | Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati. |
| US7767806B2 (en) * | 2003-09-08 | 2010-08-03 | Chugai Seiyaku Kabushiki Kaisha | Hyaluronic acid modification products and drug carriers using them |
-
2007
- 2007-07-13 JP JP2009522088A patent/JP2009545637A/ja active Pending
- 2007-07-13 CN CN2007800291575A patent/CN101501075B/zh not_active Expired - Fee Related
- 2007-07-13 US US12/375,425 patent/US8202986B2/en not_active Expired - Fee Related
- 2007-07-13 WO PCT/DK2007/000358 patent/WO2008014787A1/en active Application Filing
- 2007-07-13 CA CA002657823A patent/CA2657823A1/en not_active Abandoned
- 2007-07-13 AU AU2007280846A patent/AU2007280846B2/en not_active Ceased
- 2007-07-13 EP EP07785725A patent/EP2049572A1/en not_active Withdrawn
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