|
US4179337A
(en)
*
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4002531A
(en)
*
|
1976-01-22 |
1977-01-11 |
Pierce Chemical Company |
Modifying enzymes with polyethylene glycol and product produced thereby
|
|
DE3315000A1
(de)
*
|
1983-04-26 |
1984-10-31 |
Behringwerke Ag, 3550 Marburg |
Gewebeprotein pp(pfeil abwaerts)4(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung
|
|
KR930007434B1
(ko)
*
|
1984-09-21 |
1993-08-10 |
베링거 잉겔하임 인터내셔날 게엠베하 |
혈액응고 억제 단백질 제조방법
|
|
US5066788A
(en)
*
|
1984-09-21 |
1991-11-19 |
Boehringer Ingelheim International Gmbh |
Blood coagulation inhibiting proteins, processes for preparing them and their uses
|
|
US4897355A
(en)
*
|
1985-01-07 |
1990-01-30 |
Syntex (U.S.A.) Inc. |
N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
CA1265446A
(en)
*
|
1985-09-30 |
1990-02-06 |
Masahiro Maki |
Anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component
|
|
JPH08840B2
(ja)
*
|
1986-11-14 |
1996-01-10 |
興和株式会社 |
抗ｐｃｉモノクローナル抗体、これを用いた抗ｐｃｉの精製法及び免疫学的測定法
|
|
DE3643182A1
(de)
*
|
1986-12-18 |
1988-06-30 |
Behringwerke Ag |
Arzneimittel enthaltend das gewebeprotein pp4, verfahren zur herstellung von pp4 und zu seiner pasteurisierung sowie die verwendung von pp4
|
|
US4937324A
(en)
*
|
1987-02-06 |
1990-06-26 |
Zymogenetics, Inc. |
Chromatographic purification of human proteins having anticoagulant and anti-inflammatory activity
|
|
JP2660514B2
(ja)
*
|
1987-02-20 |
1997-10-08 |
興和株式会社 |
抗血液凝固作用を有するポリペプチド
|
|
PT87083B
(pt)
*
|
1987-03-28 |
1992-07-31 |
Boehringer Ingelheim Int |
Processo para a preparacao de uma proteina anticoagulante vascular, de adn que codifica para esta proteina e de composicoes farmaceuticas que a contem
|
|
US4965251A
(en)
*
|
1987-04-03 |
1990-10-23 |
The Board Of Regents Of The University Of Washington |
Pulse treatment of hemoglobinopathies with erythropoietin
|
|
DE3737239A1
(de)
|
1987-11-03 |
1989-10-12 |
Behringwerke Ag |
Gentechnische herstellung von anticoagulatorischem protein pp4
|
|
EP0330396B1
(en)
*
|
1988-02-26 |
1995-06-21 |
Biogen, Inc. |
DNA sequences, recombinant DNA molecules and processes for producing lipocortins III, IV, V & VI
|
|
US5324844A
(en)
*
|
1989-04-19 |
1994-06-28 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
DE4022010A1
(de)
*
|
1989-07-15 |
1991-01-17 |
Boehringer Ingelheim Int |
Ein antikoagulanz enthaltendes mittel
|
|
DE4021979A1
(de)
*
|
1989-07-15 |
1991-01-31 |
Boehringer Ingelheim Int |
Verfahren zur reinigung von annexinen
|
|
DE3937607A1
(de)
|
1989-11-11 |
1991-05-16 |
Boehringer Ingelheim Int |
Verwendung eines antikoagulanz zur behandlung von tumorerkrankungen
|
|
DE3942081A1
(de)
*
|
1989-12-20 |
1991-06-27 |
Behringwerke Ag |
Mittel zur verbesserung der wiederfindung von annexinen
|
|
US5627036A
(en)
*
|
1989-12-27 |
1997-05-06 |
Boehringer Ingelheim International Gmbh |
Use of an anticoagulant as a diagnostic agent
|
|
US5225537A
(en)
*
|
1989-12-29 |
1993-07-06 |
Zymogenetics, Inc. |
Methods for producing hybrid phospholipid-binding proteins
|
|
EP0527940A1
(en)
|
1990-05-08 |
1993-02-24 |
Liposome Technology, Inc. |
Direct spray-dried drug/lipid powder composition
|
|
EP0555328A1
(en)
|
1990-11-02 |
1993-08-18 |
Genentech, Inc. |
Platelet aggregation inhibitors
|
|
EP0558751B1
(en)
*
|
1990-11-20 |
2000-02-02 |
Kowa Co. Ltd. |
Therapeutic agent for the treatment of wounds
|
|
JP2916947B2
(ja)
|
1990-11-28 |
1999-07-05 |
興和株式会社 |
Ｃｐｂ―ｉの安定化方法及び製剤組成物
|
|
US5229367A
(en)
*
|
1991-01-21 |
1993-07-20 |
Sclavo S.P.A. |
Antiinflammatory peptide derived from human lipocortin V
|
|
US5632986A
(en)
*
|
1991-05-09 |
1997-05-27 |
The University Of Washington |
Phospholipid-targeted thrombolytic agents
|
|
CA2086437A1
(en)
|
1991-05-09 |
1992-11-10 |
Jonathan Tait |
Phospholipid-targeted thrombolytic agents
|
|
JPH051096A
(ja)
|
1991-06-26 |
1993-01-08 |
Kowa Co |
抗血液凝固活性を持つオリゴペプチド
|
|
CA2134239C
(en)
*
|
1992-06-09 |
2004-11-23 |
Donald B. Axworthy |
Pretargeting methods and compounds
|
|
WO1994001554A1
(en)
|
1992-07-08 |
1994-01-20 |
N.V. Innogenetics S.A. |
Polypeptides, derived from endonexin 2, having hepatitis b virus receptor activity and their use in diagnostic and pharmaceutical compositions
|
|
JP3416912B2
(ja)
|
1992-10-08 |
2003-06-16 |
興和株式会社 |
抗血液凝固活性を持つオリゴペプチド
|
|
JPH0772149A
(ja)
|
1993-06-30 |
1995-03-17 |
Nippon Shinyaku Co Ltd |
肝癌又は肝硬変の診断薬及び診断法
|
|
JPH0772147A
(ja)
|
1993-07-02 |
1995-03-17 |
Noboru Kaneko |
抗アネキシンｖ抗体並びに該抗体の製法及び利用
|
|
US5849600A
(en)
*
|
1993-11-10 |
1998-12-15 |
The Mclean Hospital Corporation |
Diagnostic assays for Alzheimer's disease
|
|
US5968477A
(en)
|
1994-01-24 |
1999-10-19 |
Neorx Corporation |
Radiolabeled annexin conjugates with hexose and a chelator
|
|
WO1995034315A1
(en)
|
1994-06-16 |
1995-12-21 |
Neorx Corporation |
Radiolabeled annexin-galactose conjugates
|
|
ES2139957T3
(es)
|
1994-07-23 |
2000-02-16 |
Roche Diagnostics Gmbh |
Metodo para la determinacion del estado pretrombotico.
|
|
DE19541284C2
(de)
|
1995-11-06 |
1998-09-24 |
Kalden Joachim Robert Prof Dr |
Verfahren zur Immunmodulation
|
|
IL124831A0
(en)
|
1995-12-27 |
1999-01-26 |
Genentech Inc |
Ob protein derivatives having prolonged half-life
|
|
DE69725882T2
(de)
|
1996-07-05 |
2004-07-29 |
Branton, Philip E., St. Lambert |
Adenovirus e4 proteine für induktion von zelltod
|
|
WO1998029442A1
(en)
|
1996-12-30 |
1998-07-09 |
Innogenetics N.V. |
ANNEXIN V-BINDING POLYPEPTIDES DERIVED FROM HBsAg AND THEIR USES
|
|
DK1007082T3
(da)
|
1997-01-15 |
2007-02-19 |
Phoenix Pharmacologics Inc |
Modificeret tumor nekrose faktor
|
|
US6358508B1
(en)
*
|
1997-06-11 |
2002-03-19 |
Human Genome Sciences, Inc. |
Antibodies to human tumor necrosis factor receptor TR9
|
|
US6242570B1
(en)
*
|
1997-07-10 |
2001-06-05 |
Beth Israel Deaconess Medical Center |
Production and use of recombinant protein multimers with increased biological activity
|
|
US6284475B1
(en)
|
1997-07-11 |
2001-09-04 |
Mount Sinai School Of Medicine Of The City Of New York |
Assays for diagnosis of thrombophilic disease
|
|
DE19734648A1
(de)
*
|
1997-08-11 |
1999-02-18 |
Dade Behring Marburg Gmbh |
Verwendung von Annexinen als Lupus Antikoagulans Kontrolle oder Standard in Gerinnungstesten
|
|
US6511829B1
(en)
|
1997-10-09 |
2003-01-28 |
The Regents Of The University Of California |
GFP-annexin fusion proteins
|
|
CA2305715A1
(en)
|
1997-11-06 |
1999-05-20 |
Innogenetics N.V. |
Host derived proteins binding hcv: medical, diagnostic and purification use
|
|
CA2322843A1
(en)
|
1998-03-27 |
1999-09-30 |
The Board Of Trustees Of The Leland Stanford, Jr. University |
Hypoxia-inducible human genes, proteins, and uses thereof
|
|
US20040002056A1
(en)
*
|
1998-05-12 |
2004-01-01 |
Lorens James B. |
Methods of screening for bioactive agents using cells transformed with self-inactivating viral vectors
|
|
US6169078B1
(en)
*
|
1998-05-12 |
2001-01-02 |
University Of Florida |
Materials and methods for the intracellular delivery of substances
|
|
BR9912053A
(pt)
|
1998-07-13 |
2001-04-03 |
Univ Texas |
Processos de tratamento de câncer utilizando conjugados terapêuticos que se ligam a aminofosfolipìdios
|
|
IL125908A
(en)
|
1998-08-24 |
2005-05-17 |
Nst Neurosurvival Technologies |
Peptides and pharmaceutical compositions comprising same
|
|
WO2000010673A1
(en)
|
1998-08-24 |
2000-03-02 |
Nst Neurosurvival Technologies Ltd. |
Apparatus and method for capturing particles with surface exposure of anionic phospholipids from biological fluids
|
|
EP1107983A2
(en)
|
1998-09-01 |
2001-06-20 |
Innogenetics N.V. |
Benzodiazepine and benzothiazepine derivatives and hbsag peptides binding to annexins, their compositions and use
|
|
US6387366B1
(en)
|
1998-12-31 |
2002-05-14 |
Alg Company |
Methods for reducing adverse side effects associated with cellular transplantation
|
|
US6323313B1
(en)
*
|
1999-06-01 |
2001-11-27 |
The University Of Washington |
Annexin derivative with endogenous chelation sites
|
|
US20020088015A1
(en)
*
|
1999-06-04 |
2002-07-04 |
Yang Shi |
Wilms' tumor wt1 binding proteins
|
|
EP1441028A3
(en)
*
|
1999-07-28 |
2005-01-05 |
Interface Biotech A/S |
Cell cultivation method for the preparation of chondrocytes/chondroblasts
|
|
US6645465B2
(en)
|
1999-08-06 |
2003-11-11 |
Michigan, University Of The Regents |
Annexin proteins and autoantibodies as serum markers for cancer
|
|
AU7748200A
(en)
|
1999-09-30 |
2001-04-30 |
Varian Associates, Inc. |
Hypoxia-related human genes, proteins, and uses thereof
|
|
EP1283904A2
(en)
|
1999-11-03 |
2003-02-19 |
Oncotech, Inc. |
Cancer diagnosis using cell-sorting and gene-expression-profiles
|
|
US20030113330A1
(en)
*
|
1999-11-08 |
2003-06-19 |
Uhal Bruce D. |
Methods for treating pulmonary fibrosis
|
|
FR2809181B1
(fr)
*
|
2000-05-16 |
2002-10-25 |
Biocytex |
Monoreactif pour le dosage des microparticules plaquettaires
|
|
US7449308B2
(en)
*
|
2000-06-28 |
2008-11-11 |
Glycofi, Inc. |
Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
|
|
AU2001288914A1
(en)
|
2000-09-08 |
2002-03-22 |
Board Of Regents, The University Of Texas System |
Biopanning and rapid analysis of selective interactive ligands (brasil)
|
|
US7582443B2
(en)
*
|
2000-11-28 |
2009-09-01 |
Philip Gerard Cavanaugh |
Method for the detection and measurement of Hapten-conjugated biological binding entities by western and dot-blot using anti-hapten antibodies
|
|
CA2434643C
(en)
*
|
2001-01-18 |
2013-10-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Peptides for activation and inhibition of.delta.pkc
|
|
AU2002252035A1
(en)
*
|
2001-02-21 |
2002-09-12 |
Surromed, Inc. |
Modified annexin proteins and methods for preventing thrombosis
|
|
US20030036699A1
(en)
|
2001-02-21 |
2003-02-20 |
Imetrx, Inc. |
Methods and systems which use annexin for bioprofiling body lumen
|
|
US7635676B2
(en)
*
|
2001-02-21 |
2009-12-22 |
Alavita Pharmaccuticals, Inc. |
Modified annexin proteins and methods for their use in organ transplantation
|
|
US20050222030A1
(en)
|
2001-02-21 |
2005-10-06 |
Anthony Allison |
Modified annexin proteins and methods for preventing thrombosis
|
|
US6843980B2
(en)
|
2001-04-03 |
2005-01-18 |
Theseus Imaging, Corp. |
Methods for using annexin for detecting cell death in vivo and treating associated conditions
|
|
CA2444483A1
(en)
|
2001-04-26 |
2002-11-07 |
Board Of Regents, The University Of Texas System |
Diagnostic imaging compositions, their methods of synthesis and use
|
|
WO2002087497A2
(en)
|
2001-04-26 |
2002-11-07 |
Board Of Regents, The University Of Texas System |
Therapeutic agent/ligand conjugate compositions, their methods of synthesis and use
|
|
EP1322957B1
(en)
|
2001-05-04 |
2009-08-12 |
Biosite Incorporated |
Diagnostic markers of acute coronary syndromes and methods of use thereof
|
|
WO2002101071A2
(en)
*
|
2001-06-07 |
2002-12-19 |
Rigel Pharmaceuticals, Inc. |
Cd43:modulators of mast cell degranulation
|
|
CN1343777A
(zh)
|
2001-06-26 |
2002-04-10 |
上海动物生物技术研究中心 |
葡激酶与Annexin V融合基因的构建及表达
|
|
US20030152513A1
(en)
*
|
2001-09-06 |
2003-08-14 |
Imetrix, Inc. |
Intravascular delivery of therapeutic and imaging agents to stressed and apoptotic cells using annexin V as a targeting vector
|
|
CN1277581C
(zh)
|
2001-09-14 |
2006-10-04 |
浙江中奇生物药业股份有限公司 |
一种用蚕生产抗血栓药物的方法
|
|
DE10162434A1
(de)
*
|
2001-12-18 |
2003-09-25 |
November Ag Molekulare Medizin |
Expressionsvektor und Verfahren zur Herstellung eines Expressionsvektors
|
|
US20030211548A1
(en)
*
|
2002-01-29 |
2003-11-13 |
Oncolmmunin, Inc. |
Visualization and quantitiation of cellular cytotoxicity using cell-permeable fluorogenic protease substrates and caspase activity indicator markers
|
|
US7713981B2
(en)
*
|
2002-02-28 |
2010-05-11 |
University Of Central Florida |
Method and compounds for inhibition of cell death
|
|
US20040029151A1
(en)
|
2002-04-09 |
2004-02-12 |
Affymetrix, Inc. |
Molecular genetic profiling of gleason grades 3 and 4/5 prostate cancer
|
|
WO2004006963A1
(en)
|
2002-07-12 |
2004-01-22 |
Beth Israel Deaconess Medical Center |
Conjugated infrared fluorescent substances for detection of cell death
|
|
DE60335383D1
(de)
*
|
2002-07-15 |
2011-01-27 |
Univ Texas |
Antikörper mit bindung an anionische phospholipide und aminophospholipide und ihre verwendung bei der behandlung von virusinfektionen
|
|
CN1181099C
(zh)
|
2002-07-23 |
2004-12-22 |
中国人民解放军第二军医大学 |
兼抗凝溶栓双重功能的血栓靶向融合蛋白mA5UKB
|
|
US20040042959A1
(en)
*
|
2002-08-28 |
2004-03-04 |
Michael Montalto |
Imaging cell death in vivo using non-radionuclide contrast agents
|
|
DE10253526A1
(de)
*
|
2002-11-16 |
2004-06-09 |
Johann Wolfgang Goethe-Universität Frankfurt am Main |
Endothelzellen als Diagnoseinstrument bei kardiovaskulären Erkrankungen
|
|
US20040203069A1
(en)
|
2003-04-10 |
2004-10-14 |
Chris Reutelingsperger |
Method for determining and/or isolating lipid-binding compounds
|
|
WO2005014801A1
(en)
|
2003-08-04 |
2005-02-17 |
University Court Of The University Of Edinburgh |
Improvements in cell culture productivity
|
|
IL157786A
(en)
*
|
2003-09-07 |
2010-11-30 |
Ahava Dead Sea Lab Ltd |
Personalized cosmetics
|
|
US20050084547A1
(en)
*
|
2003-09-12 |
2005-04-21 |
Phytomyco Research Corporation |
Natural product based apoptosis inducers
|
|
WO2005028490A1
(en)
|
2003-09-19 |
2005-03-31 |
Theseus Imaging Corporation |
Halogenated deoxy-glucose labeled targeting molecules
|
|
US7634360B2
(en)
*
|
2003-09-23 |
2009-12-15 |
Prediction Sciences, LL |
Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof
|
|
WO2005027965A1
(en)
|
2003-09-24 |
2005-03-31 |
Peter Krammer |
Antibodies against annexins, use thereof for therapy and diagnosis. use of annexins for therapy and diagnosis.
|
|
CA2542426A1
(en)
|
2003-10-22 |
2005-05-06 |
Fred Hutchinson Cancer Research Center |
Methods, compositions and devices for inducing stasis in cells
|
|
CA2485722A1
(en)
*
|
2003-10-22 |
2005-04-22 |
Paul Lehmann |
Soluble transferrin receptor
|
|
US20050208151A1
(en)
*
|
2003-10-30 |
2005-09-22 |
Entelos, Inc. |
Treatment of rheumatoid arthritis with FLIP antagonists
|
|
JP2007512369A
(ja)
|
2003-11-26 |
2007-05-17 |
エンテロス・インコーポレーテッド |
低酸素誘導因子１αアンタゴニストを用いる慢性関節リウマチの処置
|
|
CA2559167A1
(en)
*
|
2004-03-11 |
2005-09-22 |
Alavita, Inc. |
Modified annexin proteins and methods for preventing thrombosis
|
|
US20060099608A1
(en)
|
2004-03-29 |
2006-05-11 |
Medstar Research Institute |
Methods of diagnosing cardiovascular disease
|
|
ES2356364T3
(es)
|
2004-04-15 |
2011-04-07 |
Athera Biotechnologies Ab |
Anexina v para prevenir la ruptura de la placa.
|
|
US20060057591A1
(en)
|
2004-09-15 |
2006-03-16 |
Canadian Blood Services |
Method for preventing viral infection
|
|
CA2587923C
(en)
|
2004-11-19 |
2013-06-25 |
Universitaetsklinikum Muenster |
Genetic variant of the annexin a5 gene
|
|
WO2006060898A1
(en)
|
2004-12-06 |
2006-06-15 |
Aegera Therapeutics Inc |
Method for treating inflammatory disorders
|