JP2017511379A5 - - Google Patents
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- JP2017511379A5 JP2017511379A5 JP2017501529A JP2017501529A JP2017511379A5 JP 2017511379 A5 JP2017511379 A5 JP 2017511379A5 JP 2017501529 A JP2017501529 A JP 2017501529A JP 2017501529 A JP2017501529 A JP 2017501529A JP 2017511379 A5 JP2017511379 A5 JP 2017511379A5
- Authority
- JP
- Japan
- Prior art keywords
- modified antibody
- antibody
- modified
- cysteine
- region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1405264.1 | 2014-03-24 | ||
| GB201405264A GB201405264D0 (en) | 2014-03-24 | 2014-03-24 | Modified antibodies containing lgG2 Domains which possess agonist or antagonistic properties and therapeutic use thereof |
| GB201405275A GB201405275D0 (en) | 2014-03-25 | 2014-03-25 | Modified antibodies containing lgG2 Domains which possess agonist or antagonistic properties and therapeutic use thereof |
| GB1405275.7 | 2014-03-25 | ||
| PCT/IB2015/052166 WO2015145360A1 (en) | 2014-03-24 | 2015-03-24 | Modified antibodies containing modified igg2 domains which elicit agonist or antagonistic properties and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019204004A Division JP2020037577A (ja) | 2014-03-24 | 2019-11-11 | アゴニストまたはアンタゴニスト性を誘発する修飾されたＩｇＧ２ドメインを含む修飾された抗体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017511379A JP2017511379A (ja) | 2017-04-20 |
| JP2017511379A5 true JP2017511379A5 (enExample) | 2018-05-17 |
| JP6682498B2 JP6682498B2 (ja) | 2020-04-15 |
Family
ID=52829255
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017501529A Expired - Fee Related JP6682498B2 (ja) | 2014-03-24 | 2015-03-24 | アゴニストまたはアンタゴニスト性を誘発する修飾されたＩｇＧ２ドメインを含む修飾された抗体及びその使用 |
| JP2019204004A Pending JP2020037577A (ja) | 2014-03-24 | 2019-11-11 | アゴニストまたはアンタゴニスト性を誘発する修飾されたＩｇＧ２ドメインを含む修飾された抗体及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019204004A Pending JP2020037577A (ja) | 2014-03-24 | 2019-11-11 | アゴニストまたはアンタゴニスト性を誘発する修飾されたＩｇＧ２ドメインを含む修飾された抗体及びその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11059898B2 (enExample) |
| EP (2) | EP3590967A1 (enExample) |
| JP (2) | JP6682498B2 (enExample) |
| CN (2) | CN107172880B (enExample) |
| AU (1) | AU2015237864B2 (enExample) |
| CA (1) | CA2943167A1 (enExample) |
| WO (1) | WO2015145360A1 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104619722B (zh) | 2012-06-22 | 2022-10-04 | 达特茅斯大学理事会 | 新型vista-ig构建体和vista-ig用于治疗自身免疫性、过敏性和炎性疾病的用途 |
| WO2014124134A1 (en) | 2013-02-07 | 2014-08-14 | The General Hospital Corporation | Methods for expansion or depletion of t-regulatory cells |
| JP6742903B2 (ja) | 2013-05-02 | 2020-08-19 | アナプティスバイオ インコーポレイティッド | プログラム死−１（ｐｄ−１）に対する抗体 |
| DK3148579T3 (da) | 2014-05-28 | 2021-03-08 | Agenus Inc | Anti-gitr antistoffer og fremgangsmåder til anvendelse deraf |
| AU2015271709B2 (en) | 2014-06-06 | 2020-11-26 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof |
| PL3221346T3 (pl) * | 2014-11-21 | 2021-03-08 | Bristol-Myers Squibb Company | Przeciwciała ze zmodyfikowanym regionem stałym łańcucha ciężkiego |
| TWI711630B (zh) | 2014-11-21 | 2020-12-01 | 美商必治妥美雅史谷比公司 | 抗ｃｄ７３抗體及其用途 |
| JP7179464B2 (ja) | 2015-01-20 | 2022-11-29 | アイジーエム バイオサイエンシズ インコーポレイテッド | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
| CA2985816A1 (en) | 2015-05-15 | 2016-11-24 | The General Hospital Corporation | Antagonistic anti-tumor necrosis factor receptor superfamily antibodies |
| MX383614B (es) | 2015-05-21 | 2025-03-14 | Harpoon Therapeutics Inc | Proteinas de union triespecificas y metodos de uso. |
| JP6812364B2 (ja) | 2015-06-03 | 2021-01-13 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 癌診断用抗ｇｉｔｒ抗体 |
| KR102671348B1 (ko) | 2015-06-29 | 2024-05-30 | 브리스톨-마이어스 스큅 컴퍼니 | Cd40에 대한 항체 |
| EP3340999A4 (en) | 2015-08-28 | 2019-06-12 | The General Hospital Corporation | AGONISTIC ANTI-TUMOR NECROSIS RECEPTOR 2 ANTIBODIES |
| EP3355920A4 (en) | 2015-09-29 | 2019-05-15 | Celgene Corporation | PD-1 BINDING PROTEINS AND METHOD OF USE THEREOF |
| CA3004830A1 (en) | 2015-11-11 | 2017-05-18 | Opi Vi- Ip Holdco Llc | Composition and methods for anti-tnfr2 antibodies |
| CA3005855A1 (en) * | 2015-11-19 | 2017-05-26 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof |
| EP3383908A1 (en) | 2015-12-02 | 2018-10-10 | Stsciences, Inc. | Antibodies specific to glycosylated btla (b- and t- lymphocyte attenuator) |
| SG10201912984WA (en) | 2015-12-02 | 2020-03-30 | Agenus Inc | Antibodies and methods of use thereof |
| JP7184751B2 (ja) * | 2016-04-15 | 2022-12-06 | イミュネクスト インコーポレイテッド | 抗ヒトｖｉｓｔａ抗体およびその使用 |
| CA3253342A1 (en) | 2016-05-13 | 2026-03-02 | The General Hospital Corporation | Antagonistic anti-tumor necrosis factor receptor superfamily antibodies |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| US10100106B2 (en) | 2016-05-20 | 2018-10-16 | Harpoon Therapeutics, Inc. | Single domain serum albumin binding protein |
| EP3515943A4 (en) | 2016-09-19 | 2020-05-06 | Celgene Corporation | METHODS OF TREATING VITILIGO WITH PD-1 BINDING PROTEINS |
| WO2018053405A1 (en) | 2016-09-19 | 2018-03-22 | Celgene Corporation | Methods of treating immune disorders using pd-1 binding proteins |
| JOP20190055A1 (ar) | 2016-09-26 | 2019-03-24 | Merck Sharp & Dohme | أجسام مضادة ضد cd27 |
| EP3666794A1 (en) | 2016-11-01 | 2020-06-17 | AnaptysBio, Inc. | Antibodies directed against programmed death- 1 (pd-1) |
| MA46770A (fr) | 2016-11-09 | 2019-09-18 | Agenus Inc | Anticorps anti-ox40, anticorps anti-gitr, et leurs procédés d'utilisation |
| EP3565844B8 (en) | 2017-01-09 | 2023-04-12 | Tesaro, Inc. | Methods of treating cancer with anti-pd-1 antibodies |
| WO2018160754A2 (en) * | 2017-02-28 | 2018-09-07 | Harpoon Therapeutics, Inc. | Inducible monovalent antigen binding protein |
| TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
| AU2018265856B2 (en) | 2017-05-12 | 2023-04-27 | Harpoon Therapeutics, Inc. | Mesothelin binding proteins |
| GB201712032D0 (en) * | 2017-07-26 | 2017-09-06 | Bioinvent Int Ab | Antibodies and uses thereof |
| TWI817952B (zh) | 2017-08-25 | 2023-10-11 | 美商戊瑞治療有限公司 | Ｂ７－ｈ４抗體及其使用方法 |
| JP7346390B2 (ja) | 2017-09-19 | 2023-09-19 | マブ ディスカバリー ゲゼルシャフト ミット ベシュレンクテル ハフツング | アゴニスト性ｃｄ４０抗体 |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| SI3694529T1 (sl) | 2017-10-13 | 2024-10-30 | Harpoon Therapeutics, Inc. | Trispecifične beljakovine in načini uporabe |
| JP7284759B2 (ja) | 2017-12-27 | 2023-05-31 | ブリストル－マイヤーズ スクイブ カンパニー | 抗ｃｄ４０抗体およびその使用 |
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| BR112020016986A2 (pt) | 2018-02-21 | 2021-03-02 | Five Prime Therapeutics, Inc. | formulações de anticorpo contra b7-h4 |
| CA3091801A1 (en) | 2018-03-02 | 2019-09-06 | Five Prime Therapeutics, Inc. | B7-h4 antibodies and methods of use thereof |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| WO2020010250A2 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| IL280199B2 (en) | 2018-07-20 | 2025-08-01 | Pf Medicament | Receptor for vista |
| CA3109954A1 (en) * | 2018-08-20 | 2020-02-27 | The General Hospital Corporation | Antagonistic anti-tumor necrosis factor receptor superfamily polypeptides |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| EP3856771A4 (en) | 2018-09-25 | 2022-06-29 | Harpoon Therapeutics, Inc. | Dll3 binding proteins and methods of use |
| CN113039201A (zh) * | 2018-09-28 | 2021-06-25 | 礼进生物医药科技（上海）有限公司 | 具有经过工程化的Fc结构域的抗CD137结合分子及其治疗用途 |
| JP7652690B2 (ja) * | 2018-11-15 | 2025-03-27 | ザ ジェネラル ホスピタル コーポレイション | アゴニスト性腫瘍壊死因子受容体スーパーファミリーポリペプチド |
| GB201820547D0 (en) | 2018-12-17 | 2019-01-30 | Oxford Univ Innovation | Modified antibodies |
| GB2597851B (en) | 2019-02-21 | 2024-05-29 | Marengo Therapeutics Inc | Antibody molecules that bind to NKP30 and uses thereof |
| AU2020226893B2 (en) | 2019-02-21 | 2025-02-27 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to T cell related cancer cells and uses thereof |
| CN112592404B (zh) * | 2019-09-20 | 2023-07-25 | 上海交通大学医学院 | 抗体活性改造及其筛选方法 |
| CN113416258B (zh) * | 2019-10-24 | 2023-08-29 | 北京免疫方舟医药科技有限公司 | 一种多特异性抗体及其制备方法和用途 |
| AU2020416273A1 (en) | 2020-01-03 | 2022-07-28 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
| EP4118118A1 (en) | 2020-03-09 | 2023-01-18 | Bristol-Myers Squibb Company | Antibodies to cd40 with enhanced agonist activity |
| US20240101693A1 (en) * | 2021-01-21 | 2024-03-28 | The General Hospital Corporation | Antagonistic anti-tumor necrosis factor receptor superfamily antibodies |
| RS66868B1 (sr) | 2021-01-28 | 2025-06-30 | Regeneron Pharma | Kompozicije i postupci za lečenje sindroma oslobađanja citokina |
| KR20250093362A (ko) * | 2022-10-20 | 2025-06-24 | 베이징 솔로바이오 진테크놀로지 컴퍼니 리미티드 | TRAIL 또는 FasL에 특이적으로 결합하는 항체 조합 및 이중특이 항체 |
| WO2024121380A1 (en) | 2022-12-08 | 2024-06-13 | Pierre Fabre Medicament | Vaccinal composition and adjuvant |
| EP4560319A1 (en) | 2023-11-24 | 2025-05-28 | Pierre Fabre Medicament | Immune and tumour cells expression of vista in a panel of cancer indications |
| US20250277048A1 (en) | 2024-03-01 | 2025-09-04 | Regeneron Pharmaceuticals, Inc. | The use of cd40 inhibitors for inhibiting an immune response and enabling immunogen administration and re-administration |
| WO2025184567A1 (en) | 2024-03-01 | 2025-09-04 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response |
| WO2026075989A1 (en) * | 2024-10-01 | 2026-04-09 | Regeneron Pharmaceuticals, Inc. | Engineered igg molecules and methods of use thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5776427A (en) | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
| AU6445894A (en) | 1993-03-19 | 1994-10-11 | Duke University | Method of treatment of tumors with an antibody binding to tenascin |
| AU3272695A (en) | 1994-08-12 | 1996-03-07 | Immunomedics Inc. | Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells |
| JP2007501021A (ja) * | 2003-05-30 | 2007-01-25 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 遺伝子操作された定常領域を含む、抗体および融合タンパク質 |
| KR101223373B1 (ko) * | 2003-12-25 | 2013-01-16 | 교와 핫꼬 기린 가부시키가이샤 | 항 ｃｄ４０ 항체의 변이체 |
| US20090298195A1 (en) * | 2005-01-05 | 2009-12-03 | F-Star Biotechnologische Forschungs-Und Entwicklun Gseges M.B.H. | Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions |
| US8716451B2 (en) * | 2005-01-12 | 2014-05-06 | Kyowa Hakko Kirin Co., Ltd | Stabilized human IgG2 and IgG3 antibodies |
| US7585960B2 (en) | 2005-05-11 | 2009-09-08 | Theramab Gmbh | Nucleic acids encoding superagonistic anti-CD28 antibodies |
| AU2006329944A1 (en) | 2005-12-09 | 2007-07-05 | Seattle Genetics, Inc. | Methods of using CD40 binding agents |
| EP2158318A2 (en) * | 2007-05-14 | 2010-03-03 | Biogen Idec MA, Inc. | Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto |
| AR074438A1 (es) * | 2008-12-02 | 2011-01-19 | Pf Medicament | Proceso para la modulacion de la actividad antagonista de un anticuerpo monoclonal |
| EP2993188B1 (en) * | 2009-04-20 | 2020-08-19 | Kyowa Kirin Co., Ltd. | Anti cd40 antibody containing igg2 having three amino acid mutations introduced therein |
| JP5469390B2 (ja) * | 2009-07-15 | 2014-04-16 | 日立コンシューマエレクトロニクス株式会社 | 再生信号評価方法及び記録調整方法 |
| TW201134488A (en) * | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
| KR102049991B1 (ko) | 2013-03-28 | 2019-12-02 | 삼성전자주식회사 | 항 c-Met/항 Her2 이중 특이 항체 |
-
2015
- 2015-03-24 CN CN201580023010.XA patent/CN107172880B/zh not_active Expired - Fee Related
- 2015-03-24 WO PCT/IB2015/052166 patent/WO2015145360A1/en not_active Ceased
- 2015-03-24 US US15/128,781 patent/US11059898B2/en not_active Expired - Fee Related
- 2015-03-24 AU AU2015237864A patent/AU2015237864B2/en not_active Ceased
- 2015-03-24 EP EP19175308.6A patent/EP3590967A1/en not_active Withdrawn
- 2015-03-24 CA CA2943167A patent/CA2943167A1/en active Pending
- 2015-03-24 JP JP2017501529A patent/JP6682498B2/ja not_active Expired - Fee Related
- 2015-03-24 EP EP15716147.2A patent/EP3122779B1/en active Active
- 2015-03-24 CN CN202111024797.5A patent/CN113912723A/zh active Pending
-
2019
- 2019-11-11 JP JP2019204004A patent/JP2020037577A/ja active Pending
-
2021
- 2021-05-24 US US17/327,837 patent/US20210347907A1/en not_active Abandoned
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