JP2004248677A5 - - Google Patents

Download PDF

Info

Publication number
JP2004248677A5
JP2004248677A5 JP2004113481A JP2004113481A JP2004248677A5 JP 2004248677 A5 JP2004248677 A5 JP 2004248677A5 JP 2004113481 A JP2004113481 A JP 2004113481A JP 2004113481 A JP2004113481 A JP 2004113481A JP 2004248677 A5 JP2004248677 A5 JP 2004248677A5
Authority
JP
Japan
Prior art keywords
pro
ctla4
tyr
soluble ctla4
extracellular domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004113481A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004248677A (ja
Filing date
Publication date
Priority claimed from US08/228,208 external-priority patent/US6090914A/en
Application filed filed Critical
Publication of JP2004248677A publication Critical patent/JP2004248677A/ja
Publication of JP2004248677A5 publication Critical patent/JP2004248677A5/ja
Pending legal-status Critical Current

Links

JP2004113481A 1994-04-15 2004-04-07 Ctla4分子及びil4結合分子並びにそれらの使用 Pending JP2004248677A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/228,208 US6090914A (en) 1991-06-27 1994-04-15 CTLA4/CD28Ig hybrid fusion proteins and uses thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP7115095A Division JPH0847391A (ja) 1994-04-15 1995-04-17 Ctla4分子及びil4結合分子並びにそれらの使用

Publications (2)

Publication Number Publication Date
JP2004248677A JP2004248677A (ja) 2004-09-09
JP2004248677A5 true JP2004248677A5 (enExample) 2005-09-02

Family

ID=22856248

Family Applications (2)

Application Number Title Priority Date Filing Date
JP7115095A Withdrawn JPH0847391A (ja) 1994-04-15 1995-04-17 Ctla4分子及びil4結合分子並びにそれらの使用
JP2004113481A Pending JP2004248677A (ja) 1994-04-15 2004-04-07 Ctla4分子及びil4結合分子並びにそれらの使用

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP7115095A Withdrawn JPH0847391A (ja) 1994-04-15 1995-04-17 Ctla4分子及びil4結合分子並びにそれらの使用

Country Status (8)

Country Link
US (1) US6090914A (enExample)
EP (2) EP1666498A3 (enExample)
JP (2) JPH0847391A (enExample)
AU (1) AU701310B2 (enExample)
CA (1) CA2146895C (enExample)
FI (2) FI951801A7 (enExample)
IL (1) IL113343A (enExample)
NO (1) NO322278B1 (enExample)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6685941B1 (en) * 1988-11-23 2004-02-03 The Regents Of The University Of Michigan Methods of treating autoimmune disease via CTLA-4Ig
US6887471B1 (en) 1991-06-27 2005-05-03 Bristol-Myers Squibb Company Method to inhibit T cell interactions with soluble B7
US5637481A (en) * 1993-02-01 1997-06-10 Bristol-Myers Squibb Company Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
US5773253A (en) 1993-01-22 1998-06-30 Bristol-Myers Squibb Company MYPPPY variants of CTL A4 and uses thereof
US6824779B1 (en) * 1993-07-26 2004-11-30 Dana-Farber Cancer Institute, Inc. Methods for inhibiting the interaction of B7-2 with its natural ligand
US6084067A (en) * 1993-07-26 2000-07-04 Dana-Farber Cancer Institute CTLA4/CD28 ligands and uses therefor
US6051227A (en) * 1995-07-25 2000-04-18 The Regents Of The University Of California, Office Of Technology Transfer Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US5855887A (en) * 1995-07-25 1999-01-05 The Regents Of The University Of California Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
US5811097A (en) * 1995-07-25 1998-09-22 The Regents Of The University Of California Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
SE9601245D0 (sv) * 1996-03-29 1996-03-29 Pharmacia Ab Chimeric superantigens and their use
ATE219376T1 (de) * 1996-03-20 2002-07-15 Bristol Myers Squibb Co Verfahren zur inhibierung der immunreaktion durch blockierung der gp39/cd40 und ctla4/cd28/b7 routen und zusammensetzung zu deren verwendung
TW517061B (en) * 1996-03-29 2003-01-11 Pharmacia & Amp Upjohn Ab Modified/chimeric superantigens and their use
US20060034844A1 (en) * 1996-12-04 2006-02-16 The Regents Of The University Of California Stimulation of T cells against self antigens using CTLA-4 blocking agents
KR19980066046A (ko) * 1997-01-18 1998-10-15 정용훈 고역가의 CTLA4-Ig 융합단백질
US20030219863A1 (en) * 1997-01-31 2003-11-27 Bristol-Myers Squibb Company Soluble CTLA4 mutant molecules and uses thereof
WO1999015552A1 (en) * 1997-09-19 1999-04-01 Yoshitomi Pharmaceutical Industries, Ltd. Oligopeptide compounds
EP0947582A1 (en) * 1998-03-31 1999-10-06 Innogenetics N.V. A polypeptide structure for use as a scaffold
WO2001008700A1 (en) * 1999-07-28 2001-02-08 Genetics Institute, Inc. Preventing immune-mediated abortion by inhibiting costimulation
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
WO2001030966A2 (en) * 1999-10-22 2001-05-03 Alexion Pharmaceuticals, Inc. An engineered recombinant molecule that regulates humoral and cellular effector functions of the immune system
US7094874B2 (en) * 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
MXPA02012157A (es) 2000-06-09 2003-06-06 Bristol Myers Squibb Co Metodos para regular una respuesta inmune mediada por celulas al bloquear se°ales linfociticas y al bloquear la adhesion mediada por el antigeno 1 asociado con la funcion de linfocitos.
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
CA2630062C (en) * 2000-07-03 2014-10-14 Bristol-Myers Squibb Company Methods for treating graft versus host disease and immune disorders associated with rejection using a soluble ctla4 molecule
AU2008200400B2 (en) * 2001-01-17 2012-06-07 Aptevo Research And Development Llc Binding domain-immunoglobulin fusion proteins
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US20030133939A1 (en) * 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US7829084B2 (en) * 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
MXPA03006699A (es) * 2001-01-26 2004-05-31 Univ Emory Metodos de induccion de tolerancia al trasplante de organos y correccion de hemoglobinopatias.
US20040058445A1 (en) * 2001-04-26 2004-03-25 Ledbetter Jeffrey Alan Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB
ATE390931T1 (de) * 2001-05-23 2008-04-15 Bristol Myers Squibb Co Verfahren zum schützen eines allogenen inseltransplantats mit löslichen ctla4- mutationsmolekülen
KR100453877B1 (ko) * 2001-07-26 2004-10-20 메덱스젠 주식회사 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 TNFR/Fc 융합 단백질, 상기 단백질을 코딩하는 DNA, 상기 DNA를 포함하는벡터, 및 상기 벡터에 의한 형질전환체
ES2392287T3 (es) * 2001-12-04 2012-12-07 Theramab Llc Péptido o proteína que contiene un bucle C'-D de la familia de receptores de la CD28
US20030219436A1 (en) * 2002-03-15 2003-11-27 Ledbetter Jeffrey A. Compositions and methods to regulate an immune response using CD83 gene expressed in tumors and using soluble CD83-Ig fusion protein
NZ536420A (en) 2002-04-12 2008-04-30 Medarex Inc Methods of treatment using CTLA-4 antibodies
CN1665533A (zh) * 2002-05-02 2005-09-07 康涅狄格大学健康中心 热激蛋白用于增强抗体疗法功效的用途
JP2006500931A (ja) * 2002-09-30 2006-01-12 ファイザー・プロダクツ・インク 高レベルのヒト配列抗体を産生するハイブリドーマ
EP1575998A4 (en) * 2002-12-23 2007-07-25 Bristol Myers Squibb Co PROCESS FOR CULTIVATING MAMMALIAN CELLS FOR PROTEIN PRODUCTION
TWI328614B (en) * 2002-12-23 2010-08-11 Bristol Myers Squibb Co Product quality enhancement in mammalian cell culture processes for protein production
US7754209B2 (en) 2003-07-26 2010-07-13 Trubion Pharmaceuticals Binding constructs and methods for use thereof
NZ545314A (en) * 2003-08-04 2009-03-31 Bristol Myers Squibb Co Methods for treating cardiovascular disease using a soluble CTLA4 molecule
KR100545720B1 (ko) * 2004-05-31 2006-01-24 메덱스젠 주식회사 당화된 면역글로불린 및 이를 포함하는 면역접합체
US7453291B2 (en) * 2004-09-09 2008-11-18 The Regents Of The University Of California Switch linearized track and hold circuit for switch linearization
PL1868635T3 (pl) * 2005-04-06 2017-10-31 Bristol Myers Squibb Co Metody leczenia zaburzeń immunologicznych związanych z transplantacją narządów rozpuszczalnymi zmutowanymi cząsteczkami CTLA4
AU2006272555B2 (en) 2005-07-25 2012-03-08 Aptevo Research And Development Llc B-cell reduction using CD37-specific and CD20-specific binding molecules
NZ568016A (en) 2005-12-07 2011-12-22 Medarex Inc CTLA-4 antibody dosage escalation regimens
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
PT2253644E (pt) 2005-12-20 2014-01-23 Bristol Myers Squibb Co Composições e métodos para a produção de uma composição
ATE509033T1 (de) 2006-03-20 2011-05-15 Univ California Manipulierte anti-prostatastammzellenantigen (psca)-antikörper für krebs-targeting
US7528111B2 (en) * 2006-05-12 2009-05-05 Bristol-Myers Squibb Company Method of vaccinating subjects receiving immune modulating therapy
CN105837690A (zh) 2006-06-12 2016-08-10 新兴产品开发西雅图有限公司 具有效应功能的单链多价结合蛋白
GB0620934D0 (en) * 2006-10-20 2006-11-29 Cambridge Antibody Tech Protein variants
US8940298B2 (en) 2007-09-04 2015-01-27 The Regents Of The University Of California High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection
CA2703263C (en) * 2007-11-01 2014-03-18 Perseid Therapeutics Llc Immunosuppressive polypeptides and nucleic acids
NZ603059A (en) * 2008-04-11 2014-07-25 Emergent Product Dev Seattle Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
US7915222B2 (en) 2008-05-05 2011-03-29 Bristol-Myers Squibb Company Method of preventing the development of rheumatoid arthritis in subjects with undifferentiated arthritis
AU2009298131B2 (en) 2008-10-02 2016-07-14 Aptevo Research And Development Llc CD86 antagonist multi-target binding proteins
US9540426B2 (en) 2009-10-06 2017-01-10 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
WO2011113019A2 (en) 2010-03-12 2011-09-15 Abbott Biotherapeutics Corp. Ctla4 proteins and their uses
EP2621514B1 (en) 2010-09-28 2016-09-21 KAHR Medical (2005) Ltd Compositions and methods for treatment of hematological malignancies
WO2013062365A2 (ko) * 2011-10-26 2013-05-02 국립암센터 변이 ctla4 유전자 이입 t 세포 및 이를 포함하는 항암 면역치료용 조성물
JP6074435B2 (ja) 2011-10-26 2017-02-01 ナショナル キャンサー センター 変異ctla4遺伝子移入t細胞及びこれを含む抗がん免疫治療用組成物
HK1251480A1 (zh) 2015-09-21 2019-02-01 Aptevo Research And Development Llc Cd3结合多肽
JP2020517259A (ja) 2017-04-19 2020-06-18 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 操作された抗原受容体を発現する免疫細胞
WO2019165121A1 (en) 2018-02-21 2019-08-29 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and uses therof
CN120548323A (zh) * 2022-11-18 2025-08-26 首尔国立大学校产学协力团 利用ctla-4变体及嵌合抗原受体的双基因转导免疫细胞及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) * 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
CA2003455C (en) * 1988-11-23 2000-02-22 Craig B. Thompson Immunotherapy involving cd28 stimulation
US5770197A (en) * 1991-06-27 1998-06-23 Bristol-Myers Squibb Company Methods for regulating the immune response using B7 binding molecules and IL4-binding molecules
DE69226871T3 (de) * 1991-06-27 2009-09-24 Bristol-Myers Squibb Co. CTL4A-Rezeptor, ihn enthaltenden Fusionsproteine und deren Verwendung
AU7107794A (en) * 1993-06-10 1995-01-03 Regents Of The University Of Michigan, The Cd28 pathway immunosuppression

Similar Documents

Publication Publication Date Title
US12152060B2 (en) Interleukin-2 variants and methods of uses thereof
JP2023166395A5 (enExample)
JP2021508449A5 (enExample)
TW201134481A (en) CTLA4 proteins and their uses
JP2020521452A5 (enExample)
CN114728040A (zh) 新型白介素-2变体及其双功能融合分子
JP2023081303A5 (enExample)
KR102247704B1 (ko) 항 pd-1/항 her2 천연항체 구조 형태의 헤테로다이머 계의 이중특이성 항체 및 그 제조방법
JP2017527272A5 (enExample)
JP2010533498A5 (enExample)
JP2006526414A5 (enExample)
JP2019507589A5 (enExample)
JP2010511388A5 (enExample)
JP2006340714A5 (enExample)
JP2022523524A5 (enExample)
JP2021505156A5 (enExample)
JP2012500006A5 (enExample)
JP2011509245A5 (enExample)
JP2009517006A5 (enExample)
RU2006115835A (ru) Человеческие антитела против человеческого 4-1вв (cd137)
JP2012500020A5 (enExample)
RU2011101969A (ru) Антитела к человеческому интерлейкину-20
RU2010136940A (ru) Антитела против альфа5-бета1 и их применение
JP2007536933A5 (enExample)
CA2562764A1 (en) Method for the treatment of t cell mediated conditions by depletion of icos-positive cells in vivo