JP2004248677A5 - - Google Patents

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Publication number
JP2004248677A5
JP2004248677A5 JP2004113481A JP2004113481A JP2004248677A5 JP 2004248677 A5 JP2004248677 A5 JP 2004248677A5 JP 2004113481 A JP2004113481 A JP 2004113481A JP 2004113481 A JP2004113481 A JP 2004113481A JP 2004248677 A5 JP2004248677 A5 JP 2004248677A5
Authority
JP
Japan
Prior art keywords
pro
ctla4
tyr
soluble ctla4
extracellular domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004113481A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004248677A (ja
Filing date
Publication date
Priority claimed from US08/228,208 external-priority patent/US6090914A/en
Application filed filed Critical
Publication of JP2004248677A publication Critical patent/JP2004248677A/ja
Publication of JP2004248677A5 publication Critical patent/JP2004248677A5/ja
Pending legal-status Critical Current

Links

JP2004113481A 1994-04-15 2004-04-07 Ｃｔｌａ４分子及びｉｌ４結合分子並びにそれらの使用 Pending JP2004248677A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/228,208 US6090914A (en) 1991-06-27 1994-04-15 CTLA4/CD28Ig hybrid fusion proteins and uses thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP7115095A Division JPH0847391A (ja) 1994-04-15 1995-04-17 Ｃｔｌａ４分子及びｉｌ４結合分子並びにそれらの使用

Publications (2)

Publication Number Publication Date
JP2004248677A JP2004248677A (ja) 2004-09-09
JP2004248677A5 true JP2004248677A5 (enExample) 2005-09-02

Family

ID=22856248

Family Applications (2)

Application Number Title Priority Date Filing Date
JP7115095A Withdrawn JPH0847391A (ja) 1994-04-15 1995-04-17 Ｃｔｌａ４分子及びｉｌ４結合分子並びにそれらの使用
JP2004113481A Pending JP2004248677A (ja) 1994-04-15 2004-04-07 Ｃｔｌａ４分子及びｉｌ４結合分子並びにそれらの使用

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP7115095A Withdrawn JPH0847391A (ja) 1994-04-15 1995-04-17 Ｃｔｌａ４分子及びｉｌ４結合分子並びにそれらの使用

Country Status (8)

Country Link
US (1) US6090914A (enExample)
EP (2) EP1666498A3 (enExample)
JP (2) JPH0847391A (enExample)
AU (1) AU701310B2 (enExample)
CA (1) CA2146895C (enExample)
FI (2) FI951801A7 (enExample)
IL (1) IL113343A (enExample)
NO (1) NO322278B1 (enExample)

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US7829084B2 (en) * 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
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US20040058445A1 (en) * 2001-04-26 2004-03-25 Ledbetter Jeffrey Alan Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB
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KR100453877B1 (ko) 2001-07-26 2004-10-20 메덱스젠 주식회사 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체
EP1451224B1 (de) * 2001-12-04 2012-08-15 TheraMAB LLC Peptid oder protein enthaltend ein c'-d loop der cd28 rezeptorfamilie
US20030219436A1 (en) * 2002-03-15 2003-11-27 Ledbetter Jeffrey A. Compositions and methods to regulate an immune response using CD83 gene expressed in tumors and using soluble CD83-Ig fusion protein
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CN1665533A (zh) * 2002-05-02 2005-09-07 康涅狄格大学健康中心 热激蛋白用于增强抗体疗法功效的用途
EP1549678A4 (en) * 2002-09-30 2006-01-18 Pfizer Prod Inc HYBRIDOMAS THAT PRODUCE HIGH CONCENTRATIONS OF ANTIBODIES TO THE HUMAN SEQUENCE
KR101088223B1 (ko) * 2002-12-23 2011-11-30 브리스톨-마이어스 스큅 컴퍼니 단백질 생산을 위한 포유류 세포 배양 방법에서의 생산물품질 향상
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US7453291B2 (en) * 2004-09-09 2008-11-18 The Regents Of The University Of California Switch linearized track and hold circuit for switch linearization
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HUE026303T2 (hu) 2005-07-25 2016-06-28 Emergent Product Dev Seattle B-sejt csökkentés CD37-specifikus és CD20-specifikus kapcsoló molekulák alkalmazásával
US8110194B2 (en) 2005-12-07 2012-02-07 Medarex, Inc. CTLA-4 antibody dosage escalation regimens
TWI423986B (zh) 2005-12-20 2014-01-21 必治妥美雅史谷比公司 組合物及製造組合物之方法
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
WO2007109321A2 (en) 2006-03-20 2007-09-27 The Regents Of The University Of California Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting
US7528111B2 (en) * 2006-05-12 2009-05-05 Bristol-Myers Squibb Company Method of vaccinating subjects receiving immune modulating therapy
CN105837690A (zh) 2006-06-12 2016-08-10 新兴产品开发西雅图有限公司 具有效应功能的单链多价结合蛋白
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CA2698343C (en) 2007-09-04 2018-06-12 The Regents Of The University Of California High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection
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AU2009234277B2 (en) 2008-04-11 2014-12-04 Aptevo Research And Development Llc CD37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
US7915222B2 (en) 2008-05-05 2011-03-29 Bristol-Myers Squibb Company Method of preventing the development of rheumatoid arthritis in subjects with undifferentiated arthritis
HRP20180045T1 (hr) 2008-10-02 2018-03-23 Aptevo Research And Development Llc Proteini antagonisti cd86 koji se vežu na više meta
US9540426B2 (en) 2009-10-06 2017-01-10 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
WO2011113019A2 (en) 2010-03-12 2011-09-15 Abbott Biotherapeutics Corp. Ctla4 proteins and their uses
AU2011309689B2 (en) 2010-09-28 2015-01-15 Hadasit Medical Research Services & Development Ltd. Compositions and methods for treatment of hematological malignancies
KR101471647B1 (ko) * 2011-10-26 2014-12-11 국립암센터 변이 ｃｔｌａ4 유전자 이입 ｔ 세포 및 이를 포함하는 항암 면역치료용 조성물
WO2013062365A2 (ko) * 2011-10-26 2013-05-02 국립암센터 변이 ｃｔｌａ4 유전자 이입 ｔ 세포 및 이를 포함하는 항암 면역치료용 조성물
WO2017053469A2 (en) 2015-09-21 2017-03-30 Aptevo Research And Development Llc Cd3 binding polypeptides
CN110753555A (zh) 2017-04-19 2020-02-04 得克萨斯州大学系统董事会 表达工程化抗原受体的免疫细胞
EP3755349A4 (en) 2018-02-21 2021-11-17 Board of Regents, The University of Texas System PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES
KR20240088571A (ko) * 2022-11-18 2024-06-20 서울대학교산학협력단 Ctla-4 변이체 및 키메라 항원수용체를 이용한 이중 유전자 이입 면역세포 및 이의 용도

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