JP2004534020A5 - - Google Patents
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- JP2004534020A5 JP2004534020A5 JP2002585468A JP2002585468A JP2004534020A5 JP 2004534020 A5 JP2004534020 A5 JP 2004534020A5 JP 2002585468 A JP2002585468 A JP 2002585468A JP 2002585468 A JP2002585468 A JP 2002585468A JP 2004534020 A5 JP2004534020 A5 JP 2004534020A5
- Authority
- JP
- Japan
- Prior art keywords
- tumor cells
- antibody
- group
- composition
- binds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004881 tumor cell Anatomy 0.000 claims 34
- 239000000203 mixture Substances 0.000 claims 11
- 101100369076 Mus musculus Tdgf1 gene Proteins 0.000 claims 5
- 239000002246 antineoplastic agent Substances 0.000 claims 5
- 229940127089 cytotoxic agent Drugs 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 230000004614 tumor growth Effects 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 206010061968 Gastric neoplasm Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 210000004408 hybridoma Anatomy 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 208000037841 lung tumor Diseases 0.000 claims 3
- 208000025189 neoplasm of testis Diseases 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 201000003120 testicular cancer Diseases 0.000 claims 3
- 208000025421 tumor of uterus Diseases 0.000 claims 3
- 206010046766 uterine cancer Diseases 0.000 claims 3
- 208000024719 uterine cervix neoplasm Diseases 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 102100034134 Activin receptor type-1B Human genes 0.000 claims 1
- 101000799189 Homo sapiens Activin receptor type-1B Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28678201P | 2001-04-26 | 2001-04-26 | |
| US29302001P | 2001-05-17 | 2001-05-17 | |
| US30109101P | 2001-06-26 | 2001-06-26 | |
| US36700202P | 2002-03-22 | 2002-03-22 | |
| PCT/US2002/011950 WO2002088170A2 (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005202361A Division JP2005314436A (ja) | 2001-04-26 | 2005-07-11 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
| JP2009025420A Division JP4575983B2 (ja) | 2001-04-26 | 2009-02-05 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004534020A JP2004534020A (ja) | 2004-11-11 |
| JP2004534020A5 true JP2004534020A5 (enExample) | 2006-07-27 |
| JP4307845B2 JP4307845B2 (ja) | 2009-08-05 |
Family
ID=27501437
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002585468A Expired - Fee Related JP4307845B2 (ja) | 2001-04-26 | 2002-04-17 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
| JP2005202361A Pending JP2005314436A (ja) | 2001-04-26 | 2005-07-11 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
| JP2009025420A Expired - Fee Related JP4575983B2 (ja) | 2001-04-26 | 2009-02-05 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
| JP2010030683A Withdrawn JP2010163438A (ja) | 2001-04-26 | 2010-02-15 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005202361A Pending JP2005314436A (ja) | 2001-04-26 | 2005-07-11 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
| JP2009025420A Expired - Fee Related JP4575983B2 (ja) | 2001-04-26 | 2009-02-05 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
| JP2010030683A Withdrawn JP2010163438A (ja) | 2001-04-26 | 2010-02-15 | Ｃｒｉｐｔｏをブロックする抗体およびその使用 |
Country Status (33)
Families Citing this family (104)
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| ATE437950T1 (de) * | 2003-09-15 | 2009-08-15 | Res Dev Foundation | Cripto-antagonismus von activin und tgf-b signalisierung |
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2002
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