ATE533508T1 - Cripto-blockierende antikörper und ihre verwendung - Google Patents
Cripto-blockierende antikörper und ihre verwendungInfo
- Publication number
- ATE533508T1 ATE533508T1 AT08158456T AT08158456T ATE533508T1 AT E533508 T1 ATE533508 T1 AT E533508T1 AT 08158456 T AT08158456 T AT 08158456T AT 08158456 T AT08158456 T AT 08158456T AT E533508 T1 ATE533508 T1 AT E533508T1
- Authority
- AT
- Austria
- Prior art keywords
- cripto
- blocking antibodies
- antibodies
- blocking
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28678201P | 2001-04-26 | 2001-04-26 | |
| US29302001P | 2001-05-17 | 2001-05-17 | |
| US30109101P | 2001-06-26 | 2001-06-26 | |
| US36700202P | 2002-03-22 | 2002-03-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE533508T1 true ATE533508T1 (de) | 2011-12-15 |
Family
ID=27501437
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02731384T ATE420659T1 (de) | 2001-04-26 | 2002-04-17 | Criptoblockierende antikörper und deren verwendung |
| AT08158456T ATE533508T1 (de) | 2001-04-26 | 2002-04-17 | Cripto-blockierende antikörper und ihre verwendung |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02731384T ATE420659T1 (de) | 2001-04-26 | 2002-04-17 | Criptoblockierende antikörper und deren verwendung |
Country Status (34)
| Country | Link |
|---|---|
| US (6) | US7531174B2 (de) |
| EP (3) | EP1974749B1 (de) |
| JP (4) | JP4307845B2 (de) |
| KR (1) | KR100592357B1 (de) |
| CN (1) | CN100352501C (de) |
| AR (3) | AR037223A1 (de) |
| AT (2) | ATE420659T1 (de) |
| BG (1) | BG108363A (de) |
| BR (1) | BR0209254A (de) |
| CA (2) | CA2715570A1 (de) |
| CL (1) | CL2009002199A1 (de) |
| CY (1) | CY1108960T1 (de) |
| CZ (1) | CZ20033208A3 (de) |
| DE (1) | DE60230868D1 (de) |
| DK (1) | DK1390389T3 (de) |
| EA (1) | EA007469B1 (de) |
| EE (1) | EE200300528A (de) |
| ES (1) | ES2321065T3 (de) |
| GE (1) | GEP20074091B (de) |
| HK (1) | HK1058935A1 (de) |
| HU (1) | HUP0501113A3 (de) |
| IS (1) | IS2662B (de) |
| MX (1) | MXPA03009797A (de) |
| MY (2) | MY150237A (de) |
| NO (1) | NO20034805L (de) |
| NZ (1) | NZ566268A (de) |
| PL (1) | PL207087B1 (de) |
| PT (1) | PT1390389E (de) |
| RS (2) | RS51635B (de) |
| SG (1) | SG157951A1 (de) |
| SI (1) | SI1390389T1 (de) |
| SK (1) | SK14432003A3 (de) |
| TR (1) | TR200301846T2 (de) |
| WO (1) | WO2002088170A2 (de) |
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| US20090123470A1 (en) * | 2001-03-26 | 2009-05-14 | The Macfarlane Burnet Istitute For Medical Research And Public Health Ltd. | Antibodies Against Cancer |
| US7582299B2 (en) | 2001-04-26 | 2009-09-01 | Biogen Idec Ma Inc. | Cripto-specific antibodies |
| RS51635B (sr) | 2001-04-26 | 2011-08-31 | Biogen Idec Ma Inc. | Antitela koja blokiraju cripto i njihova upotreba |
| EP1494693B1 (de) * | 2002-03-22 | 2010-12-08 | Biogen Idec MA Inc. | Criptospezifische antikörper |
| JP5068072B2 (ja) | 2003-06-27 | 2012-11-07 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 連結ペプチドを含む改変された結合分子 |
| WO2005028433A2 (en) * | 2003-09-15 | 2005-03-31 | Research Development Foundation | CRIPTO ANTAGONISM OF ACTIVIN AND TGF-β SIGNALING |
| PT1725249E (pt) | 2003-11-06 | 2014-04-10 | Seattle Genetics Inc | Compostos de monometilvalina capazes de conjugação a ligandos |
| CA2545603A1 (en) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | Neonatal fc receptor (fcrn)-binding polypeptide variants, dimeric fc binding proteins and methods related thereto |
| CN114053429A (zh) | 2004-06-01 | 2022-02-18 | 健泰科生物技术公司 | 抗体-药物偶联物和方法 |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| DK1791565T3 (en) | 2004-09-23 | 2016-08-01 | Genentech Inc | Cysteingensplejsede antibodies and conjugates |
| WO2006074399A2 (en) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
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| JP5693004B2 (ja) * | 2006-07-28 | 2015-04-01 | チルドレンズ メモリアル ホスピタル | ヒト胚性幹細胞の微小環境を使用して腫瘍細胞の悪性度を抑制する方法 |
| JP2010529024A (ja) * | 2007-06-01 | 2010-08-26 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Ｃｒｉｐｔｏ結合分子 |
| EP2279414A4 (de) * | 2008-04-21 | 2011-06-29 | Merck Sharp & Dohme | Pankreatische beta-zellmasse-biomarker |
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