CY1108960T1 - Αντισωματα αποκλεισμου cripto και οι χρησεις τους - Google Patents

Αντισωματα αποκλεισμου cripto και οι χρησεις τους

Info

Publication number
CY1108960T1
CY1108960T1 CY20091100413T CY091100413T CY1108960T1 CY 1108960 T1 CY1108960 T1 CY 1108960T1 CY 20091100413 T CY20091100413 T CY 20091100413T CY 091100413 T CY091100413 T CY 091100413T CY 1108960 T1 CY1108960 T1 CY 1108960T1
Authority
CY
Cyprus
Prior art keywords
cripto
binding antibodies
antibodies
tumor growth
cottages
Prior art date
Application number
CY20091100413T
Other languages
English (en)
Inventor
Michele Sanicola-Nadel
Kevin Williams
Susan Schiffer
Paul Rayhorn
Original Assignee
Biogen Idec Ma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27501437&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1108960(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen Idec Ma Inc. filed Critical Biogen Idec Ma Inc.
Publication of CY1108960T1 publication Critical patent/CY1108960T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η εφεύρεση παρέχει αντισώματα αποκλεισμού Cripto, ή τα βιολογικά λειτουργικά θραύσματα τους, και τις χρήσεις τους. Παρέχονται αντισώματα που δεσμεύουν Cripto και διαμορφώνουν την σήμανση Cripto. Παρέχονται αντισώματα που δεσμεύουν Cripto και αποκλείουν την αλληλεπίδραση μεταξύ Cripto και ALK4. Παρέχονται επίσης αντισώματα που δεσμεύουν Cripto και διαμορφώνουν την αύξηση όγκου. Παρέχονται επίσης αντισώματα που δεσμεύουν Cripto, διαμορφώνουν την σήμανση, και διαμορφώνουν την αύξηση όγκου. Παρέχονται αντισώματα που δεσμεύουν Cripto, αποκλείουν την αλληλεπίδραση μεταξύ Cripto και ALK4 και διαμορφώνουν την αύξηση όγκου. Η εφεύρεση παρέχει επίσης μεθόδους χρήσης αυτών των αντισωμάτων σε θεραπευτικές, διαγνωστικές, και ερευνητικές εφαρμογές.
CY20091100413T 2001-04-26 2009-04-08 Αντισωματα αποκλεισμου cripto και οι χρησεις τους CY1108960T1 (el)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28678201P 2001-04-26 2001-04-26
US29302001P 2001-05-17 2001-05-17
US30109101P 2001-06-26 2001-06-26
US36700202P 2002-03-22 2002-03-22
EP02731384A EP1390389B1 (en) 2001-04-26 2002-04-17 Cripto blocking antibodies and uses thereof

Publications (1)

Publication Number Publication Date
CY1108960T1 true CY1108960T1 (el) 2014-07-02

Family

ID=27501437

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100413T CY1108960T1 (el) 2001-04-26 2009-04-08 Αντισωματα αποκλεισμου cripto και οι χρησεις τους

Country Status (34)

Country Link
US (6) US7531174B2 (el)
EP (3) EP2316486A3 (el)
JP (4) JP4307845B2 (el)
KR (1) KR100592357B1 (el)
CN (1) CN100352501C (el)
AR (3) AR037223A1 (el)
AT (2) ATE420659T1 (el)
BG (1) BG108363A (el)
BR (1) BR0209254A (el)
CA (2) CA2443840C (el)
CL (1) CL2009002199A1 (el)
CY (1) CY1108960T1 (el)
CZ (1) CZ20033208A3 (el)
DE (1) DE60230868D1 (el)
DK (1) DK1390389T3 (el)
EA (1) EA007469B1 (el)
EE (1) EE200300528A (el)
ES (1) ES2321065T3 (el)
GE (1) GEP20074091B (el)
HK (1) HK1058935A1 (el)
HU (1) HUP0501113A3 (el)
IS (1) IS2662B (el)
MX (1) MXPA03009797A (el)
MY (2) MY157382A (el)
NO (1) NO20034805L (el)
NZ (1) NZ566268A (el)
PL (1) PL207087B1 (el)
PT (1) PT1390389E (el)
RS (2) RS51635B (el)
SG (1) SG157951A1 (el)
SI (1) SI1390389T1 (el)
SK (1) SK14432003A3 (el)
TR (1) TR200301846T2 (el)
WO (1) WO2002088170A2 (el)

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