JP2009542679A5 - - Google Patents

Download PDF

Info

Publication number
JP2009542679A5
JP2009542679A5 JP2009518321A JP2009518321A JP2009542679A5 JP 2009542679 A5 JP2009542679 A5 JP 2009542679A5 JP 2009518321 A JP2009518321 A JP 2009518321A JP 2009518321 A JP2009518321 A JP 2009518321A JP 2009542679 A5 JP2009542679 A5 JP 2009542679A5
Authority
JP
Japan
Prior art keywords
alkyl
aryl
oso
opo
src
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009518321A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009542679A (ja
Filing date
Publication date
Priority claimed from US11/480,163 external-priority patent/US7838542B2/en
Application filed filed Critical
Publication of JP2009542679A publication Critical patent/JP2009542679A/ja
Publication of JP2009542679A5 publication Critical patent/JP2009542679A5/ja
Pending legal-status Critical Current

Links

JP2009518321A 2006-06-29 2007-06-29 キナーゼカスケードを調節するための二環式組成物および方法 Pending JP2009542679A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/480,163 US7838542B2 (en) 2006-06-29 2006-06-29 Bicyclic compositions and methods for modulating a kinase cascade
PCT/US2007/015271 WO2008002674A2 (en) 2006-06-29 2007-06-29 Bicyclic compositions and methods for modulating a kinase cascade

Publications (2)

Publication Number Publication Date
JP2009542679A JP2009542679A (ja) 2009-12-03
JP2009542679A5 true JP2009542679A5 (enExample) 2010-08-19

Family

ID=38704923

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009518321A Pending JP2009542679A (ja) 2006-06-29 2007-06-29 キナーゼカスケードを調節するための二環式組成物および方法

Country Status (7)

Country Link
US (2) US7838542B2 (enExample)
EP (1) EP2038254A2 (enExample)
JP (1) JP2009542679A (enExample)
CA (1) CA2656165A1 (enExample)
IL (1) IL196167A0 (enExample)
TW (1) TW200817327A (enExample)
WO (1) WO2008002674A2 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE494388T1 (de) * 1999-01-13 2011-01-15 Univ New York State Res Found Neues verfahren zum erschaffen von proteinkinase- inhibitoren
US7129225B2 (en) 2001-10-22 2006-10-31 The Research Foundation Of State University Of New York Protection against and treatment of hearing loss
US7005445B2 (en) * 2001-10-22 2006-02-28 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors and methods for designing them
US7838542B2 (en) * 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
AU2007305855A1 (en) * 2006-10-11 2008-04-17 Oriental Yeast Co., Ltd. Agent containing fused protein of soluble RANKL with epitope tag
WO2009126691A1 (en) 2008-04-09 2009-10-15 Infinity Pharmaceuticals, Inc Inhibitors of fatty acid amide hydrolase
CA2975841C (en) 2008-04-30 2021-05-25 Siemens Medical Solutions Usa, Inc. Substrate based pet imaging agents
EP2416660B1 (en) 2009-04-07 2014-07-02 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
WO2010118159A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
WO2010117085A1 (en) * 2009-04-09 2010-10-14 Banyu Pharmaceutical Co.,Ltd. Aryl indole derivatives
WO2010119984A1 (en) * 2009-04-16 2010-10-21 Banyu Pharmaceutical Co.,Ltd. 3-aryl or heteroaryl-substituted indole derivative
US20120035155A1 (en) * 2009-04-28 2012-02-09 Msd K.K. Indole-2-carboxamide deivative
AU2011213072C1 (en) 2010-02-03 2016-12-15 Infinity Pharmaceuticals, Inc. Fatty acid amide hydrolase inhibitors
CN103561573A (zh) * 2011-04-26 2014-02-05 印第安纳大学研究与技术公司 酪氨酸磷酸酶及其在调节参与结核分枝杆菌之病理学的酶的活性中的用途
WO2012173952A1 (en) 2011-06-13 2012-12-20 Emory University Piperazine derivatives, compositions, and uses related thereto
CN103130705B (zh) * 2011-11-23 2016-04-20 中国医学科学院医药生物技术研究所 苯并五元不饱和杂环类化合物或其药用盐及其制备方法、药物组合物及其应用
RU2673489C2 (ru) * 2013-09-12 2018-11-27 Ф. Хоффманн-Ля Рош Аг Производные индолкарбоксамида
MA39840B1 (fr) 2014-04-04 2020-10-28 Iomet Pharma Ltd Dérivés indolés destinés à être utilisés dans le domaine de la médecine
KR101551313B1 (ko) * 2014-07-28 2015-09-09 충남대학교산학협력단 신규한 인덴 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 망막 질환의 예방 또는 치료용 약학적 조성물
EP3193600A4 (en) * 2014-09-10 2018-05-23 Epizyme, Inc. Smyd inhibitors
GB201516411D0 (en) 2015-09-16 2015-10-28 Iomet Pharma Ltd Pharmaceutical compound
HUE055197T2 (hu) 2016-03-09 2021-11-29 Raze Therapeutics Inc 3-Foszfoglicerát-dehidrogenáz inhibitorok és alkalmazásuk
EP4234552A3 (en) 2016-03-09 2023-10-18 Raze Therapeutics, Inc. 3-phosphoglycerate dehydrogenase inhibitors and uses thereof
US10759765B2 (en) * 2016-04-15 2020-09-01 Ce Pharm Co., Ltd. Heterocyclic carboxylic acid amide ligand and applications thereof in copper catalyzed coupling reaction of aryl halogeno substitute
CN109311450A (zh) * 2016-05-19 2019-02-05 电缆塔制造有限公司 挡风玻璃雨刮器连接器
US10858319B2 (en) 2016-10-03 2020-12-08 Iomet Pharma Ltd. Indole derivatives for use in medicine
MX2020001759A (es) 2017-08-14 2020-12-10 Epizyme Inc Inhibidores de histona acetiltransferasa de la familia myst.
CN112585119A (zh) 2018-08-14 2021-03-30 Epizyme股份有限公司 经取代的吲哚及其使用方法
JP2022549345A (ja) * 2019-09-26 2022-11-24 ザ グローバル アライアンス フォー ティービー ドラッグ デベロップメント, インコーポレイテッド マイコバクテリア感染症の処置のためのアザインドールカルボキサミド化合物
EP4642760A1 (en) * 2022-12-29 2025-11-05 Life Technologies Corporation Tyramide and tyramide analog conjugates and uses thereof for biological target staining procedures

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2405622A1 (de) * 1974-02-06 1975-08-14 Boehringer Mannheim Gmbh Neue phenoxyalkylcarbonsaeurederivate und verfahren zur herstellung derselben
CA1261835A (en) 1984-08-20 1989-09-26 Masaaki Toda (fused) benz(thio)amides
JPH01132579A (ja) 1987-11-19 1989-05-25 Ss Pharmaceut Co Ltd インドール誘導体
GB8827189D0 (en) 1988-11-21 1988-12-29 Fujisawa Pharmaceutical Co 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same
ATE142621T1 (de) 1989-12-28 1996-09-15 Upjohn Co Diaromatische substituierte verbindungen gegen den aids-virus
US5552534A (en) * 1991-08-22 1996-09-03 The Trustees Of The University Of Pennsylvania Non-Peptide peptidomimetics
DE4307883A1 (en) 1992-03-12 1993-09-23 Westarp Martin Egon Dr Med Use of anti-retroviral substances - to treat motor-neuronal diseases
US5705585A (en) * 1993-06-30 1998-01-06 Arqule, Inc. Aminimide-containing molecules and materials as molecular recognition agents
CZ283965B6 (cs) * 1992-08-06 1998-07-15 Warner-Lambert Company 2-thioindolové, 2-indolinthionové a polysulfidové sloučeniny, 2-selenoindolové, 2-indolinselenonové a selenidové sloučeniny a farmaceutické prostředky na jejich bázi
US6011175A (en) * 1993-05-18 2000-01-04 University Of Pittsburgh Inhibition of farnesyltransferase
US5532167A (en) * 1994-01-07 1996-07-02 Beth Israel Hospital Substrate specificity of protein kinases
US5712171A (en) * 1995-01-20 1998-01-27 Arqule, Inc. Method of generating a plurality of chemical compounds in a spatially arranged array
FR2733995B1 (fr) 1995-05-09 1997-07-25 Inst Nat Sante Rech Med Inhibiteurs de l'inactivation de neuropeptides endogenes notamment la cholecystokinine, leurs procedes de preparation leur utilisation comme medicaments et procede de criblage de medicaments
JP3314938B2 (ja) 1995-06-06 2002-08-19 ファイザー・インコーポレーテッド グリコーゲンホスホリラーゼ抑制剤としての置換されたn−(インドール−2−カルボニル)−グリシンアミド類および誘導体
AP9600817A0 (en) 1995-06-06 1996-07-31 Pfizer Novel cryatal form of anhydrous 7-( [1A,5A,6A]-6-amino3-3-azabicyclo [3.1.0.] hex-3-yl) -6-fluro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt.
US5648378A (en) * 1995-06-07 1997-07-15 Research Corporation Technologies, Inc. 2-iminochromene derivatives as inhibitors of protein tyrosine kinase
WO1997011692A2 (en) * 1995-09-11 1997-04-03 Osteoarthritis Sciences, Inc. Protein tyrosine kinase inhibitors for treating osteoarthritis
EP0880503A1 (en) 1996-02-09 1998-12-02 Phytera Symbion ApS Balanol analogues
WO1998007695A1 (en) 1996-08-23 1998-02-26 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
CA2264020A1 (en) 1996-08-26 1998-03-05 Jean Bemis Inhibitors of phospholipase enzymes
US5952322A (en) 1996-12-05 1999-09-14 Pfizer Inc. Method of reducing tissue damage associated with non-cardiac ischemia using glycogen phosphorylase inhibitors
CN1251577A (zh) 1997-02-21 2000-04-26 武田药品工业株式会社 稠环化合物及其生产和应用
US6420338B1 (en) * 1997-06-13 2002-07-16 New York University Medical Center Inhibition of the Src kinase family pathway as a method of treating HBV infection and hepatocellular carcinoma
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
EP1024134A4 (en) * 1997-10-09 2003-05-14 Ono Pharmaceutical Co DERIVATIVES OF AMINOBUTANIC ACID
JP2002507598A (ja) 1998-03-26 2002-03-12 スージェン・インコーポレーテッド チロシン蛋白質キナーゼを調節するためのヘテロ環式化合物のファミリー
AU3534699A (en) 1998-04-23 1999-11-08 Takeda Chemical Industries Ltd. Naphthalene derivatives, their production and use
CA2332279A1 (en) 1998-05-15 1999-11-25 Jia-He Li Carboxamide compounds, compositions, and methods for inhibiting parp activity
ATE494388T1 (de) 1999-01-13 2011-01-15 Univ New York State Res Found Neues verfahren zum erschaffen von proteinkinase- inhibitoren
US7070936B1 (en) * 1999-01-13 2006-07-04 The Research Foundation Of State University Of New York Method for designing protein kinase inhibitors
CA2382789A1 (en) 1999-08-27 2001-03-08 Sugen, Inc. Phosphate mimics and methods of treatment using phosphatase inhibitors
US6921763B2 (en) 1999-09-17 2005-07-26 Abbott Laboratories Pyrazolopyrimidines as therapeutic agents
DE19963178A1 (de) 1999-12-27 2001-07-05 Gruenenthal Gmbh Substituierte Indol-Mannichbasen
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
AU2868601A (en) 2000-01-27 2001-08-07 Ribotargets Ltd Biaryl compounds, their preparation and their use in therapy
ATE369359T1 (de) 2000-02-15 2007-08-15 Sugen Inc Pyrrol substituierte indolin-2-on protein kinase inhibitoren
GEP20063751B (en) 2000-04-28 2006-02-27 Baxter Healthcare Sa 2-Acyl Indol Derivatives and Their Use as Anti-Tumour Agents
KR100423899B1 (ko) 2000-05-10 2004-03-24 주식회사 엘지생명과학 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸
US6414013B1 (en) 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
CN100351253C (zh) 2000-06-26 2007-11-28 辉瑞产品公司 作为免疫抑制剂的吡咯并[2,3-d]嘧啶化合物
AU2001270475A1 (en) 2000-07-07 2002-01-21 Novo-Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
CA2440438C (en) 2001-03-09 2011-05-03 Ortho-Mcneil Pharmaceutical, Inc. Heterocyclic compounds
KR100429841B1 (ko) 2001-07-19 2004-05-04 삼성전자주식회사 Grin 렌즈를 구비하는 광 기록헤드
US7005445B2 (en) 2001-10-22 2006-02-28 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors and methods for designing them
US7129225B2 (en) * 2001-10-22 2006-10-31 The Research Foundation Of State University Of New York Protection against and treatment of hearing loss
BR0214642A (pt) * 2001-12-04 2004-11-03 Hoffmann La Roche Compostos, métodos para a preparação de um composto, composições farmacêuticas que compreendem o mesmo e método para o tratamento e/ou prevenção de enfermidades que estão associadas com protéases de cisteìna e utilização desses compostos
JP2005532290A (ja) * 2002-04-10 2005-10-27 スミスクライン ビーチャム コーポレーション 骨喪失を治療するためのカテプシンk阻害剤としての1−(オキソアミノアセチル)ペンチルカルバマート誘導体
CA2484209C (en) 2002-05-03 2013-06-11 Exelixis, Inc. Protein kinase modulators and methods of use
WO2004014581A2 (en) * 2002-08-08 2004-02-19 Consolidated Engineering Company, Inc. Methods and apparatus for heat treatment and sand removal for castings
AU2003258491A1 (en) * 2002-09-05 2004-03-29 Neurosearch A/S Amide derivatives and their use as chloride channel blockers
CA2501611A1 (en) * 2002-10-11 2004-04-22 Astrazeneca Ab 1,4-disubstituted piperidine derivatives and their use as 11-betahsd1 inhibitors
AU2003299797A1 (en) 2002-12-19 2004-07-14 Neurogen Corporation Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators
US20050197364A1 (en) 2003-10-07 2005-09-08 Kelly Michael G. Amide compounds as ion channel ligands and uses thereof
US7141596B2 (en) * 2003-10-08 2006-11-28 Incyte Corporation Inhibitors of proteins that bind phosphorylated molecules
AU2005273986A1 (en) * 2004-08-10 2006-02-23 Incyte Corporation Amido compounds and their use as pharmaceuticals
FR2878849B1 (fr) * 2004-12-06 2008-09-12 Aventis Pharma Sa Indoles substitues, compositions les contenant, procede de fabrication et utilisation
CA2620818A1 (en) 2005-09-02 2007-03-08 Astellas Pharma Inc. Amide derivatives as rock inhibitors
JP5346589B2 (ja) * 2006-02-02 2013-11-20 シンタルガ・ビーブイ 水溶性cc−1065類似体及びその接合体
US7838542B2 (en) * 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade

Similar Documents

Publication Publication Date Title
JP2009542679A (ja) キナーゼカスケードを調節するための二環式組成物および方法
JP2009542679A5 (enExample)
JP5564251B2 (ja) キナーゼカスケードを調節するためのビアリール組成物および方法
JP6022657B2 (ja) キナーゼカスケードを調節するための組成物および方法
RU2569299C2 (ru) Композиции для модуляции киназного каскада и способы их применения
JP2009542680A5 (enExample)
JP4623962B2 (ja) タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法
JP6329871B2 (ja) キナーゼカスケードを調節するための組成物の調製のための方法ならびにその使用方法
US20100256147A1 (en) Biaryl acetamide derivatives as modulators of the kinase cascade for the treatment of hearing loss, osteoporosis and cell proliferation disorders
TW200526635A (en) Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
JP2011207909A (ja) フラザノベンゾイミダゾール
JP2009242437A (ja) スルホンアミド誘導体
TW200812970A (en) Inhibitors of AKT (protein kinase B)
JP2020518595A (ja) 癌、網膜障害及び心筋症の治療のための三置換ピリミジン化合物及び組成物
JP2015028067A (ja) キナーゼカスケードをモジュレートするための医薬組成物およびその使用の方法
TW201825489A (zh) 五環類化合物、包含其之藥物組合物及其應用
TWI398440B (zh) 雙芳基組成物與調節激酶級聯之方法
CN115232030A (zh) 芳基脲类化合物及其制法和药物用途
WO2014190872A1 (zh) 一种含硒化合物及其医药用途
HK1136570B (en) Composition and methods for modulating a kinase cascade