JP2009542679A5 - - Google Patents

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Publication number
JP2009542679A5
JP2009542679A5 JP2009518321A JP2009518321A JP2009542679A5 JP 2009542679 A5 JP2009542679 A5 JP 2009542679A5 JP 2009518321 A JP2009518321 A JP 2009518321A JP 2009518321 A JP2009518321 A JP 2009518321A JP 2009542679 A5 JP2009542679 A5 JP 2009542679A5
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Japan
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aryl
oso
opo
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JP2009518321A
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English (en)
Japanese (ja)
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JP2009542679A (ja
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Priority claimed from US11/480,163 external-priority patent/US7838542B2/en
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Publication of JP2009542679A5 publication Critical patent/JP2009542679A5/ja
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JP2009518321A 2006-06-29 2007-06-29 キナーゼカスケードを調節するための二環式組成物および方法 Pending JP2009542679A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/480,163 US7838542B2 (en) 2006-06-29 2006-06-29 Bicyclic compositions and methods for modulating a kinase cascade
PCT/US2007/015271 WO2008002674A2 (en) 2006-06-29 2007-06-29 Bicyclic compositions and methods for modulating a kinase cascade

Publications (2)

Publication Number Publication Date
JP2009542679A JP2009542679A (ja) 2009-12-03
JP2009542679A5 true JP2009542679A5 (enExample) 2010-08-19

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009518321A Pending JP2009542679A (ja) 2006-06-29 2007-06-29 キナーゼカスケードを調節するための二環式組成物および方法

Country Status (7)

Country Link
US (2) US7838542B2 (enExample)
EP (1) EP2038254A2 (enExample)
JP (1) JP2009542679A (enExample)
CA (1) CA2656165A1 (enExample)
IL (1) IL196167A0 (enExample)
TW (1) TW200817327A (enExample)
WO (1) WO2008002674A2 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0007532A (pt) * 1999-01-13 2001-11-20 Univ New York State Res Found Métodos para identificar inibidores de proteìnaquinase, para testar compostos para umacapacidade de inibir a atividade de proteìnaquinase e para inibir uma proteìna quinase, inibidorde proteìna tirosina quinase não peptìdica, e,método de tratar uma condição responsiva a uminibidor de proteìna quinase em um paciente
CA2464214C (en) 2001-10-22 2011-02-08 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors, methods for designing them, and methods of using them
US7005445B2 (en) * 2001-10-22 2006-02-28 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors and methods for designing them
US7838542B2 (en) * 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
JO3598B1 (ar) * 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
EP2083073B1 (en) * 2006-10-11 2013-09-04 Oriental Yeast Co., Ltd. Reagent containing fused protein of soluble rankl with epitope tag
AU2009233711B2 (en) 2008-04-09 2015-02-12 Infinity Pharmaceuticals, Inc Inhibitors of fatty acid amide hydrolase
JP5627569B2 (ja) 2008-04-30 2014-11-19 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッドSiemens Medical Solutions USA,Inc. 新規基質に基づくpet造影剤
US8546564B2 (en) 2009-04-07 2013-10-01 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
AU2010234449A1 (en) 2009-04-07 2011-11-03 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
EP2448921A4 (en) * 2009-04-09 2013-01-23 Msd Kk ARYLINDOLDERIVATE
US20120028990A1 (en) * 2009-04-16 2012-02-02 Msd K.K 3 aryl or heteroaryl-substituted indole derivative
US20120035155A1 (en) * 2009-04-28 2012-02-09 Msd K.K. Indole-2-carboxamide deivative
CA2788587C (en) 2010-02-03 2020-03-10 Infinity Pharmaceuticals, Inc. Fatty acid amide hydrolase inhibitors
WO2012149049A1 (en) * 2011-04-26 2012-11-01 Indiana University Research And Technology Corporation Tyrosine phosphatase inhibitors and uses thereof to modulate the activity of enzymes involved in the pathology of mycobacterium tuberculosis
US9428478B2 (en) 2011-06-13 2016-08-30 Emory University Piperazine derivatives, compositions, and uses related thereto
CN103130705B (zh) * 2011-11-23 2016-04-20 中国医学科学院医药生物技术研究所 苯并五元不饱和杂环类化合物或其药用盐及其制备方法、药物组合物及其应用
JP6231691B2 (ja) * 2013-09-12 2017-11-15 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft インドール−カルボキサミド誘導体
HRP20201621T1 (hr) * 2014-04-04 2021-03-05 Iomet Pharma Ltd. Derivati indola za uporabu u medicini
KR101551313B1 (ko) * 2014-07-28 2015-09-09 충남대학교산학협력단 신규한 인덴 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 망막 질환의 예방 또는 치료용 약학적 조성물
SG10201901192TA (en) * 2014-09-10 2019-03-28 Epizyme Inc Smyd inhibitors
GB201516411D0 (en) * 2015-09-16 2015-10-28 Iomet Pharma Ltd Pharmaceutical compound
PL3426244T3 (pl) 2016-03-09 2023-09-25 Raze Therapeutics, Inc. Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania
HUE055197T2 (hu) 2016-03-09 2021-11-29 Raze Therapeutics Inc 3-Foszfoglicerát-dehidrogenáz inhibitorok és alkalmazásuk
JP6878460B2 (ja) * 2016-04-15 2021-05-26 浙江中科▲創▼越▲薬▼▲業▼有限公司 複素環カルボン酸アミド配位子および銅触媒によるハロゲン化アリールのカップリング反応におけるその使用
US10766462B2 (en) * 2016-05-19 2020-09-08 Pylon Manufacturing Corporation Windshield wiper connector
US10858319B2 (en) 2016-10-03 2020-12-08 Iomet Pharma Ltd. Indole derivatives for use in medicine
MX2020001759A (es) 2017-08-14 2020-12-10 Epizyme Inc Inhibidores de histona acetiltransferasa de la familia myst.
WO2020037079A1 (en) 2018-08-14 2020-02-20 Epizyme, Inc. Substituted indoles and methods of use thereof
BR112022005736A2 (pt) * 2019-09-26 2022-08-23 Global Alliance For Tb Drug Development Inc Compostos de azaindol carboxamida para o tratamento de infecções micobacterianas
EP4642760A1 (en) * 2022-12-29 2025-11-05 Life Technologies Corporation Tyramide and tyramide analog conjugates and uses thereof for biological target staining procedures

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2405622A1 (de) * 1974-02-06 1975-08-14 Boehringer Mannheim Gmbh Neue phenoxyalkylcarbonsaeurederivate und verfahren zur herstellung derselben
CA1261835A (en) 1984-08-20 1989-09-26 Masaaki Toda (fused) benz(thio)amides
JPH01132579A (ja) 1987-11-19 1989-05-25 Ss Pharmaceut Co Ltd インドール誘導体
GB8827189D0 (en) 1988-11-21 1988-12-29 Fujisawa Pharmaceutical Co 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same
CA2071529C (en) 1989-12-28 2001-03-20 Donna Lee Romero Diaromatic substituted anti-aids compounds
US5552534A (en) * 1991-08-22 1996-09-03 The Trustees Of The University Of Pennsylvania Non-Peptide peptidomimetics
DE4307883A1 (en) 1992-03-12 1993-09-23 Westarp Martin Egon Dr Med Use of anti-retroviral substances - to treat motor-neuronal diseases
US5705585A (en) * 1993-06-30 1998-01-06 Arqule, Inc. Aminimide-containing molecules and materials as molecular recognition agents
JPH08503450A (ja) * 1992-08-06 1996-04-16 ワーナー−ランバート・コンパニー 蛋白チロシンキナーゼを阻害し、かつ抗腫瘍特性を有する2−チオインドール(セレノインドール)および関連ジスルフィド(セレニド)
US6011175A (en) * 1993-05-18 2000-01-04 University Of Pittsburgh Inhibition of farnesyltransferase
US5532167A (en) * 1994-01-07 1996-07-02 Beth Israel Hospital Substrate specificity of protein kinases
US5712171A (en) * 1995-01-20 1998-01-27 Arqule, Inc. Method of generating a plurality of chemical compounds in a spatially arranged array
FR2733995B1 (fr) 1995-05-09 1997-07-25 Inst Nat Sante Rech Med Inhibiteurs de l'inactivation de neuropeptides endogenes notamment la cholecystokinine, leurs procedes de preparation leur utilisation comme medicaments et procede de criblage de medicaments
FI974437L (fi) 1995-06-06 1997-12-05 Pfizer Substituoituja N-(indoli-2-karbonyyli)amideja ja johdannaisia glykogeenifosforylaasi-inhibiittoreina
DK0832065T3 (da) 1995-06-06 2001-11-19 Pfizer Substituerede N-(indol-2-carbonyl)glycinamider og derivater som glycogenphosphorylaseinhibitorer
US5648378A (en) * 1995-06-07 1997-07-15 Research Corporation Technologies, Inc. 2-iminochromene derivatives as inhibitors of protein tyrosine kinase
WO1997011692A2 (en) * 1995-09-11 1997-04-03 Osteoarthritis Sciences, Inc. Protein tyrosine kinase inhibitors for treating osteoarthritis
JP2000504672A (ja) 1996-02-09 2000-04-18 フィテラ シンビオン エイピーエス バラノール類似体
EP0929520B1 (en) 1996-08-23 2005-11-02 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
EP0922028A1 (en) 1996-08-26 1999-06-16 Genetics Institute, Inc. Inhibitors of phospholipase enzymes
US5952322A (en) 1996-12-05 1999-09-14 Pfizer Inc. Method of reducing tissue damage associated with non-cardiac ischemia using glycogen phosphorylase inhibitors
AU6229698A (en) 1997-02-21 1998-09-09 Takeda Chemical Industries Ltd. Fused ring compounds, process for producing the same and use thereof
US6420338B1 (en) * 1997-06-13 2002-07-16 New York University Medical Center Inhibition of the Src kinase family pathway as a method of treating HBV infection and hepatocellular carcinoma
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
CN1282319A (zh) * 1997-10-09 2001-01-31 小野药品工业株式会社 氨基丁酸衍生物
JP2002507598A (ja) 1998-03-26 2002-03-12 スージェン・インコーポレーテッド チロシン蛋白質キナーゼを調節するためのヘテロ環式化合物のファミリー
US6573289B1 (en) 1998-04-23 2003-06-03 Takeda Chemical Industries, Ltd. Naphthalene derivatives, their production and use
AU9297998A (en) 1998-05-15 1999-12-06 Guilford Pharmaceuticals Inc. Carboxamide compounds, compositions, and methods for inhibiting parp activity
BR0007532A (pt) 1999-01-13 2001-11-20 Univ New York State Res Found Métodos para identificar inibidores de proteìnaquinase, para testar compostos para umacapacidade de inibir a atividade de proteìnaquinase e para inibir uma proteìna quinase, inibidorde proteìna tirosina quinase não peptìdica, e,método de tratar uma condição responsiva a uminibidor de proteìna quinase em um paciente
US7070936B1 (en) * 1999-01-13 2006-07-04 The Research Foundation Of State University Of New York Method for designing protein kinase inhibitors
EP1212296B9 (en) 1999-08-27 2006-05-10 Sugen, Inc. Phosphate mimics and methods of treatment using phosphatase inhibitors
US6921763B2 (en) 1999-09-17 2005-07-26 Abbott Laboratories Pyrazolopyrimidines as therapeutic agents
DE19963178A1 (de) 1999-12-27 2001-07-05 Gruenenthal Gmbh Substituierte Indol-Mannichbasen
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
AU2868601A (en) 2000-01-27 2001-08-07 Ribotargets Ltd Biaryl compounds, their preparation and their use in therapy
ATE369359T1 (de) 2000-02-15 2007-08-15 Sugen Inc Pyrrol substituierte indolin-2-on protein kinase inhibitoren
BR0110414A (pt) 2000-04-28 2003-02-11 Baxter Healthcare Sa Derivados de 2-acil indol e seu uso como agentes antitumores
KR100423899B1 (ko) 2000-05-10 2004-03-24 주식회사 엘지생명과학 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸
US6414013B1 (en) 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
DK1686130T3 (da) 2000-06-26 2009-04-06 Pfizer Prod Inc Pyrrolo-[2,3-d]-pyrimidinforbindelser som immunsuppressive midler
ATE321052T1 (de) 2000-07-07 2006-04-15 Novo Nordisk As Modulatoren von protein tyrosin phosphatasen (ptpasen)
EP1373204B1 (en) 2001-03-09 2016-10-26 Janssen Pharmaceuticals, Inc. Heterocyclic compounds
KR100429841B1 (ko) 2001-07-19 2004-05-04 삼성전자주식회사 Grin 렌즈를 구비하는 광 기록헤드
US7005445B2 (en) * 2001-10-22 2006-02-28 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors and methods for designing them
CA2464214C (en) * 2001-10-22 2011-02-08 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors, methods for designing them, and methods of using them
KR20050044660A (ko) * 2001-12-04 2005-05-12 에프. 호프만-라 로슈 아게 치환된 2-아미노-사이클로알칸카복스아마이드 및 시스테인프로테아제 저해제로서의 이의 용도
JP2005532290A (ja) * 2002-04-10 2005-10-27 スミスクライン ビーチャム コーポレーション 骨喪失を治療するためのカテプシンk阻害剤としての1−(オキソアミノアセチル)ペンチルカルバマート誘導体
CA2484209C (en) 2002-05-03 2013-06-11 Exelixis, Inc. Protein kinase modulators and methods of use
EP2027953A3 (en) * 2002-08-08 2010-01-20 Consolidated Engineering Company, Inc. Methods and apparatus for heat treatment and sand removal for castings
AU2003258491A1 (en) * 2002-09-05 2004-03-29 Neurosearch A/S Amide derivatives and their use as chloride channel blockers
EP1556349A1 (en) * 2002-10-11 2005-07-27 Astrazeneca AB 1,4-disubstituted piperidine derivatives and their use as 11-betahsd1 inhibitors
AU2003299797A1 (en) 2002-12-19 2004-07-14 Neurogen Corporation Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators
CA2541299A1 (en) 2003-10-07 2005-04-14 Renovis, Inc. Amide compounds as ion channel ligands and uses thereof
US7141596B2 (en) * 2003-10-08 2006-11-28 Incyte Corporation Inhibitors of proteins that bind phosphorylated molecules
AU2005273986A1 (en) * 2004-08-10 2006-02-23 Incyte Corporation Amido compounds and their use as pharmaceuticals
FR2878849B1 (fr) * 2004-12-06 2008-09-12 Aventis Pharma Sa Indoles substitues, compositions les contenant, procede de fabrication et utilisation
US8211919B2 (en) 2005-09-02 2012-07-03 Astellas Pharma Inc. Amide derivatives as rock inhibitors
US8940784B2 (en) * 2006-02-02 2015-01-27 Syntarga B.V. Water-soluble CC-1065 analogs and their conjugates
US7838542B2 (en) * 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade

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