JP2009539367A5 - - Google Patents
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- Publication number
- JP2009539367A5 JP2009539367A5 JP2009513764A JP2009513764A JP2009539367A5 JP 2009539367 A5 JP2009539367 A5 JP 2009539367A5 JP 2009513764 A JP2009513764 A JP 2009513764A JP 2009513764 A JP2009513764 A JP 2009513764A JP 2009539367 A5 JP2009539367 A5 JP 2009539367A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- fkbp
- seq
- fragment
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0611405.2 | 2006-06-09 | ||
| GBGB0611405.2A GB0611405D0 (en) | 2006-06-09 | 2006-06-09 | FKBP-L: A novel inhibitor of angiogenesis |
| PCT/GB2007/002107 WO2007141533A2 (en) | 2006-06-09 | 2007-06-08 | Fkbp-l and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009539367A JP2009539367A (ja) | 2009-11-19 |
| JP2009539367A5 true JP2009539367A5 (enExample) | 2010-07-29 |
| JP5474535B2 JP5474535B2 (ja) | 2014-04-16 |
Family
ID=36745574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009513764A Expired - Fee Related JP5474535B2 (ja) | 2006-06-09 | 2007-06-08 | Ｆｋｂｐ−ｌおよびその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9381228B2 (enExample) |
| EP (1) | EP2040728B1 (enExample) |
| JP (1) | JP5474535B2 (enExample) |
| CN (1) | CN101489575B (enExample) |
| AU (1) | AU2007255196B2 (enExample) |
| CA (1) | CA2657947C (enExample) |
| CY (1) | CY1116970T1 (enExample) |
| DK (1) | DK2040728T3 (enExample) |
| ES (1) | ES2548332T3 (enExample) |
| GB (1) | GB0611405D0 (enExample) |
| HU (1) | HUE028099T2 (enExample) |
| IL (1) | IL195580A (enExample) |
| NZ (2) | NZ600690A (enExample) |
| PL (1) | PL2040728T3 (enExample) |
| PT (1) | PT2040728E (enExample) |
| SI (1) | SI2040728T1 (enExample) |
| WO (1) | WO2007141533A2 (enExample) |
| ZA (1) | ZA200810323B (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| WO2005044839A2 (en) | 2003-11-05 | 2005-05-19 | Dana-Farber Cancer Institute, Inc. | Stabilized alpha helical peptides and uses thereof |
| US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
| PL2118123T3 (pl) | 2007-01-31 | 2016-06-30 | Dana Farber Cancer Inst Inc | Stabilizowane peptydy p53 i ich zastosowania |
| JP5631201B2 (ja) | 2007-03-28 | 2014-11-26 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ステッチングされたポリペプチド |
| GB0724393D0 (en) * | 2007-12-14 | 2008-01-23 | Univ Ulster | Use of FKBPL gene to identify a cause of infertility |
| US20110144306A1 (en) | 2008-07-23 | 2011-06-16 | President And Fellows Of Harvard College | Ligation of stapled polypeptides |
| CN104961795A (zh) | 2008-09-22 | 2015-10-07 | 爱勒让治疗公司 | 用于制备纯化的多肽组合物的方法 |
| AU2010204648B2 (en) | 2009-01-14 | 2016-09-01 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| GB0908589D0 (en) | 2009-05-19 | 2009-06-24 | Univ Belfast | Assay method |
| BR112012000867A2 (pt) | 2009-07-13 | 2019-09-24 | Harvard College | "polipeptídeos bifuncional costurado e uso do mesmo" |
| JP2013505300A (ja) | 2009-09-22 | 2013-02-14 | エルロン・セラピューティクス・インコーポレイテッド | ペプチド模倣大環状分子 |
| KR102104762B1 (ko) | 2010-08-13 | 2020-04-24 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| WO2012040459A2 (en) | 2010-09-22 | 2012-03-29 | President And Fellows Of Harvard College | Beta-catenin targeting peptides and uses thereof |
| WO2012174423A1 (en) | 2011-06-17 | 2012-12-20 | President And Fellows Of Harvard College | Stabilized polypeptides as regulators of rab gtpase function |
| US20140308260A1 (en) * | 2011-10-07 | 2014-10-16 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
| EP2768518A4 (en) | 2011-10-18 | 2015-05-27 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES |
| CA2864120A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| RU2642299C2 (ru) | 2012-02-15 | 2018-01-24 | Эйлерон Терапьютикс, Инк. | P53 пептидомиметические макроциклы |
| RS61957B1 (sr) | 2012-09-26 | 2021-07-30 | Harvard College | Uvezani peptidi blokirani prolinom i njihove upotrebe |
| BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
| KR20150131244A (ko) | 2013-03-13 | 2015-11-24 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스테이플드 및 스티치드 폴리펩티드 및 그의 용도 |
| BR112015031277A2 (pt) | 2013-06-14 | 2017-09-19 | Harvard College | Moduladores do receptor de insulina de polipeptídeos estabilizados, análogos de insulina, composições farmacêuticas compreendendo os referidos polipeptídeos e métodos de preparação e usos dos mesmos |
| EP3145523A4 (en) | 2014-05-21 | 2018-02-21 | President and Fellows of Harvard College | Ras inhibitory peptides and uses thereof |
| EP3197478A4 (en) | 2014-09-24 | 2018-05-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CN107106642B (zh) | 2014-09-24 | 2021-02-26 | 艾瑞朗医疗公司 | 拟肽大环化合物及其制剂 |
| JP2018516844A (ja) | 2015-03-20 | 2018-06-28 | エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ペプチド模倣大環状分子およびその使用 |
| US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| EP3347372A4 (en) | 2015-09-10 | 2019-09-04 | Aileron Therapeutics, Inc. | PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1 |
| US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
| US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
| SG11201805942UA (en) | 2016-01-11 | 2018-08-30 | Epicentrx Inc | Compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone |
| US20190381127A1 (en) | 2016-02-02 | 2019-12-19 | Splash Pharmaceuticals, Inc. | Combination therapy with a6, chemotherapeutic agents, radiation therapy, or a combination thereof for the treatment of cancer |
| EP3474882A1 (en) * | 2016-06-22 | 2019-05-01 | Almac Discovery Limited | Treatment of ocular disease |
| EA201990949A1 (ru) | 2016-10-14 | 2019-10-31 | Сульфоксиалкильные органические нитросоединения и родственные соединения и фармацевтические композиции для применения в медицине | |
| WO2018073591A1 (en) * | 2016-10-19 | 2018-04-26 | The Queen's University Of Belfast | Use of fkbp-l polypeptides and nucleic acids for the treatment of obesity |
| CN108362870A (zh) * | 2017-01-27 | 2018-08-03 | 武汉三鹰生物技术有限公司 | 一种用于人fkbpl蛋白的酶联免疫检测及制备方法 |
| KR102869384B1 (ko) | 2017-07-07 | 2025-10-15 | 에피센트알엑스, 인코포레이티드 | 치료제의 비경구 투여를 위한 조성물 |
| WO2019164593A2 (en) | 2018-01-08 | 2019-08-29 | Epicentrx, Inc. | Methods and compositions utilizing rrx-001 combination therapy for radioprotection |
| CN111603567B (zh) * | 2019-02-22 | 2024-12-27 | 赣江新区博瑞创新医药有限公司 | Cd44靶向多臂偶联物 |
| CN113702632A (zh) * | 2021-09-02 | 2021-11-26 | 深圳市光与生物科技有限公司 | 一种快速检测子痫前期的免疫层析检测卡及其制备方法与应用 |
| CN114702564A (zh) * | 2021-12-15 | 2022-07-05 | 江苏省人民医院（南京医科大学第一附属医院） | 一种外泌体肽及其制备方法和应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3194732A (en) | 1960-10-03 | 1965-07-13 | Neuhauser Irene | Assisting healing of skin-denuded areas on the body with dried non-fibrous egg-shellmembrane products and compositions therefor |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| AU7757581A (en) | 1980-11-19 | 1982-05-27 | United Energy Technologies Inc. | Enhanced surface tubing |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
| EP0142541B1 (en) | 1983-05-09 | 1987-07-08 | THE GENERAL ELECTRIC COMPANY, p.l.c. | Cathode ray tube display device |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US4615885A (en) | 1983-11-01 | 1986-10-07 | Terumo Kabushiki Kaisha | Pharmaceutical composition containing urokinase |
| JP3065628B2 (ja) * | 1988-12-19 | 2000-07-17 | 三井化学株式会社 | ヒト免疫グロブリン遺伝子関連ｄｎａ断片及び該ｄｎａ断片を用いる診断方法 |
| US5766883A (en) | 1989-04-29 | 1998-06-16 | Delta Biotechnology Limited | Polypeptides |
| FR2650598B1 (fr) | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | Derives de l'albumine a fonction therapeutique |
| US5073627A (en) | 1989-08-22 | 1991-12-17 | Immunex Corporation | Fusion proteins comprising GM-CSF and IL-3 |
| AU648140B2 (en) | 1991-02-01 | 1994-04-14 | Virtual Drug Development, Inc. | Reverse antimicrobial peptides and antimicrobial compositions |
| IL99120A0 (en) | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| ATE240394T1 (de) | 1992-10-23 | 2003-05-15 | Immunex Corp | Methoden zur herstellung löslicher, oligomerer proteine |
| US5359030A (en) | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| US5681811A (en) | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
| BR9407035A (pt) | 1993-06-29 | 1996-03-12 | Chiron Corp | Fragmento de fator de crescimento de queratinócitos conjugado composição terapêutica molécula de DNA vetor de expressão célula hospedeira processo para produzir fragmento de fator de crescimento de queratinócitos processo para cicatrização de ferimento e processo de tratamento de doença hiperproliferativa da epiderme |
| ES2293137T3 (es) | 1995-10-11 | 2008-03-16 | Novartis Vaccines And Diagnostics, Inc. | Combinacion de pdgf, kgf,igf e igfbp para curacion de heridas. |
| AU7469998A (en) | 1997-05-01 | 1998-11-24 | Amgen, Inc. | Chimeric opg polypeptides |
| US6583168B1 (en) | 1997-11-25 | 2003-06-24 | Applera Corporation | Sulfonated diarylrhodamine dyes |
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| CN1281465A (zh) * | 1998-10-09 | 2001-01-24 | 上海第二医科大学 | 人fk506结合蛋白(fkbp) |
| JP4821031B2 (ja) | 1999-04-13 | 2011-11-24 | 株式会社林原生物化学研究所 | シアニン色素 |
| EP1210046A4 (en) | 1999-06-22 | 2007-05-02 | Res Dev Foundation | IMPROVED DRESSING THAT CAN ACCELERATE THE HEALING OF INJURIES |
| JP2003504024A (ja) * | 1999-07-06 | 2003-02-04 | インサイト・ゲノミックス・インコーポレイテッド | ヒト免疫応答分子 |
| US6413507B1 (en) | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
| US20030125246A9 (en) * | 2000-01-31 | 2003-07-03 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
| US6821731B2 (en) | 2000-11-28 | 2004-11-23 | Wyeth | Expression analysis of FKBP nucleic acids and polypeptides useful in the diagnosis of prostate cancer |
| AU2002255478A1 (en) * | 2001-01-10 | 2002-09-12 | Pe Corporation (Ny) | Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof |
| US7235358B2 (en) * | 2001-06-08 | 2007-06-26 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
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| US20070105133A1 (en) * | 2005-06-13 | 2007-05-10 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
-
2006
- 2006-06-09 GB GBGB0611405.2A patent/GB0611405D0/en not_active Ceased
-
2007
- 2007-06-08 DK DK07733118.9T patent/DK2040728T3/en active
- 2007-06-08 NZ NZ600690A patent/NZ600690A/en not_active IP Right Cessation
- 2007-06-08 HU HUE07733118A patent/HUE028099T2/en unknown
- 2007-06-08 NZ NZ573425A patent/NZ573425A/en not_active IP Right Cessation
- 2007-06-08 US US12/303,343 patent/US9381228B2/en not_active Expired - Fee Related
- 2007-06-08 SI SI200731701T patent/SI2040728T1/sl unknown
- 2007-06-08 PT PT77331189T patent/PT2040728E/pt unknown
- 2007-06-08 AU AU2007255196A patent/AU2007255196B2/en not_active Ceased
- 2007-06-08 EP EP07733118.9A patent/EP2040728B1/en not_active Not-in-force
- 2007-06-08 JP JP2009513764A patent/JP5474535B2/ja not_active Expired - Fee Related
- 2007-06-08 CA CA2657947A patent/CA2657947C/en not_active Expired - Fee Related
- 2007-06-08 WO PCT/GB2007/002107 patent/WO2007141533A2/en not_active Ceased
- 2007-06-08 PL PL07733118T patent/PL2040728T3/pl unknown
- 2007-06-08 CN CN2007800276683A patent/CN101489575B/zh not_active Expired - Fee Related
- 2007-06-08 ES ES07733118.9T patent/ES2548332T3/es active Active
-
2008
- 2008-11-27 IL IL195580A patent/IL195580A/en not_active IP Right Cessation
- 2008-12-04 ZA ZA2008/10323A patent/ZA200810323B/en unknown
-
2015
- 2015-11-26 CY CY20151101070T patent/CY1116970T1/el unknown
-
2016
- 2016-05-31 US US15/169,452 patent/US20160340401A1/en not_active Abandoned
- 2016-05-31 US US15/169,460 patent/US10577406B2/en not_active Expired - Fee Related