CA2657947C - Fkbp-l and uses thereof - Google Patents
Fkbp-l and uses thereof Download PDFInfo
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- CA2657947C CA2657947C CA2657947A CA2657947A CA2657947C CA 2657947 C CA2657947 C CA 2657947C CA 2657947 A CA2657947 A CA 2657947A CA 2657947 A CA2657947 A CA 2657947A CA 2657947 C CA2657947 C CA 2657947C
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- fkbp
- seq
- polypeptide
- amino acid
- acid sequence
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Endocrinology (AREA)
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| GBGB0611405.2A GB0611405D0 (en) | 2006-06-09 | 2006-06-09 | FKBP-L: A novel inhibitor of angiogenesis |
| GB0611405.2 | 2006-06-09 | ||
| PCT/GB2007/002107 WO2007141533A2 (en) | 2006-06-09 | 2007-06-08 | Fkbp-l and uses thereof |
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| CA2657947A1 CA2657947A1 (en) | 2007-12-13 |
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| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| EP1680443B9 (en) | 2003-11-05 | 2014-09-03 | Dana-Farber Cancer Institute, Inc. | Stabilized alpha helical peptides and uses thereof |
| US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
| US8889632B2 (en) | 2007-01-31 | 2014-11-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| CA2682174C (en) | 2007-03-28 | 2021-04-06 | President And Fellows Of Harvard College | Stitched polypeptides |
| GB0724393D0 (en) * | 2007-12-14 | 2008-01-23 | Univ Ulster | Use of FKBPL gene to identify a cause of infertility |
| US20110144306A1 (en) | 2008-07-23 | 2011-06-16 | President And Fellows Of Harvard College | Ligation of stapled polypeptides |
| BRPI0918838A2 (pt) | 2008-09-22 | 2015-12-08 | Aileron Therapeutics Inc | processos para preparação de composições de polipeptídeos purificados |
| WO2010083347A2 (en) | 2009-01-14 | 2010-07-22 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| GB0908589D0 (en) * | 2009-05-19 | 2009-06-24 | Univ Belfast | Assay method |
| US9163330B2 (en) | 2009-07-13 | 2015-10-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
| CN102712675A (zh) | 2009-09-22 | 2012-10-03 | 爱勒让治疗公司 | 拟肽大环化合物 |
| RU2582678C2 (ru) | 2010-08-13 | 2016-04-27 | Эйлерон Терапьютикс, Инк. | Пептидомиметические макроциклы |
| US8957026B2 (en) | 2010-09-22 | 2015-02-17 | President And Fellows Of Harvard College | Beta-catenin targeting peptides and uses thereof |
| US9487562B2 (en) | 2011-06-17 | 2016-11-08 | President And Fellows Of Harvard College | Stabilized polypeptides as regulators of RAB GTPase function |
| WO2013052803A2 (en) | 2011-10-07 | 2013-04-11 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
| RU2639523C2 (ru) | 2011-10-18 | 2017-12-21 | Эйлерон Терапьютикс, Инк. | Пептидомиметические макроциклы и их применение |
| WO2013123266A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES CROSS-LINKED WITH TRIAZOLE AND THIOETHER |
| SMT202100337T1 (it) | 2012-09-26 | 2021-07-12 | Harvard College | Peptidi graffati bloccati con prolina e loro usi |
| CN104812384B (zh) | 2012-11-01 | 2020-09-18 | 爱勒让治疗公司 | 二取代的氨基酸及其制备和使用方法 |
| SG10201913593WA (en) | 2013-03-13 | 2020-02-27 | Harvard College | Stapled and stitched polypeptides and uses thereof |
| CN105492460A (zh) | 2013-06-14 | 2016-04-13 | 哈佛大学的校长及成员们 | 稳定化多肽胰岛素受体调控剂 |
| US10533039B2 (en) | 2014-05-21 | 2020-01-14 | President And Fellows Of Harvard College | Ras inhibitory peptides and uses thereof |
| BR112017005598A2 (pt) | 2014-09-24 | 2017-12-12 | Aileron Therapeutics Inc | macrociclos peptidomiméticos e usos dos mesmos |
| SG10201902598VA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof |
| US10253067B2 (en) | 2015-03-20 | 2019-04-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CN108368161A (zh) | 2015-09-10 | 2018-08-03 | 艾瑞朗医疗公司 | 作为mcl-1调节剂的拟肽大环化合物 |
| US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
| US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
| MX2018008528A (es) | 2016-01-11 | 2019-05-16 | Epicentrx Inc | Composiciones y métodos para la administración intravenosa de 2-bromo-1-(3,3 dinitroazetidin-1-il)etanona. |
| EP3411058B1 (en) | 2016-02-02 | 2023-03-08 | Splash Pharmaceuticals, Inc. | Combination therapy with a6 and paclitaxel for the treatment of ovarian cancer |
| EP3474882A1 (en) * | 2016-06-22 | 2019-05-01 | Almac Discovery Limited | Treatment of ocular disease |
| US11008287B2 (en) | 2016-10-14 | 2021-05-18 | Epicentrx, Inc. | Sulfoxyalkyl organonitro and related compounds and pharmaceutical compounds for use in medicine |
| WO2018073591A1 (en) * | 2016-10-19 | 2018-04-26 | The Queen's University Of Belfast | Use of fkbp-l polypeptides and nucleic acids for the treatment of obesity |
| CN108362870A (zh) * | 2017-01-27 | 2018-08-03 | 武汉三鹰生物技术有限公司 | 一种用于人fkbpl蛋白的酶联免疫检测及制备方法 |
| CA3069004A1 (en) | 2017-07-07 | 2019-01-10 | Epicentrx, Inc. | Compositions for parenteral administration of therapeutic agents |
| WO2019164593A2 (en) | 2018-01-08 | 2019-08-29 | Epicentrx, Inc. | Methods and compositions utilizing rrx-001 combination therapy for radioprotection |
| CN111603567B (zh) * | 2019-02-22 | 2024-12-27 | 赣江新区博瑞创新医药有限公司 | Cd44靶向多臂偶联物 |
| CN113702632A (zh) * | 2021-09-02 | 2021-11-26 | 深圳市光与生物科技有限公司 | 一种快速检测子痫前期的免疫层析检测卡及其制备方法与应用 |
| CN114702564A (zh) * | 2021-12-15 | 2022-07-05 | 江苏省人民医院（南京医科大学第一附属医院） | 一种外泌体肽及其制备方法和应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3194732A (en) | 1960-10-03 | 1965-07-13 | Neuhauser Irene | Assisting healing of skin-denuded areas on the body with dried non-fibrous egg-shellmembrane products and compositions therefor |
| US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| AU7757581A (en) | 1980-11-19 | 1982-05-27 | United Energy Technologies Inc. | Enhanced surface tubing |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4485045A (en) * | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| EP0088046B1 (de) | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipide in wässriger Phase |
| DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
| US4630115A (en) | 1983-05-09 | 1986-12-16 | The General Electric Company, P.L.C. | Cathode ray tube display device |
| US4544545A (en) * | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| DE3474511D1 (en) | 1983-11-01 | 1988-11-17 | Terumo Corp | Pharmaceutical composition containing urokinase |
| JP3065628B2 (ja) * | 1988-12-19 | 2000-07-17 | 三井化学株式会社 | ヒト免疫グロブリン遺伝子関連ｄｎａ断片及び該ｄｎａ断片を用いる診断方法 |
| US5766883A (en) * | 1989-04-29 | 1998-06-16 | Delta Biotechnology Limited | Polypeptides |
| FR2650598B1 (fr) | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | Derives de l'albumine a fonction therapeutique |
| US5073627A (en) * | 1989-08-22 | 1991-12-17 | Immunex Corporation | Fusion proteins comprising GM-CSF and IL-3 |
| AU648140B2 (en) | 1991-02-01 | 1994-04-14 | Virtual Drug Development, Inc. | Reverse antimicrobial peptides and antimicrobial compositions |
| IL99120A0 (en) * | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
| FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| WO1994010308A1 (en) | 1992-10-23 | 1994-05-11 | Immunex Corporation | Methods of preparing soluble, oligomeric proteins |
| US5359030A (en) * | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| US5681811A (en) * | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
| DK0706563T3 (da) * | 1993-06-29 | 2005-01-31 | Chiron Corp | Afkortet keratonocyt-vækstfaktor (KGF) med foröget biologisk aktivetet |
| ES2224178T3 (es) * | 1995-10-11 | 2005-03-01 | Chiron Corporation | Cobinacion de pdgf, kgf,igf e igfbp para la cicatrizacion de heridas. |
| EP0980432A1 (en) | 1997-05-01 | 2000-02-23 | Amgen, Inc. | Chimeric opg polypeptides |
| US6583168B1 (en) | 1997-11-25 | 2003-06-24 | Applera Corporation | Sulfonated diarylrhodamine dyes |
| US6180095B1 (en) * | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| WO1999065939A1 (en) | 1998-06-18 | 1999-12-23 | Curagen Corporation | INTERACTION OF p27(KIP1) WITH FKBP-12 |
| CN1281465A (zh) * | 1998-10-09 | 2001-01-24 | 上海第二医科大学 | 人fk506结合蛋白(fkbp) |
| WO2000061687A1 (en) | 1999-04-13 | 2000-10-19 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Cyanine dye |
| RU2245722C2 (ru) * | 1999-06-22 | 2005-02-10 | Рисерч Дивелопмент Фаундейшн | Усовершенствованное раневое покрытие для улучшения заживления ран |
| JP2003504024A (ja) * | 1999-07-06 | 2003-02-04 | インサイト・ゲノミックス・インコーポレイテッド | ヒト免疫応答分子 |
| US6413507B1 (en) * | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
| US20030125246A9 (en) * | 2000-01-31 | 2003-07-03 | Rosen Craig A. | Nucleic acids, proteins, and antibodies |
| EP2316976A1 (en) * | 2000-11-28 | 2011-05-04 | Wyeth LLC | Expression analysis of FKBP nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer |
| WO2002068579A2 (en) * | 2001-01-10 | 2002-09-06 | Pe Corporation (Ny) | Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof |
| US7235358B2 (en) * | 2001-06-08 | 2007-06-26 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| KR100702373B1 (ko) * | 2001-06-22 | 2007-04-02 | 에프. 호프만-라 로슈 아게 | 레트로바이러스 표면 당단백질을 함유하는 가용성 복합체 |
| US6856185B2 (en) * | 2001-10-23 | 2005-02-15 | Arris International, Inc. | Simple RMS to DC converter |
| US20040053388A1 (en) * | 2002-01-03 | 2004-03-18 | Eckert Jorg H. | Detection of protein conformation using a split ubiquitin reporter system |
| US20040047835A1 (en) * | 2002-09-06 | 2004-03-11 | Cell Therapeutics, Inc. | Combinatorial drug therapy using polymer drug conjugates |
| US20070105133A1 (en) * | 2005-06-13 | 2007-05-10 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
-
2006
- 2006-06-09 GB GBGB0611405.2A patent/GB0611405D0/en not_active Ceased
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2007
- 2007-06-08 ES ES07733118.9T patent/ES2548332T3/es active Active
- 2007-06-08 SI SI200731701T patent/SI2040728T1/sl unknown
- 2007-06-08 CN CN2007800276683A patent/CN101489575B/zh not_active Expired - Fee Related
- 2007-06-08 NZ NZ600690A patent/NZ600690A/en not_active IP Right Cessation
- 2007-06-08 PL PL07733118T patent/PL2040728T3/pl unknown
- 2007-06-08 EP EP07733118.9A patent/EP2040728B1/en not_active Not-in-force
- 2007-06-08 HU HUE07733118A patent/HUE028099T2/en unknown
- 2007-06-08 NZ NZ573425A patent/NZ573425A/en not_active IP Right Cessation
- 2007-06-08 CA CA2657947A patent/CA2657947C/en not_active Expired - Fee Related
- 2007-06-08 AU AU2007255196A patent/AU2007255196B2/en not_active Ceased
- 2007-06-08 DK DK07733118.9T patent/DK2040728T3/en active
- 2007-06-08 PT PT77331189T patent/PT2040728E/pt unknown
- 2007-06-08 JP JP2009513764A patent/JP5474535B2/ja not_active Expired - Fee Related
- 2007-06-08 US US12/303,343 patent/US9381228B2/en not_active Expired - Fee Related
- 2007-06-08 WO PCT/GB2007/002107 patent/WO2007141533A2/en not_active Ceased
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2008
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- 2008-12-04 ZA ZA2008/10323A patent/ZA200810323B/en unknown
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2015
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2016
- 2016-05-31 US US15/169,460 patent/US10577406B2/en not_active Expired - Fee Related
- 2016-05-31 US US15/169,452 patent/US20160340401A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007141533A3 (en) | 2008-07-31 |
| CN101489575B (zh) | 2013-08-28 |
| JP2009539367A (ja) | 2009-11-19 |
| DK2040728T3 (en) | 2015-10-26 |
| CY1116970T1 (el) | 2017-04-05 |
| EP2040728B1 (en) | 2015-09-02 |
| IL195580A0 (en) | 2011-08-01 |
| US9381228B2 (en) | 2016-07-05 |
| ES2548332T3 (es) | 2015-10-15 |
| AU2007255196A1 (en) | 2007-12-13 |
| ZA200810323B (en) | 2013-05-29 |
| GB0611405D0 (en) | 2006-07-19 |
| AU2007255196B2 (en) | 2013-10-03 |
| EP2040728A2 (en) | 2009-04-01 |
| NZ573425A (en) | 2012-07-27 |
| US20090192085A1 (en) | 2009-07-30 |
| PL2040728T3 (pl) | 2016-02-29 |
| CN101489575A (zh) | 2009-07-22 |
| CA2657947A1 (en) | 2007-12-13 |
| IL195580A (en) | 2013-07-31 |
| JP5474535B2 (ja) | 2014-04-16 |
| WO2007141533A2 (en) | 2007-12-13 |
| SI2040728T1 (sl) | 2015-12-31 |
| US10577406B2 (en) | 2020-03-03 |
| US20160340401A1 (en) | 2016-11-24 |
| HUE028099T2 (en) | 2016-11-28 |
| PT2040728E (pt) | 2015-10-29 |
| US20160340402A1 (en) | 2016-11-24 |
| NZ600690A (en) | 2014-03-28 |
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