|
WO1992007065A1
(en)
|
1990-10-12 |
1992-04-30 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Modified ribozymes
|
|
US5652094A
(en)
|
1992-01-31 |
1997-07-29 |
University Of Montreal |
Nucleozymes
|
|
EP1903054A3
(de)
|
2001-06-05 |
2008-07-23 |
CureVac GmbH |
Stabilisierte mRNA mit erhöhtem G/C-Gehalt und optimierter Codon Usage für die Gentherapie
|
|
CA2530248A1
(en)
|
2003-06-25 |
2005-01-06 |
Gencia Corporation |
Modified vectors for organelle transfection
|
|
WO2005056752A2
(en)
|
2003-10-24 |
2005-06-23 |
Gencia Corporation |
Methods and compositions for delivering polynucleotides
|
|
HUE043492T2
(hu)
|
2005-08-23 |
2019-08-28 |
Univ Pennsylvania |
Módosított nukleozidokat tartalmazó RNS és eljárások az alkalmazására
|
|
WO2008016473A2
(en)
|
2006-07-28 |
2008-02-07 |
Applera Corporation |
Dinucleotide mrna cap analogs
|
|
WO2009058911A2
(en)
|
2007-10-31 |
2009-05-07 |
Applied Biosystems Inc. |
Preparation and isolation of 5' capped mrna
|
|
JP5697988B2
(ja)
|
2007-12-27 |
2015-04-08 |
プロチバ バイオセラピューティクス インコーポレイティッド |
干渉rnaを使用したポロ様キナーゼ発現のサイレンシング方法
|
|
JP5749494B2
(ja)
|
2008-01-02 |
2015-07-15 |
テクミラ ファーマシューティカルズ コーポレイション |
核酸の送達のための改善された組成物および方法
|
|
NZ588583A
(en)
|
2008-04-15 |
2012-08-31 |
Protiva Biotherapeutics Inc |
Novel lipid formulations for nucleic acid delivery
|
|
WO2010037408A1
(en)
|
2008-09-30 |
2010-04-08 |
Curevac Gmbh |
Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
|
|
JP5777519B2
(ja)
|
2008-10-09 |
2015-09-09 |
テクミラ ファーマシューティカルズ コーポレイション |
改良されたアミノ脂質および核酸の送達方法
|
|
WO2010048536A2
(en)
|
2008-10-23 |
2010-04-29 |
Alnylam Pharmaceuticals, Inc. |
Processes for preparing lipids
|
|
EP4241767B1
(en)
|
2008-11-10 |
2024-10-23 |
Arbutus Biopharma Corporation |
Novel lipids and compositions for the delivery of therapeutics
|
|
US20120101148A1
(en)
|
2009-01-29 |
2012-04-26 |
Alnylam Pharmaceuticals, Inc. |
lipid formulation
|
|
SG176553A1
(en)
|
2009-05-05 |
2012-01-30 |
Muthiah Manoharan |
Lipid compositions
|
|
TR201811076T4
(tr)
|
2009-06-10 |
2018-08-27 |
Arbutus Biopharma Corp |
Geliştirilmiş lipit formulasyonu.
|
|
KR101161622B1
(ko)
*
|
2009-08-31 |
2012-07-04 |
헬릭스 주식회사 |
번역 효율 증진용 dna 단편 및 이를 포함하는 재조합 벡터
|
|
PL3338765T3
(pl)
|
2009-12-01 |
2019-06-28 |
Translate Bio, Inc. |
Pochodna steroidowa dla dostarczania mrna w ludzkich chorobach genetycznych
|
|
CA2800401C
(en)
|
2010-06-03 |
2020-09-15 |
Alnylam Pharmaceuticals, Inc. |
Biodegradable lipids for the delivery of active agents
|
|
WO2012000104A1
(en)
|
2010-06-30 |
2012-01-05 |
Protiva Biotherapeutics, Inc. |
Non-liposomal systems for nucleic acid delivery
|
|
PT2717893T
(pt)
|
2011-06-08 |
2019-08-20 |
Translate Bio Inc |
Composições de nanopartículas lipídicas e métodos para transferência de arnm
|
|
EP2763701B1
(en)
|
2011-10-03 |
2018-12-19 |
Moderna Therapeutics, Inc. |
Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
|
|
EP4721752A2
(en)
|
2011-12-30 |
2026-04-08 |
Cellscript, Llc |
Herstellung und verwendung von in vitro-synthetisierter ssrna zur einführung in säugetierzellen zur induktion einer biologischen oder biochemischen wirkung
|
|
US9254311B2
(en)
|
2012-04-02 |
2016-02-09 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
|
US20140090108A1
(en)
|
2012-09-18 |
2014-03-27 |
Freydoun Garabagi |
Vectors and Methods For Enhancing Recombinant Protein Expression in Plants
|
|
EP2931319B1
(en)
|
2012-12-13 |
2019-08-21 |
ModernaTX, Inc. |
Modified nucleic acid molecules and uses thereof
|
|
CA2901969A1
(en)
|
2013-02-20 |
2014-08-28 |
Valerion Therapeutics, Llc |
Methods and compositions for treatment of forbes-cori disease
|
|
US20160022840A1
(en)
|
2013-03-09 |
2016-01-28 |
Moderna Therapeutics, Inc. |
Heterologous untranslated regions for mrna
|
|
US8912147B2
(en)
*
|
2013-04-15 |
2014-12-16 |
BioBlast Pharma Ltd. |
Mitochondrial proteins constructs and uses thereof
|
|
AU2014296278C1
(en)
*
|
2013-07-30 |
2023-02-02 |
Genevant Sciences Gmbh |
Block copolymers and their conjugates or complexes with oligonucleotides
|
|
WO2015051169A2
(en)
|
2013-10-02 |
2015-04-09 |
Moderna Therapeutics, Inc. |
Polynucleotide molecules and uses thereof
|
|
MX2016005239A
(es)
|
2013-10-22 |
2016-08-12 |
Shire Human Genetic Therapies |
Tratamiento con acido ribonucleico mensajero para la fenilcetonuria.
|
|
NZ720174A
(en)
|
2013-11-18 |
2018-11-30 |
Arcturus Therapeutics Inc |
Ionizable cationic lipid for rna delivery
|
|
JP6822841B2
(ja)
|
2014-03-09 |
2021-01-27 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
オルニチントランスカルバミラーゼ(otc)欠損症の処置において有用な組成物
|
|
WO2015192092A1
(en)
|
2014-06-13 |
2015-12-17 |
Valerion Therapeutics, Llc |
Methods and compositions for treatment of glycogen storage diseases and glycogen metabolism disorders
|
|
AU2015338923B2
(en)
|
2014-11-02 |
2021-10-21 |
Arcturus Therapeutics, Inc. |
Messenger UNA molecules and uses thereof
|
|
EP3218508A4
(en)
|
2014-11-10 |
2018-04-18 |
Modernatx, Inc. |
Multiparametric nucleic acid optimization
|
|
WO2016077125A1
(en)
|
2014-11-10 |
2016-05-19 |
Moderna Therapeutics, Inc. |
Alternative nucleic acid molecules containing reduced uracil content and uses thereof
|
|
HK1244479A1
(zh)
|
2014-11-18 |
2018-08-10 |
阿克丘勒斯治疗公司 |
用於rna递送的可电离阳离子脂质
|
|
US9709490B2
(en)
|
2014-12-08 |
2017-07-18 |
Canon Kabushiki Kaisha |
Refractive index distribution measuring method, refractive index distribution measuring apparatus, and optical element manufacturing method
|
|
CN114642735A
(zh)
*
|
2015-01-21 |
2022-06-21 |
菲泽尔克斯公司 |
用于将治疗剂和诊断剂递送到细胞中的方法、组合物和系统
|
|
CN108136040B
(zh)
|
2015-07-31 |
2022-03-01 |
阿克丘勒斯治疗公司 |
用于药物递送的多配体试剂
|
|
HUE064227T2
(hu)
|
2015-09-21 |
2024-02-28 |
Trilink Biotechnologies Llc |
Módszer 5'-sapkával ellátott rns-ek szintetizálására
|
|
WO2017100551A1
(en)
|
2015-12-09 |
2017-06-15 |
Alexion Pharmaceuticals, Inc. |
HETEROLOGOUS UTR SEQUENCES FOR ENHANCED mRNA EXPRESSION
|
|
US9834510B2
(en)
|
2015-12-30 |
2017-12-05 |
Arcturus Therapeutics, Inc. |
Aromatic ionizable cationic lipid
|
|
CN109312313A
(zh)
|
2016-06-13 |
2019-02-05 |
川斯勒佰尔公司 |
用于治疗鸟氨酸转氨甲酰酶缺乏症的信使rna疗法
|
|
IL308824A
(en)
|
2016-08-17 |
2024-01-01 |
Factor Bioscience Inc |
Nucleic acid products and methods of administration thereof
|
|
WO2018075827A1
(en)
|
2016-10-19 |
2018-04-26 |
Arcturus Therapeutics, Inc. |
Trinucleotide mrna cap analogs
|
|
MX2019004913A
(es)
|
2016-10-26 |
2019-09-16 |
Curevac Ag |
Vacunas de nanoparticulas lipidicas que comprenden acido ribonucleico mensajero (arnm).
|
|
JP7560946B2
(ja)
|
2016-11-10 |
2024-10-03 |
トランスレイト バイオ, インコーポレイテッド |
メッセンジャーrnaの皮下送達
|
|
WO2018119163A1
(en)
|
2016-12-21 |
2018-06-28 |
Payne Joseph E |
Ionizable cationic lipid for rna delivery
|
|
US10526284B2
(en)
|
2016-12-21 |
2020-01-07 |
Arcturus Therapeutics, Inc. |
Ionizable cationic lipid for RNA delivery
|
|
US10383952B2
(en)
|
2016-12-21 |
2019-08-20 |
Arcturus Therapeutics, Inc. |
Ionizable cationic lipid for RNA delivery
|
|
WO2018127382A1
(en)
*
|
2017-01-03 |
2018-07-12 |
Ethris Gmbh |
Ornithine transcarbamylase coding polyribonucleotides and formulations thereof
|
|
US10227302B2
(en)
|
2017-02-09 |
2019-03-12 |
Arcturus Therapeutics, Inc. |
Ionizable cationic lipid for RNA delivery
|
|
US11407800B2
(en)
|
2017-02-28 |
2022-08-09 |
Arcturus Therapeutics, Inc. |
Translatable molecules and synthesis thereof
|
|
US11377643B2
(en)
|
2017-05-31 |
2022-07-05 |
Ultragenyx Pharmaceutical Inc. |
Therapeutics for glycogen storage disease type III
|
|
WO2018222890A1
(en)
|
2017-05-31 |
2018-12-06 |
Arcturus Therapeutics, Inc. |
Synthesis and structure of high potency rna therapeutics
|
|
EP3714048B1
(en)
|
2017-11-22 |
2025-04-09 |
ModernaTX, Inc. |
Polynucleotides encoding ornithine transcarbamylase for the treatment of urea cycle disorders
|
|
US11167043B2
(en)
|
2017-12-20 |
2021-11-09 |
Translate Bio, Inc. |
Composition and methods for treatment of ornithine transcarbamylase deficiency
|
|
PL3891274T3
(pl)
|
2018-12-06 |
2024-03-25 |
Arcturus Therapeutics, Inc. |
Kompozycje i sposoby leczenia niedoboru transkarbamylazy ornityny
|
|
CA3133858A1
(en)
|
2019-03-19 |
2020-09-24 |
Arcturus Therapeutics, Inc. |
Method of making lipid-encapsulated rna nanoparticles
|
|
WO2021178510A1
(en)
|
2020-03-03 |
2021-09-10 |
Arcturus Therapeutics, Inc. |
Compositions and methods for the treatment of ornithine transcarbamylase deficiency
|