|
ES2061416T3
(es)
|
1990-10-12 |
1997-03-01 |
Max Planck Gesellschaft |
Ribozimas modificadas.
|
|
US5652094A
(en)
|
1992-01-31 |
1997-07-29 |
University Of Montreal |
Nucleozymes
|
|
ES2340499T3
(es)
|
2001-06-05 |
2010-06-04 |
Curevac Gmbh |
Arnm de antigeno tumoral estabilizado con un contenido de g/c aumentado.
|
|
CA2530248A1
(en)
|
2003-06-25 |
2005-01-06 |
Gencia Corporation |
Modified vectors for organelle transfection
|
|
CA2543257C
(en)
*
|
2003-10-24 |
2013-12-31 |
Gencia Corporation |
Methods and compositions for delivering polynucleotides
|
|
PL2578685T3
(pl)
|
2005-08-23 |
2020-01-31 |
The Trustees Of The University Of Pennsylvania |
Rna zawierający zmodyfikowane nukleozydy i sposoby jego zastosowania
|
|
US8304529B2
(en)
|
2006-07-28 |
2012-11-06 |
Life Technologies Corporation |
Dinucleotide MRNA cap analogs
|
|
WO2009058911A2
(en)
|
2007-10-31 |
2009-05-07 |
Applied Biosystems Inc. |
Preparation and isolation of 5' capped mrna
|
|
ES2535419T3
(es)
|
2007-12-27 |
2015-05-11 |
Protiva Biotherapeutics Inc. |
Silenciamiento de expresión de quinasa tipo polo usando ARN interferente
|
|
WO2009086558A1
(en)
|
2008-01-02 |
2009-07-09 |
Tekmira Pharmaceuticals Corporation |
Improved compositions and methods for the delivery of nucleic acids
|
|
CA2721333C
(en)
|
2008-04-15 |
2020-12-01 |
Protiva Biotherapeutics, Inc. |
Novel lipid formulations for nucleic acid delivery
|
|
WO2010037408A1
(en)
|
2008-09-30 |
2010-04-08 |
Curevac Gmbh |
Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
|
|
CA2740000C
(en)
|
2008-10-09 |
2017-12-12 |
Tekmira Pharmaceuticals Corporation |
Improved amino lipids and methods for the delivery of nucleic acids
|
|
WO2010048536A2
(en)
|
2008-10-23 |
2010-04-29 |
Alnylam Pharmaceuticals, Inc. |
Processes for preparing lipids
|
|
CN111808084A
(zh)
|
2008-11-10 |
2020-10-23 |
阿布特斯生物制药公司 |
用于递送治疗剂的新型脂质和组合物
|
|
EP3243504A1
(en)
|
2009-01-29 |
2017-11-15 |
Arbutus Biopharma Corporation |
Improved lipid formulation
|
|
SG10201911942UA
(en)
|
2009-05-05 |
2020-02-27 |
Muthiah Manoharan |
Lipid compositions
|
|
KR101766408B1
(ko)
|
2009-06-10 |
2017-08-10 |
알닐람 파마슈티칼스 인코포레이티드 |
향상된 지질 조성물
|
|
KR101161622B1
(ko)
*
|
2009-08-31 |
2012-07-04 |
헬릭스 주식회사 |
번역 효율 증진용 ｄｎａ 단편 및 이를 포함하는 재조합 벡터
|
|
EP3318248B1
(en)
|
2009-12-01 |
2019-04-10 |
Translate Bio, Inc. |
Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases
|
|
KR20190039347A
(ko)
|
2010-06-03 |
2019-04-10 |
알닐람 파마슈티칼스 인코포레이티드 |
활성제의 전달을 위한 생분해성 지질
|
|
US9006417B2
(en)
|
2010-06-30 |
2015-04-14 |
Protiva Biotherapeutics, Inc. |
Non-liposomal systems for nucleic acid delivery
|
|
RU2013154295A
(ru)
|
2011-06-08 |
2015-07-20 |
Шир Хьюман Дженетик Терапис, Инк. |
КОМПОЗИЦИИ ЛИПИДНЫХ НАНОЧАСТИЦ И СПОСОБЫ ДЛЯ ДОСТАВКИ мРНК
|
|
DE19216461T1
(de)
|
2011-10-03 |
2021-10-07 |
Modernatx, Inc. |
Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
|
|
EP3144389B1
(en)
|
2011-12-30 |
2018-05-09 |
Cellscript, Llc |
Making and using in vitro-synthesized ssrna for introducing into mammalian cells to induce a biological or biochemical effect
|
|
US9254311B2
(en)
|
2012-04-02 |
2016-02-09 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
|
US20140090108A1
(en)
|
2012-09-18 |
2014-03-27 |
Freydoun Garabagi |
Vectors and Methods For Enhancing Recombinant Protein Expression in Plants
|
|
WO2014093924A1
(en)
|
2012-12-13 |
2014-06-19 |
Moderna Therapeutics, Inc. |
Modified nucleic acid molecules and uses thereof
|
|
WO2014130722A1
(en)
|
2013-02-20 |
2014-08-28 |
Valerion Therapeutics, Llc |
Methods and compositions for treatment of forbes-cori disease
|
|
US20160022840A1
(en)
|
2013-03-09 |
2016-01-28 |
Moderna Therapeutics, Inc. |
Heterologous untranslated regions for mrna
|
|
US8912147B2
(en)
|
2013-04-15 |
2014-12-16 |
BioBlast Pharma Ltd. |
Mitochondrial proteins constructs and uses thereof
|
|
AU2014296278C1
(en)
|
2013-07-30 |
2023-02-02 |
Genevant Sciences Gmbh |
Block copolymers and their conjugates or complexes with oligonucleotides
|
|
EP3052511A4
(en)
|
2013-10-02 |
2017-05-31 |
Moderna Therapeutics, Inc. |
Polynucleotide molecules and uses thereof
|
|
JP6506749B2
(ja)
|
2013-10-22 |
2019-04-24 |
シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド |
フェニルケトン尿症のためのｍＲＮＡ療法
|
|
AU2014348212C1
(en)
|
2013-11-18 |
2018-11-29 |
Arcturus Therapeutics, Inc. |
Ionizable cationic lipid for RNA delivery
|
|
SMT202000531T1
(it)
|
2014-03-09 |
2020-11-10 |
Univ Pennsylvania |
Composizioni utili in trattamento di deficit di ornitina transcarbamilasi(otc)
|
|
WO2015192092A1
(en)
|
2014-06-13 |
2015-12-17 |
Valerion Therapeutics, Llc |
Methods and compositions for treatment of glycogen storage diseases and glycogen metabolism disorders
|
|
AU2015338923B2
(en)
|
2014-11-02 |
2021-10-21 |
Arcturus Therapeutics, Inc. |
Messenger UNA molecules and uses thereof
|
|
WO2016077125A1
(en)
|
2014-11-10 |
2016-05-19 |
Moderna Therapeutics, Inc. |
Alternative nucleic acid molecules containing reduced uracil content and uses thereof
|
|
WO2016077123A1
(en)
|
2014-11-10 |
2016-05-19 |
Moderna Therapeutics, Inc. |
Multiparametric nucleic acid optimization
|
|
JP6637988B2
(ja)
|
2014-11-18 |
2020-01-29 |
アークトゥルス セラピューティクス， インコーポレイテッド |
Ｒｎａ送達のためのイオン化可能カチオン性脂質
|
|
US9709490B2
(en)
|
2014-12-08 |
2017-07-18 |
Canon Kabushiki Kaisha |
Refractive index distribution measuring method, refractive index distribution measuring apparatus, and optical element manufacturing method
|
|
JP2018509387A
(ja)
|
2015-01-21 |
2018-04-05 |
フェーズアールエックス インコーポレイテッド |
細胞に治療および診断剤を送達するための方法、組成物、ならびにシステム
|
|
KR20180031025A
(ko)
|
2015-07-31 |
2018-03-27 |
아크투루스 쎄라퓨틱스, 인크. |
약물 전달을 위한 다중 리간드 제제
|
|
CN120842296A
(zh)
|
2015-09-21 |
2025-10-28 |
垂林克生物技术有限公司 |
用于合成5’-加帽rna的组合物和方法
|
|
WO2017100551A1
(en)
|
2015-12-09 |
2017-06-15 |
Alexion Pharmaceuticals, Inc. |
HETEROLOGOUS UTR SEQUENCES FOR ENHANCED mRNA EXPRESSION
|
|
US9834510B2
(en)
|
2015-12-30 |
2017-12-05 |
Arcturus Therapeutics, Inc. |
Aromatic ionizable cationic lipid
|
|
EP3469074B1
(en)
*
|
2016-06-13 |
2020-12-09 |
Translate Bio, Inc. |
Messenger rna therapy for the treatment of ornithine transcarbamylase deficiency
|
|
IL308824A
(en)
|
2016-08-17 |
2024-01-01 |
Factor Bioscience Inc |
Nucleic acid products and methods of administration thereof
|
|
US10487105B2
(en)
|
2016-10-19 |
2019-11-26 |
Arcturus Therapeutics, Inc. |
Trinucleotide MRNA cap analogs
|
|
CA3040337A1
(en)
|
2016-10-26 |
2018-05-03 |
Curevac Ag |
Lipid nanoparticle mrna vaccines
|
|
MA46761A
(fr)
|
2016-11-10 |
2019-09-18 |
Translate Bio Inc |
Administration sous-cutanée d'arn messager
|
|
US10526284B2
(en)
|
2016-12-21 |
2020-01-07 |
Arcturus Therapeutics, Inc. |
Ionizable cationic lipid for RNA delivery
|
|
US10383952B2
(en)
|
2016-12-21 |
2019-08-20 |
Arcturus Therapeutics, Inc. |
Ionizable cationic lipid for RNA delivery
|
|
WO2018119163A1
(en)
|
2016-12-21 |
2018-06-28 |
Payne Joseph E |
Ionizable cationic lipid for rna delivery
|
|
WO2018127382A1
(en)
|
2017-01-03 |
2018-07-12 |
Ethris Gmbh |
Ornithine transcarbamylase coding polyribonucleotides and formulations thereof
|
|
US10227302B2
(en)
|
2017-02-09 |
2019-03-12 |
Arcturus Therapeutics, Inc. |
Ionizable cationic lipid for RNA delivery
|
|
US11407800B2
(en)
|
2017-02-28 |
2022-08-09 |
Arcturus Therapeutics, Inc. |
Translatable molecules and synthesis thereof
|
|
ES3039647T3
(en)
|
2017-05-31 |
2025-10-23 |
Arcturus Therapeutics Inc |
Synthesis and structure of high potency rna therapeutics
|
|
BR112019025224A2
(pt)
|
2017-05-31 |
2020-12-08 |
Ultragenyx Pharmaceutical Inc. |
Terapêutica para doença de armazenamento de glicogênio tipo iii
|
|
CA3079428A1
(en)
|
2017-11-22 |
2019-05-31 |
Modernatx, Inc. |
Polynucleotides encoding ornithine transcarbamylase for the treatment of urea cycle disorders
|
|
US11167043B2
(en)
|
2017-12-20 |
2021-11-09 |
Translate Bio, Inc. |
Composition and methods for treatment of ornithine transcarbamylase deficiency
|
|
AU2019394996B2
(en)
|
2018-12-06 |
2025-11-06 |
Arcturus Therapeutics, Inc. |
Compositions and methods for treating ornithine transcarbamylase deficiency
|
|
SG11202110036RA
(en)
|
2019-03-19 |
2021-10-28 |
Arcturus Therapeutics Inc |
Method of making lipid-encapsulated rna nanoparticles
|
|
US12351834B2
(en)
|
2020-03-03 |
2025-07-08 |
Arcturus Therapeutics, Inc. |
Compositions and methods for the treatment of ornithine transcarbamylase deficiency
|