JP2022520148A - 修飾タンパク質および関連の処置方法 - Google Patents
修飾タンパク質および関連の処置方法 Download PDFInfo
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Abstract
Description
本出願は、2018年12月6日に出願された米国仮出願第62/776,322号の優先権を主張するものである。この出願の内容は、参照によりその全体が本明細書に組み込まれる。
本出願は、ASCIIフォーマットで電子的に提出された配列表を含んでおり、参照によりその全体が本明細書に組み込まれる。2019年12月4日に作成された前記ASCIIコピーの名称は049386_522001WO_SL.txtであり、363キロバイトのサイズである。
用語「ミトコンドリアタンパク質」とは、ミトコンドリア内に局在しているものとして同定されているタンパク質である。
本開示は、例えば、本開示の修飾タンパク質を発現するためのmRNA療法を使用する、タンパク質欠損症に関連する疾患、例えばオルニチントランスカルバミラーゼ(OTC)欠損症を処置するための改善された方法および組成物を提供する。本開示は、安定化修飾ヒトタンパク質またはそのような安定化修飾ヒトタンパク質の活性断片をコードする本明細書に記載したmRNA配列を含む組成物を、処置を必要とする対象に、タンパク質欠損症の少なくとも1つの症状または特徴が強度、重症度、もしくは頻度において低減されるか、または発症が遅延されるような有効量および投与間隔で投与することを含む、タンパク質欠損症を処置する方法を提供する。本開示はまた、野生型ヒトタンパク質と比較して、改善された特性、例えば、安定性およびタンパク質分解に対する耐性および半減期の増強などを有する、mRNA配列によってコードされている修飾タンパク質も提供する。
* OTCタンパク質は、翻訳され、ミトコンドリアへの転座に関与するシグナルペプチドを含む。このシグナルペプチドは、配列番号3および配列番号4において下線を付けた最初の32アミノ酸によって表される。配列番号4のシグナル配列はまた、配列番号3と比較して修飾されている。アミノ酸のバリンが配列番号4の3位に挿入されている。この修飾は、配列番号3の野生型ヒトOTCと比較して、配列番号4の修飾OTCのより良好なミトコンドリア局在を提供する。
好ましいmRNA配列のコンストラクトを表5に示す。
*コザック配列は、GCCACC(配列番号23)として定義されている。部分的(P)コザックは、GCCA(配列番号24)として定義されている。
**コンストラクトは、配列番号4の修飾ヒトOTCタンパク質をコードしている。
本開示によって使用するためのmRNAは、限定するものではないが、化学合成、インビトロ転写(IVT)、またはより長い前駆体の酵素的切断または化学的切断などを含む、任意の利用可能な技術によって調製することができる。RNAを合成する方法は、当技術分野において公知である。
(i)全体的なウラシル含有量の増加または減少(すなわち、核酸のセクション、例えばオープンリーディングフレームの核酸における総ヌクレオチド含有量のウラシルのパーセンテージ);または、
(ii)局所的なウラシル含有量の増加または減少(すなわち、ウラシル含有量の変化は特定のサブ配列に限定される);または、
(iii)全体的なウラシル含有量において変化を伴わないウラシル分布における変化;または、
(iv)ウラシルクラスター形成における変化(例えば、クラスターの数、クラスターの位置、もしくはクラスター間の距離);または、
(v)それらの組合せ。
本明細書に記載した修飾タンパク質は、修飾治療用タンパク質であり得る。目的の治療用ヒト野生型タンパク質は、本明細書に記載した修飾に適している。いくつかの実施形態では、治療用タンパク質は、細胞内抗体であり得る。例示的な治療用タンパク質には、限定するものではないが、以下のヒト野生型タンパク質の活性を有する本開示の修飾治療用タンパク質が含まれる:
AIBG; AICF; A2M; A2MLI: A4GNT; AAAS; AACS: AADAC; AAGAB; AAKI; AANAT; AARD; AARS2; AARS; AASDH; AASDHPPT;
AASS; AATF; AATK; ABAT; ABCAI2; ABCAI3; ABCAI; ABCA2; ABCA3; ABCA5; ABCAB; ABCA7; ABCA9; ABCBII; ABCBI; ABCB4; ABCB5;
ABCB6; ABCB7; ABCB8; ABCB9; ABCCIO; ABCCII; ABCCI2; ABCCI; ABCC2; ABCC3; ABCC4; ABCC5; ABCC6; ABCC8; ABCC9; ABCDI;
ABCD2; ABCD3; ABCD4; ABCEI; ABCFI; ABCF2; ABCGI; ABCG2; ABCG4; ABCG5; ABCG8; ABHDI2B; ABHDI2; ABHDIBA; ABHDI7B; ABHD2;
ABHD5; ABHDB; ABII; ABI2; ABI3BP; ABI3; ABU; ABL2; ABLIMI: ABLIM2; ABO; ABRA; ABR; ABTI; ACAAI; ACAA2; ACACA; ACACB5; ACADIO; ACAD8; ACAD9: ACADL; ACADSB; ACADS; ACADVL; ACAN; ACATI; ACAT2; ACBD3; ACBD4; ACBD5; ACBDB; ACCS; ACD; ACE2;
ACE; ACER2; ACER3; ACHE; ACINI; ACKRI; ACKR2; ACKR3; ACKR4; ACLY; ACMSD; ACDI: AC02; AC0TI3; ACOTI; ACDT2; AC0T9; ACDXI;
AC0X2; AC0X3; AC0XL; ACPI; ACP2; ACP5; ACP6; ACPP; ACRBP; ACRC; ACR; ACVI; ACSBGI; ACSBG2; ACSF3; ACSLI; ACSL3; ACSL5;
ACSLB; ACSMI; ACSM2B; ACS3; ACSSI; ACSS2; ACSS3; ACTAI; ACTA2; ACTB; ACTBL2; ACTCI; ACTGI; ACTG2; ACTLBA; ACTLBB;
ACTL8; ACTL9; ACTNI; ACTN2; ACTN3; ACTN4; ACTRIA; ACTRIB; ACTR2; ACTR3B; ACTR3; ACTR5; ACTRTI; ACVRIB; ACVRIC; ACVRIO; ACVR2A; ACVR2B; ACVRLI; ACYI; ACY3; ACYP2; ADADI; ADA; ADAMIO; ADAMII; ADAMI2; ADAMI5; ADAMI7; ADAMI9; ADAM20; ADAM2I;
ADAM22; ADAM23; ADAM28; ADAM29; ADAM2; ADAM33; ADAM7; ADAM8; ADAM9; ADAMDECI: ADAMTSIO; ADAMTSI2; ADAMTSI3;
ADAMTSI4; ADAMTSI5; ADAMTSIB; ADAMTSI7; ADAMTSI8; ADAMTSI9; ADAMTSI; ADAMTS20; ADAMTS2; ADAMTS3; ADANTS4;
ADAMTS5; ADAMTSB; ADAMTS7; ADAMTSB; ADAMTS9; ADAMTSLI; ADAMTSL2; ADAMTSL3; ADAMTSL4; ADAMTSL5; ADAPI; ADAP2;
ADARBI; ADARB2; ADAR; ADAT2; ADAT3; ADCK3; ADCK4; ADCYIO; AOCYI; ADCY2; ADCY3; ADCY5; ADCYB; ADCY7; ADCY8; ADCY9; ADCYAPI; ADCYAPIRI; ADD1; ADD2; ADD3; ADGB; ADGRAI; ADGRA2; ADGRA3; ADGRBI; ADGRB2; ADGRB3; ADGRDI; ADGRD2; ADBREI; ADGREZ; ADGRE5; ADGRF5; ADGRGI; ADGRGZ; ADGRG3; ADGRGB; ADGRG7; ADGRL1; ADGRL3; ADGRVI; AOHIA; ADHIB; ADH4; ADH5;
ADHB; ADH7; ADHFEI; AOIt; AOIG; ADIPBD; ADIPBRI; ADIPDR2; ADIRF; ADK; ADM2; ADM; ADNP; ADO; ADDRAI; AD0RA2A; AD0RA2B;
ADPGK; ADPRH; ADPRHL1; ADPRHL2; ADRAIA; ADRAIB; ADRAID; ADRA2A; ADRA2B; ADRA2C; ADRBI; ADRB2; ADRB3; AORB1; ADRBK2;
ADRMI; ADSL; ADSS; ADSSLI; ADTRP; AEBP2; AEN; AES; AFAPI; AFAPIL; AFAPIL2; AFFI; AFF2; AFF3; AFF4; AFG3L2; AF; AFP; AGA; AGAPt; AGAP2; AGAP3; AGAP4; AGBLI; AGBL2; AGBL3; AGBL4; AGER; AGFGI; AGFG2; AGGFI; AG; AGMD; AGD2; ABPATI: AGPAT2;
AGPAT3; AGPAT4; AGPAT9; AGPS; AGR2; AGR3; ABRN; AGRP; AGT; AGTPBPI; AGTRI; AGTR2; AGXT2; AGXT; AHCY; AHCYL2; AHII;
AHNAK; AHR; AHRR; AHSAI; AHSA2; AHSG; AICDA; AIDA; AIR: AIFMI: AIFM2; AIFM3; AIGI: AIM1: AIM2; AIP1; AIMP2; AIP: AIPLI; AIRE;
AJAPI; AJUBA; AI; A3; AB; AK7; AK8; AK9; AKAPID; AKAPI2; AKAPI3; AKAPI7A; AKAPI; AKAP2; AKAP3; AKAP4; AKAP5; AKAPB;
AAP7; AKAPB; AIPI: AKIRIN2; ANA; AKRIBID; AKRIBI; AICI: AKRIC2; AKRIC3; AKRIC4; AKRIDI; AKRIE2; AKR7A3; AKTI; AKTISI; ID AKT2; AKT3; AKTIP; ALAD; ALASI; ALAS2; ALB; ALCAM; ALDHIBAI: ALDHI8AI: ALDHIAI: ALDHIA2; ALDHIA3; ALDHIBI; ALDHIU; ALDH2;
ALDH3AI; ALDH3A2; ALDH3BI: ALDH4AI; ALDH5AI: ALDHBAI: ALDH7AI: ALDH9AI: ALDDA; ALDDB; ALDDC; ALGIOB; ALGIQ; ALGII; ALGI2;
ALGI3; ALGI; ALGIL; ALG2; ALG3; ALG8; ALG9; ALKBHI; ALKBH2; ALKBH3; ALKBH7; ALKBH8; ALK; ALLC; ALMSI; ALDXI2B; ALDXI2;
AL0XI5B; ALDXI5; ALDX5AP; AL0X5; ALDXE3; ALPI: ALPKI; ALPK2; ALPK3; ALPP; ALPPL2; ALS2CL; ALS2CRI2; ALS2; ALXI; ALX4;
ALYREF; AMACR; AMBN; AMBP; AMBRAI; AMDI; AMELX; AMELY; AMERI; AMER2; AMER3; AMFR; AMH; AMHR2; AMICAI; AMIGD2; 15 AMMECRI; AMN; AMOT; AMDTLI: AMPD2; AMPD3; AMPH; AMT; AMZI; ANAPCIO; ANAPCII; ANAPCI3; ANAPCl; ANAPC2; ANAPC4; ANAPC5;
ANAPC7; ANG; ANGPTI; ANGPT2; ANGPT4; ANGPTLI: ANGPTL2; ANGPTL4; ANGPTLG; ANKI; ANK2; ANK3; AN FNI: ANKFYI: ANKHDI-EIF4EBP3; ANKHD1; ANKH; ANKKt; ANKLEI; ANKLE2; ANKMYI; ANKRDIO; ANKRDII; ANKRDI2; ANKRDI8A; ANKRDI; ANKRD23; ANKRD2B;
ANKRD28; ANKRD2; ANKRD3DA; ANKRD3BB; ANKRD3B; ANKRD37; ANKRD44; ANKRD45; ANKRD4B; ANK D5D; ANKRD55; ANKRDB;
ANKRD7; ANKSIA; ANKSIB; ANKS4B; ANKSB; ANLN; ANDID; ANDI; AN02; AN03; AND4; AND5; AN06; AND7; ANP32A; ANP32B; ANP32D;0 ANPEP; ANTXRI; ANTXR2; ANXAID; ANXAII; ANXAI3; ANXAI: ANXA2; ANXA2R; ANXA3; ANXA4; ANXA5; ANXAB; ANXA7; ANXA8; ANXABLI;
ADAH; AOCI; AOC2; AOC3; ADXI: APIAR; APIBI; APIGI; APIMI; APIM2; APISI; APIS2; APIS3; AP2AI; APZBI; AP2MI; AP2SI; AP3BI; AP3DI;
AP3M2; AP3SI; AP3S2; AP4BI; AP4EI; AP4MI; AP4SI: AP5MI: AP5ZI; APAFI; APBAI; APBA2; APBA3; APBBI; APBBIIP; APBB2; APBB3;
APC2; APCDDI; APCDDIL; APC; APCS; APEH; APEXI; APEX2; APHIB; APIS; APIP; APLN; APLNR; APLPI; APLP2; APDAIBP; AP0A2; AP0A4;
APDA5; APDBECI; APDBEC2; APDBEC3AJ; AP0BEC3B; APDBEC3C; APDBEC3F; APDBEC3G; AP0BEC3H; APDB; APOBR; APOC5; APDC2; AP0C3; AP0C4; APDD; APDE; APDF; APDH; APDLI: APDL2; APDL3; AP0L4; APOLB; APOLDI: APDM; APDD; APOPTI: APPBP2;
APP; APPLI; APPL2; APRT; APTX; AflPID; ADPI; A0P2; ADP3; ADP4; ADP5; ADPB; ADP7; ADP8; ADP9; ARAF; ARAPI; ARAP3; ARC;
ARCNI; AREG; ARFI; ARF3; ARF4; ARFB; AFGAPI; ARFGAP2; ARFGAP3; ARFGEFI; ARFGEF2; ARFGEF3; AFiPf; ARFRPI: ARB1; ARGLUI;
ARHGAPID; ARHGAPIIA; ARHGAPIIB; ARHGAPI5; ARHGAPI8; ARHGAPI; ARHGAP2D; ARHGAP2I; ARHGAP22; ARHGAP23; ARHGAP24;
ARHGAP25; ARHGAP2B; ARHGAP27; ARHGAP28; ARHGAP30; ARHGAP3I; ARHGAP32; ARHGAP35; ARHGAP42; ARHGAP4; ARHGAP5;D ARHGAPB; ARHGAP9; ARHGDIA; ARHGDIB; ARHGEFIO; ARHGEFIDL; ARHGEFII: ARHGEFI2; ARHGEFI5; ARHGEFIB; ARHGEFI7; ARHGEFI:
ARHGEF25; ARHGEF2B; ARHGEF28; ARHGEF2; ARHGEF38; ARHGEF3; ARHGEF4; ARHGEF5; ARHGEFB; ARHGEF7; ARHGEF9; AR; ARIDIB;
ARID2; ARID3A; ARID3B; ARID4A; ARID4B; ARID5B; ARIHI; ARUI; ARLI3A; ARLI3B; ARLI4EP; ARLI4; ARLI5; ARLI; ARL2BP; ARL2; ARL3;
ARL4A; ARL4C; ARL4D; ARL5A; ARL5B; ARLB; ARLBIPI; ARLBIP5; ARMCIO; ARMCI: ARMC2; ARMC3; ARMC4; ARMC5; ARMC8; ARMC9;
ARMCXI; ARMS2; ARMTI: ARNT2; ARNT; ARNTL2; ARNTL; ARPCIA; ARPCIB; ARPC2; ARPC3; ARPC5; ARPIN; ARPP2I; ARR3; ARRBI;5 ARRB2; ARRDC2; ARRDC3; ARRDC4; ARSA; ARSB; ARSD; ARSE; ARSF; ARSG; ARSH; ARSI: ARSJ; ARSK; ARTI; ART3; ART4; ARVCF; ARX; AS3MT; ASAHI; ASAH2; ASAPI; ASAP2; ASBID; ASBI3; ASBI5; ASBIS; ASBI; ASB2; ASBB; ASB7; ASCCI; ASCC2; ASCC3; ASCLI;
ASCL2; ASCL4; ASFIA; ASFIB; ASHIL; ASH2L; ASICI; ASIC2; ASIC3; ASIC4; ASICS; ASIP; ASL; ASMT; ASMTL; ASNAI; ASMS; ASPA; ASPG;
ASPH; ASPM; ASPN; ASPRVI; ASPSCRI; ASRBLI; ASSI: ASTN2; ASUN; ASXLI; ASXL2; ASXL3; ASZI; ATAD2; ATAD3B; ATAD3C; ATAD5;
ATATI; ATCAY; ATEI; ATFI; ATF2; ATF3; ATF4; ATF5; ATFBB; ATFB; ATF7; ATF7IP; ATBIO; ATGI2; ATGIBLI: ATG2B; ATG3; ATG4A; ATG4B; ATG4C; ATG5; ATG7; ATG9A; ATIC; ATLI; ATL2; ATL3; ATM; ATNI; ATDHI; ATDH7; ATOXI; ATPIDA; ATPIOB; ATPIOD; ATPIIA; ATPIIAUN;
ATPIIB; ATPI2A; ATPI3A3; ATPI3A4; ATPIA2; ATPIA3; ATPIA4; ATPIBI; ATPIB2; ATP2AI; ATP2A2; ATP2A3; ATP2BI; ATP2B2; ATP2B3;
ATP2B4; ATP2CI; ATP2C2; ATP4A; ATP4B; ATP5AI; ATP5B; ATP5CI; ATP5D; ATP5E; ATP5GI; ATP5G2; ATP5G3; ATP5H; ATP5J2; ATP5J;
ATP5L; ATP5D; ATPBAPI; ATPBAPIL; ATPBAP2; ATP6V0AI; ATPBV0A2; ATPBV0A4; ATPBVOC; ATPBVDDI; ATPBVOEI; ATPGV0E2;
ATPBVIBI; ATPGVIB2; ATPBVICI; ATPBVIO; ATPBVIEI; ATPBVIF; ATPBVIGI; ATPBVIG2; ATPBVIG3; ATP7A; ATP7B; ATP8AI; ATP8A2; ATP8BI; ATP8B3; ATP8B4; ATP9B; ATPAF2; ATRAID; ATR; ATRIP; ATRN; ATRNLI; ATRX; ATXNIO; ATXNI; ATXNIL; ATXN2; ATXN2L; ATXN 3;
ATXN7; ATXN7L3B; AUH; AURKA; AU KB; AURKC; AUTS2; AVEN; AVP; AVPII; AVPRIA; AVPRIB; AVPR2; AWATI; AXDNDI; AXINI: AXIN2;
AXL; AZGPI; AZI2; AZINI; AZIN2; AZUI; B2M; B3GALNTI; B3GALNT2; B3GALT2; B3GALT4; B3GALT5; B3GALTL; B3GATI; B3GAT2; B3GAT3;
B3GNT2; B3GNT3; B3GNT5; B3GNTB; B3GNT8; B3GNTLI; B4GALNTI; B4GALNT2; B4GALNT3; B4GALTI; B4GALT3; B4GALT4; B4GALT5;
B4GALTB; B4GALT7; B4GATI; B9DI: B9D2; BAALC; BAAT; BABAMI; BACEI; BACE2; BACHI; BACH2; BAD; BAG); BAG3; BAG4; BAGS; BAGB; BAIAP2LI; BAIAP3; BAKU BAMBI: BANFI: BANKI; BANP; BAPI; BARDI; BARHLI; BARXI: BARX2; BASPI; BATF2; BATF; BAX; BAZIA; BAZIB;
BAZ2A; BAZ2B; BBC3; BBIPI; BBOXI; BBSID; BBSI2; BBS1; BBS2; BBS4; BBSS; BBS7; BBSS; BBX; BCAM; BCAN; BCAP29; BCAP3I;
BCARI; BCASI; BCAS3; BCAS4; BCATI; BCAT2; BCCIP; BCDIN3D; BCHE; BC DHA; BC DHB; BC DK; BCLIO; BCLIIA; BCLIIB; BCL2AI;
BCL2; BCL2LI0; BCL2LII; BCL2LI2; BCL2LI3; BCL2LI4; BCL2LI; BCL2L2; BCL2L2-PABPNI; BCL3; BCLBB; BCLB; BCL7A; BCL7B; BCL7C;
BCL9L; BCLAFI; BCDI; BC02; BCDR; BCORLI; BCR; BCSIL; BDHI; BDH2; BDKRBI; BDKRB2; BDNF; BDPI; BEANI: BEGAIN; BENDS; BEND4; BESTI; BEST2; BETI; BETIL; BEXI; BEX2; BEX4; BFAR; BFSPI; BFSP2; BGLAP; BGN; BHLHAI5; BHLHA9; BHLHB9; BHLHE22; BHLHE23;
BHLHE40; BHLHE4I; BHMT2; BHMT; BICCI; BICDI; BICD2; BID; BINI: BIN2; BINS; BIRC2; BIRC3; BIRC5; BIRCB; BIRC7; BIVM; BLCAP;
BUD; BLK; BLMH; BLM; BLNK; BLOCIS2; BLDCIS3; BLOCIS4; BLOCIS5; BLDCISB; BLVRA; BLVRB; BLZFI: BMF; BMII: BMPIO; BMPI5;
BMPI; BMP2; BMP2K; BMP3; BMP4; BMP5; BMPG: BMP7; BMP8B; BMPER; BMPRIA; BMPRIB; BMPR2; BMSI; BMX; BNCI; BNC2; BNIPI;
BNIP2; BNIP3; BNIP3L; BNIPL; BDC; BODIL2; BO ; BOLA3; BDLL; BDPI: BORA; BPGM; BPIFAI; BPIFA2; BPIFA3; BPIFBI: BPIFB2; BPIFC; BPI; BPNTI; BPTF; BPY2; BRAF; BRAP; BRATI; BRCAI; BRCA2: BRCC3; BRDI; BRD2; BRD3; BRD4; BRD7; BRD8; BRE; BRFI; BRF2;
BRI3BP; BRI3; BRINPI; BRINP2; BRINP3; BRIPI; BRKI; BRMSI; BRMSIL; BRS3; BRSI; BRSK2; BRWDI: BRWD3; BSCL2; BSG; BSN;
BSPHI; BSPRY; BSTI; BST2; BSX; BTBDID; BTBDII; BTBDIB; BTBDI; BTBD2; BTBD3; BTBD9; BTC; BTD; BTF3; BTGI; BTG2; BTG3; BTG4;
BTK; BTLA; BTNIAI; BTN2AI; BTN2A2; BTN3AI; BTN3A2; BTN3A3; BTNL2; BTRC; BUBIB; BUBI; BUB3; BUDI3; BUD3I; BVES; BYSL;
BZRAPI; BZWI; CID; CIGALTICI; CIGALTI;
CIOB; CIDBP; CIQLI; CIDL3; CIQTNFI; CIQTNF3; C1QTNF5: CIOTNFB; CIOTNF7; CIDTNF9B-ASI; CIR: CIRL; CIS; C2CO3; C2CD4A; C2CD4B; C2CD5; C2; C4A; C4B2; C4B; C4BPA; C4BPB; C5ARI:
C5AR2; C5; CB;
CAIO; CAM; CAI2; CAI3; CAI; CA2; CA3; CA4; CA5A; CAB; CA8; CAB39; CAB39L; CABINI; CABLES!; CABP2; CABP4; CABSI;
CABYR; CACNAIA; CACNAIB; CACNAIC; CACNAID; CACNAIE; CACNAiF: CACNAIG; CACNAIH; CACNAII: CACNAIS; CACNA2DI; CACNA2D2;
CACNA2D3; CACNA2D4; CACNBI; CACNB2; CACNB3; CACNB4; CACNG2; CACNG3; GACNG4; CACNG5; CACNGB; CACULI; CACYBP; CAD; ID CADMI; CADM2; CADM3; CADM4; CADPS2; CADPS; GAGEI; CALBI; CALB2; CALCA; CALCB; CALCOCDI; CALCDCD2; CALCR; CALCRL;
CALDI; CALHMI; CALHM2; CALHM3; CALM2; CALML3; CALML5; CALNI: CALR3; CALR; CALU; CALY; CAMKID; CAMKIG; CAMKI; CAMK2A;
CAMK2B; CAMK2D; CAMK2G; CAMK4; CAM KI: CAMKK2; CAMKMT; CAMLG; CAMP; CAMSAPI; CAMSAP2; CA TAI; CANOI: CAND2; CANTI:
CANX; CAPI; CAP2; CAPG; CAPNID; CAPNI3; CAPNI4; CAPNI: CAPN2; CAPN3; CAPN5; CAPNB; CAPN7; CAPN9; CAPNSI: CAPRINI;
CAPRIN2; CAPS2; CAPS; CAPSL; CAPZA2; CAPZA3; CARDID; CARDII; CARDI4; CARDIB; CARDB; CARDS: CARD9; CARF; CARKD; CARMI; 15 CARS; CARTPT; CASCI; CASC3; CASC4; CASC5; CASDI; CASK; CASPIO; CASPI4; CASPI; CASP2; CASP3; CASP4; CASP5; CASPB;
CASP7; CASP8AP2; CASPB; CASPB; CASDI: CASR; CASS4; CAST: CASZI: CAT; CATSPERI; CATSPER2; CAVI; CAV2; CAV3; CBFA2T2;
CBFA2T3; CBFB; CBLB; CBL; CBLLI; CBLNI; CBLN2; CBLN4; CBRI; CBR3; CBR4; CBS; CBXI; CBX2; CBX3; CBX4; CBX5; CBXB; CBX7;
CBX8; CBYI; CC2DIA; CC2DIB; CC2D2A; CCARI; CCAR2; CCBEI; CCBLI; CCDCIDI; CCDCI02B; CCDCID3; CCDCID5; CCDCID8; CCDCII4;
CCDCII5; CCDCI2I; CCDCI22; CCDCI29; CCDCI3D; CCDCI34; CCDCI3B; CCDCI40; CCDCI4I; CCDCI48; CCDCI5I; CCDCIB7; CCDCIB9-D S0HLH2; CCDCI70; CCDCI7I; CCDCI75; CCDCI7B; CCDCI78; CCDCI8D; CCDCI8I: CCDCI85; CCDC22; CCDC28A; CCDC39; CCDC3;
CCDC4D; CCDC42B; CCDC42; CCDC5D; CCDC54; CCDCBD; CCDCB2; CCDCB3; CCDCG5; CCDCBB; CCDCB7; CCDCB8; CCDCB;
CCDC78; CCDC8D; CCDC83; CCDC85A; CCDCBB; CCDC88A; CCDC88C; CCDC8; CCDC9I; CCDC94; CCDC97; CCHCRI; CCKAR; CCKBR;
CCK; CGLII; CCLI3; CCLI4; CCLI5; CCLIB; CCLI7; CCLI8; CCLI9; CCD; CCL2D; CCLZI: CCL22; CCL23; CCL24; CCL25; CCL2G; CCL27;
CCL28; CCL2; CCL3; CCL3L3; CCL4; CCL4LI; CCL4L2; CCL5; CCL7; CCL8; CCM2; CCNAI; CCNA2; CCNBI; CCNB2; CCNB3; CCNC; CCNDt:5 CCND2; CCND3; CCNDBPI: CCNEI; CCNE2; CCNF; CCNBI: CCNG2; CCNH; CCNI; CCNJ; CCNJL; CCNK; CCNL1; CCNL2; CCNO; CCNTI;
CCNY; CCPIID; CCRID; CCRI; CCR2; CCR3; CGR4; CCR5; CCRB; CCR7; CCR8; CCR9; CCRL2; CCRN4L; CCSERI; CCS; CCT2; CCT3; CCT4;
CCT5; CCTGA; CCTBB; CCT7; CDI09; CDI4; CDI5I; CDIB3; CDIB3LI; CDIB4; CDI77; CDI8D; CDI9; CDIA; CDIB; CDIC; CDID; CDIE; CD20D;
CD2DDRI; CD2D7; CD2D9; CD22B; CD22; CD244; CD247; CD248; CD24; CD274; CD27B; CD27; CD28; CD2AP; CD3DDA; CD3D0C;
CD3D0LF; CD302; CD320; CD33; CD34; CD3B; CD37; CD38; CD3D; CD3EAP; CD3E; CD3G; CD40; CD4DLG; CD44; CD4B; CD47; CD48;D CD4; CD55; CD59; CD5; CD5L; CDB3; CDG8; CDB9: CDB; CD72; CD74; CD79A; CD79B; CD7; CD8D; CD8I; CD82; CD83; CD84; CD8B;
CD8A; CD8B; CD93; CD9B; CD99; CDB; CDADCI: CDANI; CDCI23; CDCI4A; CDCI4B; CDCIG; CDC2DB; CDC23; CDC25A; CDC25B;
CDC25C; CDC27; CDC34; CDC37; CDC37LI; CDC42BPA; CDC42BPB; CDC42BPG; CDC4ZEPI: CDC42EP3; CDC42SE2; CDC45; CDC5L;
CDCB; CDC73; CDC7; CDCA2; CDCA3; CDCA5; CDCA7; CDCA7L; CDCPI; CDHID; CDH11: CDHI3; CDHI5; CDHIB; CDHI7; CDHI8; CDHI9;
CDHI; CDH2D; CDH22; CDH23; CDH2B; CDH2; CDH3; CDH4; CDH5; CDHB; CDH7; CDH8; CDH9; CDHRI; CDHR2; CDHR3; CDHR5; CDIPT;5 CDKID; CDKIIB; CDKI2; CDKI3; CDKI4; CDKI5; CDKIB; CDKI7; CDKI8; CDKI9; CDKI; CDK2D; CDK2API; CDK2AP2; CDK2; CDK3; CDK4; C0K5; CDK5 I: CDK5R2; CDK5RAPI: CDK5RAP2; CDK5 AP3; CDKB; CDK7; CDK8; CDK9; CDKALI; CDKLI: CDKL2; C0KL3; CDKL4;
CDKL5; CDKNIA; CDKNIB; CDKNIC; CDKN2A; C0KN2A1P: CDKN2B; CDKN2C; CDKN2D; CDKN3; CDNF; COOI; CDON; CDRI; CDR2; CDS2;
CDTI: CDV3; CDXI: CDX2; CDX4; GDYIB; CDY2B; CDYL2; CDYL; CEACAMIB; CEACAMIB; CEACAMI; CEACAM2I; CEACAM3; CEACAM4;
CEACAM5; CEACAMB; CEACAM7; CEACAM8; CEBPA; CEBPB; CEBPD; CEBPE; CEBPG; CEBPZ; CECRI; CECR2; CELAI: CELA3B; CELFI; CELF2; CELF4; CELF5; CELFB; GEL; CELSRI; CELSR3; CEMIP; CEMPI; CENDI; CENPA; CENPB; CENPC; CENPE; CENPF; CENPH; CENPJ;
CENPK; CENPN; CENPO; CENPO; CENPU; CENPV; CENPW; CEPII2; CEPI2D; CEPI28; CEPI3I; CEPI35; CEPI52; CEPIB2; CEPIB4; CEPI7D;
CEPI92; CEPIB; CEP25D; CEP29D; CEP4I; CEP55; CEP57; CEPB3; CEPG8; CEP72; CEP7B; CEP83; CEP85L; CEP83; CERI; CERK; CERKL;
CERSI; CERS2; CERS3; CERS4; CERSB; CESh CES2; CES3; CETNI; CETN2; CETN3; CETP; CFAPI2B; CFAP3B; CFAP44; CFAP52; CFAP53;
CFAP57; CFAP58; CFAPBI; CFAPBB; CFAP97; CFB; CFCIB; CFCI; CFD; CFDPI; CFH; CFHRI; CFHR2; CFHR3; CFHR4; CFH 5; CFI; CFLI; CFL2; CFLAR; CFP; CFTR; CGA; CGBI; CGB2; CGB5; CGB7; CBN; CGNLI; CGRRFI: CH25H; CHACI; CHAD; CHAFIA; CHAFIB; CHAMPI: CHAT;
CHCHDIO; CHCHDI; CHCHD3; CHCHD5; CHCHDB; CHCHD7; CHDI; CHD2; CHD3; CHD4; CHDB; CHD7; CHD8: CHDH; CHEKI; CHEK2;
CHERP; CHFR; CHGA; CHGB; CHI3LI; CHICI; CHIC2; CHITI; CHKA; CHKB; CHLI; CHM; CHML; CHMPIA; CHMPIB; CHMP2B; CHMP3;
CHMP4A; CHMP4B; CHMP4C; CHMP5; CHMI: CHN2; CHDDL; CHORDCI; CHPI: CHP2; CHPF; CHPTI: CHRACI; CHRD; CHRDLI: CHRFAM7A;
CHRMI; CHRM2; CHRM3; CHRM4; CHRM5; CHRNAIO; CHRNAI; CHRNA2; CHRNA3; CHRNA4; CHRNA5; CHRNAB; CH NA7; CHRNBI; CHRNB2; CHRNB3; CHRNB4; CHRND; CHRNE; CHRNG; CHSTIO; CHSTII; CHSTI2; CHSTI3; CHSTI4; CHSTI5; CHSTI; CHST2; CHST3;
CHST4; CHST5; CHSTB; CHST8; CHST9; CHSYI; CHSY3; CHTFI8; CHTOP; CHURCI; CIADI; CIAPINI; CIBI; CIB2; CIC; CIDEB; CIDEC; CIITA;
CILP2; CILP; CINP; CIPC; GIRL CIRBP; CIRHIA; CISDI; CISD2; CISH; CITED1; CITED2; CIT; CIZI: CKAP2; CKAP2L; CKAP4; CKAP5; CKB;
CKLF; CKM; CKMTIA; CKMTIB; CKMT2; CKSIB; CKS2; CLASPI; CLASP2; CLCA2; CLCA4; CLCFI; CLC; CLCNI; CLCN2; CLCN3; CLGN4;
CLCN5; CLCNB; CLCN7; CLCNKB; CLDNID; CLDNII; CLDNI4; CLDNI5; CLDNIB; CLDNI8; CLDNl; CLDN23; CLDN2; CLDN5; CLDNB; CLDN7; CLDN8; CLDNB; CLECIDA; CLECIIA; CLECI2A; CLECI4A; CLECIBA; CLECIB; CLEC2A; CLEC2B; CLEC2D; CLEC2L; CLEC3B; CLEC4A;
CLEC4C; CLEC4D; CLEC4E; CLEC4G; CLEC4M; CLEC5A; CLECBA; CLEC7A; CLEC9A; CLECLI; CLGN; CLICI; CLIC3; CLIC5; CLICB; CLINTI;
CLIP1; CLIP2; CLKl; CLK2; CLLUI; CLMN; CLMP; CLN3; CLN5; CLNB; CLNB: CLNK; CLNSIA; CLOCK; CLPI; CLPP; CLPS; CLPTMI; CLPTMIL;
CLRNI; CLSPN; CLSTNI; CLSTN2; CLTA; CLTC; CLTCLI: CLUAPI; CLU; CLULI; CLVSI: CLYBL; CMAI; DMAS; CMCI; CMC2; CMC4; CMIP;
CMKLRI; CMPK2; CMSSI; CMTM3; CMTM5; CMTM7; CMTM8; CMTRI; CMTR2; CMYA5; CNBDI; CNBP; CNDPI; CNDP2; CNGAI; CNGA3; CNGBI; CNGB3; CNIH3; CNKSRI; CNKSR2; CNKSR3; CNNI; CNN2; CNNMI: CNNM2; CNNM4; CNQTI; CNBT2; CNDT3; CN0T4; CNDTB;
CNOTGL; CN0T7; CN0T8; CNP; CNPY2; CNPY3; CNRI: CNR2; CNRIPI: CNST; CNTF; CNTFR; CNTLN; CNTNI; CNTN2; CNTN3; CNTN4;
CNTN5; CNTNB; CNTNAPI; CNTNAP2; CNTNAP3; CNTNAP4; CNTNAP5; CNTRL; CNTROB; COAI; C0A5; CDASY; COBL; COBLLI; COCH;
COGI; COG2; COG3; COG4; COG5; COGB; COG7; COG8; COIL; COLIDAI; COLIIAI; COLIIA2; COLI2AI; COLI3AI; COLI4AI; COLI5AI; COLIBAI;
COLI7AI; COLI8AI; COLIAI; COLIA2; COL2OAI; COL2IAI; COL22AI; COL23AI: COL24AI; COL25AI; COL2BAI; COL27AI; COL28AI; COL2AI; COL3AI; COL4AI; COL4A2; COL4A3BP; COL4A3; COL4A4; COL4A5; COL4AB; COL5AI; COL5A2; COL5A3; COLGAI; COLBA2; COLBA3;
COLBA5; COL7AI; COL8AI; COL8A2; COLGAI; COL9A2; COL9A3; COLCAI; COLCA2; COLECIO; COLECII: COLECI2; COLGALT2; COLQ;
COMMDIO; COMMDI; COMMD3-BMII; COMMD5; COMMD7; COMP; COMT; COPA; COPBI; COPB2; COPE; COPG2; COPRS; COPS2; COPS3;
COPS4; COPS5; COPSE; COPS7A; COPS8; COPZ2; COD2; COO3; COO4; COO5; COO6; COO7; COO9; CORIN; CORDIA; CORDIB; COROIC;
CORO2A; CORO2B; COROB; CORO7; CORO7-PAMIG; COTLI; COXIO; COXII; COXI4; COXI5; COXIB; COXI7; COXI8; COX19; COX4II; COX4I2; COX5A; COX5B; COXBAI; COXBA2; COXBBI; COXGC; COX7AI; COX7A2; COX7A2L; COX7B2; COX7B; COX7C; COX8A; CPA1; CPA2; CPA3; CPA4; CPAB; CPAMD8; CPBI; CPB2; CPD; CPEBI; CPEB3; CPEB4; CPEOI; CPE; CP; CPLXI; CPLX2; CPLX3; CPLX4; CPM; CPNI; CPN2;
CPNEI; CPNE2; CPNE3: CPNE4; CPNE7; CPNE8: CPD; CPDX: CPPEOI; CPD; CPSI; CPSFI; CPSF2; CPSF3; CPSF3L; CPSF4; CPSFB;
CPSF7; CPTIA; CPTIB; CPTIC; CPVL; CPXCRI; CPZ; CRI; CR2; CRABPI; CRABP2; CRACR2A; CRADD; CRAMPIL; CRAT; C BI; CRB2; CRB3;
CRBN; CRCP; CRCTI; CREBI; CREB3; CREB3LI; CREB3L2; CREB3L3; CREB3L4; CREB5; CREBBP; CREBRF; CREBZF; CREGI; CRELDI; CRELD2; CREM; CRHBP; CRH; CRHRI: CRHR2; CRIMI; CRIP2; CRIP3; CRIPAK; CRIPT; CRISPI; CRISP2; CRISP3; CRISPLDI; CRISPLD2;
CRK; CRKL; CRLFI; CRLF2: CRLF3; CRLSI; CRMPI; CRNKLI: CRNN; CRDCC; CROT; CRP; CRTACI: CRTAM; CRTAP; CRTCI; CRTC2; CRTC3;
CRX; CRYI; CRY2; CRYAB; CRYBAI; CRYBA2; CRYBA4; CRYBBI; CRYBB2; CRYBB3; CRYGB; CRYGC; CRYGD; CRYGS; CRYLI: CRYM;
CRYZLI; CSAD; CSAG3; CSEIL; CSFIR; CSF2; CSF2RA; CSF2RB; CSF3; CSGALNACTI; CSGALNACT2; CSHI; CSH2; CSHLI; CS; CSK;
CSMDI; CSMD2; CSMD3; CSNISI; CSN2; CSN3; CSNKIAI: CSNKID; CSNKIG3; CSNK2AI: CSNK2A2; CSNK2B; CSPG4; CSPG5; CSPPI; CSRNPI; CSRNP3; CSRPI: CSRP2BP; CSRP2; CSRP3; CSTI; CST2; CST3; CST4; CST5; CSTB; CST7; CST8; CST9; CSTBL; CSTA; CSTB;
CSTFI; CSTF2; CSTF2T: CSTLI: CT45AI; CT55; CT83: CTAGIA; CTAG2; CTAGEI; CTAGE5; CTBPI; CTBP2; CTCI; CTCF; CTCFL; CTDP1:
CTDSPI; CTDSP2; CTDSPL; CTFI; CTGF; CTHRCI; CTIF; CTLA4; CTNNAI; CTNNA2; CTNNA3; CTNNALI; CTNNBt; CTNNBLI: CTNNDI;
CTNND2; CTNS; CTPSI; CTR9; CTRBI; CTRB2; CTRC; CTRL; CTSA; CTSB; CTSC; CTSD; CTSE; CTSF; CTSG; CTSH; CTSL; CTSD; CTSV;
CTSW; CTSZ; CTTNBP2; CTTN; CTUI; CTXN3; CUBN; CUEDCI; CUEDC2; CULI: CUL2; CUL3; CUL4A; CUL4B; CUL5; CUL7; CUL9; CUTA; CUXI; CUX2; CUZDI; CWC22; CWC27; CWFIBLI; CWFIBL2; CWH43; CX3CLI; CX3CRI; CXADR; CXCLIO; CXCLII: CXC LIZ; CXCLI3; CXCLI4;
CXCLIB; CXCLI7; CXCLI; CXCL2; CXCL3; CXCL5; CXCLB; CXCL8; CXCL9; CXCRI; CXCR2; CXCR3; CXCR4; CXCR5; CXCRB;
CXXCI; CXXC4; CYB5BID2; CYB5BI; CYB5A; CYB5B; CYB5R3; CYB5R4; CYBA; CYBB; CYBRDI: CYCI; CYCS; CYFIPI;
CYFIP2; CYGB; CYLCI; CYLC2; CYLD; CYP11A1; CYPIIBI: CYPIIB2; CYPI7AI; CYPI9AI; CYP1A1: CYPIA2; CYPIBI; CYP2IA2; CYP24AI;
CYP2BAI; CYP2BBI; CYP2GCI; CYP27AI; CYP27BI; CYP27CI: CYP2AI3; CYP2AB; CYP2A7; CYP2BB; CYP2CI8; CYP2CI9; CYP2C8; CYP2C9; CYP2DG; CYP2EI; CYP2FI; CYP2RI; CYP2SI; CYP2UI; CYP2WI; CYP39AI; CYP3A43; CYP3A4: CYP3A5; CYP3A7-CYP3A5IP;
CYP3A7; CYP4BAI; CYP4AII; CYP4BI; CYP4FII; CYP4FI2; CYP4F22; CYP4F2; CYP4F3; CYP4F8; CYP4V2; CYP5IAI; CYP7AI; CYP7BI;
CYP8BI; CYSI; CYSLTRI; CYTHI; CYTH3; CYTIP; CYTLI; CYYRI; D2HGDH; DAAMI: DAAM2; DAB2; DAB2IP; DACHI; DACH2; DACTI; DACT2;
DACT3; DADI: DAGI; DAND5; OAOA: DAD; DAPS; DAP; DAPKI: DAPK2; DAPK3; DARS2; DARS; DAWi: DAXX; DAZI; DAZ2; DAZ3; DAZ4;
DAZAPl; DAZAP2; DAZL; DBF4; DBH; DBI; DBNI; DBNL; DBP; DBRI; DBXI; DCAFI2; DCAFI3; DCAFI7; DCAF4; DCAF5; DCAFB; DCAF7; DCAF8; DCANPI; DCBLDI: DCBLD2; DCC; DCDC2C; DCDC2; DCD; DCHSI; DCHS2; DCK; DCLKI; DCLK2; DCLK3; DCLREIA; DCLREIC; DCN;
DCPIA; DCPIB; DCPS; DCSTI; DCST2; DCSTAMP; DCTD; DCT; DCTNI; DCTN2; DCTN3; DCTN4; DCTN5; DCTNB; DCUNIDI: OCX; DCXR;
DDAHI; DDAH2; DDBI: DDB2; DDC; DDHDI; DDHD2; DON: DDIAS; DDIT3; DDIT4; DDIT4L; DON; ODD: DDRI; DDR2; DDRGKI; DDT; DDTL;
DDXIO; DDXII; DDXI7; DDXI8; DDXIBA; DDXI; DDX2I; DDX25; DDX27; DDX28; DDX31; DDX39A; DDX39B; DDX3X; DDX3Y; DDX4I; DDX42;
DDX43; DDX4G; DDX4; DDX5D; DDX5I; DDX52; DDX53; DDX54; DDX5B; 00X58; DDX59; D0X5; DDXBD; D0X6; DEAR; DECI: DECRI; DEDD; DEFG; DEFAIB; DEFA3; DEFA4; DEFA5; DEFAG; DEFB103B; DEFBI04B; DEFBI05A; DEFBIOBA; DEFBI08B; DEFBII2; DEFBI25;
DEFBI2G; DEFBI; DEFB4A; DEBSI; DEGS2; DEK: DENNDIA; DENNDIB; DENND2A; DENND4A; DENR; DEPDCIB; DEPDC5; DEPTDR; DERA;
OERLI; DERL2; DERL3; DES; DESI2; DEXI; DFFB; DFNA5; DFNB3I: 0FNB59; DGATI; DGAT2; DGCR2; DGCRBL; DGCR8; DGKA; DGKB;
DGKD; DGKE; DGKG; DGKH; DGKI; DGKK; DGKfl; DGKZ; DGUOK; DHCR7; DHDH; DHFR; DHFRLI; DHH; DHDDH; DHPS; DHRSII; DHRS2;
DHRS4; DHRS7C; DHRS9; DHTKDI; DHXI5; DHXIB; DHX32; DHX34; DHX3B; DHX38; DHX4D; DHX58; DHX8; DHX9; DIABLO; DIAPHI; DIAPH2; DIAPH3; DICERI; DIDOI; DIEXF; DIP2A; DIP2B; DIP2C; DIRASI; DIRAS2; DIRCI; DIRC2; DIS3; DIS3L2; DIS3L; DISCI; DISPI: OIXOCI; DKCI: DKKI: DKK2; DKK3; DKK4; DKKLI; DLAT; DLCI; DLO; DLEC1; DLEU7; DLGI; DLB2; DLG3; DLG4; DLG5; DLGAPI; DLGAP2;
DLGAP3; DLGAP5; DLKI; DLL1; DLLS; DLL4; DLST; DLXI: DLX2; DLX3; DLX4; DLX5; OLXG; DMBTI; DMCI; DMD; DMGDH; DMKN; DMPI:
DMPK; DM TI: DMRT2; DMRT3; DMRTAI; DMTFf; DMTN; DMWD; DMXLI: DMXL2; DNA2; ONAAFI; DNAAF2; DNAAF3; DNAAF5; DNAHII;
DNAHI2; DNAHI7; DNAHI; DNAH2; DNAH3; DNAH5; ONAHB; DNAH7; DNAH8; DNAH9; DNAII; DNAI2; DNAJAI: DNAJA2; DNAJA3; DNAJBM: DNAJBI3; DNAJBI; DNAJB2; DNAJB5; DNAJBB; DNAJB7; DNAJB8; DNAJB9; DNAJCIO; DNAJC12; DNAJGI3; DNAJCI4; DNAJCI5;
DNAJC18; DNAJCI9; ONAJCI; DNAJC27; DNAJC28; DNAJC2; DNAJC3; DNAJC5; DNAJC7; DNALI; DNASEI; DNASEIL2; DNASEIL3;
DNASE2B; DNASE2; DNDI; DNER; DNHDI; DNLZ; DNMI: DNMIL; DNM2; DNM3; DNMBP; DNMTI; DNMT3A; DNMT3B; DNMT3L; DNPEP;
DNTT; DDC2A; DDC2B; DOCKIO; DDCKII: DDCKI; DDCK2; DOCKS; D0CK4; DDCK5; DOCKS; DDCK7; DDCK8; DDCKFJ; DDHH; DDKI; DOK2;
DDK3; D0K4; DDKS; DDKB; DDK7; DDLK; DDNSDN; DDPEY2; DDTIL; DPABTI: DPCD; DPCRI: DPEPI; DPEP2; DPEP3; DPF1; DPF3; DPHI; DPH3; DPHB; DPH7; DPMI; DPM2; DPM3; DPPID; DPP3; DPP4; DPPG; DPP7; DPP8; DPPB; DPPA2; DPPA3; DPPA4; DPT; DPYI9L2;
DPYI9L3; DPY30; DPYS; DPYSL2; DPYSL3; DPYSL4; DPYSL5; DRAMI; DRAPI; ORCI; DRDI; DRD2; DRD3; DRD4; DR05; DRGI; DRGX;
DRDSHA: DRP2; OSCI; DSC2; DSC3; DSCAM; DSCAMLI; DSCCI: DSCR4; DSE; DSEL; DSGI; DSG2; DSG3; DSG4; DSP; DSPP; DST; DSTN;
DSTYK; DTDI; DTHDI: DTL; DTNA; DTNB; DTNBPI; DTXI: DTX2; DTX3; DTX4; DTYMK; DUOXI; DU0X2; OUDXAI; D00XA2; DUPDI; DUS2;
DUSPIO; DUSPII; DUSPI2; DUSPI3; DUSPI4; DUSPI5; DOSPIB; DUSPI8; DUSPI; DUSP2I; DUSP22; DUSP23; DUSP27; DUSP28; DUSP2; DUSP3; DUSP4; DUSP5; DOSPB; DUSP7; D0SP8; DUSP9; OUT; DUX4; DVL2; DVL3; DXO; DYM; DYNAP; DYNCIHI; DYNC1I1: DYNCII2;
DYNCILII; DYNCZHI: DYNLLI; DYNLL2; DYNLRBI; DYNLTI; DYNLT3; DYRKIA; DYRKIB; DYRK2; DYRK3; DYSF; DYXIC1: DZIPI; EZFI; E2F3;
E2F4; E2F5; E2FB; E2F7; E2F8; E4FI; EAR; EAF2; EARS2; EBAG9; EBFI: EBF2; EBF3; EBF4; EBI3; EBP; EBPL; ECD; ECE2; ECELI; ECHDC1:
ECHDC3; ECHSI; ECU; ECI2; ECSCR; ECSIT; ECT2; EDA2R; EDA; EDARADD; EDAR; EDC4; EDEMI; EDIL3; EDNI; EDN3; EDNRA; EDNRB;
EEAI; EED; EEFIAI; EEFIA2; EEFIB2; EEFID; EEFIEI; EEFIG; EEF2; EEFSEC; EFCABII; EFCABI; EFEMPI; EFEMP2; EFHB; EFHCI; EFHC2; EFHOI; EFNAI; EFNA2; EFNA3; EFNA4; EFNA5; EFNBI; EFNB2; EFNB3; EFR3A; EFR3B; EFS; EFTUDI; EFTUD2; EGF; EGFLB; EGFL7; EGFL8; EGFLAM;
EGFR; EGLNI; EGLN2; EGLN3; EGRI; EGR2; EGR3; EGR4; EHBPI: EHDI; EHD2; EHD3; EHD4; EHF; EHHADH; EHMTI; EHMT2; EI24; EIDI:
EIFIAD; EIFIAX; EIFIAY; EIFI; EIF2A; EIF2AKI: EIF2AK2; EIF2AK3; EIF2AK4; EIFZBI: EIF2B2; EIF2B3; EIF2B4; EIF2B5; EIFZSI; EIF2S2;
EIF2S3; EIF3A; EIF3B; EIF3C; EIF3E; EIF3F; EIF3H; EIF3J; EIF3K; EIF3M; EIF4AI; EIF4A2; EIF4A3; EIF4B; EIF4E2; EIF4E3; EIF4EBPI;
EIF4EBP2; EIF4EBP3; EIF4E; EIF4ENIFI: EIF4GI; EIF4G2; EIF4H; EIF5A2; EIF5A; EIF5; EIFB; ELACI; ELAC2; ELANE; ELAVLI; ELAVL2; ELAVL3; ELAVL4; ELFI; ELF2; ELF3; ELF4; ELF5; ELKI; ELK3; ELK4; ELL2; ELL; EL DI; ELMO2; ELMODI; ELMOD2; ELMOD3; ELSANI; ELN;
ELOFI; ELOVL2; ELOVL4; ELOVL5; ELOVLB; ELOVL7; ELP2; ELP3; ELP4; ELPB; ELSPBPI; EMB; EMCIO; EMC2; EMC3; EMC7; EMC8; EMCN;
EMD; EMEI; EMGI; EMILINI; EMILIN2; EMILIN3; EMU; EML2; EML4; EML5; EMLB; EMPI: EMP2; EMXI; EMX2; ENI; EN2; ENAH: ENAM; ENCI;
ENDDG; ENDDU; ENDDV; ENGASE; ENG; ENHO; ENO2; ENO3; ENO4; ENBPHI: ENOSFI: ENDXI: EN0X2; ENPEP; ENPPI; ENPP2; ENPP3;
ENPP5; ENPP7; ENTHD2; ENTPDI; ENTPD2; ENTPD4; ENTPD5; ENTPDB; ENTPD7; EOGT; EOMES; EP300; EP400; EPASI; EPB4ILI: EPB4IL2; EPB4IL3; EPB4IL4A; EPB4IL4B; EPB42; EPCI: EPC2; EPCAM; EPDRI; EPG5; EPGN; EPHAI: EPHA3; EPHA4; EPHA5; EPHAB;
EPHA7; EPHBI; EPHB3; EPHB4; EPHBB; EPHXI; EPHX2; EPHX3; EPM2A; EPM2AIPI; EPNI; EPO; EPOR; EPPIN; EPPIN-WFDCB; EPP I:
EPRS; EPSI5LI; EPS8; EPS8L2; EPSTil: EPX; EPYC; ERALI; ERAPI; ERAP2; ERAS; ERBB2; ERBB2IP; ERBB3; ERBB4; ERCI; ERC2; ERCCI;
ERCC2; ERCC3; ERCC4; ERCC5; ERCCB; ERCCBL2; ERCCB-PGBD3; ERCC8; EREG; ERF; ERG; ERGICI; ERGIC2; ERGIC3; ERI3; ERICH5;
ERICHBB; ERLECI; ERLINI; ERLIN2; ERMAP; ERMARD; ERMPI; ERNI; ERN2; EROILB; ERDIL; ERP29; ERP44; ERV3-I: ERVW-I; ESAM; ESCOI; ESC02; ESD; ESFI; ESMI; ESPLI; ESPN; ESRI; ESR2; ESRPI; ESRP2; ESRRA; ESRRB; ESRRG; ESXI; ESYTI: ESYT2; ESYT3; ETAAI; ETFI; ETFA; ETFB; ETFDH; ETHEI; ETN I: ETNK2; ETNPPL; ETSI: ETS2; ETVI: ETV3; ETV4; ETV5; ETVB; ETV7; EVAIA; EVAIC; EVC2; EVC;
EVI2A; EVI2B; EVI5; EVL; EVPL; EVX1; EVX2; EWSRI: EXO2; EXO3; EXOI; EXOCI; EXOC2; EXOC3LI; EXOC3L2; EXOC4; EXOC5; EXOC7;
EXOG; EXBSCI; EXDSC2; EXBSC3; EXBSC4; EXDSC5; EXDSCB: EXBSC7; EXDSC8; EXPH5; EXTI; EXT2; EXTL2; EXTL3; EYAI; EYA2; EYA4;
EYS; EZHI; EZH2; EZR; FID; Fll; FUR; FI2; FI3AI; FI3B; F2; F2R; F2RLI; F2RL2; F2RL3; F5; F7; F8; FB; FA2H; FAAH2; FABPI: FABP2; FABP4; 5 FABP5; FABPB; FABP7; FABPB; FADD; FADSI: FADS2; FADS3; FAF2; FAHD2A; FAH; FAIM2; FAIM3; FAMID2A; FAMI03AI; FAMID5A;
FAMID7A; FAMI07B; FAMI09A; FAMIIBA; FAMIIBB; FAMIIBC; FAMIItB; FAMII4AI: FAMI20B; FAMI2DC; FAMI24B; FAMI2BA; FAMI29A;
FAMI29B; FAMI34B; FAMI35A; FAMI35B; FAM13BA; FAMI3A; FAMI3C; FAMI49A; FAMI50B; FAMI55A; FAMIBOBI; FAMI6IA; FAMIB3A;
FAMIB3B; FAMIB7A; FAMIB8A; FAMIB8B; FAMIB9B; FAMI7DA; FAMI72A; FAMI73B; FAMI74A; FAMI75A; FAMI75B; FAMI77AI: FAMI77B;
FAMI78A; FAMI78B; FAMI79B; FAMI8DA; FAMI84A; FAMI84B; FAMI87B; FAMI88A; FAMI88B; FAMI89B; FAMI93B; FAMIBBA; FAMI9BB; ID FAMI98B; FAMI9AI: FAMI9A2; FAMI9A4; FAMI9A5; FAM2D4A; FAM2D5A; FAM2DA; FAM2DB; FAM20C; FAM2IDB: FAM2I3A; FAM2I4A;
FAM2IBA; FAM220A; FAM227B; FAM32A; FA 3A: FAM3B; FAM3C; FAM3D; FAM4BA; FAM4BD; FAM49A; FAM49B; FAM5BB; FAM53B;
FAM57A; FAM58A; FAMBDA; FAMB3B; FAMB4A; FAM65B; FAMBBC; FAM7IFI; FAM7IF2; FAM72B; FAM78B; FAM8IB; FAM83A; FAM83B;
FAM83D; FAM83H; FAM84A; FAM84B; FAM89A; FAM92AI; FAM92B; FAM9B; FAN1; FANCA; FANCB; FANCC; FANGD2; FANCE; FANCF;
FANCG; FANCI; FANCL; FANCM; FANKI; FAP; FARI; FARPl; FARP2; FARS2; FARSA; FAS; FASLG; FASN; FASTKD2; FASTK; FATI; FAT2; FATS; I5 FAT4; FATEI; FALL FBFI; FBL; FBLIMI; FBLNI; FBLN2; FBLN5; FBNI; FBN2; FBN3; FBPI; FBP2; FBRS; FBXLI5: FBXLI7; FBXLI9; FBXL2D;
FBXL2; FBXL3; FBXL4; FBXL5; FBXL7; FBXOID; FBXDII; FBX0I5; FBXDI7; FBXDI8; FBXD28; FBXD3D; FBXD3I; FBXD32; FBXD33; FBXD38;
FBXD3; FBXD4D; FBX047; FBXD4; FBX05; FBXD7; FBXD8; FBXD9; FBXWIL FBXW4; FBXW7; FBXW8; FCAR; FCERIA; FCERIG; FCER2;
FCGBP; FCGR2A; FCGR2B; FCGR3A; FCGR3B; FCGRT; FCHOI; FCHD2; FCHSD2; FCN FCN2; FCRLI; FCRL2; FCRL3; FCRL4; FCRL5;
FCRLB; FCRLA; FCRLB; FDFTI; FDPS; FDXI; FDXIL; FDXR; FECH; FEMIA; FEMIB; FEMIC; FENI; FERD3L; FER; FERMTI; FERMT2; FERMT3;0 FES; FEV; FEZI; FEZ2; FEZFI; FEZF2; FFARI; FFAR2; FFAR3; FFAR4; FGA; FGB; FGDI; FGD2; FGD3; FGD4; FGD5; FGDB; FGFID; FBFII; FGFI2;
FGFI3; FGFI4; FGFIB; FGFI7; FGFI8; FGFI9; FBFI; FGF2D; FGF2I: FGF23; FGF2; FGF3; FGF4; FGF5; FGFB; FGF7; FGF8; FGF9; FGFBPI;
FGFBP2; FGFBP3; FGFRI; FGFRIDP2; FGFRIDP; FGFR2; FGFR3; FGFR4; FGFRLI; FGG; FGGY; FGLI; FGL2; FGR; FHDCI: FH; FHIT; FHLL FHL2;
FHL5; FHDDI; FHDD3; FIBP; FIG4; FIGF; FIGLA; FIGN; FILIPI; FILIPIL; FIP1L1; FISL FIT I; FITM2; FJXI; FKBPID; FKBPII; FKBPI4; FKBPI5;
FKBPIA; FKBPIB; FK8P2; FKBP3; FKBP4; FKBP5; FKBPB; FKBP7; FKBP8; FKBP9; FKBPL; FKRP; FKTN; FLADI: FLCN; FLG2; FLG; FLU; FLU;5 FLNA; FLNB; FLNC; FLOTI; FLDT2; FLRT2; FLRT3; FLTI: FLT3; FLT3LG; FLT4; FLVCRI; FLVCR2; FMNL FMN2; FMNLI; FNL2; FMNL3; FHOI:
FMD2; FMD3; FMD4; FMOD; FMRI; FNI; FN3K; FN3KRP; FNBPI; FNDCI; FNDC3A; FNDC3B; FNDC4; FNTA; FNTB; FDCAD; FOLHI: FDLRl;
FDLR2; FDLR3; FOPNL; FOSB; FDS; FDSLI: FDSL2; FOXA1; FOXA2; FOXA3; FOXBI; FOXCI: FOXC2; FOXDI; FOXEI; FOXFI; FOXF2; FOXGI;
FOXHI; FOXII; FDXJI; FDXJ2; FOXKI; FOXK2; FOXLI; FOXL2; FOXMI; FOXNI; FOXN2; FOXN3; FOXO1; FOXO3; FOXO4; FOXOB; FOXPI: FOXP2;
FOXP3; FOXP4; FOXQI; FOXRI; FOXR2; FOXREDI; FPGS; FPRI; FPR2; FPR3; FRASI; FRATI; FRAT2; FREMf: FREM2; FREM3; FRGI; FRG2;0 FRK; FRMD3; FRMD4A; FRMD4B; FRMD5; FRMDB; FRMD7; FRMPDI; FRMPD2; FRMPD4; FRRSIL; FRS2; FRS3; FRY; FRYL; FRZB; FSBP;
FSCB; FSCNI; FSCN2; FSDI; FSDIL; FSD2; FSHB; FSHR; FSIPI; FST; FSTLI; FSTL3; FSTL4; FSTL5; F D; FTHI: FTL; FTMT; FTO; FTSJI;
FTSJ2; FTSJ3; FUBPI: FUBP3; FUCAt: FOCA2; FUNDCI: FONDC2; FDRIN; FUS; FOTIO; FOTII; FUTI; FDT2; FUT3; FUT4; FUT5; FUTG; FUT7;
FUT8; FOT9; FUZ; FXN; FXRI; FXR2; FXYDI; FXYD2; FXYD3; FXYD5; FXYDB; FYS; FYCDI; FYN; FZDIO; FZDI; FZD2; FZD3; FZD4; FZD5; FZDB;
FZD7; FZDB; FZD9; FZRI; GDS2; G2E3; G3BPI; GGPC2; GGPC3; GBPC; GBPD; GAA; GABI; GAB2; GAB3; GABARAP; GABARAPLI; 5 GABARAPL2; GABBRI: GABBR2; GABPA; GABPBI; GABRAI; GABRA2; GABRA3; GABRA4; GABRA5; GABRAB; GABRBI; GABRB2; GABRB3; GABRE; GABRGI; GABRG2; GABRG3; GABRP; GABRQ; GABRRI; GABRR2; GADI; GAO2; GADD45B; GAOD45G; GADD 5GIPI; GADLI;
GAGEID; GAGEI; GAK; GALC; GAL; GALKI; GALK2; GALN; GALNS; GALNTI2; GALNTI3; GALNTI4; GALNTI5; GALNTI8; GALNTI; GALNT2;
GALNT3; GALNT4; GALNT5; GALNTB; GALNT7; GALNT8; GALNT9; GALNTLB; GALP; GALRI; GALR2; GALR3; GALT; GAMT; BANAB: GANG;
GAN; GAP43; GAPDH; GAPDHS; GARI; GAREM; GARNL3; GARS; GART; GASI; GAS2; GAS2LI; GASB; GAS7; GAS8; GAST; GATAI: GATA2; GATA3; GATA4; GATA5; GATAB; GATADI: GATAO2A; GATAD2B; GATB; GATM; GBA2; GBA; GBAS; GBEI; GBFI; GBGTI; BBXf; GBX2; GCA;
GCCI; GCDH; GCFC2; GCG; GCGR; GCHI; GCHFR; GC; GCK; GCKR; GCLC; GCMI; GCM2; GCNILI; GCNTI; GCNT2; GCNT3; GCNT7; GCOHI;
GCSAM; GCSAML; GCSH; GDA; GDAPI; GOEI; GDFIQ; GDFII; GDFI5; GDFI: GDF2; GDF3; GDF5; GDFB; GDF7; GDF9; GDII; GDI2; GDNF;
GDPD3; GDPO5; GEM; GEMIN2; GEMIN4; GE IN6; GENI: GET4; GFAP; GFER; GFIIB; GFII; GFMI; GFPTI; GFPT2; GFRAI; GFRA2; GFRA3;
GFRA4; GGAI; GGA3; GGACT; GGCT: GGCX; GGH; GGNBP2: GGN; GGPSI; GGTI; GGT2; GGT5; GGTLCI; GHI; GH2; BHITM; GHRH; GHR; GHRHR; GHRL; GHSR; GID8; GIF; GIGYFI; GIGYF2; GIMAP5; GIMAP7; GIMAP8; GINI; GINSI; GINS2; GIPCI; GIPC3; GIP; GIPR; GITI; GIT2;
GJAI; GJA3; GJA8; GJBI; GJB2; GJBB; GJCI; GJC2; GJC3; GJD2; GJB3; GK; GKNI: GKN2; GLA; GLBI; GLCCII; GLCE; GLDC; GLDN; GLEI;
GLGI; GUI: GLI2; GLI3; GLIPRI; GLIPR2; GLIS2; BLISS; GLMN; GLDI: GLDD4; GLPIR; GLP2R; GLRAI; GLRA2; GLRA3; GLRB; GLRX2; GLRX3;
GLRX5; GLRX; GLS2; GLS; GLTIDI; GLTBDI; GLT8DI; GLTSCRI; GLTSCR2; GLUDI: GLUD2; GLUL; GLYAT; GLYATL3; GLYCTK; GM2A; GMCLI;
GMDS; GMFB; GMFG; GMIP; GML; GMNN: GMPPA; GMPPB; GMPR2; GMPR; GMPS; GNAII; GNAI2; GNAI3; GNAI4; GNAI5; GNAII; GNAI2; GNAL; GNADI; GNAQ: GNAS; GMATI: GNATS; GNAZ; GNBIL; GNB2LI; GNB3; GNB4; GNB5; GNE; GNGIB; GNGII; GNG2; GNG4; GNG7; GNG8;
GNGTI; GNGT2; GNU; GNL3; GNL3L; GNLY; GNMT; GNPAT; GNPDAI; GNPDA2; GNPTAB; GNPTG; GNRHI; GNRH2; GNRHR; GNS; GOLGAI;
GDLGA2; G0LGA3; GDLGA4; GDLGA5; GDLGA8B; GDLGBI; GDLMI; GBLPH3; GBLTIA; GBLTIB; GBN4L; GDPC; GDRAB; GDRASPI;
GDRASP2; GDSRI; G0SR2; GDTI: GDT2; GPIBA; GPIBB; GP2; GP5; BPS; GP9; GPA33; GPAAI; GPALPPI; GPAM; GPANKI; GPAT2;
GPATCHI; GPATCH2; GPATCH2L; GPATCH8; GPBARI; GPCI; GPC2; GPC3; GPC4; GPC5; GPCB; GPCPDI; GPDI; GPDIL; GPD2; GPERI; GPHA2; GPHN; GPIHBPI; GPI; GPKOW; GPLDI; GPMBA; GPMBB; GPNI; GPNMB; GPRIDI: GPRIIB; GPRI2; GPRI32; GPRI35; GPRI37C;
GPRI39; GPR143; GPRI48; GPRI49; GPRI50; GPRI5I; GPRI52; GPR153; GPRI55; GPRI5B; GPRI58; GPRI5; GPRIBO; GPRIGI; GPRIB2;
GPRI7I; GPRI74; GPRI7B; GPRI7B; GPRI7; GPRI80; GPRI82; GPRI83; GPRI9; GPRI: GPR2D; GPR22; GPR2B; GPR34; GPR35; GPR37;
GPR37LI; GPR39; GPR4; GPR5D; GPR52; GPR55; GPRB5; GPRB8; GPRB; GPR75; GPR78; GPR83; GPR87; GPRASPI; GPRC5A; GPRC5B;
GPRC5C; GPRC5D; GPRCBA; GPRINI: GPRIN2; GPRIN3; GPS2; GPSHI: GPSM2; GPSM3; GPT2; GPT; GPX5; GRAMOIB; GRAMB3; GRAMD4; GRAP2; GRAP; GRASP; GRBID; GRBI4; GRB2; GRB7; GREBl; GREMI; GREM2; GRHLI; GRHL2; GRHPR; GRIAI; GRIA2; GRIA3;
GRIA4; GRIDI; GRID2; GRIKI; GRIK2; GRIK4; GRIK5; GRINI: GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRIN3A; GRIN3B; GRINA; GRIPI; GRKI;
GRK4; GRK5; GRKB; GRK7; GRMI; GRM2; GRM3; GRM4; GRM5; GRMB; GRM7; GRMB; GRN; GRPELI; GRP; GRPR; GRSFI; GRXCRI; GRXCR2;
GSC2; GSC; GSDMA; GSDMB; GSDMC; GSDMD; GSEI; GSGIL; GSK3A; GSK3B; GSN; GSPTI; GSPT2; GSR: GSS; GSTAI; GSTA2; GSTA4;
GSTA5; GSTCD; GSTI: GSTM3; GSTDI: GSTD2; GSTPI; GSTTI: GSTT2B; GSTT2; GSTZI; GSXI: GSX2; GTDCI: GTF2AI; GTF2AIL; GTF2A2; GTF2EI; GTF2E2; GTF2FI; GTF2F2; GTFZHI: GTF2H2C2; GTF2H2C; GTF2H2; GTF2H3; GTF2H4; GTF2H5; GTF2I; GTF2IRDI; GTF2IRD2;
GTF3A; GTF3CI; GTPBPI: GTPBP3; GTP8P4; GTSFI: GDCA1A; GUCAIB; GUCDI; GUCYIA2; GDCYIA3; GDCYIB3; GUCY2C; GUGY2D;
GUCY2F; GDKI; GULPI; GDSB; GYGI; GYG2; GYLTLIB; GYPA; GYPB; GYPC; GYPE; GYSI; GYS2; GZFI: GZMA; GZMB; GZMH; GZMK; GZMM;
HIFD; HIFX; H2AFJ; H2AFX; H2AFY2; H2AFY; H2AFZ; H2BFWT; H3F3B; HAAO; HABP2; HABP4; HACDI: HAC02; HACD4; HACEI; HACLI;
HADHA; HADHB; HADH; HAGH; HAL; HAMP; HANOI; HAND2; HADI: HA02; HAPI; HAPLNI: HAPLN4; HARS2; HARS; HASf: HAS2; HAS3; HATI; HAVCRI; HAVCR2; HAXI; HBA2; HBB; HBO; HBEI: HBEGF; HBGI: HBG2; HBM; HBPI; HBQI: HBSIL; HBZ; HCARI; HCAR2; HCAR3; HCCS; HCFCI; HCFCZ; HCK; HCLSI; HCNI; HCN2; HCN3; HCN4; HCRT; HCRTRZ; HCST; HDACIO; HDACIt HDACI; HDACZ; HDAC3; HDAC4;
HDAC5; HDACB; HDAC7; HDAC8; HDAC9; HDC; HDDCZ; HDGF; HDBFLI; HDGF P3; HDHDI; HDLBP; HEAT I; HEATR3; HEATR5B; HEATRB;
HEBPI; HEBPZ; HECA; HECTDZ; HECTD4; HECWI: HECWZ; HEGI; HELLS; HELQ; HELT; HELZZ; HELZ; HEMGN; HEPACAM; HEPH; HEPNI;
HERCI; HERC2; HERC3; HERC5; HERCB; HERPUOI; HESI; HES2; HESB; HES7; HESXI; HEXA; HEXB; HEXDC; HEXIMI; HEYI; HEYZ; HFE; 5 HFMI; HGD; HGFAC; HGF; HGHI; HGS; HGSNAT; HHAT; HHATL; HHEX; HHIP; HHIPLI; HHLAI; HHLAZ; HIATI; HIBAOH: HIBGH; HICl; HICZ;
HIDI; HIFIA; HIFIAN; HIF3A; HIGDIA; HIGDIC; HIGDZA; HILPDA; HINFP; HINTI; H1NT2; HIPI; HIPIR; HIPKI; HIPKZ; HIPK3; HIRA; HIRIP3;
HISTIHIA; HISTIHIB; HISTIHIC; HISTIHID; HISTIHIE; HISTIHIT; HISTIHZAE; HISTIH2AH; HISTIHZBG; HISTIH2BH; HISTIH2BM; HISTIH3G;
HISTIH4D; HIST3H3; HIVEPI; HIVEP2; HJURP; HKI; HK2; HK3; HKDCI; HLA-A; HLA-B; HLA-C; H LA-DMA; HLA-DMB; HLA-DOA; H LA-DOB;
HLA-DPAI; HLA-DPBI; HLA-DQAI; HLA-DQA2; HLA-OQBI: HLA-DOB2; HLA-DRA; HLA-DRBI; HLA-DRB3; HLA-DRB4; HLA-DRB5; HLA-E; ID HLA-F; HLA-G; HLCS; HLF; HLTF; HLX; HMI3; HMBOXI; HMBS; HMCNI; HMG2DA; HMG2OB; HMGAI: HMGA2; HMGBI; HMGBZ; HMGB3;
HMGCR; HMGCSI; HMGNI; HMGN4; HMGN5; HMGXB3; HMGXB4; HMHAI; HMMR; HMOXI; HMDXZ; HMPIB; HMSD; HMXI; HNI; HNIL; HNFIA;
HNFIB; HNF4A; HNF4G; HNT: HNRNPAO; HNRNPAI: HNRNPAZBI; HNRNPA3; HNRNPAB; HNRNPC; HNRNPD; HNRNPDL; HNRNPF;
HNRNPHI; HNRNPHZ; HNRNPK; HNRNPL; HNRNPM; HNRNPR; HNRNPU; HNRNPULI: HDGAI; HOMER): HOMERZ; HOMERS: HOMEZ;
HODKZ; HODK3; HOPX; HORMAD2: HOXAIO; HOXAII; HOXAI3; HOXAI; HOXA2; HOXA3; HOXA4; HOXA5; HOXAB; HOXA7; HOXA9; HOXBI3; HOXBI; HOXB2; HOXB3; HOXB4; HOXB5; HOXB6; HOXB7; HOXB8; HOXB9; HOXC10; HOXCII; HOXCI2; HOXCI3; HOXC4; HOXC5; HOXCB;
HOXC8; HOXCB; HOXDIO; HOXDII; HOXDI2; HOXDI3; HOXDI: HOXD3; HOXO4; HOXO8; HOXO9; HPIBP3; HPCALI; HPD; HPGD; HPGDS; HP;
HPN; HPR; HPRTI; HPSI; HPS3; HPS4; HPS5; HPSB; HPSE2; HPSE; HPX; HRAS; HRASLS; HRC; HRG; HRHI; HRH2; HRH3; HRH4; HR;
HRK; HRNR; HRSPIZ; HSIBP3; HS3STI; HS3STZ; HS3ST3AI; HS3ST3BI; HS3ST4; HS3ST5; HS3STB; HSBSTI; HSBSTZ; HSBST3; HSBPI;
HSDIIBI; HSOIIBIL; HSDIIB2; HSDI7BI0; HSDI7BII; HSDI7BI2; HSDI7BI3; HSDI7BI4; HSDI7BI; HSDI7B2; HSDI7B3; HSDI7B4; HSDI7B6; HSDI7B7; HSDI7BB; HSD3BI; HSD3B7; HSDLI; HSDL2; HSFI; HSFZ; HSF4; HSF5; HSFY2; HSH2D; HSP90AAI: HSP90ABI; HSP90BI;
HSPAI2A; HSPAI2B; HSPAI3; HSPAI4; HSPAIA; HSPAIL; HSPA2; HSPA4; HSPA4L; HSPA5; HSPAB; HSPA8; HSPA9; HSPBI: HSPB2;
HSPB3; HSPBB; HSPB7; HSPB8; HSPB9; HSPBAPI; HSPBPI: HSPDI; HSPEI: HSPG2; HSPHI; HTATIPZ; HTNI; HTN3; HTRIA; HTRIB;
HTRIE; HTRIF; HTRZA; HTRZB; HTRZC; HTR3A; HTR3B; HTR3C; HTR3D; HTR3E; HTR4; HTR5A; HTR7; HTRAI; HTRAZ; HTRA3; HTRA4;
HTT; HUNK; HUSIB; HUSI; HUWEI; HVCNI; HYALI; HYALZ; HYAL3; HYAL4; HYDIN; HYKK; HYLSI; HYOUI: HYPM; IAPP; IARS2; IARS; IBA57;5 IBSP; IBTK; ICAI; ICAMI; ICAMZ; ICAM3; ICAM4; ICAM5; ICEI: ICE2; ICK; ICMT; ICOS; ICOSLG; IDI: ID2; 104; IDE; IDHI; IDH2; IDH3B; IDNK;
IDOI; IDO2; IDS; IDUA; IER2; IER3; IER3IPI; IER5; IFFOI: IFFOZ; IFIIB; IFIZ7; IFI30: IFI35: IFI44; IFIHI; IFITI; IFITZ; IFIT3; IFIT5: IFITMI;
IFITMZ; IFITM3; IFITM5; IFNAIO; IFNAI3; IFNAI4; IFNAIB; IFNAI7; IFNAI; IFNAZI; IFNA2; IFNA4; IFNA5; IFNAG; IFNA7; IFNA8; IFNARI:
IFNAR2; IFNBI; IFNE; IFNG; IFNGRI; IFNGR2; IFNK; IFNLI: IFNL2; IFNL3; IFNWI; IFRDI; IFTI22; IFTI40; IFTI72; IFT27; IFT43; IFT57; IFT74;
IFT80; IFT88; IGBPI; IGDCC3; IGFI; IGFIR; IGF2BPI; IGF2BP2; IGF2BP3; IGF2; IGF2R; IGFALS; IGFBPI; IGFBP2; IGFBP3; IGFBP4; IGFBP5;0 IGFBPB; IGFBP7; IGFBPLI; IGFLI: IGFLRI; IGHMBP2; IGJ; IGLLI; IGSFIO; IGSFII; IGSFI; IGSF5; IGSFB; IGSF8; IHH; IKB AP; IKBKB; IKBKE;
IKBKG; IK; IKZFI; IKZF2; IKZF3; IKZF4; ILIO; ILIORA; ILIORB; ILII; ILIIRA; ILIZA: ILI2B; ILI2RBI; ILI3; ILI3RAI; ILI3RA2; ILI5: ILI5RA; ILIB;
ILI7A; ILI7B; ILI7C; ILI7D: ILI7F; ILI7RA; ILI7RB; ILI7RC; ILI7RD; ILI7RE; ILI7REL; ILI8BP; ILI8: ILI8RI; ILI8RAP; ILI9; ILIA; ILIB; ILIFIO;
ILIRI; ILIRZ: ILIRAP; ILIRAPLI: ILIRAPLZ; ILIRLI; ILIRLZ; ILIRN; ILZO; ILZDRA; ILZORB; ILZI; ILZIR; ILZZ; IL22RA2; ILZ3A; IL23R; IL24;
IL25; IL2B; IL27; ILZ7RA; IL2: IL2RA; IL2RB; IL2RG; IL3I; IL3IRA; IL32; IL33; IL34; IL3BA; IL3BB; IL3GG; IL3GRN; IL37; IL3: IL3RA; IL4;5 IL4II; IL4R; IL5; IL5RA; ILB; ILBR; ILBST; IL7; IL7R; IL9: IL9R; ILDRI; ILDRZ; ILFZ; ILF3; ILK; IMMPIL; IMMPZL; IMMT; IMPS; IMPAI; IMPAZ; IMPACT; IHPAD!; IMPDHI; IMPDH2; IMPBI; IMPG2; 1NADL: INA; INCENP; INF2; INGI; ING2; ING3; ING4; ING5; 1NHA; INHBA; INHBB; INHBC; INHBE; INB8BB; INOSDD; IND8D; INPPI: INPP4A; INPP4B; INPP5A; INPP5B; INPP5D; INPP5E; INPP5F; INPP5K; INPPLI; INSC: INS; INSIGI; INSIG2; INS-IGF2; INSL3; INSL4; INSLB; INSMI: INSM2; INSR; INSRR; INTSI2; INTSI; INTS2; INTS3; INTS4; INTS5; !NTSB; 1NTS7; INTS8; INTU; INVS; !PBKI; IP6K2; IPGK3; IPCEFI; IPM ; IPBtl; IPDI3; IPB7; IPB8; IPB9; IDCBI; IDCG; IQCH; IQCJ; IDCJ-SCHIPI: IflC; IDGAPI; IBGAP2; IQGAP3: IDSECI: IQSEC2; IQSEC3; IRAKIBPI; IRAKI; IRAK2; IRAK3; IRAK4; IREB2; IRFI; IRF2BP2; IRF2BPL; IRF2; IRF3; IRF4; IRF5; IRFB; IRF7; IRF8; IRF9; IRGI: IRGM; IRSI; IRS2; IRS4; IRXI; IRX2; IRX3; IRX4; IRX5; ISCU; ISG2B; ISLI; ISMI: ISM2; ISPD; ISTI; ISX; ISYNAI; ITCH; ITFGI; ITFG3; ITGAIO; ITGAII; ITGAI; ITGA2B; ITGA2; ITGA3; ITGA4; ITGA5; ITGAB; ITGA7; ITGA8; ITGA9; ITGAD; ITGAE; ITGAL; ITGAM; ITGAV; ITGAX; ITGBIBPI; ITGBI; ITGB2; ITGB3; ITGB4; ITGB5; ITGBB; ITGB7; ITGB8; ITGBLI; ITIHI; ITIH2: ITIH3; ITIH4; ITIH5: ITK; ITLNI: ITLN2; ITM2A; ITM2B; ITM2C; ITPA; ITPKt; ITPKA; ITPKC; ITPRI; ITPR2; ITPR3; ITSNI; ITSN2; IVD: IVL; IVNSIABP; IYD: IZUMBI; JAOEI; JADE2; JABI: JAG2; JAGNI; JAK2; JAK3; JAK IPI: JAKMIP2; JAKMIP3; JAM2; JAM3; JARID2; JAZFI: JDP2; JMJOIC; JMJDB; JMY; JPH2; JPH3; JPH4; JR ; JS PI; JTB; JUNB; JUNO; JUP; KALI; KALRN; KANKI; KANK2; KANK4; KANSLI: KANSL3; KARS; KAT2A; KAT2B; KAT5; KATBA; KATBB; KAT7; KAT8; KATNAI; KATNAL2; KATNBI; KAZALDI; KAZN; KBTBDII: KBTBDI3; KBTBD8; KCMFI; KCHAI: KCNA4; KCNA5; KGNAB; KCNA7; KCNABI: KCNAB2; KCNAB3; CNBI; KCNB2; KCNCI; KCNC2; KCNC3; KCND2; KCNEi: KCNE2; KCNE3; KCNE4; KCNE5; KCNG3; KCNG4; CNHI; KCNH2; KCNH3; KCNH4; KCNH5; KCNHB; KCNH7; KCNH8; KCNIPI; KCNIP2; KCNIP3; KCNIP4; KCNJID; KCNJ1I; KCNJ12; KCNJI3; KCNJ14; KCNJI5; KCNJIB; KCNJI8; KCNJi; KCNJ2; KCNJ3; KCNJ4; KCNJ5; KCNJ6; KCNJB; KCNJ9; KCNKIB; KCNKI2; KCNKIB; KCNKI7; KCNKI8; CNKI; KCNK2; KCNK3; KCN 5; KGNKB; KCNK9; KCNMAI; KCN BI; KCNMB2; KCNMB3; KCNMB4; KCNNI; KCNN2; KCNN3; KCNN4; KCNOI; KCN02; KCN03; KCNQ5; KCNRG; KCNSI; KCNS3; KCNTI; KCNT2; CNUI; KCNVI; KCNV2; KCTDID; CTDII; KCTDI2; KCT0I3; KCTDI5; KCTDIB; KCTDI; KCTD2I; KCTD2; KCTD3; KCTDB; KCTD7; KCTD9; KDELCI: KDELRI; KDM2A; KDM2B; KDM3A; KDM3B; KDM4B; KDM4C; KDM5A; KDM5B; KDM5C; KDM5D; KDMBA; KDMBB; KDR; KOSR; KEAPI; KEL; KERA; KHDC3L; KHDRBS2; KHBRBS3; KHK; KHSRP; KIAADB2B; KIAAQD4D; KIAADIBD; KIAADIDI: KIAADIBB; KIAAD22G; KIAAD22BL; KIAAD232; KIAAD3I9; KIAAD3I9L; KIAAD355; KIAAD3BI; KIAAB58G; KIAAD825; KIAAD9D7; KIAAD922; KIAAID24; KIAAI033; KIAAII09; KIAAII47; KIAAIIBI; KIAAI2II; KIAAI2IIL; KIAAI2I7; KIAAI279; KIAAI324; KIAAI324L; KIAAI377; KIAAI45B; KIAAI4B2; KIAAI4B8; KIAAI524; KIAAI549; KIAAI55I; KIAAI598; KIAAI7I5; KIAAI8D4; KIAAI84I; KIAAI9I9; KIAA2D22; KIDINS220; KIFII; KIFI3A; KIFI4; KIFI5: KIFIBB; KIFI7; KIFI8A; KIFIA; KIFIC; KIF20A; KIF2BB; KIF2IA; KIF2IB; KIF22; KIF23; KIF24; KIF25; KIF2BA; KIF2BB; KIF2A; KIF2B; KIF2C; KIF3A; KIF3B; KIF3C; KIF4A; KIF4B; KIF5A; KIF5B; KIF5C; KIFB; KIF7; KIF9; KIFAP3; KIFCI; KIFC3; KIN; KIR2DLI; KIR2DL2; KIR2DL3; KIR2DL4; KIR2DL5A; KIR2DL5B; KIR2DSI; KIR2DS2; KIR2DS3; KIR2DS4; KIR3DLI; KIR3DL2; KIR3DL3; KIRREL2; KIRREL3; KIRREL; KISSI; ISSi; KIT; KITLG; KLB; KLCI; KLFID; KLFII: KLFI2; KLFI3; KLFI4; KLFI5; KLFIB; KLFI: KLF2; KLF3; KLF4; KLF5; KLFB; KLF7; KLF8; KLF9; KLHDCI; KLHDC2; KLHDC8A; KLHDC8B; KLHLIO; KLHLI2; KLHLI; KLHL2D; KLHL25; KLHL2B; KLHL29; KLHL2; KLHL3I; KLHL35; KLHL3; KLHL40; KLHL4I; KLHL42; KLHL5; KLHLB; KLHL7; KLHLB; KL; KLKIO; KLKII; KLKI2; KLKI3; KLKI4; KLKI5; KLKI; KLK2; KLK3; KLK4; KLK5; KLKB; KLK7; KLK8; KLK9; KLKBI; KLLN; KLRBI; KLRCI; KLRC2; KLRC4; KLRC4-KLRKI: KLRDI; KLRGI; KLRG2; KMD; KMT2A; KMT2B; KMT2C; KMT2D; KMT2E; KNGI; KNSTRN; KNTCl; KPNAI; KPNA2; KPNA3; KPNA4; KPNAB; KPNA7; KPNBI; KPRP; KPTN; KRAS; KRB0X4; KREMEN1; KRITI; KRTID; KRTI2; KRTI3; KRTI4; KRTI5; KRTIB; KRTI7; KRTI8; KRTI9; KRTI; KRT2D; KRT23; KRT2; KRT3I: KRT32; KRT34; KRT35; KRT3; KRT4; KRT5; KRTBA; KRTBB; KRTGC; KRT7I; KRT72; K T74; KRT75; KRT7B; KRT78; KRT7; KRT8D; KRT8I; KRT82; KRT83; KRT85; KRT8G; KRT8; KRT9; KRTAPII-I; KRTAP5-I; KRTAP5-9; KSRI: KSR2; TNI; KYNU; LICAM; L2HGDH; L3MBTLI; L3MBTL2; L3MBTL3; L3MBTL4; LACCI; LACEI; LACRT; LACTB; LADI; LAG3; LAIRI: LAIR2; LALBA; LAMAI; LAMA2; LAMA3; LAMA4; LAMA5; LAMB!: LAMB2; LAMB3; LAMB4; LA CI; LAMC2; LAMC3; LAMP1: LAMP2; LAMP3; LAMTORI; LAMTQR2; LAMT0R3; IANCLI: LANCL2; LAP3; LAPTM4B; LARGE; LARP1;
LARP4; LARPG; LARP7; LARS2; LARS; LASIL; LASPI; LAT2; LAT; LATSI; LATS2; LAXI; LAYH; LBH; LBP; LBR; LBXI: LBX2; LCA5; LCAT;
LCEIC; LCE3A; LCE3B: LCE3C; LCE3D; LCE3E; LCE5A; LCK; LCLATI; LCMTI; LCNI: LCN2; LCOR; LCPt: LCP2; LCT; LDBI; LDB2; LDB3;
LDHA; LDHALBB; LDHB; LDHC; LDHD; LDLRAD3; LDLRAD4; LDLR; LDDCI; LDDCIL; LEAP2; LECT1; LECT2; LEFI; LEFTYI; LEFTY2; LEKRI; LEMD2; LEMD3; LEDI; LEP; LEPRDTLI; LETMI; LETMDI; LEUTX; LFNG; LGALSI2; LGALSI3; LGALSI4; LGALSIB; LGALSI; LGALS2; LGALS3BP;
LGALS3; LGALS4; LGALS7B; LGALS8; LGALSB; LGALSL; LGII; LGI2; LGI4; LGMN; LGR4; LGR5; LGRB; LGSN; LHB; LHCGR; LHFP; LHFPLI:
LHFPL2; LHFPL3; LHFPL4; LHFPL5; LHPP; LHXI; LHX2; LHX3; LHX4; LHX5; LHXB-. LHX9; LIAS; LIE; LIFR; LIGI; LIG3; LIG4; LILRAI; LILRA2;
LILRA3; LILRA4; LILRA5; LILRBI; LILRB2; LILRB3; LILRB4; LILRB5; LIM2; LIMAI: LIMCHI; LIMDI; LIND2; LIMKI; LI K2; LIMSI; LIMS2;
LIN28B; LIN52; LIN7A; LIN7B; LIN7C; UNO; LINGDI; LING02: LINGB4; LINS; LIPA; LIPC; LIPE; LIPF; LIPG; LIPH; LIPI; LIPN; LIPTI: LIPT2; LITAF; LIXI; LLGLI; LLGL2; LMANI; LMANIL: LMAN2L; LMBRI; LMBRDI; LMBRD2; L CDI; LMFi: LMLN; LMNA; LMNBI: L NB2; LMNTDI; LMOI;
LMO2; LMO3; LMO7; LMODI; LDD3; LMTK2; LT3; LMXIA; LMXIB; LNPEP; LNXI; LNX2; LDCID02889BB; LOCIOIOBD32I;
LDCID2723475; L0CI0272399B; L0CI02724I27; LDC1027245BD; LDCI02724770; LQCI027250IB; L0CID2725035; LDC400499;
LOC400927-CSNKIE; LOCB45I77; LONPI; LONRFI: LOR; LOXHDI: LOX; LOXLI; LOXL2; LOXL3; LOXL4; LPA; LPARI; LPAR2; LPAR3; LPARB;
LPCATI; LPCAT2; LPCAT3; LPCAT4; LPGATI; LPINI; LPIN2; LPL; LPD; LPP; LPPR2; LPPR4; LPXN; LRAT; LRBA; LRCHI; LRCH4; LRFN2; LRFN5; LRGI; LRGUK; LRIFI; LRIGI; LRIG3; LRITI; LRIT3; LRMP; LRPID; LRPI2; LRPIB; LRPI; LRP2BP; LRP2; LRP4; LRP5; LRPB; LRPAPI;
LRPPRC; LRRI; LRRCI5; LRRCIBA; LRRCIBB; LRRCI7; LRRCI8; LRRCI; LRRC2D; LRRC2B; LRRC3D; LRRC32; LRRC37A; LRRC37B;
LRRC39; LRRC49; LRRC4B; LRRC4C; LRRC4; LRRC52; LRRC59; LRRCBI; LRRCB3; LRRCB9; LRRCB; LRRC74A; LRRC7; LRRC8A;
LRRC8C; LRRCCI; LRRFIPI; LRRFIP2; LRR I; LRRK2; LRRNI; LRRN2; LRRN3; LRRN4; LRRTMI; LRRTM2; LRRTM3; LRRTM4; LRSAMI;
LRTMI; LRTDMT; LSAMP; LSMII: LSMI: LSM2; LSM3; LSM4; LS 5; LSMB; LSM7; LSPI; LSR; LSS: LSTI; LTA4H; LTA; LTB4R2; LTB4R: LTB; LTBPI; LTBP2; LTBP3; LTBP4; LTBR; LTC4S; LTF; LTK; L0C7L3; L0C7L; LUM; LURAPIL; LUZP4; LOZPB; LVRN; LXN; LYBD; LYBE; LYBG5B;
LYBG5C; LYBGBC; LYBGBF; LYB; LY75-CD302; LY75; LY8B; LY9B; LY9; LYL1; LYN; LYNX; LYPDI; LYPD2; LYPD3; LYPD4; LYPD5;
LYPOB; LYPD8; LYPLAI; LYPLALI; LYRM1: LYR 4; LYRM7; LYRM9; LYST; LYVEI; LYZ; LYZLI; LYZL2; LYZLB; LZTFLI: LZTRI: LZTSI; MBPR;
MAATSI; MAB2ILI; MAB2IL2; MAB2IL3; MACCI; MACRDDI; MACR0D2; MAOILI; MAD2LIBP; MAO2LI; MAD2L2; MADCAMI; MAOD; MAEA:
MAEL; MAPI; MAFA; MAFB; MAFF; MAFG; MAF; MAFK; MAGEAIO; MAGEAII; MAGEAI2; MAGEAI; MAGEA2B; MAGEA3; MAGEA4; MAGEAB; MAGEA9; MAGEBI7; MAGEBI; MAGEB2; MAGEBB; MAGECI; MAGEC2; MAGEC3; MAGEDI; MAGED2; MAGED4B; MAGED4; MAGEEI; MAGEHI;
MAGEL2; MAG; MAGII; MAGI2; MAGI3; MAGTI; MAKIB; MAK; MAL; MALL; MALRDI; MALTI; MAMLI; MAML2; MAML3; MAMLOI: MANIAI;
MANIBI; MAN2AI: MAN2A2; MAN2BI; MAN2CI: MANBA; MANEA; MANF; MANSCI; MAOA; MAOB; MAPIO; MAPIA; MAPIS; MAPILC3A;
MAPILC3B2; MAPILC3B; MAPIS; MAP2; MAP2KI; MAP2K2; MAP2K3; MAP2K4; MAP2K5; MAP2 B; MAP2K7; MAP3KI0; MAP3KII;
MAP3KI2; MAP3KI3; MAP3KI4; MAP3KI9; MAP3KI; MAP3K2; MAP3K3; MAP3K4; MAP3K5; MAP3KB; MAP3K7CL; MAP3K7; MAP3K8; MAP3K9; MAP4; MAP4KI; MAP4K2; MAP4K3; MAP4K4; MAP4K5; MAPG; MAP7; MAPS: MAPKIO; MAPKII; MAPKI2; MAPKI3; MAPKI4;
MAPKI5; MAPKI; MAPK3; MAPKB; MAPK7; MAPKB; MAPK8IPI; MAPK8IP2; MAPK8IP3; MAPK9; MAPKAPI: MAPKAPK2; MAPKAPK3;
MAPKBPI: MAPREI; MAPRE2; MAPRE3; MAPT: MARCI; MARC2: MARCHI; MARCH2-、MARCH5; MARCHB; MARCH7; MARCH8; MARCKS;
MARCO; MARKI; MARK2; MARK3; MARK4; MARS2; MARS; MARVELDI; MARVELD2; MARVELD3; MASI; MASIL; MASPI; MAST2; MAST4;
MASTL; MATIA; MAT2A; MAT2B; MATK; MATN2; MATN3; MATR3; MAU2; MAVS; MAX; MAZ; MB2IDI; MB2ID2; MBDI; MBD2; MBD3; MBD3L2; MBD4; MBD5; MBDB; MB; MBIP; MBL2; MBNLI; MBNL2: MBDATI; MB0AT2; MBDAT4; MBP; MBTDI; MBTPSI; MBTPS2; MCIR; MC2R; C3R; MC4R; MC5R; MCAM; MCAT; MCCCI; MCCCZ; MCCDI: MCC; MCEE; MCP2; NCF2L2; CF2L; MCFD2; MCHRI; MCHR2;
MCIDAS; MCMIO; CM2: MCM3AP; MCM3; MCM4; MCM5; MCMG; CM7; CM8: MCM9; CMBP; MCDLNI; MC0LN3; MCPHI; MCRSI;
MCTPI: MCTP2; MCTSI: MCG; MCURI; MDCI; DFIC; DFI; MDGAI; MDGA2; MDHI: MDH2; MD; MDMI: MDM2; MDM4; MEI: ME2; ME3;
MEAI: MECDM; MECP2; MEDI2; MEDI2L; MEDI3; MEDI3L; MEDI4; MEDI5; MEOIG; MEDI7; MEDI9; MEDI; MED22; MED23; MED24; MED25: MED28; MED29; MED3D; MED4; MEDG; MED9; MEF2A; MEF2B; MEF2BNB-MEF2B; MEF2C; MEF2D; MEFV; MEGFIO; MEGFII; MEGF8;
MEGF9; MEIl; MEISI; MEIS2; MELK; MEMDI; MENI; MEDXI; ME0X2; MEPIA; MEPE; MERTK; MESDCI; MESDC2; MESP2; MEST; METAPID;
METAPI; METAP2; MET; METRN; METTLI3; METTLIG; METTLI7; METTLI8; METTLI; METTL2IA; METTL2IB; METTL2IC; METTL24; METTLE;
METTL7A; METTL9; MEX3B; MEX3C; MEX3D; MFAP3; MFAP4; MFAP5; MFGE8; MFHASI: MFI2; MFNI; MFRP; MFSDII: MFSDI2; MFSDI:
MFSOG; MFSD7; MFS08; MGA; MGAM; MGARP; MGATI; MGAT2; MGAT3; MGAT4A; MGAT4B; MGAT4C; MGAT5B; MGAT5; MGEA5; MGLL; MGMEI; MGMT; MGP; MGRNf: MGSTI; MGST2; MGST3; MIA2; MIA3; MIA; MIBI; MIB2; MICA; MICAL2; MICALCL; MICB; MICUI; MICU3; MIDI;
MID2; MIENt: MIER2; MIER3; MIF; MILRI; MINA; MINKI; MINPPI; MIDX: MIPEP; MIP; MIPDLI; MIRI-IHG; MISI8BPI; MITF; MIXLI; MKIG7;
MKKS; MKLI; MKL2; MKLN1; MKNKI; MKNK2; MKRNI; MKRN3; MKSI; MLANA; MLCI; MLEC; MLFI; MLF2; MLHI: MLH3; MLKL; MLLTIO; MLLTI;
MLLT3; MLLT4; MLLTG; MLN; MLNR; MLPH; MLST8; MLX; MLXIP; MLXIPL; MLYCD; MMAA; MMAB; MMADHC; MMD2; MMD; MME; MMELI;
MMPID; MMPII; MMPI2; MMPI3; MMPI4; MMPI5; MMPIG; MMPI7; MMPI9; MMPI; MMP20; MMP2I; MMP24; MMP25; MMP2B: MMP28; MMP2; MMP3; MMP7; MMP8; MMP9; MMRNI; MMRN2; MMSI9: MMS22L; MNI; MNATI; MNDA; MNSI: MNT; MNXI; MDAPI; MDBIA; MDBIB;
MDB2; M0B3B; M0B4; MOBP; MOCDS; MOCSI; M0CS2; MOGATI; M0GAT2; M0GAT3; MOG; MOGS; MDK; MONIA; MONIB; MDN2; MDRC3;
MDRF4LI; MORNI; M0RN2; MDRN5; MOS; MOVIOLI: MPCI; MPC2; MPDUt; MPDZ; MPEGI: MPG; MPHDSPHIO; MPHDSPHB; MPHDSPH8;
MPHDSPH9; MPI; MPLKIP; MPD; MPPI; MPP2; MPP3: MPP5; MPP7; MPPEI; MPPED2; MPRIP; MPST; MPVI7; MPVI7L2; MPZ; MPZLI;
MPZL2; MPZL3; MRI; MRAP2; MRAP; MRAS; MRCI: MRC2; MREIIA; MREG; MRFAPI: MRGBP; MRGPRF; MRGPRXI; MRGPRX3; MRGPRX4; MRU; MRMI; MR0H2B: MRO; MRPLIO; MRPL1I; MRPLI3; MRPLI5; MRPLI7; MRPLI9; MRPLI; MRPL23; MRPL28; MRPL33; MRPL3B; MRPL3;
MRPL4D; MRPL4I; MRPL44; MRPL4B; MRPL52; MRPL9; MRPSII; MRPSI2; MRPSIG; MRPSI8B; MRPS22; MRPS23; MRPS28; MRPS30;
MRPS3I; MRPS33; MRPSB; MRPS7; MRPS9; MRRF; MRS2; MRVII; MS4AI2; MS4AI; MS4A2; MS4A3; MS4A4A; MS4AGA; MS4A8;
MSANTD3-TMEFFI; MSC; MSGNI; MSH2; MSH3; MSH5; MSHB: MSII; MSI2; MSLN; MSMB; MSMOI; MSMP; MSN; MSRI; MSRA; MSRB2;
MSRB3; MSTI; MSTIR; MSTN; MSTDI; MSXI; MSX2; MTIA; MTIB; MTIE: MTIF; MTIG; MTIH; MTIM; MTIX; MT2A; MT3; MT4; MTAI: MTA2; MTA3; MTAP; MTBP; MTCHI: MTCH2; MTCLI; MTCPI; MTDH; MTERFI; MTFI: MTFMT; MTFPI; MTGI; MTHFDI; MTHFDIL; MTHFD2; MTHFR;
MTHFS; MTIF2; MTIF3; MTL5; MTMI: MTMRII; MTMRI2; MTMRI4; MTMRI; MTMR2; MTMR3; MTMR4; MTMRG; MTMR7; MTMR8; MTMR9;
MTNRIA; MTNRIB; MTDI; MTPAP; MTPN; MTRFI; MTR; MTRNR2L7; MTRR; MTSSI; MTTP; MTDRN; MTUSI; MTUS2; MTXI; MTX2; MUCI2;
MDCI3; MUCI5; MUCI7; MUCI9; MUCI; MUC2D; MUC2I; MUC22; MUC2; MUC3A; MUC4; M0C5AC; MDC5B; MUCB; MDC7; MUCLI: MUMI;
MDRC; MUS8I; MUSK; MOT; MUTYH; MVBI2B; MVD; MVK; MVP; MXI; MX2; MXDI; MXD3; MXD4; MXII; MXRA5; MYADM; MYBBPIA; MYB; MYBLI; MYBL2; MYBPCI; MYBPC2; MYBPC3; MYBPH; MYCBP2; MYCBPAP; MYC; MYCN; MYCTI; MYD88; MYDGF; MYEF2; MYEOV; MYF5;
MYFG; MYHIO; MYHII; MYHI3; MYHI4; MYHI5; MYHI: MYH2; MYH3; MYH4; MYHG; MYH7B; MYH7; MYH8; MYH9; MYLI2A; MYLI2B; MYLI;
MYL2; MYL3; MYL4; MYLG; MYL7; MYL9; MYLIP; MYLK2; MYLK3; MYLK; MYLPF; MYNN; MYDID; MYDI5A; MYOIG; MY0I8B; MYDIA; MYOIB;
MYDIC; MYDID; MYDIE; MYDIF; MYD3A; MYD3B; MY05A; MY05B; MYD5C; MYDG; MYD7A; MYD7B; MYD9A; MYD9B; MYDCD; MYOC;
MYODI; MYDF; MYDG; MYDMI; MY0M2; MYOT; MYOZI; MYDZ2; MYDZ3; MYPN; MYRF; MYRFL; MYRIP; MYTI; MYTIL; MYZAP; MZBI: MZFI; N4BPI; N4BP2LI; N4BP2L2; NAAID; NAAI5; NAAIB; NAA20; NAA25; NAA30; NAA35; NAA4D; NAA50; NAAGD; NAAA; NAALAD2; NAALAOLI; NAALADL2; NASI: NAB2; NABPf; NABP2; NACA; NACCi; NACC2; NAOSYNI; NAEI; NAFI; NAGA; NAGK; NAGLU; NAGPA; NAGS;
NAIP; NALCN; NA PT; NANOG; NANDSI; NANDS2; NAN0S3; NANS; NAPILI: NAPIL3; NAPIL4; NAPIL5; NAPA; NAPEPLD; NAPG; NAPRT;
NAPSA; NARFL; NARR; NA S; NATID; NATI4; NATI; NAT2; NATB; NAT8B; NATS; NAT8L; NAVI: NAV2; NAV3; NBAS; MBEA; NBEALi;
NBEAL2; NBN; NBPF3; NBRI; NCALD; NCAMI; NCAM2; NCAN; NCAPD2; NCAPD3; NCAPG2; NCAPG; NCBP2; NCEHI; NCFI; NCF2; NCF4; 5 NCKI: NCK2; NCKAPI; NCKAPIL; NCKAP5; NCKIPSD; NCL; NCOAI; NCDA2; NC0A3; NC0A4; NCDA5; NCDAB; NCDA7; NCDRI; NCDR2;
NCRI; NCR2; NCR3; NCR3LGI; NCSI; NCSTN; NDC8D; NDEI; NDELI; NDFIPI; NDFIP2; NDNF; NDN; NDP; NDRGI; NDRG2; NDRG3; NDRG4;
NDSTI; NDST2; NDST3; NDST4; NDUFAID; NDUFAII; NDUFAI2; NDUFAI3; NDUFAI; NDUFA2; NDUFA5; NDUFAB; NDUFAB; NDUFABI;
NDUFAFI; NDUFAF2; NDUFAF3; NDUFAF4; NDUFAF5; NDUFAFB; NDUFBID; NDUFBII: NDUFB2; NDUFB3: NDUFB4; NDUFB5; NDUFBB;
NDUFB8; NDUFBB; NDUFC2; NDUFSI; NDUFS2; NDUFS3; NDUFS4; NDUFSB; NDUFS7; NDUFSB; NDUFV1; NDUFV2; NDUFV3; NEB; NEBL; ID NECABI; NECAB3; NECAPI; NEDDI; NEDD4; NEDD4L; NEDD8; NEDD9; NEFH; NEFM; NEILI; NEIL2; NEIL3; NE IO; NEKII; NEK1: NEK2; NEK3;
NEK4; NEKB; NE 7; NE 8; NEK9; NELFA; NELFB; NELFCD; NELFE; NELLI; NELL2; NEMF; NEDI; NES; NETI; NETOI; NETD2; NEW; NEU3;
NEURLI; NEURL2; NEURODI; NELIR0D2; NEURDD4; NEURDDB; NEURDGI; NEURDG2; NEURDG3; NFI; NF2; NFAMI; NFASC; NFAT5; NFATCI:
NFATC2; NFATC3; NFATC4; NFE2; NFE2LI: NFE2L2; NFE2L3; NFIA; NFIB; NFIC; NFIL3; NFIX; NFKBI; NFKB2; NFKBIA; NFKBIB; NFKBIE;
NFKBILI; NFKBIZ; NFRKB; NFSI: NFUI; NFYA; NFYB; NFYC; NGB; NGDN; NGEF; NGF; NGFRAPI; NGFR; NGLYI; NHEJI; NHLHI; NHLRCI: 15 NHLRC3; NHP2; NHP2LI; NHS; NHSLI; NICNI; NIDI; NID2; NIF3LI; NIMIK; NIN; N1NJI: NINJ2; NINL; NIPAI; NIPA2; NIPAL3; NIPAL4; NIPBL;
NIPSNAPI; NIPSNAP3B; NISCH; NITI; NIT2; NKAIN2; NKAIN3; NKAP; NKDI; NKD2; NKG7; NKIRASI; NKIRAS2; NKRF; NKTR; NKXI-I; NKXI-2;
NKX2-I; NKX2-2; NKX2-3; NKX2-5; NKX2-B; NKX2-8; NKX3-I; NKXB-I; NKXB-2; NLEI; NLGNI; NLGN2; NLGN3; NLGN4X; NLGN4Y; NLK;
NLN; NLRC3; NLRC4; NLRC5; NLRPIO; NLRPII; NLRPI2; NLRPI3; NLRPI4; NLRPI; NLRP2; NLRP3; NLRP4; NLRP5; NLRPB; NLRP7; NLRP8;
NLRP9; NMB; NMBR; NMEI; NMEI-NME2; NME2; NME3; NME4; NME5; NMEB; NME7; NME8; NME9; NMI; N NATI; N NAT2; NMNAT3; NMS; NMTI; NMT2; N U; NMURI; NMUR2; NNAT; NNMT; NNT; NOAf; NOBI; NDBDX; NDC3L; NODI: NDD2; NODAL; NOG; NOLII: NDL3; NDL4;
NOLB; NDL8; NOLCI; NDMI: ND OI; NOND; NOPID; NDPI4; NDPIB; N0P2; NDP5G; NDPB; NOSIAP; NOSI; NDS2; N0S3; NOSIP; NDSTRIN;
NOTCHI; NOTCH2; NOTCH3; NOTCH4; NOTUM; NDVAI: NOVA2; NOV; NOX1; NOX3; NOX4; NOX5; NOXAI: NOXDI; NPAPI; NPAS2; NPAS3;
NPAS4; NPAT; NPB; NPBWRI; NPCI; NPCILI: NPC2; NPDCI; NPEPLI; NPEPPS; NPFF; NPFFR2; NPHPI; NPHP3; NPHP4; NPHSI: NPHS2;
NPL; NPL0C4; NPMI; NPM2; NPNT; NPPC; NPRI; NPR2; NPR3; NPRL2; NPRL3; NPS; NPSRI; NPTN; NPTXI; NPTX2; NPTXR; NPVF; NPW;5 NPYIR; NPY2R; NPY5R; NPY; NODI; NDD2; NROBI; NRIDI; NRID2; NRIH2; NRIH3; NRIH4; NRII2; NRII3; NR2CI: NR2C2; NRZEI; NR2E3;
NR2FI; NR2F2; NR2FB; NR3CI; NR3C2; NR4AI; NR4A2; NR4A3; NR5AI: NR5A2; NRGAI; NRAP; NRARP; NRBPI; NRBP2; NRCAM; NRDI:
NRDE2; NREP; NRFI; NRGI; NRG2; NRG3; NRG4; NRGN; NRIPI; NRIP2; NRK; NRL; NRM; NRNI: NRPI; NRP2; NRSNI; NRSN2; NRTN; NRXNI;
NRXN2; NRXN3; NSA2; NSDI: NSDHL: NSF; NSFLIC; NSGI; NSMAF; NSMCE2; NSMF; NSRPI; NSUN2; NSUN3; NSUN5; NSUN7; NT5CIB;
NT5CIB-RDHI4; NT5C2; NT5C3A; NT5C; NT5DCI; NT5DC3; NT5E; NT5M; NTANI; NTF3; NTF4; NTHLI; NTM; NTNI; NTN4; NTNGI: NTNG2;0 NTPCR; NTRKI; NTRK2; NTRK3; NTS; NTSRI; NTSR2; NUAKI; NUAK2; NUBI; NUBPI; NUBP2; NUBPL; NUCBI; NUCB2; NUCKSI; NUDCD;
NUDCD3; NUDC; NUDTIO; NUDTII; NUDTI5; NUDTI9; NUDTI: NUDT2I; NUDT2; NUDT3; NUDTB; NUDT7; NUF2; NUFIPI; NUFIP2; NUGGC;
NUMAI; NUMB; NUMBU NUPI53; NUPI55; NUP205; NUP2I0; NUP2I4; NUP35; NUP37; NUP43; NUP50; NUPB2; NUP85; NUP88; NUP93;
NUPB8; NUPL2; NUPRI; NUSI; NUSAPI; NUTF2; NUTMI; NUTM2A; NUTM2B; NVL; NWDI; NXFI; NXF2B; NXF3; NXF5; NXN; NXNL1; NXNL2;
NXPEI; NXPE2; NXPE4; NXPHI: NXPH2; NXTI: NXT2; NYAP2; NYX; OARDI; OASI; OAS2; OAS3; OASL; OAT; OAZI; OAZ2; OBFCI; OBP2A;5 OBSCN; OBSLI; OC90; OCA2; OCIADI; OCIAD2; OCLM; OCLN; OCM2; OCM; OCRL; ODAM; ODCI; ODFI; ODF3B; ODF4; OFCCt OFDI; OGDH; OGDHL; OGFDDI; OGFR; OGGI; OGN; OGT; OIPS; OIT3; OLAI; OLFMI; OLFM2; OLFM4; OLFMLZB; OLI6I; OLIG2; OL1G3: OLRI; OMD; OMG;
OMP; ONECUTI; ONECUT2; OPAI; OPA3; OPCML; OPHNI; OPNILW; OPNIMW2; OPNISW; OPN3; OPN4; OPN5; OPRKI; OPRU; OPRMI; OPTC;
OPTN; ORIDA2; ORIOA4; ORIOCI; ORIOJI; ORIOJ3; ORIOJ5; ORIOKI; ORIOK2; ORIOR2; ORIOT2; ORIOXI; ORIOZI; ORIIAI; ORI2D2;
ORI2D3; ORI3C3; ORI3C4; ORI3FI: ORI3GI; ORI3JI; ORI4JI; ORIAI; ORICI; ORID2; ORIEI; ORIE2; ORIJ2; ORIKI; ORIL8; ORIMI: ORINI; ORIN2; OR2A25; OR2AGI; OR2AK2; OR2AT4; OR2B2; OR2B3; OR2BB; OR2CI; OR2F2; OR2G2; OR2G3; OR2H2; OR2J2; OR2J3; OR2L2;
OR2M3; OR2M4; OR2M7; OR2S2; OR2TID; OR2TI2; OR2TI; OR2T2; OR2T33; OR2T4; OR2T5; OR2W1; ORZYI: OR2ZI; OR3AI; OR4AI5;
OR4CI2; OR4CI3; OR4CB; OR4DI0; OR4KI3; OR4P4; OR4S2; OR5IA2; OR5IA7; OR5IEI; OR5IE2; OR5IF2; OR5IVI; OR52B2: OR52B4;
OR52DI; OR52EG; OR52II; OR52I2; OR52KI; OR52K2; OR5ZMI: OR5DI8; OR5H2; OR5HB; OR5KI; OR5K2; OR5VI; ORGBI; OR6B2; ORBCI:
ORBFI; ORGK2; ORGK3; ORBK6; ORBNI; OR6N2; ORBXI: ORGYI; OR7CI; OR7D2; OR7EZ4; OR8SI: ORBK2; OR9Q2; ORAM; ORAI3; ORAOVI; ORC3; ORC4; ORC5; ORCB; ORMI: ORM2; ORMDL3: OS3; OSBP2; OSBP; OSBPLID; OSBPLII; OSBPLIA; OSBPL2; OSBPL3;
OSBPL5; OSBPLB; OSBPL8; OSBPLB; OSCAR; OSERI: OSGEP; OSGINI; OSM; OSMR; OSRI; OSR2; OSTFI; OSTMI; OTC; OTDA; OTOF;
OTDG; OTDGL; OTOLI; OTOPI; OTOR; OTP; OTUBI; OTUDI; OTUD4; OTUD7A; OTUD7B; OTULIN; OTXI; OTX2; OVCA2; OVDLI; OVDL2; OXAIL;
OXCTI; OXERI; OXGRI; OXRI; OXSRI; OXT; OXTR; P2RXI; P2RX2; P2RX3; P2RX4; P2RX5: P2RXG; P2RX7; P2RYII; P2RYI2; P2RYI3;
P2RYI4; P2RYI; P2RY2; P2RY4; P2RYB; P2RY8; P3H2; P3H3; P3H4; P4HAI; P4HA2; P4HB; P4HTM; PA2G4; PABPCI; PA8PC3; 15 PABPC4L; PABPNI; PACRG; PACSI; PACS2; PACSINI; PACSIN2; PADI4; PAEP; PAFI; PAFAHIBI; PAFAHIB2; PAFAH2; PAGI: PAGEI; PAGE4;
PAGE5; PAGRI; PAH; PAICS; PAIPI; PAIP2; PAKI; PAKIIPI; PAK2; PAK3; PAK4; PAKB; PAK7; PALB2; PALDI; PALLD; PALM2-AKAP2;
PAMIB; PAM; PAMRI; PAN2; PANS; PANKI; PANK2; PANXI; PANX2; PAOX; PAP07; PAPL; PAPOLA; PAPOLG; PAPPA2; PAPPA; PAPSSI;
PAPSS2; PA0R3; PAQR5; PADR7; PARD3B; PARD3; PAROBA; PARDGB; PARG; PARK2; PARL; PARMI; PARN; PARPI2; PARPI4; PARPI5;
PARPI; PARP2; PARP3; PARP4; PARPB; PARPB; PARPBP; PARS2; PARVA; PARVB; PARVG; PASDI; PASK; PATEI; PATZI; PAWR; PAXI:D PAX2: PAX3; PAX4; PAX5; PAXB; PAX8; PAXB; PAXIPI; PBK; PBLD; PBOVI: PBRMI; PBXI; PBX2; PBX3; PBX4; PCBDI: PCBD2; PCBPI;
PCBP2; PCBP3; PCBP4; PCCA; PCCB; PCDHID; PCDHIIX; PCDHIIY; PC0HI5; PCDHI7; PCDHI8; PCDHI9; PCDHI: PCDH2D; PCDH7;
PCDH8; PCDHB; PCDHAI; PCDHA4; PCDHAB; PCDHBI: PCDHB2; PCDHB3; PCDHB8; PCDHGAII; PCDHGA3; PCDHGB4; PCDHGBB;
PCDHGC3; PCEDIB; PCFII; PCGFI: PCGF2; PCGF3; PCGFB; PC; PCID2; PCKI; PCK2; PCLO; PCMI: PCMTI: PCMTDI; PCNA; PCNT; PCNXL2;
PCNXL4; PC0LCE2; PCDLCE; PCP2; PCP4; PCSKI; PCSKIN; PCSK2; PCSK4; PCSK5; PCSKB; PCSK7; PCTP; PCYTIA; PCYTIB; PDAPI;5 POCDIO; PDCDI; PDCDILG2; PDCD2; PDCD4; PDCD5; PDCD6; PDCOGIP; PDCD7; PDC; PDCL2; PDCL3; PDEIDA; PDEIIA; PDEI2; PDEIA;
PDEIB; PDEIC; PDE2A; PDE3A; PDE3B; PDE4A; PDE4D; PDE5A; PDEBA; PDEBB; PDEGC; PDEBD; PDEGG; PDEGH; PDE7A; PDE7B: PDE8A;
PDE8B; PDE9A; PDF; PDGFA; POGFB; POGFC; PDGFD; PDGFRA; PDGFRB; PDGFRL; PDHAI; PDHB; PDHX; PDIA2; PDIA3; PDIA4; PDIA5;
PDIAB; PDKI; PDK2; PDK3; PDK4; PDLIMI; PDLIM2; PDLIM3; PDLIM4; PDLIM5; PDLIM7; PDPI: PDP2; PDPKI; PDPR; PDRGI; PDS5A;
PDS5B; PDSSI; PDSS2; PDXI; PDXDCI; PDXK; PDXP; PDYN; PDZD2; PDZD4; PDZD7; PDZD8: PDZKI; PDZRN3; PDZRN4; PEAI5; PEAKI; PEARI; PEBPI; PEBP4; PECAMI; PECR; PEGID; PEG3; PELII: PELI2; PELPI; PEMT; PENK; PEPD; PERI; PER2; PER3; PERM!: PERP; PESI;
PETIOD; PETII7; PEXIIA; PEXI2; PEXI3; PEXI4; PEXIG; PEXI9; PEXI; PEX2B; PEX2; PEX3; PEX5; PEX5L; PEXB; PEX7; PF4; PF4VI; PFDN4;
PFDN5; PFDNB; PFKFBI; PFKFB2; PFKFB3; PFKFB4; PFKL; PFKM; PFKP; PFNI; PFN2; PGA3; PGA4; PGA5; PGA I; PGAM2; PGAM4; PGAPI;
PGAP2; PGAP3; PGBDI; PGBD5; PGC; PGD; PGF; PGGTIB; PGKI; PGK2; PGLS; PGLYRPI; PGLYRP2; PGLYRP3; PGLYRP4; PGM3; PGPEPI;
PGP; PGR; PGRMCI; PGRMC2; PHACTRI; PHACTR2; PHACTR3; PHB2; PHB; PHCI; PHC2; PHC3; PHEX; PHFIO; PHFII; PHFI2; PHFI9; PHFI;5 PHF20; PHF2IA; PHF23; PHF2; PHF3; PHF5A; PHFB; PHF8; PHGDH; PHIP; PHKAI; PHKA2; PHKB; PHKGI; PHKG2; PHLDAI; PHLDA2; PHLDA3; PHLDBI: PHLPPI; PHLPP2; PH0X2A; PH0X2B; PHPTI; PHRFI; PHTFf; PHTF2; PHYH; PHYHIP; PHYKPL; PII5; PUB; PI3; PI4 2A;
PI4 2B; PI4KA; PI4 B; PIASt; PIAS2; PIAS4; PIBFI; PICALM; PICKI; PIDI; PIDDI; PIEZDI; PIEZD2; PIFI; FIFO; PIGA: PIGF; PIGG; PIGL;
PIGM; PIGN; PIGD; PIGP; PIGB; PIGR; PIGT; PIGU; PIGW: PIGY; PIHIDI; PIK3API; PIK3C2A; PI 3C2B; PIK3C2G; PI 3C3; PIK3CA; PIK3CB;
PIK3CD; PIK3CG; PIK3IPI; PIK3R1: PI 3R2; PIK3R3; PIK3R4; PI 3R5; PIKFYVE; PILRA; PIMI; PIM2; PIM3; PINI: PIN4; PINXI: PIP4K2A; PIP4K2B; PIP4K2C; PIP5KIA; PIP5 IB; PIP5 IC; PIP5KLI; PIP; PIPOX; PIR; PISD; PITPNA; PITPNMI; PITPNM3: PITRMI; PITXl; PITX2;
PITX3; PIWILI; PIWIL2; PIWIL3; PIWIL4; PJAI; PJA2; P DI; PKDILI; PKDIL2; PKDIL3; PKD2; PKD2LI; PKDCC; PKDREJ; PKHDI; PKIA; PKIB;
PKLR; PKM; PKMYTI; PKNI; PKN2; PKN3; PKNOXI; PKN0X2; PKPI; PKP2; PKP3; PKP4; PLA1A; PLA2GIO; PLA2GI2A; PLA2GI2B; PLA2GI5;
PLA2GIB; PLA2GIB; PLA2G3; PLA2G4A; PLA2G4B; PLA2G4C; PLA2G4D: PLA2G5; PLA2GB; PLA2G7; PLA2RI; PLAA; PLACI; PLAC8;
PLAGI; PLAGLI; PLAGL2; PLAT; PLAU; PLAUR; PLBh PLBDI; PLCBI; PLCB2; PLCB3; PLCB4; PLCDI: PLCD3; PLCD4; PLCEI; PLCGI; PLCG2; PLCHI; PLCLI; PLCL2; PLCXD2; PLCXD3; PLCZI; PLDI; PLD2; PLD3; PLD4; PLD5; PLEC; PLEK2; PLEKHAI; PLEKHA2; PLEKHA5; PLEKHAB;
PLEKHA7; PLEKHBI; PLEKHDI; PLEKHFI; PLEKHF2; PLEKHGI; PLEKHG2; PLEKHG3; PLEKHG4; PLEKHGB; PLEKHH2; PLEKHMI; PLEKHDI;
PLEKH02; PLEK; PLG; PLGLB2; PLINI; PLIN2; PLIN3; PLIN4; PLIN5; PLKi: PLK2; PLK4; PLK5; PLLP; PLN; PL0D2; PLPI; PLP2; PLRGI;
PLSI; PLS3; PLSCRI; PLSCR3; PLSCR4; PLSCR5; PLTP; PLVAP; PLXDCI; PLXDC2; PLXNAI; PLXNA2; PLXNA3; PLXNA4; PLXNB1; PLXNB3;
PLXNCI; PLXNDI; PM2DDI; PMAIPI: PMCH; PMEL; PMEPAI; PMFI-BGLAP; PMFI; PML; PMMI; PMM2; PMP22; PMPCA; PMPCB; PMSI; PMS2; PMVK; PNCK; PNKD; PNKP; PNLDCI; PNLIP; PNLIPRP2; PNMAI; PNMA2; PNMT; PNN; PNDI; PNOC; PNP; PNPLA1; PNPLA2; PNPLA3;
PNPLA4; PNPLA5; PNPLAG; PNPLA8; PNPO; PNPTI; PNRCf; POCIA; POCIB; POC5; PDDXL; POFIB; POFUTI; POFUT2; POGK; POGLUTI;
POLAI; POLA2; POLB; PDLOI; POLD2; POLD3; PDLD4; POLDIP3; POLE2; POLE3; POLE4; POLE; POLG2; POLG; POLH; POLL POLK; POLL;
POLM; POLN; POLO; POLRIA; POLRIB; POLRIC; POLRID; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2G; POLR2H;
POLR2J; POLR2K; POLR2M; POLR3A; POLR3B; POLR3E; POLR3K; POLRMT; POMI2I; POMC; POMGNTI; POMGNT2; POMK; POMP; POMTI; POMT2; POMZP3; PONI: PON2; PONS; POP1; POP4; POPDC3; PORCN; POR; POSTN; POTI; POTED; POTEF; POTEG; POTEH; POTEM;
POUIFI; POO2AFI; POU2FI; POU2F2; POU2F3; POU3F2; POU3F3; POU3F4; POU4FI; POU4F2; POO4F3; POU5FIB; POU5FI: POUBFI:
POOBF2; PPAI; PPA2; PPAP2A; PPAP2C; PPAPDCIB; PPAPDC2; PPAPDC3; PPARA; PPARD; PPARGCIA; PPARGCIB; PPARG; PPAT; PPBP;
PPCDC; PPEFI; PPEF2; PPFIAI: PPFIA2; PPFIA4; PPFIBPI: PPFIBP2; PPIA; PPIB; PPIC; PPID; PPIF; PPIG; PPILI; PPIL2; PPIL3; PPIP5I;
PPL; PPMIA; PPMIB; PPMID; PPMIE; PPMIF; PPMIG; PPMIH; PPMIK; PPMIL; PPMIM; PPMEI; PPOX; PPPICA; PPPICC; PPPIRIO; PPPIRII; PPPIRI2A; PPPIRI2B; PPPIRI2C; PPPIRI3B; PPPIRI3L; PPPIRI4A; PPPIRI4B; PPPIRI4C; PPPIRI5A; PPPIRI5B; PPPIRI7; PPPIRI8;
PPPIRIA; PPPIRIB; PPPIR2; PPPIR3A; PPPIR3B; PPPIR3C; PPPIR42; PPPIR7; PPPIR9A; PPP2CA; PPP2CB; PPP2RIA: PPP2RIB;
PPP2R2A; PPP2R2B; PPP2R2C; PPP2R3A; PPP2R3B; PPP2R4; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E; PPP3CA;
PPP3CB; PPP3CC; PPP3RI; PPP3R2; PPP4C; PPP4RI; PPP5C; PPPBC; PPPBR2; PPPBR3; PPRCI; PPT2; PPY; PQBPI: P0LC3; PRACI;
PRAC2; PRADCI; PRAF2; PRAMI; PRAME; PRAPI; PRBI; PRB2; PRB3; PRB4; PRCI; PRCC; PRCD; FRCP; PRDMIO; PRDMII; PRDMI3; PRDMI4; PRDMI; PRDM4; PRDM5; PRDMB; PRDM7; PRDM8; PRDM9; PR0X2; PRDX3; PRDX4; PRDX5; PRDXG; PREB; PRELP; PREP;
PREPL; PREXI; PREX2; PRFI; PRG2; PRG4; PRHI; PRH2; PRICKLEI; PRICKLE2; PRICKLE4; PRIM1; PRIMAL PRIMPOL; PR AAI; PRKABI;
PRKACA; PRKACB; PRKACG; PRKABI: PRKAG2; PRKAG3; PRKARIA; PRKARIB; PRKAR2A; PRKAR2B; PRKCA; PRKCB; PRKCDBP; PRKCD;
PRKCE; PRKCG; PRKCH; PRKCI; PRKCQ; PRKCSH; PRKCZ; PRKDI; PRKD3; PRKOC; PRKGI; PRKG2; PRKRA; PRKRIR; PRKX; PRLH; PRL;
PRLHR; PRLR; PRMI: PRM2; PRM3; PRMTI; PRMT2; PRMT3; PRMT5; PRMT8; PRND; PRNP; PROC; PROCR; PRODH; PR0K2; PRBKRI: PR0KR2; PROLI; PROMI; PR0M2; PROPL PROSI; PROSERI; PRBXI: PROZ; PRPFI9; PRPF3I: PRPF3BB; PRPF3; PRPF40A; PRPF4B; PRPF4; PRPFFJ; PRPF8; PRPH2; PRPH; PRPSI; PRPSILI; PRPS2; PRPSAPI; PRPSAP2; PRRII; PRRI3; PRRI5; PRRIB; PRR34; PRR3;
PRR5; PRR9; PRRCI: PRRC2A; PRRC2C; PRRG4; PRRTI; PRRT2; PRRXI; PRRX2; PRSSI2; PRSSI6; PRSSI: PRSS2I; PRSS22; PRSS23;
PRSS27; PRSS2; PRSS33; PRSS35; PRSS3; PRSS5D; PRSS53; PRSS55; PRSS57; PRSS58; PRSS8; PRTFDCI; PRTG; P TN3; PRUNE2;
PRUNE; PRX; PRY; PSAP; PSATI; PSCA; PSD3; PSD4; PSD; PSENI: PSEN2; PSENEN; PSBI; PSB2; PSG5; PSGB; PSG8; PSG9; PSIPI; 5 PSKHI; PSMAI; PSMA2; PSMA3; PSMA4; PSMAB; PSMA7; PSMBID; PSMBI; PSMB4; PSMB5; PSMBB; PSMB7; PSMBB; PSMB9; PSMCI;
PSMC2; PSMC3; PSMC3IP; PSMC4; PSMC5; PSMCB; PSMDIO; PSMDI2; PSMDI3; PSMDI4; PSMDI: PSMD2: PSMD3; PSMD4; PSMDB;
PSMD7; PSMD8; PSMDB; PSMEI; PSME2; PSME3; PSME4; PSMFI; PSMBI; PSMG2; PSMG3; PSORSIGI; PS0RSIC2; PSPCI; PSPH; PSPN;
PSTPIPI; PSTPIP2; PTBPI; PTBP2; PTCDI; PTCHI: PTCHDI; PTCHD4; PTCRA; PTDSSI; PTEN; PTER; PTFIA; PTGDR2; PTGDR; PTGDS;
PTGERI; PTGER2; PTGER3; PTGER4; PTGES2; PTGES3; PTGES; PTGIR; PTGIS; PTG i; PTGSI; PTGS2; PTHIR; PTH2; PTH2R; PTH; PTHLH; ID PTK2B; PTK2; PTKB; PTK7; PTMA; PTMS; PTN; PTDVI; PTP4AI; PTP4A3; PTPMTI; PTPNII; PTPNI2; PTPNI3; PTPNI4; PTPNI8; PTPNI;
PTPN2I; PTPN22; PTPN23; PTPN2; PTPN3; PTPN4; PTPN5; PTPNB; PTPN7; PTPN9; PTPRA; PTPRB; PTPRCAP; PTPRD; PTPRE; PTPRG;
PTPRH; PTPRJ; PTPRK; PTPRM; PTPRN2; PTPRN; PTPRD; PTPRfl; PTPRR; PTPRS; PTPRT; PTPRZI; PTRF; PTRHI; PTRH2; PTRHDI; PTS;
PTTGI: PTTGIIP; PHG2; PTX3; PUFBD; PDM2; PURA; PURB; PUSID; PUS1; PVALB; PVR; PVRLI; PVRL2; PVRL3; PVRL4; PWP2; PWWP2B;
PXDN; PXDNL; PXK; PXMP2; PXN; PXTI; PYCARD; PYCRI; PYDCI; PYDC2; PYGB; PYGL; PYGM; PYGDI; PYGD2; PYHINI: PYROXDI; PYY; PZP; OARS; DDPR; OKI; QPCT; QPCTL; OPRT; QRFP; ORFPR; ORSLI; OSDXI; QSOX2; QTRTI; R3HCCI; R3HCCIL; R3HDMI; R3HDML;
RABIIA; RABI1B; RABIIFIPI; RABIIFIP2; RABIIFIP3; RABIIFIP4; RABIIFIP5; RABI2; RABI4; RABI5; RABI8; RABIA; RABIB; RAB20; RAB2I;
RAB22A; RAB23; RAB24; RAB25; RAB27A; RAB27B; RAB28; RAB2B; RAB2A; RAB3I; RAB32; RAB33B; RAB34; RAB35; RAB3B; RAB37;
RAB38; RAB39A; RAB39B; RAB3A; RA83D; RAB3GAPI; RAB3GAP2; RAB3ILI; RAB3IP; RAB40AL; RAB4DB; RAB4DC; RAB4A; RAB4B;
RAB5A; RAB5B; RAB5C; RABGA; RABBB; RABBC; RAB7A; RAB8A; RAB8B; RAB9A; RABACI; RABEPI; RABEP2; RABEPK; RABGAPIL; RABGEFI; RABIF; RABLB; RACI; RAC2; RAC3; RACGAPI; RADI7; RADI8; RADI; RAD2I; RAD2ILI; RAD23A; RAD23B; RAD50; RAD5IAPI:
RAD5IB; RAD5IC; RAD5ID; RA05I: RAD52; RAD54B; RAD9A; RAD9B; RAEI; RAETIE; RAETIL; RAFI; RAGI; RAG2; RAII4; RAIL RAI2; RALA;
RALB; RALBPI; RALGAPAI: RALGAPA2; RALGAPB; RALGDS; RALGPSL RALY; RALYL; RAMP RAMP2; RAMP3; RANBPIO; RANBPI7;
RANBPI; RANBP2; RANBP3; RANBP3L; RANBPB; RANBP9; RANGAP RANGRF; RAN; RAPIB; RAPIGAP2; RAPIGDSI; RAP2A; RAP2B;
RAPGEFI; RAPGEF2; RAPGEF3; RAPGEF4; RAPGEF5; RAPH RAPSN; RARA; RARB; RARG; RARRESL RARRES2; RARRES3; RARS2; RARS;5 RASAI; RASA2; RASALL RASAL2; RASDL RASD2; RASEF; RASGEFIA; RASGEFIC; RASBRFI; RASGRF2; RASGRPI; RASGRP2; RASGRP3;
RASGRP4; RASIPI; RASLIOA; RASLIDB; RASLIIA; RASLIIB; RASLI2; RASSF RASSF2; RASSF3; RASSF4; RASSF5; RASSFB; RASSF7;
RASSF8; RAX2; RAX; RBICCI; RBI; RBAK; RBBP5; RBBPB; RBBP7; RBBP8; RBBP9; RBCKL RBFBXI; RBFDX2; RBFDX3; RBLI; RBL2;
RBMID; RBMI2; RBMI4; RBMI4-RBM4; RBMI5; RBMI7; RBM2D; RBM25; RBM2B; RBM27; RBM28; RBM38; RBM39; RBM3; RBM45;
RBM4B; RBM47; RBM4; RBM5; RBMB; RBM7; RBMS RBMS2; RBMS3; RBMX2; RBMX; RBMXL2; RBMYIAL RBPI; RBP2; RBP3; RBP4; RBPJ; RBPMS2; RBSN; RBXI; RC3HI; RCANI; RCAN2; RCBTBI: RCBTB2; RCHYI; RCLL RCN RCN2; RCBRI; RCSDL RCVRN; RD3; RDHIO;
RDHII; RDHI2; RDHI4; RDHIB; RDH5; RDH8; RD I; RDX; REC8; RECK; REC0L5; RECOL; REEPI; REEP2; REEP3; REEP5; REEPB; REGIA;
REGIB; REG3A; RELA; RELB; REL; RELN; REM RENBP; REN; REPSL REPS2; RERG; RERGL; REST; RET; RETN; RETNLB; RETSAT: REVI;
REV3L; REXDI; REXD2; REX04; RFCI; RFC2; RFC3; RFC4; RFC5; RFFL; RFK; RFPL RFTI; RFTNL RFTN2; RFWD2; RFWD3; RFX RFX2;
RFX3; RFX4; RFX5; RFXG; RFX8; RFXANK; RFXAP; RGCC; RBLI: RGL2; RGL4; RGMA; RGMB; RGN; RGPD2; RGR; RGSID; RGSII; RGSI2;5 RGSI3; RGSI4; RGSIB; RGSI7; RGSI8; RGSI9; RGSI; RGS20; RGS2I; RGS22; RGS2; RGS3; RGS4; RGS5; RGSB; RGS7BP; RGS7; RGS8; RBS9BP; RBS9; RGSLI; RHAB; RHBD02; RHBDD3; RHBDFI: RHBDF2; RHBDLI: RHBDL2; RHCE; RHCG; RHEB; RHEBLI: RHNDI: RHOB;
RHBBTBI; RHDBTB2; RH08TB3; RHOD; RHDF; RHOG; RHDH; RHD; RHDJ; RHDll: RHDTI; RHDU; RHOV; RHOXFI: RHDXF2: HPNI: RHPN2;
RIBC2; RICI; RIC3: RICTOR; RIFI; RILP: RILPLI: RIMBP2; RIMBP3C: RIMSI: RIMS2; RIMS4: RINI; RIN2; RIN3; INB1; RINTI; RIDKI; RI0K2;
RI0K3; RIP I; RIP 2; RIP 3; RIP 4: RIPPLY2; RITI; RIT2: RITAI: RLBPI: RLF; RUM; RLNI: RLN2; RLN3; RMDNI; R DN2; RMDN3; RMII; RMI2; RHNDI; RNASEII; RNASEI2; RNASEI3: RNASEI: RNASE2; RNASE3; RNASE4; RNASEB; RNASE7; RNASE8; RNASEB; RNASEHI;
RNASEH2A; RNASEH2B; RNASEH2C; RNASEK; RNASEL; RNASET2; RNDI; RND3; RNFI03-CHMP3; RNFI03; RNFIII; NF112: RNFII4;
RNFI23; RNFI25; RNFI28; RNFI30; RNFI35: RNFI38; RNFI39; RNFI44A; RNFI44B; RNFI4B; RNFI49; RNFI4; RNFI50; RNFI52; RNFI57;
RNFIG7; RNFIB8; RNFI7D; RNFI80; RNFI82: RNFI9A; RNF2D7; RNF20; RNF2I3; RNF2I4; RNF2IB; RNF24; RNF2; RNF3I: RNF34; RNF39;
RNF40; RNF4I; RNF43; RNF44; RNF4; RNF5; RNFB; RNF7; RNFS; RNGTT; RNHI; RNLS; RNMT; RNPEP; RNPEPLI; RNPSI; RDBOI; R0BD2; R0B03; R0B04; ROCKI: R0C 2; ROGDI; ROMI; RDPNIB; RDPNI; ROPNIL: RORI; R0R2; RORA; RORB; RDRC; RDSI; RPI: RPILI; RP2; RP9;
RPAI; RPA2; RPA3; RPA4; RPAIN; RPAPI; RPE; RPGR; RPGRIPI; RPGRIPIL; RPH3A; RPH3AL: RPIA; RPLIOA; RPLIO; RPLIDL; RPLI2;
RPLI3; RPLI4; RPLI5; RPLI7; RPLI8; RPLI9; RPL2I; RPL23A: RPL23: RPL24; RPL27A; RPL29; RPL3D; RPL3I; RPL34;
RPL35; RPL3BA; RPL3BAL; RPL37A; RPL38; RPL39; RPL39L; RPL3; RPL4I; RPL4; RPLB; RPL7A; RPL7; RPLPD; RPLPI: RPNI; RPN2;
RPPI4; RPP2I; RPP25; RPP38; RPP4D; RPRDIA; RPRDIB; RPRD2; RPRM; RPSIO; RPSI4; RPSI5A; RPSIB; RPSI8; RPSI9BPI; RPS20; RPS24; RPS27A; RPS27; RPS27L; RPS29; RPS2; RPS3A; RPS3; RPS4X; RPS4YI: RPSBKA2; RPSBKA3; RPSBKA4; RPSBKA5; RPSG AG;
RPSBKBI; RPSBKB2; RPS9; RPSA; RPTOR; RDCDI; RRAD; RRAGA: RRAS2: RRAS; RRBPl; RREBI; RRH; RRMI; RRM2B; RRN2; RRN3;
RRNADI; RRPIB; RRP1; RRP9; RRSI: RSI: RSAD2; RSFI: RSLIDI; RSL24DI; RSPHI: RSPH4A; RSPH9; RSPO2; RSPQ3: RSP04; RSRCI;
RSRC2; RSRPI; RSUI; RTCB; RTELI; RTKN2; RTKN; RTLI: RTNI: RTN2; RTN3; RTN4: RTN4IPI: RTN4R: RTP3; RTP4; RTTN; RUFYI; RUFY3;
RUNDC3B; RUNXI; RUNXITI: RUNX2; RUNX3: RUVBLI; RUVBL2; RXFPI: RXFP2; RXFP3; RXRA; RXRB; RXRG; RYBP; RYK: RYRI; RYR2; RYR3; SIDDAIO; SIODAII; SIODAI2: SIDOAI3; SIDOAI4; SIOOAIB; SIODAI; SIOOA2; SIDOA3; SIODA4: SIOOA5; SIODAB; SIOOA7A; SIOOA7;
SIDDA8; SIODAB; SIOOB; SIDOP: SIDOZ; SIPR2; SIPR3; SIPR4; SIPR5; SAAI: SAA2: SAA4; SAALI; SAC3DI; SACMIL; SACS; SAEI; SAFB2;
SAFB; SAGEI; SAG; SALLI; SALL2; SALL3; SALL4; SAMDI4; SAMDI; SAMD4A; SAMD5; SAMD9; SAMD9L; SAMHDI; SAMM5D; SAMSNI;
SAP30BP; SAP3DL; SAPCDf; SAPCD2; SARIA; SARIB; SARDH; SARMI; SARNP; SARS2; SARTI; SART3; SASHI; SASH3; SATI; SAT2;
SATBI; SATB2; SATLI; SAVI: SBDS; SBFI: SBF2; SBNOI; SBND2; SBSN; SC50; SCAFII; SCAFI; SCAF4; SCAF8; SCAI; SCAMP2; SCAMP5; SCAPER; SCAP; SCARA3; SCARAB; SCARBI; SCARB2; SCARF2; SCCPDH; SCD5; SCO; SCFDI; SCFD2; SCG2; SCG3; SCG5; SCGBIAI;
SCGBIDI; SCGBID2; SCGB2AI: SCGB2A2; SCGB2B2; SCGB3AI; SCGB3A2; SCGN; SCHIPI; SGIN; SCLTI; SCLY; SCML2; SCML4; SCNIBA;
SCNIIA; SGNIA; SCNIB; SCN2A; SCN2B; SCN3A; SCN3B; SCN4A; SCN4B; SCN5A; SCN7A; SCN8A; SCN9A; SCNMI; SCNN1A; SCNNIB;
SCNNID; SCNNIG; SCDI; SC02; SCPZDI: SCPEPI: SCRIB; SCRNI; SCT; SCTR; SCUBEI: SCUBE2; SCUBE3; SCYLI; SCYL3; SDCI; SDC2;
SDC3; SDC4; SDCBP2; SDCBP; SDCCAG3; SDCCAG8; SDF2; SDF2LI; SDF4; SDHAFI; SDHAF2; SDHAF4; SDHA; SDHC; SDHD; SDKI; SDK2; SDPR; SDR42EI; SDR9C7; SOS; SECIIA; SECIIC; SECI3; SECI4LI; SECI4L2; SECI4L3; SECIBB; SEC23A; SEC23B; SEC23IP;
SEC24A; SEC24B; SEC24C; SEC3IA; SECBIAI; SECBIB; SECB2; SECB3; SECISBP2; SECISBP2L; SECTMI; SELIL; SELE; SELENBP1; SELL;
SELP; SELPLG; SEMA3A; SEMA3B; SEMA3C; SEMA3D; SEMA3E; SEMA3F; SEMA3G; SEMA4A; SEMA4B; SEMA4D; SEMA4F; SEMA4G;
SEMA5A; SEMA5B; SEMABA; SEMABB; SEMABD; SEMA7A; SEMGI; SEMG2; SENPI; SENP2; SENP3; SENP5; SENPB; SENP8: SEPHSI;
SEPSECS; SERACI; SERFIA; SERGEF; SERINCI: SERINC3; SERINC5; SERPI; SERP2; SERPINAIO; SERPINAII; SERPINAI2; SERPINAI: SERPINA3; SERPINA4; SERPINA5; SERPINAB; SERPINA7; SERPINA9; SERPINBIO; SERPINBI3; SERPINBI; SERPINB2; SERPINB3; SERPINB4; SERPINB5; SERPINBG; SERPINB7; SERPINB8; SERPINB9; SE PINCI; SERPINDI; SERPINEI; SERPINE2; SERPINE3; SERPINFI:
SERPINF2; SERPINGI; SERPINHI; SERPINII; SERPINI2; SERTADI: SERTA02; SESNI; SESN3; SETBPI; SETDIA; SETDIB; SETD2; SETD3;
SETD5; SET07; SETD8; SETDB2; SET; SETMAR; SETX; SEZB; SEZBL2; SEZGL; SFI: SF3AI; SF3BI; SF3B2; SF3BB; SFII; SFMBTI; SFMBT2;
SFRI; SFRPI; SFRP2; SFRP4; SFRP5; SFSWAP; SFT2D2; SFT203; SFTA2; SFTA3; SFTPAI; SFTPA2; SFTPB; SRPC; SFTPD; SFXNI; SFXN2; SFXN4; SGCA; SGCB; SGCD; SGCE; SGCG; SGCZ; SGIPI; SGKi; SGK223; SGK2; SGK3; SGMSI: SGMS2; SGDLI; SGPLI; SGPPI; SGPP2;
SGSH; SGSM2; SGSM3; SGTA; SH2BI; SH2B2; SH2B3; SH2DIA; SH202A; SH2D3A; SH2D3C; SH2D4A; SH2D4B; SH3BGR; SH3BGRL2;
SH3BGRL; SH3BPI; SH3BP2; SH3BP4; SH3BP5; SH3DI9; SH3GLI; SH3GL2; SH3GL3; SH3 BPI; SH3PXD2A; SH3PXD2B; SH3RFI;
SH3RF3; SH3TC2; SH3YLI; SHANKI; SHANK2; SHANK3; SHARPIN; SHBG; SHB; SHCI; SHC2; SHC3; SHC4; SHCBPI; SHE; SHFMI; SHH;
SHISA2; SHISA3; SHISAB; SHISA9; SHMTI; SHMT2; SH0C2; SHDX2; SHDX; SHPK; SHPRH; SHQI; SHRDDM2; SHRDDM3; SHR0DM4; SIAE; SIAHI; SIAH2; SIDTI; SIGIRR; SIGLECII; SIGLECI4; SIGLECI; SIGLEC5; SIGLEC7; SIGLECB; SIGLEC9; SIGMARI; SI; SIKI: SIK2; SI3;
Sill; SIMI; SIM2; SIN3A; SIN3B; SIPAI; SIPAIL2; SIPAIL3; SIRPA; SIRPBI; SIRPG; SIRTI; SIRT2; SIRT3; SIRT4; SIRT5; SIRTG; SIRT7; SITI;
SIVAI; SIX1; SIX2; SIX3; SIX4; SIX5; SIXG; SKAI; SKA2; SKAPI: SKAP2; SIL; SIV2L2; SIV2L; SKORI; SOR2; SKPI; SKP2; SLA2; SLA;
SLAIN2; SLAMFI; SLAMFB; SLAMF7; SLAMF8; SLBP; SLCIDAI; SLCIQA2; SLCIDAG; SLCIDA7; SLCIIAI; SLCIIA2; SLCI2AI; SLCI2A2;
SLCI2A3; SLCI2A4; SLCI2A5; SLCI2AB; SLCI2A7; SLCI2A8; SLCI2A9; SLCI3AI; SLCI3A2; SLCI3A3; SLCI3A5; SLCI4AI; SLCI4A2; SLCI5A1; SLCI5A2; SLCI5A4; SLCIBAIO; SLCIBAII; SLCIBAI2; SLCIBAI3; SLCIBAI; SLCIBA2; SLCIBA3; SLCIBAB; SLCIBA7; SLCIBA8;
SLCIBA9; SLCI7AI; SLCI7A2; SLCI7A3; SLCI7A4; SLCI7A5; SLCI7AB; SLCI7A7; SLCI7A8; SLCIBAI; SLCI8A2; SLCI8A3; SLCI9AI:
SLCI9A2; SLCI9A3; SLCIAI; SLCIA2; SLCIA3; SLCIA4; SLCIA5; SLCIAB; SLC2DAI: SLC20A2; SLC22AII; SLC2ZAI2; SLC22AI3; SLC22AI4;
SLC22AIB; SLC22AI7; SLC22AI8AS; SLC22AI8; SLC22AI; SLC22A23; SLC22A24: SLC22A2; SLC22A3; SLC22A4; SLC22A5; SLC22AB;
SLC22A7; SLC22A8; SLCZ3AI; SLC23A2; SLC24AI; SLC24A2; SLC24A3; SLC24A4; SLC24A5; SLC25AIQ; SLC25AI2; SLC25AI3; SLC25AI4; SLC25AI5; SLC25AIB; SLC25AI8; SLC25AI9; SLC25AI; SLC25A20; SLCZ5A2I: SLC25A22; SLC25A23; SLC25A25;
SLC25A27; SLC25A2; SLC25A3B; SLC25A37; SLC25A38; SLC25A3; SLC25A40; SLC25A4I; SLC25A42; SLC25A43; SLC25A45;
SLC25A4B; SLC25A47; SLC25A4; SLC25A52; SLC25A5; SLC25AB; SLC2BAI; SLC2BA2; SLC2BA3; SLC2BA4; SLC2BA5; SLC2BAB;
SLC2BA7; SLC2BA8; SLC2BA9; SLC27AI; SLC27A2; SLC27A3; SLC27A4; SLC27A5; SLC28AI; SLC28A2; SLC28A3; SLC29AI; SLC29A2;
SLC29A3; SLC29A4; SLC2AI0; SLC2AII; SLC2AI2; SLC2AI3; SLC2AI4; SLC2A2; SLC2A3; SLC2A4RG; SLC2A5; SLC2AB; SLC2A8; SLC2A9; SLC30AI0; SLC30AI: SLC30A3; SLC30A4; SLC30A5; SLC30AB; SLC30A7; SLC30A8; SLC30A9; SLC3IAI: SLC3IA2; SLC32AI;
SLC33AI; SLC34AI; SLC34A2; SLC34A3; SLC35AI; SLC35A2; SLG35A3; SLC35A4; SLC35B2; SLC35B4; SLC35CI: SLC35D3; SLC35FI;
SLC35F2; SLC35F3; SLC35F4; SLC35FB; SLC35GI; SLC35G2; SLC35G5; SLC35GB; SLC3BAI; SLC3BA2; SLC37AI; SLC37A2;
SLC37A4; SLC38AI; SLC38A2; SLC38A4; SLC38A5; SLC38AB; SLC38A7; SLC38A8; SLC38A9; SLC39AID; SLC39AII; SLC39AI2;
SLC39AI3; SLC39AI4; SLC39AI; SLC39A2; SLC39A3; SLC39A4; SLC39AB; SLC39A7; SLC39A8; SLC39A9; SLG3AI; SLC3A2; SLC4DAI; SLC4IAI; SLC43AI; SLC43A2; SLC43A3; SLC44AI; SLC44A2; SLC44A4; SLC44A5; SLC45A2; SLC45A3; SLC45A4; SLC4BAI:
SLC4BA2; SLC47AI; SLC48AI; SLC4AIO; SLC4AII: SLC4AIAP; SLC4AI; SLC4A2; SLG4A3; SLC4A4; SLC4A5; SLC4A7; SLC4A9; SLC5OAI;
SLC5IA; SLC5IB; SLC5ZAI; SLC52A2; SLC52A3; SLC5AII; SLC5AI2; SLC5AI: SLC5A2; SLC5A3; SLC5A4; SLC5A5; SLC5AB; SLC5A7;
SLC5A8; SLCBAII; SLCBAI2; SLCBAI3; SLGBAI4; SLCBAI5; SLCBAI8; SLCBAI9: SLCBAI: SLCBA20; SLCBA2; SLCBA4; SLCBA5; SLCBAB;
SLCBA7; SLCBAB; SLCBA9; SLC7AI0; SLC7AII; SLC7AI3; SLC7AI4; SLC7AI; SLC7A2; SLC7A3; SLC7A4; SLC7A5; SLC7AB; SLC7A7; SLC7A8; SLC7A9; SLCBAI: SLC8A2; SLC8A3; SLCBAI: SLC9A2; SLC9A3; SLC9A3RI: SLC9A3R2; SLC9A4; SLC9A5; SLCBAB; SLC9A7; SLCBAB; SLC9A9; SLC9BI: SLC9B2; SLC9CI; SLC9C2; SLGQIA2; SLCGIBi; SLC0IB3; SLCDIB7; SLCDICI: SLCD2AI: SLCD2BI; SLCB3AI;
SLCD4AI; SLCB4CI; SLCD5AI; SLCOBAI; SLFNI2; SLFNI2L; SLFNI4; SLFN5: SLITI: SLIT2; SLIT3; SLIT KI: SLITRK2; SLITRK3; SLITR 5;
SLITR B; SLK; SL AP; SLM02; SLN; SLPI; SLTM; SLU7; SLURP1: SLX4; SLX4IP; SMADI; SMAD2; SMAD3; S AD4; SMAD5; SMADB;
SMAD7; SMAD9; SMAGP; SMAPI; SMARCAI; SMARCA2; SMARCA4; SMARCA5; SMARCADI; SMARCALI; SMARCBI; SMARCCI; SMARCC2; SMARCDI; SMARCD3; SMARCEI; SMCIA; SMCIB; SMC2; SMC3; SMC4; SMC5; SMCB; SHCHDI; SMCD4; SMCP; SMEKI; SME 2; SMGI;
SMGB; SMG8; SMIMI5; SMIMI9; SMIM2D; SMIM2I; SMIM23; SMIM5; SMN2; SMDCI; SMBC2; SMO; SMQX; SMPDI; SMPD2; SMPD3;
SMPOL3A; SMPDL3B; SMPX; SMR3B; SMS; SMTN; SMTNLI; SMUI; SMUGI; SMURFI; SMURF2; SMYDI; SMYD2; SMYD3; SMYD4; SMYD5;
SNAII; SNAI2; SNAI3; SNAP23; SNAP25; SNAP29; SNAP47; SNAP9I; SNAPCI: SNAPC4; SNAPC5; SNCA; SNCAIP; SNCB; SNCG; SNDI;
SNEDI; SNF8; SNIPI: SNRK; SNRNP2BD; SNRNP27; SN NP7D; SNRPA; SNRPB; SNRPC; SN PDI: SNRPD3; SNRPE: SNRPF; SNRPN; SNTAI; SNTBI; SNTGI; SNTB2; SNUPN; SNURF; SNWI; SNXIO; SNXI2; SNXI4; SNXIB; SNXI8; SNXI9; SNXI: SNX2D; SNX24: SNX25;
SNX29; SNX2; SNX3D; SNX3; SNX5; SNX9; SB ATI; SDAT2; SDBP; SOCSI: SDCS2; SDCS3; SDCS4; S0CS5; SDCSB; SDCS7; SDDI;
SDD2; SDD3; SDHLHI; SDHLH2; SDN; SDRBSI; SDRBS2; SDRBS3; SDRCSI; SDRCS2; SDRCS3; SORD; SDRLI; SCSI: S0S2; SDSTDCI;
SDST; SDXIO; SDXII: SDXI2; SDXI3; SDXI4; S0XI5; SDXI7; SDXI8; SOXI; S0X2I; SDX2; SDX3; S0X4; S0X5; SOXB; SDX7; SDX8; SDX9;
SPIOD; SPUD; SPI4D; SPI; SP2; SP3; SP4; SP5; SPB; SP7; SP8; SPAI7; SPACAI; SPACA3; SPAGIIA; SPAGIIB; SPAGIB; SPAGI; SPAG4; SPAG5; SPAGB; SPAG7; SPAG8; SPAG9; SPAM1; SPANXA2; SPANXBI: SPANXD; SPANXN4; SPARC; SPARCLI: SPAST; SPATAI3;
SPATAIB; SPATAI7; SPATAIB; SPATAIB; SPATA2D; SPATA2I; SPATA22; SPATA25; SPATA2; SPATA5; SPATA7; SPATA8; SPATA9; SPATCI;
SPC24; SPC25; SPCS3; SPDEF; SPDLI; SPDYA; SPECCI: SPECCIL; SPEF2; SPEG; SPESPI; SPGII; SPG2D; SPG2I; SPG7; SPHKI; SPHK2;
SPHKAP; SPII; SPIB; SPIC; SPIDR; SPIN1; SPIN2A; SPINKI; SPINK2; SPIN4; SPIN5; SPIN6; SPINK7; SPINTI; SPINT2: SPNSI: SPNS2;
SPOII: SPDCKI; SPDC 2; SP0C 3; SPDNt; SPDN2; SPDP; SPPI; SPP2; SPPL2A; SPPL2B; SPPL2C; SPPL3; SPREDI; SPRED2; SPRED3; SPR; SPRN; SPRRIA; SPRRIB; SPRR2A; SPRR2B; SPRR3; SPRTN; SPRYI; SPRY2; SPRY3; SPRY4; SPRYD7; SPSB3; SPSB4; SPTAI;
SPTANI; SPTB; SPTBNI; SPTBN2; SPTBN4; SPTBN5; SPTLCI; SPTLC2; SPTLC3; SPTSSB; SPTY2DI; SPZI: SOLE; SDRDL; SQSTMI: SRAI;
SRBDI; SRCAP; SRC; SRCINI; SRD5AI; SRD5A2; SRD5A3; SREBFI; SREBF2; SREKI; SREKIIPI; SRFBPI; SRF; SRGAP1; SRGAP2; SRGAP3;
SRGN; SRI; SRL; SRMS; SRPI4; SRPI9; SRPG8; SRP72; SRP9; SRPI; SRPK2; SRPRB; SRPR; SRPX2; SRPX; SRR; SRRMI; SRRM2;
SRRM4; SRRT; SRSFID; SRSFII; SRSFI2; SRSFI; SRSF2; SRSF3; SRSF4; SRSF5; SRSFB; SRSF7; SRSF9; SRXNI; SRY; SSI8; SSI8LI; SSB; SSBPI; SSBP2; SSFA2; SSHI; SSH2; SSMEMI; SSNAI; SSPN; SSPD; SSRI; SSR2; SSRPI; SSSCAI; SST; SSTRI; SSTR2; SSTR3;
SSTR4; SSTR5; SSUH2; SSXI: SSX2B; SSX2IP; SSX4B; SSX5; STI3; STI4; STI8; ST20; ST3GALI; ST3GAL2; ST3GAL4; ST3GAL5;
ST3GALB; ST5; STBGALI; STBGAL2; STBGALNACI; STBGALNAC2; STGGALNAC4; STGGALNACB; ST7; ST7L; ST8SIAI; ST8SIA2; ST8SIA3;
ST8SIA4; ST8SIAB; STABI; STAB2; STAC3; STAC; STAGI; STAG2; STAGS; STAM2; STAMBP; STAMBPLI; STAM; STAPI; STAP2; STARDIO;
STARDI3; STARD3; STARD3NL; STARD5; STARD7; STARD8; STARD9; STAR; STATI; STAT2; STAT3; STAT4; STAT5A; STAT5B; STATE; STATH; STAU2; STBDI; STCI; STC2; STEAPI; STEAP2; STEAP3; STEAP4; STH; STIL; STIMI; STIM2; STIPI; ST IO; STKII: STKIIIP; ST I7A;
ST I7B; ST I9; STK24; ST 25; STK2B; STK3I; ST 32A; STK32B; ST 32C; STK33: ST 35; ST 38L; STK39; ST 3; STK4; STMN2; STMN3;
STMN4; STOM; STDMLI; STDML2; STOML3; ST0NI-GTF2AIL; STDNI: STOXI; STRAI3; STRAB; STRA8; STRADA; STRADB; STRAP; STRC;
STRN3; STRN4; STRN; STS; SH3A: STT3B; STUBI; STXII; STXIG; STXI7; STXI8; STXIA; STXIB; STX2; STX3; STX4: STX5; STXB; STX8;
STXBPI; STXBP2; STXBP4; STXBP5; STXBP5L; STXBPB; STYKI; STYX; SUBI; SUCLA2; SUCLGI; SUCLG2; SUCNRI: SUCO; SOOS3; SOFU; SUGCT; SOGPI; SUGTI; SULFI; SULF2; SULTIAI; SOLTIA2; SOLT1A4; SULTIBI; SULTIC2; SOLTIEI; SULT2A1: SOLT2BI; SULT4AI; SUMFI; SUMFZ; SUMDI; SUM02; SUM03; SUMD4; SUNI; SUN2; SUN3; SUOX; SUPT2DH; SUPT3H; SUPT4HI; SUPT7L; SUPV3LI; SURFI; SURF4;
SUSDI; SUSD2; SUSD4; SUSDB; S0V39HI; SUV39H2; SUV420H2; SUZI2; SV2B; SV2C; SVEPI: SVIL; SVIP; SVOP; SWAP7D: SWTI; SYBU;
SYCEI; SYCEIL; SYCP2; SYCP2L; SYCP3; SYK; SYMPK; SYHI; SYN2; SYN3; SYNCRIP; SYNDIBI; SYNEI: SYNE2; SYNE4; SYNGAPI;
SYNGRI; SYNG 2; SYNJI: SYNJ2BP; SYNJ2; SYNM; SYNP02; SYNPD; SYNPR; SYP; SYPLI; SYPL2; SYTII; SYT12; SYTI3; SYTI4; SYTI; SYT4; SYTB; SYT9; SYTLI; SYTL2; SmS; SYVNI; TAARI; TAAR2; TAAR5; TAARB; TABI; TAB2; TAB3; TACt; TAGS; TAC4; TACCI: TACC2;
TACC3; TACDI; TAC I; TACR2; TAGR3; TADAI; TADA2A; TADA3; TAFI5; TAFIB; TAFIC; TAFID; TAFI; TAF2; TAF3; TAF4B; TAF4; TAF5L;
TAFB; TAF7; TAF7L; TAF8; TAFB; TAGAP; TAGLN2; TAGLN; TALI; TAL2; TALDOI; TAMM4I; TANCI; TANC2; TANG02; TANK; TADKI; TAD 2;
TAD3; TAPI; TAP2; TAPBP; TAPBPL; TARBPI; TARBP2; TARP; TARS; TARSL2; TAS2RIB; TAS2RI3; TAS2RI4; TAS2RIB; TAS2RI;
TAS2R38; TAS2R5B; TAS2RBB; TAS2R9; TASPI; TATDNI; TAT; TAXIBPI; TAXIBP3; TAZ; TBATA; TBCIDI5; TBCIDIB; TBCIDI; TBCID2D; TBCID22A; TBCID22B; TBCID24; TBCID25; TBCID2; TBCID32; TBCID3C; TBCID3F; TBCID4; TBCID5; TBCID7; TBCID8; TBCID9; TBCA;
TBCC; TBCD; TBCE; TBCEL; Ml: TBKBPI; TBLIX; TBLIXRI; TBLIY; TBL2; TBL3; TBP; TBPLI; TBPL2; TBRI; TBRGI; TBXID; TBXI8; TBXI9;
TBXI: TBX2D; TBX2I; TBX22; TBX2; TBX3; TBX4; TBX5; TBXB; TBXA2R; TBXASI; TCAIM; TCAP; TCEAI; TCEA2; TCEA3; TCEALI; TCEAL2;
TCEAL4; TCEAL7; TCEBI: TCEB2; TCEB3C; TGERGI; TCERGIL; TCFI2; TCFI5; TCFI9; TCF2B; TCF2I; TCF25; TCF3; TCF4; TCF7; TCF7LI;
TGF7L2; TCFL5; TCHH; TCHP; TGIRGI; TCLIA; TCLIB; TCNI; TCN2; TCDFI; TCPIB; TCPIDL2; TCPIILI; TCPI; TCTA; TCTEI; TCTNI; TCTN2; TCTN3; TDGFI; TDG; TDD2; TDPI; TDP2; TDRDI; TDRD3; TDRD5; TDRDB; TDRD7; TDRD9; TDR H; TDRP; TEADI; TEAD2; TEAD3; TEAD4;
TEC; TECPR2; TECR; TECRL; TECTA; TEF; TEFM; TEK; TEKTI; TEKT5; TEL02; TENMI; TENM2; TENM3; TENM4; TEPI; TEPP; TERFI; TERF2;
TERF2IP; TERT; TESC; TES; TESPAI: TETI; TET2; TET3; TEXIDI; TEXII; TEXI4; TEXI5; TEX2B4; TEX29; TEX3D; TEX35; TEX40; TFAM; TFAP2A;
TFAP2B; TFAP2C; TFAP4; TFBIM; TFB2M; TFCP2; TFDPI: TFDP2; TFDP3; TFE3; TFEB; TFEC; TFFI: TFF2; TFF3; TFG; TF; TFIPII: TFPI2; TFPI;
TFPT; TFR2; TFRC; TGFA; TGFBI; TGFBIII; TGFB2; TGFB3; TGFBI; TGFBRI; TGFBR2; TGFBRAPI; TG; TGIFI; TGIF2-CZ0orf24; TGIF2; TGIF2LX; TGMI; TGM2; TGM3; TGM4; TGM5; TGMB; TGM7; TG0LN2; TGSI: THADA; THAPIO; THAP1J: THAPI; THAP2; THAPG; THBD; THBSI;
THBS2; THBS3; THBS4; THEG; THEM4; THEM5; THE G; THEMIS2; THEMIS; THGIL; TH; THNSLI; THNSL2; THDCI; THDC2; THDC5; THDCB;
THDPI; THPD; THRA; THRB; THRSP; THSDI; THSD4; THSD7A; THYNI; TIAI: TIAFI: TIALI; TIAMI: TIAM2; TICAMI; TICAM2; TICRR; TIFA;
TIGD2; TIGIT; TIMD4; TIMELESS; TIMMID; TIMMI7A; TIMM2I; TIMM22; TIMM23; TIMM44; TIMM5D; TIMM8A; TIMM8B; TIMMOCI; TIMPI;
TIMP2; TIMP3; TIMP4; TINAG; TINF2; TIPARP; TIPIN; TIPRL; TIRAP; TJPfc TJP2; TJP3; TKI; T 2; TKT; TKTLI; T TL2; TLDCI; TLEI; TLE2; TLE3; TLE4; TLEG; Ml; TLK2; TLLI; TLL2; TLNI; TLN2; TLRIO; TLRI; TLR2; TLR3; TLR4; TLR5; TLRB; TLR7; TLR8; TLR9; TLXI; TLX2; TLX3;
TM4SFI; TM4SF2D; TM4SF4; TM4SF5; TMBSF2; TM7SF2; TM9SF2; TM9SF4; TMBIM4; TMBIMB; TMCI; TMC2; TMC3; TMC5; TMCB; TMC8;
TMCCI; TMCC2; TMCC3; TMCDI; TMCD4; TMCD5A; TMEDID; TMEDI; TMED2; TMED3; TMED4; TMED7; TMED7-TICAM2; TMEDB; TMEFFI;
TMEFF2; TMEMIOO; TMEMIDI; TMEMID5; TMEMIDBB; TMEMI08; TMEMII4; TMEMII5; TMEMII7; TMEMII; TMEMI2BA; TMEMI27; TMEMI28;
TMEMI32A; TMEMI32B; TMEMI32C; TMEMI32D; TMEMI32E; TMEMI34; TMEMI35; TMEMI38; TMEMI5DB; TMEMI5IA; TMEMI5IB; TMEMI54; TMEMI58; TMEMIGO; TMEMIBIB; TMEMIB3; TMEMIG5; TMEMIB9; TMEMI70A; TMEM17I; TMEMI73; TMEMI75; TMEMI7GB; TMEMI78A;
TMEMI82; TMEMI83A; TMEMI84C; TMEMI85A; TMEMI87; TMEMI89; TMEMI89-UBE2VI; TMEMI8; TMEMI99; TMEM2D0A; TMEM205;
TMEM207; TMEM209; TMEM2I3; TMEM2I5; TMEM2IB; TMEM2I7; TMEM2I9; TMEM220; TMEM229A; TMEM23I; TMEM233; TMEM237;
TMEM24I; TMEM244; TMEM245; TMEM259; TMEM25; TMEM2BI; TMEM27; TMEM2; TMEM30A; TMEM30B; TMEM37; TMEM38A; TMEM38B;
TMEM39A; TMEM40; TMEM43; TMEM45A; TMEM47; TMEM50B; TMEM55A; TMEM57; TMEM5; TMEMBO; TMEMB2; TMEMB3A; TMEMB7; TMEM70; TMEM74B; TMEM79; TMEM87A; TMEM88; TMEM89; TMEM8B; TMEM95; TMEMB7; TMEM98: TMFI; TMIE; TMIGD2; TMIG03; TMLHE; TMODI: TMDD2; TMDD3; TM0D4; TMPO; TMPRSSIIA; TMPRSSIIB; TMPRSSIID; TMPRSSItE; TMPRSSI3; TMPRSSI5; TMPRSS2;
TMPRSS3; TMPRSS4; T PRSSB: TMPRSS7; T PRSS9; TMSBID; TMSBI5B; TMSB4X; T TCI; TMTC2; TMTC3; TMXI: TMX2; TMX3; TNC;
TNFAIPI: TNFAIP2; TNFAIP3; TNFAIP6; TNFAIP8; TNFAIP8L2; TNFAIP8L3; TNF; TNFRSFIOA; TNFRSFfOB; TNFRSFIOC; TNFRSFIOD;
TNFRSFIIA; TNFRSFIIB; TNFRSF12A; TNFRSFI3B; TNFRSFI3C; TNFRSFI4; TNFRSFI8; TNFRSFIA; TNFRSFIB; TNF SF2I; TNFRSFBB; TNFRSF8; TNFSFIO; TNFSFII; TNFSFI2; TNFSFI2-TNFSFI3; TNFSFI3B; TNFSFI3: TNFSFI4; TNFSFI5; TNFSFIB; TNFSF4; TNFSFB; TNFSF3;
TNIK; TNIPI; TNIP2; TNIP3; TNKI; TNK2; TNKS2; TNKS; TNMD; TNNCI; TNN; TNNII; TNNI2; TNNI3; TNNTI; TNNT2; TNNT3; TNPI; TNP2;
TNPBI; TNPB2; TNPD3; TNRCI8; TNRCBA; TNRCBB; TNR; TNSI; TNS2; TNS3; TNS4; TNXB; TOBl; TDB2; TOLLIP; TDMI: TOMILl; TOMM20;
TOMM34; TOMM40; TOMM70A; TONSL; TOPI; T0P2A; T0P2B; T0P3A; T0P3B; TOPBPI; TOPORS; TORIA; TORIAIPI; T0RIAIP2; TORIB;
TOR2A; T0X2; T0X3; T0X4; TOX; TP53AIPI; TP53BPI: TP53BP2; TP53; TP53III; TP53II3; TP53I3; TP53INPI; TP53INP2; TP53RK; TP53TG3C; TPB3; TP73; TPBG; TPCNI; TPCN2; TPD52; TPD52LI; TPD52L2; TPGS2; TPHI; TPH2; TPIt; TPKI; TPMI; TPM2; TPM3; TPM4;
TPMT; TPD; TPPI; TPP2; TPPP2; TPPP3; TPPP; TPRGI; TPR; TPRN; TPSABI; TPSB2; TPSDI; TPSGI; TPTI; TPTE2; TPTE; TPX2; TRA2A;
TRA2B; TRABD2A; TRABD; TRADD; TRAFI; TRAF2; TRAF3; TRAF3IPI; TRAF3IP2; TRAF4; TRAF5; TRAFB; TRAF7; TRAFDI: TRAKI; TRAK2;
TRAMI; TRAMILI; TRAM2; TRAPI; TRAPPCIO; TRAPPCII; TRAPPCI; TRAPPC2; TRAPPC4; TRAPPC9; TRATI; TRDMTI: TRDN; TREH; TREMI;
TREM2; TREMLI; TREML2; TRERFI; TREXI; TREX2; TRHDE; TRH; TRHR; TRIAPI; TRIBI; TRIB2; TRIB3; TRIMIO; TRIMII: TRIMI3; TRIMI5; TRIMIB; TRIMI7; TRIMZI: TRIM22; TRIM23; TRIM24; TRIM25; TRIM2B; TRIM27; TRIM28; TRIM29; TRIM2; TRIM3I; TRIM32; TRIM34;
TRIM35; TRIM3B; TRIM37; TRIM38; TRIM39; TRIMS; TRIM40; TRIM42; TRIM44; TRIM50; TRIM5B; TRIM58; TRIM59; TRIMS; TRIMB2;
TRIMBB; TRIMB8; TRIMB9; TRIMB-TRIM34; TRIM7I; TRIM72; TRIM73; TRIM74; TRIMS; TRIMS; TRIDBP; TRIO: TRIPIO; TRIPII; TRIPI3;
TRIP4; TRIPB; TIQK; TRMTIOA; TRMTI2; TRMT1; TRMT44; TRMT5; TRMU; TRO; TROVE2; TRPAI; TRPCI; TRPC3; TRPC4AP; TRPC4; TRPC5;
TRPCG; TRPC7; TRPMI; TRPM2; TRPM3; TRPM4; TRPM5; TRPMB; TRPM7; TRPM8; TRPSI; TRPVfc TRPV2; TRPV3; TRPV4; TRPV5; TRPVB; TRRAP; TSACC; TSCI: TSC22DI; TSC22D3; TSC22D4; TSC2; TSEN2; TSEN34; TSEN54; TSFM; TSGIDI; TSGAIO; TSHR; TSHZI; TSHZ2;
TSHZ3; TSLP; TSNAX; TSN; TSPANIO; TSPANII; TSPANI2; TSPANI3; TSPANI4; TSPANIB; TSPANI8; TSPAN3I; TSPAH32; TSPAN33;
TSPAN4; TSPANB; TSPAN7; TSPAN8; TSPAN9; TSPEAR; TSP02; TSPO; TSPYIO; TSPYI; TSPY3; TSPY4; TSPYLI; TSPYL2; TSPYL4;
TSPYL5; TSRI; TSSCI; TSSKIB; TSSK2; TSSK4; TSTA3; TSTDI; TST; TTB I; TTBK2; TTCI2; TTCI7; TTCI9; TTCI; TTC2IB; TTC28; TTC29;
TTC37; TTC39A; TTC39B; TTC3; TTC5; TTC6; TTC7A; TTC7B; TTC8; TTC9B; TTC9C: TTC9; TTFI; TTF2; TTII: TTI2; TTK; TTL; TTLLID; TTLLII; TTLLI2; mU; TTLL3; TTLL4; TTLL5; TTLLB; TTLL7; TTLL8; TTLL9; TTPA; TTR; TTYHI; TTYH2; TUBAIA; TUBAIB; TUBAIC; TUBA3D; TUBA4A;
TUBA8; TUBBI; TUBB2A; TUBB2B; TUBB3; TUBB4A; TUBB4B; TUBBB; TUBB; TUBDI; TUBEI: TUBGI; TUBG2; T0BGCP2; TUBGCP3;
TUBGCP4; TUBGCP5; TUBGCPB; TUB; TUFM; TUFTI; TULPI; T0LP2; TULP3; T0LP4; TUSCI; TUSC2; TUSC3; TUSC5; l; TVP23B; TWFI;
TWISTI; TWIST2; TWSGI; TXK; TXLNG; TXN2; TXNDCI5; TXNDCIB; TXN0CI7; TXNDC5; TXN; TXNLI; TXNRD2; TXNRD3NB; TYK2; TYMP;
TYMS; TYR; TYRD3; TYROBP; TYRPI; TYSNDI: TYWIB; U2AFI: U2AF2; UACA; UAPI; UBAI; UBA2; UBA3; UBA7; UBACI; UBAC2; UBAPI; UBAP2; UBASH3A; UBASH3B; UBB; OBC; UBD; UBE2A; UBE2B; 0BE2C; UBE2D1; UBE2D2; UBE2D3; UBE2EI; UBE2E2; UBE2E3; UBE2GI;
UBE2G2; UBE2H; UBE2I; UBE2JI; UBE2K; UBE2L3; UBE2LB; UBE2M; UBE2N; UBE202; UBE2DLI; UBE2R2; UBE2S; UBE2T; UBE2U;
UBE2VI; UBE2V2; UBE2Z; UBE3A; UBE3B; DBE3C; UBE4A; UBE4B: UBIAOI; UBL3; UBL4A; UBL5; UBL7; UBLCPI: UBNI; UB0X5; UBPI:
UBOLNI; UBQLN2; UBOLNL; UBRI; UBR3; 0BR4; 0BR5; UBR7; UBTD2; UBTF; UBXNI; UBXN2A; UBXN2B; UBXN4; UCHLI; UCHL3; UCHL5;
UCKI; UCK2; UCKLI; UCMA; 0CN2; UCN3; UCN; UCPI; UCP2; UCP3; UEVLD; UFOIL; UFLI; OFMI; UGCG; OGDH; UGGTI; UGGT2; UGP2; UGTIAIO; UGTIAI; UGTIA3; 0GTIA4; UGTIA5; UGTIAB; UGTIA7; UGTIA8; UGTIA9; UGT2AI; UGT2A2; UGT2A3; DGT2BI0; UGT2BII; UGT2BI5; UGT2B28; UBT2B4; UGT2B7; UGT3A2; UGT8; UHMKI; UHRFIBPI; UHRFI; UHRF2; UIMCI; ULBPI; ULBP2; ULBP3; ULKI; ULK2; ULK3; ULK4;
UMBO; UMDOLI; UMPS; UNCII9; UNCI3A; UNCI3B; UNCI3C; UNCI3D; UNC45A; UNC45B; UNC5A; UNC5B; UNC5C; UNC5D; UNC79;
UNCB3A; UNC93BI; UNG; UPBI; UPFI; UPF2; UPF3A; UPF3B; UPKIA; UPKIB; UPK2; UPK3A; UPPI; UPP2; UPRT; UQCCI; UQCC2; UQCRB;
UDCRCI; UBCRC2; UQCRFSI: UflCRO; URB2; URGCP; URII; URMI; URDCI; U OD; UROS; USBI; USEI: USFi: USF2; USHIC; USHIG; USH2A; 5 USUI; USPIO; USPII; USPI2; USPI3; USPI4; USPI5; USPI7L2; USPI7L3D; USPI8; USP20; USP22; USP25; USP2B; USP28; USP2; USP32;
USP33; USP3B; USP37; USPS; USP4B; USP42; USP43; USP44; USP4B; USP48; USP49; USP4; USP5; USPB; USPBNL; USP7; USPS;
USP9X; USP9Y; USPLI; UST; UTFI; UTPI4A; UTPI4C; UTP2B; UTRN; UTS2B; UTS2; UTS2R; UTY; UVRAG; UVSSA; UXSI: UXT; VACI4;
VAMPI; VAMP2; VAMP4; VAMP7; VAMP8; VANGL2; VAPA; VAPB; VARS2; VARS; VASHI; VASH2; VASP; VATI; VATIL; VAVI; VAV2; VAV3;
VAXI; VAX2; VBPI; VCAN; VCL; VCP; VCX2; VCX3A; VCX3B; VCX; VCY; VDACI; VDAC2; VDR; VEGFA; VEGFB; VEGFC; VENTX; VEPHI; VEZT; ID VGF; VGLLI; VGLL2; VGLL3; VGLL4; VHL; VHLL; VILI; VIM; VIPAS39; VIP; VIPRI; VIPR2; VIT; VKDRCI; VLDLR; VMA2I; VMDI; VMPI; VNIR2;
VNIR4; VNNI: VNN2; VNN3; VOPPI: VPRBP; VPREBI; VPREB3; VPSII; VPSI3A; VPSI3B; VPSI3C; VPS2BA; VPS28; VPS33A; VPS33B;
VPS35; VPS3B; VPS37A; VPS37B; VPS37C; VPS39; VPS4I; VPS4A; VPS4B; VPS5I; VPS52; VPS53; VPS54; VPS72; VPS8; VRKI: VRK2;
VSIGID; VSIGI; VSIG2; VSIG4; VSNLI: VSTMI; VSXI; VSX2; VTAI; VTCNI; VTIIA; VTIIB; VTN; VWA2; VWA3A; VWA3B; VWA5A; VWA5BI:
VWA7; VWA8; VWCE: VWDE; VWF; WAPAL; WARS2; WARS; WASFI; WASF3; WASHI; WAS; WASL; WBPIL; WBP2; WBSCRI7; WBSCR22; 15 WDFY2; WDFY4; WDHDI; WDPCP; WDRII; WDRI2; WDRI7; WDRI9; WDRI; WDR2D; WDR2B; WDR3I; WDR34; WDR35; WDR3B; WDR37;
WDR43; WDR45B; WDR45; WDR4B; WDR48; WDR49; WDR4; WDR55; WDR5; WDRBD; WDRB2; WDRB4; WDRBB; WDR7D; WDR72;
WDR74; WDR7B; WDR78; WDR7; WDR8I; WDR83; WDR8B; WDR93; WEEI; WFDCI: WFDC2; WFSI; WHSCI; WHSCILI; WIFI: WIPFI: WIPF2;
WIPF3; WIPII; WIPI2; WISPI; WISP2; WISP3; WLS; WNKI; WNK2; WNK3; WNK4; WNTIDA; WNTIDB; WNTII; WNTIB; WNTI; WNT2B; WNT2;
WNT3A; WNT3; WNT4; WNT5A: WNT5B; WNTB; WNT7A; WNT7B: WNT8A; WNT8B; WNT9A; WNT9B; WRAP53; WRB; WRN; WRN1P1; WSBI; WSCDI; WSCD2; WTI; WTAP; WTIP; WWCI; WWC2; WWDX; WWPI; WWP2; WWTRI; XAB2; XAFI; XAGEIB; XAGEIE; XBPI; XCLI; XCL2; XCRI;
XDH; XG; XIAP; XIRPI; XIRP2; XK; XKR4; XKRG; XKR9; XPA; XPC; XPNPEPI; XPNPEP2; XPNPEP3; XPDI; XP04; XPD5; XPOB; XP07; XPRI;
XRCCI; XRCC2; XRCC3; XRCC4; XRCC5; XRCCBBPI; XRCCB; XRNI; XRN2; XRRAI; XXYLTI; XYLB; XYLTI; XYLT2; YAEIOI; YAPI; YARS2;
YBX2; YBX3; YDJC; YEATS4; YESI; YIFIA: YIPFI; YIPF3; YIPF5; YKTB; YLPMI; YMEILI; YPELI: YPEL2; YPEL3; YPEL4; YPEL5; YTHDCI;
YTHDC2; YWHAB; YWHAE; YWHAG; YWHAH; YWHAD; YWHAZ; YYIAPI; YYI; ZACN; ZAK; ZAP7D; ZARI; ZARIL; ZASP; ZBEDI; ZBED4; ZBED5;5 ZBPI; ZBTBID; ZBTBI2; ZBTBI4; ZBTBIB; ZBTBI7; ZBTBI8; ZBTB2D; ZBTB2I; ZBTB22; ZBTB24; ZBTB2; ZBTB32; ZBTB33; ZBTB34;
ZBTB38; ZBTB4I; ZBTB4B; Z8TB48; ZBTB49; ZBTB4; ZBTB5; ZBTB7C; ZBTB9; ZC2HCIB; ZC3HI0; ZC3HIIA; ZC3HI2C; ZC3HI2D; ZC3HI4;
ZC3HI5; ZC3H3; ZC3H4; ZC3H7A; ZC3H7B; ZC3HAVI; ZC3HCI; ZC4H2; ZCCHCII; ZCCHCI2; ZCCHCI4; ZCCHC2; ZCCHC3; ZCCHCB;
ZCCHC8; ZCRBI; ZCWPWI; ZDBF2; ZDHHCII; ZDHHCI2; ZDHHCI3; ZDHHCI4; ZDHHCI5; ZDHHCI7; ZDHHCI; ZDHHC2; ZDHHC7; ZDHHC8;
ZDHHC9; ZEBI; ZEB2; ZFAND3; ZFAND5; ZFANDB; ZFAT; ZFC3HI: ZFHX2; ZFHX3; ZFHX4; ZFPI; ZFP30; ZFP3B; ZFP3GLI: ZFP3BL2; ZFP37; ZFP42; ZFP57; ZFPB4; ZFP82; ZFPBI; ZFPMI; ZFPM2; ZFR2; ZFR; ZFX; ZFY; ZFYVEI9; ZFYVE2I; ZFYVE2B; ZFYVE27; ZFYVE28; ZFYVE9;
ZGIBB; ZGLPI; ZGPAT; ZHXI; ZHX2; ZICI; ZIC2; ZIC3; ZIC4; ZIC5; ZIKI; ZIM2; ZKSCANI; ZKSCAN3; ZKSCAN7; ZMAT3; ZMAT4; ZMIZI;
ZMYM2; ZMYM3; ZMYM4; ZMYM5; ZMYNDID; ZMYNDII; ZMYND8; ZNFIDB; ZNFID7; ZNFID; ZNFII2; ZNFI2I: ZNFI3I; ZNFI32; ZNFI33; ZNFI4I;
ZNFI43; ZNFI4B; ZNFI48; ZNFI54; ZNFIBD; ZNFIB9; ZNFI75; ZNFI77; ZNFI82; ZNFI84; ZNFI85; ZNFI89; ZNFI97; ZNF2D2; ZNF2D5; ZNF2D;
ZNF2I2; ZNF2I4; ZNF2I5; ZNF2I7; ZNF224; ZNF22; ZNF23D; ZNF23B; ZNF239; ZNF23; ZNF248; ZNF24; ZNF253; ZMF2B0; ZHF2B3;5 ZNF2G4; ZNF2BB; ZNF2B7; ZNF2B8; ZNF273; ZNF274; ZNF27B; ZNF277; ZNF280B; ZNF28DD; ZNF28I; ZNF282; ZNFZ8BB; ZNF29B: ZNF2; ZNF3DD; ZNF3II; ZNF3I8; ZNF32D; ZNF322; ZNF32; ZNF33D; ZNF33I; ZNF334; ZNF335: ZNF343; ZNF35D; ZNF354A; ZNF35;
ZNF3B5; ZNF3FJFJ; ZNF3B7; ZNF3B2; ZNF3B3: ZNF3S4; ZNF385A; ZNF385B; ZNF385D; ZNF39I: ZNF395; ZNF338; ZNF407; ZNF4ID;
ZNF415; ZNF4I3; ZNF4I; ZNF423; ZNF430; ZNF432; ZNF433; ZNF438; ZNF443; ZNF444; ZNF44; ZNF45I: ZNF45; ZNF4B2; ZNF4B9:
ZNF483; ZNF49D; ZNF4B2; ZNF4BB; ZNF5DI; ZNF5D7; ZNF5I2B; ZNF5I2; ZNF5I3; ZNF5IB; ZNF5I9; ZNF52I; ZNF53B; ZNF555; ZNF55B; 5 ZNF5B8; ZNF5B9; ZNF577; ZNF5SD; ZNF58I; ZNF582; ZNF583; ZNF585B; ZNF5B2: ZNF53B; ZNFBOB; ZNFBD7; ZNFB08; ZNFBI5;
ZNFBI8; ZNFB27; ZNFB23; ZNFB33; ZNFB44; ZNFB45; ZNFB4B; ZNFB52; ZNF654; ZNFSB4; ZNFBB7; ZNFBB8; ZNFG74; ZNFB7B; ZNFB78;
ZNFB83; ZNFB87; ZNFB83; ZNF703; ZNF7D4; ZNF7DB; ZNF7II; ZNF7I6; ZNF7I7; ZNF74B; ZNF74; ZNF750; ZNF7B3; ZNF7B4; ZNF7B5;
ZNF7B; ZNF774: ZNF77B; ZNF778; ZNF7B4; ZNF79; ZNF7; ZNF8DD: ZNF804A; ZNF804B; ZNF80; ZNF8I2; ZNF8I3; ZNFS1B; ZNF8I;
ZNF823; ZNF827; ZNF823; ZNFB3I: ZNF9I; ZNF32; ZNF33; ZNF38; ZNFX1; ZNHIT2; ZNHIT3; ZNRDI; ZN F3; ZPI; ZP4; ZPBP2; ZPLDI; ID ZPRI; ZRANB3; ZRSR2; ZSCANI8; ZSCAN22; ZSCAN2B; ZSCAN3I: ZSCAN32; ZSCAN9; ZSWIM2; ZSWIMB; ZWIO: ZWILCH; ZWINT; ZYX;
ZZEFI;およびZZZ3。
脂質ベースの製剤は、それらの生体適合性と大規模生産の容易さから、RNAの最も有望なデリバリーシステム(本明細書ではデリバリー媒体または担体とも呼ばれる)の1つとして次第に認識されてきた。カチオン性脂質は、RNAデリバリーのための合成材料として広く研究されてきた。一緒に混合した後、核酸はカチオン性脂質によって凝縮され、リポプレックスとして公知である脂質/核酸複合体を形成する。これらの脂質複合体は、遺伝物質をヌクレアーゼの作用から保護し、負に帯電した細胞膜と相互作用することにより、細胞に遺伝物質をデリバリーすることができる。リポプレックスは、生理学的pHで正に荷電した脂質と負に荷電した核酸とを直接混合することによって調製することができる。
(a)核酸、
(b)カチオン性脂質、
(c)凝集低減剤(例えばポリエチレングリコール(PEG)脂質またはPEG修飾脂質)、
(d)適宜、非カチオン性脂質(例えば中性脂質)、および
(e)適宜、ステロール。
R1およびR2は両方とも、1~14個の炭素からなる直鎖アルキル、または2~14個の炭素からなるアルケニルまたはアルキニルからなり;
L1およびL2は両方とも、5~18個の炭素からなるか、またはNと複素環を形成する、直鎖アルキレンまたはアルケニレンからなり;
XはSであり;
L3は、結合、または1~6個の炭素からなるか、もしくはNと複素環を形成する、直鎖アルキレンからなり;
R3は、1~6個の炭素からなる直鎖または分岐アルキレンからなり;
R4およびR5は同一であるかまたは異なり、それぞれ水素、または1~6個の炭素からなる直鎖または分岐アルキルからなる)
あるいは、その薬学的に許容される塩
である。
好ましくは、本開示は、目的の修飾ヒト治療用タンパク質をコードするコドン最適化mRNAを含んでおり、好ましくは、脂質デリバリーシステムまたは脂質担体中で製剤化され、好ましくは、薬学的に許容される賦形剤を含む、医薬組成物を提供する。本明細書に開示した医薬組成物は、好ましくは、インビボでのmRNAの発現を促進する。
mRNA配列、本明細書に記載したmRNA配列を転写する一次DNAコンストラクト、およびそれらの医薬組成物は、多数のインビボおよびインビトロ方法を提供し、タンパク質の欠損症を処置するのに有用である。処置は、タンパク質の欠損症のヒト患者を処置することを含み得る。同様に、本明細書に記載した組成物は、細胞または動物に基づくモデルにおけるOTC欠損症を研究するためにインビトロまたはエキソビボ(ex vivo)で使用することができる。例えば、目的のタンパク質発現を欠損した細胞を使用して、目的のタンパク質の発現および/または活性を回復する能力、ならびに発現および/または活性が持続する期間を分析することができる。そのような細胞および動物モデルはまた、同じ生化学経路における結合パートナーまたは因子であるかどうかにかかわらず、経路に関与している他の因子を同定するのに適切である。他の実施形態では、本明細書に記載した組成物を使用して、ミトコンドリアデリバリーを研究または追跡することができる。
本開示のmRNA、タンパク質またはその医薬製剤の有効用量は、細胞および/または患者におけるORFタンパク質欠損症を処置するのに十分な量であり得る。治療有効用量は、治療効果をもたらすのに十分な薬剤または製剤の量であり得る。治療有効用量は、1回または複数回の別々の投与で、異なる経路により投与することができる。一般に、治療有効用量は、対象に有意な利益を達成するのに十分である(例えば、フェニルケトン尿症を処置、調節、治癒、予防、および/または改善する)。例えば、治療有効量は、所望の治療効果および/または予防効果を達成するのに十分な量であり得る。一般に、それを必要とする対象に投与される治療剤の量は、対象の特徴に依存する。そのような特徴には、対象の状態、疾患の重症度、全体的健康状態、年齢、性別および体重が含まれる。当業者は、これらのおよび他の関連要因に応じて適切な用量を容易に決定することができる。さらに、客観的アッセイおよび主観的アッセイの両方を、最適な用量範囲を特定するために使用してもよい。
本明細書に記載したcDNA一次コンストラクト、mRNAまたはコードされた修飾治療用タンパク質は、1つまたは複数の他の治療剤、予防剤、診断剤、または画像化剤と組み合わせて使用することができる。「と組み合わせて」とは、これらのデリバリーの方法は本開示の範囲内であるが、薬剤が同時に投与され、および/またはデリバリーのために一緒に製剤化されなければならないことを意味することを意図しない。組成物は、1つまたは複数の他の所望する治療手順または医療手順と同時に、その前に、またはその後に投与され得る。一般に、それぞれの薬剤は、その薬剤に対して決定された用量および/または時間スケジュールで投与される。好ましくは、本開示の処置の方法は、バイオアベイラビリティを改善し、代謝を低下および/または修正し、排出を抑制し、および/または体内分布の修正し得る薬剤と組み合わせた、医薬組成物、予防組成物、診断組成物、または画像化組成物のデリバリーを包含する。非限定的な例として、配列番号4の修飾タンパク質をコードする本明細書に記載したmRNAは、OTC欠損症を処置するための薬剤と組み合わせて使用することができる。薬剤には、限定するものではないが、フェニル酪酸ナトリウム、フェニル酪酸グリセロール、フェニル酢酸ナトリウム、安息香酸ナトリウム、アルギニン、シトルリン、マルチビタミン、カルシウムサプリメント、または低タンパク質/高カロリー食と組み合わせたものの1つまたは複数が含まれる。一般に、組み合わせて用いられる薬剤は、個別に使用されるレベルを超えないレベルで使用されることが期待される。いくつかの実施形態では、組み合わせて用いられるレベルは、個別に使用されるレベルよりも低くなる。一実施形態では、組合せは、それぞれまたは一緒に、当技術分野において公知の分割投与レジメンによって投与され得る。
インビトロ転写プロトコル
mRNAは、T7RNAポリメラーゼ媒介型DNA依存性RNA転写を使用してインビトロで合成し、ウリジン三リン酸(UTP)を、それぞれのUTRの組合せにごとに直鎖状の鋳型を使用して、修飾UTP、例えば5メトキシUTP(5MeOU)、N1-メトキシメチルシュードUTP(N1-MOM)、5-ヒドロキシメチルUTP、5-カルボキシUTP、および修飾の混合物で置換および非置換した。mRNAはカラムクロマトグラフィーを使用して精製し、酵素反応を使用してDNAおよびすべてのmRNAの二本鎖mRNA混入を除去し、mRNAを濃縮し、バッファー交換した。
脂質カプセル化mRNA粒子は、エタノール中の脂質(ATX脂質:DSPC:コレステロール:PEG-DMG)を、クエン酸バッファーに溶解した所望の治療用ポリペプチドをコードするmRNAと混合することにより調製した。この混合材料をリン酸バッファーで瞬間的に希釈した。エタノールを、再生セルロース膜(100kD MWCO)を使用したリン酸バッファーで透析するか、または変性ポリエーテルスルホン(mPES)中空糸膜(100kD MWCO)を使用したタンジェンシャルフロー濾過(tangential flow filtration、TFF)によって除去した。エタノールを完全に除去した後、緩衝液を、50mMのNaClおよび9%のスクロースを含有するHEPES(4-(2-ヒドロキシエチル)-1-ピペラジンエタンスルホン酸)緩衝液、pH7.3と交換した。この製剤を濃縮し、続いてPESフィルターを使用して0.2μm濾過を行った。次いで、この製剤中のmRNA濃度をRibogreen蛍光アッセイによって測定した後、グリセロールを含有する、50mMのNaCl、9%スクロース含むHEPESバッファー、pH7.3で希釈することにより、濃度を所望する最終濃度に調整した。次いで、最終製剤を0.2μmフィルターで濾過し、ガラス製バイアルに充填して栓をし、蓋をして-70±5℃に置いた。この凍結製剤を、RibogreenアッセイによるmRNA含有量およびカプセル化率、フラグメントアナライザーによるmRNA完全性、高速液体クロマトグラフィー(HPLC)による脂質含有量、Malvern Zetasizer Nano ZSでの動的光散乱による粒子サイズ、pHおよびオスモラリティに関して特徴付けた。
96ウェルのコラーゲンプレートを使用して、ダルベッコ改変イーグル培地(DMEM)/ウシ胎児血清(FBS)培地に適切な密度で細胞を播種した。最適なコンフルエンスで、細胞を、トランスフェクション試薬ミックス(MessengerMaxおよびOpti-MEM)で希釈した標的mRNAでトランスフェクトした。細胞をCO2インキュベーター内も置き、増殖させた。所望する時点で、培地を除去し、細胞を4%の新鮮なパラホルムアルデヒド(PFA)で20分間固定した。その後、固定液を除去し、細胞を、TWEENを入れたトリスバッファー生理食塩水(TBST)で5分間にわたり数回、透過処理した。透過処理洗浄が完了したら、細胞をブロッキングバッファー[ODYSSEY(登録商標)ブロッキングバッファー(PBS)(Li-Cor, Lincoln, NE)]と共に45分間インキュベートした。次いで、一次抗体を添加し、室温で1時間インキュベートした。次いで、細胞をTBSTで数回洗浄し、ブロッキングバッファーで希釈し、CellTag700染色剤を含む二次抗体と1時間インキュベートした。最後に、細胞をTBSTで数回洗浄し、続いてトリス緩衝生理食塩水(TBS)で最終洗浄を実施した。プレートはLicor検出システムを使用して画像化し、データはCellTag700で標識した細胞の総数に対して正規化した。
UTRライブラリーは、OTCに関する、配列番号34の配列をCDS(コード配列)として含むmRNAコンストラクト#571を使用して、インビトロでスクリーニングした。実施例1に記載したIn-Cell Westernアッセイを使用して、市販のトランスフェクション試薬を使用し、異なるmRNAをHepa1,6およびHep3Bにトランスフェクトした。OTCタンパク質の発現レベルは、近赤外蛍光イメージングシステムによって測定した。市販のOTC用抗体を検出に使用した。トランスフェクトされていない配列および参照配列を内部対照として使用した。図1のパネルAは、24時間でのHepa1,6細胞およびHep3B細胞において確認されたOTCタンパク質の発現レベルの散布図である。図1のパネルBは、48時間でのHepa1,6細胞およびHep3B細胞において確認されたOTCタンパク質の発現レベルの散布図である。スクリーニングの目的は、ヒト(Hep3B)およびマウス(Hepa1,6)肝細胞株においてOTC発現レベルに対するUTR固有の影響を判定することであり、どのUTRが両モデルにおいて最も有益であり得るのか、特にマウスからヒトへの翻訳可能性を判断する上で有益である。高発現UTRをさらなるプロファイリング試験において使用した。
タンパク質安定性のアプローチに基づいて設計された表5の特定のmRNAコンストラクトのインビトロスクリーニングを実施した。mRNAコンストラクトは、2つの異なる化学物質N1-メチルシュードウリジン(N1MPU)および5-メトキシウリジン(5MeOU)で試験したが、このことは、各mRNA中のウリジンの100%がN1MPUのみであったか、または5MeOUのみであった(5MeOUまたはN1MPUの組合せではない)ことを意味する。実施例1に記載したIn-Cell Western(ICW)アッセイを使用して、市販のトランスフェクション試薬を使用し、異なるmRNAをHepa1,6およびHep3Bにトランスフェクトした。OTCタンパク質の発現レベルは、近赤外蛍光イメージングシステムによって測定した。市販のOTC用抗体を検出に使用した。トランスフェクトされていない配列および参照配列を内部対照として使用した。図2のパネルAは、N1MPUおよび5MeOU化学物質で試験したmRNAの関数として、24時間でのHepa1,6細胞におけるOTCタンパク質の発現レベルの相関を示す散布図である。図2、パネルBは、N1MPUおよび5MeOU化学物質で試験したmRNAの関数として、24時間でのHep3B細胞におけるOTCタンパク質の発現レベルの相関を示す散布図である。これらの図は、2つの異なる化学物質からのmRNAをマウス肝細胞株およびヒト肝細胞株において試験した場合の発現レベルの変動の程度を示す。この実験においては、N1MPU化学物質をmRNAで使用した場合、ほとんどの化合物がより良好に発現することが明らかであり得る。
Spf/ashマウスに、PBSまたは脂質製剤化OTC-mRNAコンストラクト1799.7(5MeOU化学物質)のいずれかを3つの異なる用量:0.3mg/kg、1mg/kgおよび3mg/kgでIV注射した。WTおよびspf/ashマウスを使用して、ベースラインおよび高尿中オロト酸塩レベルをそれぞれ決定した。spf/ashの時間経過が決定され、尿中オロト酸塩レベルが各時点で測定された。結果は図9で見ることができる。尿中オロト酸塩はクレアチニンに対して正規化され、これは時間経過を通じてY軸のグラフに示され、また注射後のOTC活性の機能回復の概念実証として有用である。3mg/kgで、最大14日間まで尿中オロト酸塩レベルの持続的減少が観察された。
spf/ashマウスに、PBSまたは脂質製剤化OTC-mRNAのいずれかを1mg/kgおよび3mg/kgでIV注射した。WTマウスを内部対照として使用した。サンプル分画は、肝臓サンプルで、サイトゾル分画とミトコンドリア分画を分離して実施した。OTCレベルは、ヒト特異的(hOTC)抗体および交差反応性(crOTC)抗体を使用して、WBによって測定した(図11)。シクロオキシゲナーゼIV(CoxIV)をミトコンドリア対照として使用した。OTCタンパク質の発現レベルは、近赤外蛍光イメージングシステムによって測定し、総タンパク質に対して正規化した。WBは、2016mRNAおよび2260mRNAがspf/ashマウスに送られた場合のミトコンドリア分画およびサイトゾル分画内のOTC発現レベルの差異を示している。2260mRNAは、本明細書に記載したように、修飾シグナルペプチドを有するタンパク質をコードする。これらの結果は、両化合物がミトコンドリアを効率的に標的化することができることを示唆している。
Claims (87)
- ヒト野生型タンパク質のアミノ酸配列に由来するアミノ酸配列を有する修飾タンパク質であって、ヒト野性型タンパク質のアミノ酸配列が、ヒト野性型タンパク質のアミノ酸配列中には存在しているが、相同非ヒト動物野性型タンパク質中には存在しないと同定された1つまたは複数のユビキチン化部位を除去するように修飾されている、修飾タンパク質。
- 相同非ヒト動物野生型タンパク質がマウスタンパク質である、請求項1に記載の修飾タンパク質。
- 1つのユビキチン化部位がヒト野生型タンパク質のアミノ酸配列から除去されている、請求項1または2に記載の修飾タンパク質。
- 2つのユビキチン化部位がヒト野生型タンパク質のアミノ酸配列から除去されている、請求項1または2に記載の修飾タンパク質。
- 1つまたは複数のユビキチン化部位がユビキチン化部位のアミノ酸を変更することによって除去される、請求項1または2に記載の修飾タンパク質。
- 1つまたは複数のユビキチン化部位が1つまたは複数のリジン残基と非リジン残基の存在を特徴とする、請求項1または2に記載の修飾タンパク質。
- 1つまたは複数のユビキチン化部位のアミノ酸残基がアルギニン残基に変更されている、請求項1または2に記載の修飾タンパク質。
- 末端部分に位置しているシグナルペプチドを有する野生型タンパク質のアミノ酸配列に由来するアミノ酸配列を有する修飾タンパク質であって、シグナルペプチドのアミノ酸配列が、+1位もしくは+2位のアミノ酸を変更することによって、または+1位もしくは+2位にアミノ酸を新たに付加することによって修飾されている、修飾タンパク質。
- シグナルペプチドがN末端に位置している、請求項8に記載の修飾タンパク質。
- シグナルペプチドが細胞外排出のための野生型タンパク質の移行を指示する、請求項8または9に記載の修飾タンパク質。
- シグナルペプチドが、ミトコンドリア、核、リソソーム、ペルオキシソーム、小胞体、ゴルジ体、および細胞膜からなる群から選択されるオルガネラへの野生型タンパク質の移行を指示する、請求項8または9に記載の修飾タンパク質。
- シグナルペプチドが、野生型タンパク質の細胞内オルガネラの内部部分への移行を指示する、請求項8または9に記載の修飾タンパク質。
- 細胞内オルガネラがミトコンドリアである、請求項11または12に記載の修飾タンパク質。
- シグナルペプチドが、+1位または+2位のアミノ酸を変更することによって修飾されている、請求項8から13のいずれか一項に記載の修飾タンパク質。
- +1位または+2位のアミノ酸が、アラニン、グリシン、メチオニン、セリン、スレオニン、バリン、およびプロリンからなる群から選択される安定化アミノ酸に変更される、請求項14に記載の修飾タンパク質。
- シグナルペプチドが、+1位または+2位に新たにアミノ酸を付加することによって修飾されている、請求項8から13のいずれか一項に記載の修飾タンパク質。
- +1位または+2位に付加されるアミノ酸が、アラニン、グリシン、メチオニン、セリン、スレオニン、バリン、およびプロリンからなる群から選択される安定化アミノ酸である、請求項16に記載の修飾タンパク質。
- ヒト野生型タンパク質のアミノ酸配列に由来するアミノ酸配列を有する修飾タンパク質であって、ヒト野生型タンパク質が末端部分に位置しているシグナルペプチドを有しており、
i)シグナルペプチドのアミノ酸配列が、+1位もしくは+2位のアミノ酸を変更することによって、または+1位もしくは+2位にアミノ酸を新たに付加することによって、修飾されており;
ii)ヒト野生型タンパク質のアミノ酸配列が、ヒト野生型タンパク質のアミノ酸配列中には存在するが、相同非ヒト動物の野生型タンパク質には存在しないと同定された1つまたは複数のユビキチン化部位を除去するように修飾されている、
修飾タンパク質。 - 相同非ヒト動物野生型タンパク質がマウスタンパク質である、請求項18に記載の修飾タンパク質。
- 1つのユビキチン化部位がヒト野生型タンパク質のアミノ酸配列から除去されている、請求項18または19に記載の修飾タンパク質。
- 2つのユビキチン化部位がヒト野生型タンパク質のアミノ酸配列から除去されている、請求項18または19に記載の修飾タンパク質。
- 1つまたは複数のユビキチン化部位がユビキチン化部位のアミノ酸を変更することにより除去される、請求項18または19に記載の修飾タンパク質。
- 1つまたは複数のユビキチン化部位がリジン残基の存在を特徴とする、請求項18または19に記載の修飾タンパク質。
- 1つまたは複数のユビキチン化部位のアミノ酸残基がアルギニン残基に変更されている、請求項22に記載の修飾タンパク質。
- シグナルペプチドがN末端に位置している、請求項18から24のいずれか一項に記載の修飾タンパク質。
- シグナルペプチドが、細胞外排出のためのヒト野生型タンパク質の移行を指示する、請求項25に記載の修飾タンパク質。
- シグナルペプチドが、ミトコンドリア、核、リソソーム、ペルオキシソーム、小胞体、ゴルジ体、および細胞膜からなる群から選択されるオルガネラへのヒト野生型タンパク質の移行を指示する、請求項25に記載の修飾タンパク質。
- シグナルペプチドが、ヒト野生型タンパク質のオルガネラの内部部分への移行を指示する、請求項25に記載の修飾タンパク質。
- オルガネラがミトコンドリアである、請求項28に記載の修飾タンパク質。
- シグナルペプチドが、+1位または+2位のアミノ酸を変更することによって修飾されている、請求項25から29のいずれか一項に記載の修飾タンパク質。
- +1位または+2位のアミノ酸が、アラニン、グリシン、メチオニン、セリン、スレオニン、バリン、およびプロリンからなる群から選択される安定化アミノ酸に変更される、請求項30に記載の修飾タンパク質。
- シグナルペプチドが、+1位または+2位にアミノ酸を付加することによって修飾されている、請求項25から29のいずれか一項に記載の修飾タンパク質。
- +1位または+2位に付加されるアミノ酸が、アラニン、グリシン、メチオニン、セリン、スレオニン、バリン、およびプロリンからなる群から選択される安定化アミノ酸である、請求項32に記載の修飾タンパク質。
- 修飾タンパク質のインビボ半減期が、ヒト野生型タンパク質のインビボ半減期と比較して増加される、前述の請求項のいずれか一項に記載の修飾タンパク質。
- ヒト野生型タンパク質が、OTC、ASL、PAH、ABCB4、ABCB11、PAH、AGL、CFTR、MUT、PCCA、PCCB、ASS1、FAH、HMBS、ATP7B、PFIC2、LDLR、G6PC、AGXT、FXN、PAL、BCKDHA、BCKDHB、DBT、UGT1A1、SLC25A13、CD46、CFH、CFI、FIX、FVII、FVIII、C2、C3、C5、GCHD、CBS、MPI、LNL、SERPING1、UROC1、SMPD1、GLA、GAA、GRHPR、ATP8B1、SERPINC1、PROS1、GBA、ACADVL、HFE、BCKDA、CDG1B、SERPINA1、BMPR2、ENG、ACVR1、SMAD4、BMPR9、HBB、FLCN、HSP1、AP3B1、HPS3、HPS4、HPS5、HPS6、DTNBP1、BLOC1S3、PLDN、AP3D1、BRAF、NF-1、SLC34A2、FBN1、COL1A1、COL1A2、COL1A3、COL5A1、COL5A2、ADAMTS2、PLOD1、TNXB、ABCA3、SP-B、SP-C、GBA、NPC1、NPC2、FOXF1、NKX2-1、SFTPB、SFTPC、ABCA3、CSF2RA、SFTPD、MUC5B、BMPR2、EIF2AK4、CSF2RB、DNAH5、DNAI1、DNAH11、AKR1D1、AMACR、ATP8B1、CYP7A1、FOXC2、GATA2、GHR、HSD3B7、IGFALS、IKBKG、JAG1、KIF11、NOTCH1、NOTCH2、NR1H4、SOX18、TJP2、P53、P73、P63、VIPAS39、VPS33B、EPO、ARG1、CPS1、NAGS、NOS、KRAS、OX40L、IL12、VEGF-A、MMA、TTR、PCSK9、AT、およびALAS1からなる群から選択される、前述の請求項のいずれか一項に記載の修飾タンパク質。
- 前述の請求項のいずれか一項に記載の修飾ペプチドをコードする配列を含むポリヌクレオチド。
- ポリヌクレオチドがDNAである、請求項36に記載のポリヌクレオチド。
- ポリヌクレオチドがメッセンジャーRNA(mRNA)である、請求項36に記載のポリヌクレオチド。
- mRNAが修飾タンパク質をコードするオープンリーディングフレームを含む、請求項38に記載のポリヌクレオチド。
- オープンリーディングフレームがコドン最適化オープンリーディングフレームである、請求項39に記載のポリヌクレオチド。
- オープンリーディングフレーム配列が修飾タンパク質をコードするために可能な理論上最小のウリジンを有するように最適化されている、請求項39に記載のポリヌクレオチド。
- mRNAが5’キャップ、5’非翻訳領域(UTR)、3’UTR、修飾タンパク質をコードするオープンリーディングフレーム、およびポリAテールを含む、請求項38から41のいずれか一項に記載のポリヌクレオチド。
- mRNAが、5-ヒドロキシシチジン、5-メチルシチジン、5-ヒドロキシメチルシチジン、5-カルボキシシチジン、5-ホルミルシチジン、5-メトキシシチジン、5-プロピニルシチジン、2-チオシチジン;5-ヒドロキシウリジン、5-メチルウリジン、5,6-ジヒドロ-5-メチルウリジン、2’-O-メチルウリジン、2’-O-メチル-5-メチルウリジン、2’-フルオロ-2’-デオキシウリジン、2’-アミノ-2’-デオキシウリジン、2’-アジド-2’-デオキシウリジン、4-チオウリジン、5-ヒドロキシメチルウリジン、5-カルボキシウリジン、5-カルボキシメチルエステルウリジン、5-ホルミルウリジン、5-メトキシウリジン、5-プロピニルウリジン、5-ブロモウリジン、5-ヨードウリジン、5-フルオロウリジン;シュードウリジン、2’-O-メチル-シュードウリジン、N1-ヒドロキシシュードウリジン、N1-メチルシュードウリジン、2’-O-メチル-N1-メチルシュードウリジン、N1-エチルシュードウリジン、N1-ヒドロキシメチルプソイドウリジン、およびアラウリジン;N6-メチルアデノシン、2-アミノアデノシン、3-メチルアデノシン、7-デアザアデノシン、8-オキソアデノシン、イノシン;チエノグアノシン、7-デアザグアノシン、8-オキソグアニン、および6-O-メチルグアニンからなる群から選択される1つまたは複数の化学修飾ヌクレオチドを含む、請求項38から42のいずれか一項に記載のポリヌクレオチド。
- 化学修飾ヌクレオチドがN1-メチルシュードウリジンである、請求項38から41のいずれか一項に記載のポリヌクレオチド。
- 化学修飾ヌクレオチドが5-メトキシウリジンである、請求項38から41のいずれか一項に記載のポリヌクレオチド。
- 化学修飾ヌクレオチドがシュードウリジンおよびN1-メチルシュードウリジンの組合せである、請求項38から41のいずれか一項に記載のポリヌクレオチド。
- 化学修飾ヌクレオチドが5-メチルシチジンおよびN1-メチルシュードウリジンの組合せである、請求項38から41のいずれか一項に記載のポリヌクレオチド。
- 化学修飾ヌクレオチドが5-メトキシウリジンおよびN1-メチルシュードウリジンの組合せである、請求項38から41のいずれか一項に記載のポリヌクレオチド。
- 化学修飾されたヌクレオチドが5-メトキシウリジン、5-メチルシチジンおよびN1-メチルシュードウリジンの組合せである、請求項38から41のいずれか一項に記載のポリヌクレオチド。
- ポリヌクレオチドの翻訳効率が、ヒト野生型タンパク質をコードするmRNAと比較して、少なくとも50%増加される、請求項38から49のいずれか一項に記載のポリヌクレオチド。
- ポリヌクレオチドの翻訳効率が、ヒト野生型タンパク質をコードするmRNAと比較して、少なくとも3倍増加される、請求項38から49のいずれか一項に記載のポリヌクレオチド。
- 200ヌクレオチド~5,000ヌクレオチドを含む、請求項38から51のいずれか一項に記載のポリヌクレオチド。
- 化学修飾ヌクレオチドがヌクレオチドの1~99%を構成する、請求項38から52のいずれか一項に記載のポリヌクレオチド。
- 化学修飾ヌクレオチドがヌクレオチドの50~99%を構成する、請求項38から53のいずれか一項に記載のポリヌクレオチド。
- 翻訳エンハンサーを含む、請求項38から54のいずれか一項に記載のポリヌクレオチド。
- 請求項38から55のいずれか一項に記載の1つまたは複数のポリヌクレオチドおよび薬学的に許容される担体を含む組成物。
- 担体がトランスフェクション試薬、ナノ粒子、またはリポソームを含む、請求項56に記載の組成物。
- 医学療法において使用するための請求項56または57の組成物。
- ヒトの身体の処置において使用するための請求項56または57に記載の組成物。
- ヒト野生型タンパク質の欠損に関連する疾患または状態を改善、予防、発症遅延、または処置するための医薬を調製または製造するための請求項56または57に記載の組成物。
- 欠損症に罹患していると同定された対象におけるヒト野生型タンパク質の欠損に関連する疾患または状態を改善、予防、発症遅延、または処置するための方法であって、前述の請求項のいずれか一項の組成物を対象に投与することを含む、方法。
- 投与が静脈内投与、皮下投与、肺投与、筋肉内投与、腹腔内投与、経皮投与、経口投与、経鼻投与、または吸入である、請求項61に記載の方法。
- 投与が、1日、1週間、2週間、または1か月に1回、2回、3回、または4回である、請求項61または62に記載の方法。
- 投与が0.01~10mg/kgの有効用量を含む、請求項61から63のいずれか一項に記載の方法。
- 投与が対象の肝臓、血清、肺、血漿、腎臓、脾臓、眼、心臓、筋肉、脳、脳脊髄液、またはリンパ節における修飾タンパク質の発現を増加させる、請求項61から64のいずれか一項に記載の方法。
- インビボにおいて修飾ヒトタンパク質を発現させるためのキットであって、0.1~500mg用量の請求項38から55のいずれか一項に記載の1つもしくは複数のポリヌクレオチド、または請求項56から60のいずれか一項に記載の組成物、および用量を投与するためのデバイスを含むキット。
- 前記デバイスが注射針、静脈内針、液滴デバイス、または吸入デバイスである、請求項66に記載のキット。
- 目的のタンパク質を修飾する方法であって、目的のタンパク質がヒト野生型タンパク質である方法であり、
i)相同非ヒト動物野生型タンパク質のアミノ酸配列には存在しないヒト野生型タンパク質のアミノ酸配列におけるユビキチン化部位を同定する工程と、
ii)ヒト野生型タンパク質のアミノ酸配列から工程(i)で同定されたユビキチン化部位の少なくとも1つを除去して、目的の修飾タンパク質を提供する工程と
を含む、方法。 - 1つのユビキチン化部位がヒト野生型タンパク質のアミノ酸配列から除去される、請求項68に記載の方法。
- 2つのユビキチン化部位がヒト野生型タンパク質のアミノ酸配列から除去される、請求項68に記載の方法。
- 相同非ヒト動物野生型タンパク質がマウスタンパク質である、請求項68から70のいずれか一項に記載の方法。
- 工程(ii)の除去がユビキチン化部位の少なくとも1つのアミノ酸残基を置き換えることを含む、請求項68から71のいずれか一項に記載の方法。
- 工程(ii)の除去がユビキチン化部位の少なくとも1つのリジン残基をアルギニン残基で置き換えることを含む、請求項68から71のいずれか一項に記載の方法。
- ヒト野生型タンパク質が末端部分にシグナルペプチドを含み、方法が、+1位もしくは+2位のアミノ酸を変更することによって、または+1位もしくは+2位にアミノ酸を付加することによって、シグナルペプチドのアミノ酸配列を修飾することをさらに含む、請求項68から73のいずれか一項に記載の方法。
- シグナルペプチドがN末端に位置している、請求項74に記載の方法。
- シグナルペプチドが細胞外排出のためのヒト野生型タンパク質の移行を指示する、請求項74または75に記載の方法。
- シグナルペプチドが、ミトコンドリア、核、リソソーム、ペルオキシソーム、小胞体、ゴルジ体、および細胞膜からなる群から選択されるオルガネラへのヒト野生型タンパク質の移行を指示する、請求項74または75に記載の方法。
- シグナルペプチドが、ヒト野生型タンパク質のオルガネラの内部部分への移行を指示する、請求項74または75に記載の方法。
- オルガネラがミトコンドリアである、請求項78に記載の方法。
- シグナルペプチドのアミノ酸配列を修飾することが+1位または+2位のアミノ酸を変更させることを含む、請求項74から79のいずれか一項に記載の方法。
- +1位または+2位のアミノ酸がアラニン、グリシン、メチオニン、セリン、スレオニン、バリン、およびプロリンからなる群から選択される安定化アミノ酸に変更される、請求項80に記載の方法。
- シグナルペプチドのアミノ酸配列を修飾することが+1位または+2位にアミノ酸を付加することを含む、請求項74から79のいずれか一項に記載の方法。
- +1位または+2位に付加されるアミノ酸がアラニン、グリシン、メチオニン、セリン、スレオニン、バリン、およびプロリンからなる群から選択される安定化アミノ酸である、請求項82に記載の方法。
- 修飾タンパク質のインビボ半減期が、ヒト野生型タンパク質のインビボ半減期と比較して、増加される、請求項74から83のいずれか一項に記載の方法。
- ヒト野生型タンパク質がOTC、ASL、PAH、ABCB4、ABCB11、PAH、AGL、CFTR、MUT、PCCA、PCCB、ASS1、FAH、HMBS、ATP7B、PFIC2、LDLR、G6PC、AGXT、FXN、PAL、BCKDHA、BCKDHB、DBT、UGT1A1、SLC25A13、CD46、CFH、CFI、FIX、FVII、FVIII、C2、C3、C5、GCHD、CBS、MPI、LNL、SERPING1、UROC1、SMPD1、GLA、GAA、GRHPR、ATP8B1、SERPINC1、PROS1、GBA、ACADVL、HFE、BCKDA、CDG1B、SERPINA1、BMPR2、ENG、ACVR1、SMAD4、BMPR9、HBB、FLCN、HSP1、AP3B1、HPS3、HPS4、HPS5、HPS6、DTNBP1、BLOC1S3、PLDN、AP3D1、BRAF、NF-1、SLC34A2、FBN1、COL1A1、COL1A2、COL1A3、COL5A1、COL5A2、ADAMTS2、PLOD1、TNXB、ABCA3、SP-B、SP-C、GBA、NPC1、NPC2、FOXF1、NKX2-1、SFTPB、SFTPC、ABCA3、CSF2RA、SFTPD、MUC5B、BMPR2、EIF2AK4、CSF2RB、DNAH5、DNAI1、DNAH11、AKR1D1、AMACR、ATP8B1、CYP7A1、FOXC2、GATA2、GHR、HSD3B7、IGFALS、IKBKG、JAG1、KIF11、NOTCH1、NOTCH2、NR1H4、SOX18、TJP2、P53、P73、P63、VIPAS39、VPS33B、EPO、ARG1、CPS1、NAGS、NOS、KRAS、OX40L、IL12、VEGF-A、MMA、TTR、PCSK9、AT、およびALAS1からなる群から選択される、請求項74から83のいずれか一項に記載の方法。
- 修飾タンパク質をコードするポリヌクレオチドを調製することをさらに含む、請求項74から84のいずれか一項に記載の方法。
- ポリヌクレオチドがメッセンジャーRNA(mRNA)である、請求項86に記載の方法。
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