JP2009538145A5 - - Google Patents
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- Publication number
- JP2009538145A5 JP2009538145A5 JP2009512277A JP2009512277A JP2009538145A5 JP 2009538145 A5 JP2009538145 A5 JP 2009538145A5 JP 2009512277 A JP2009512277 A JP 2009512277A JP 2009512277 A JP2009512277 A JP 2009512277A JP 2009538145 A5 JP2009538145 A5 JP 2009538145A5
- Authority
- JP
- Japan
- Prior art keywords
- monatin
- composition
- reaction
- component
- pathway
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- RMLYXMMBIZLGAQ-UHFFFAOYSA-N (-)-monatin Natural products C1=CC=C2C(CC(O)(CC(N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-UHFFFAOYSA-N 0.000 claims 24
- RMLYXMMBIZLGAQ-HZMBPMFUSA-N (2s,4s)-4-amino-2-hydroxy-2-(1h-indol-3-ylmethyl)pentanedioic acid Chemical compound C1=CC=C2C(C[C@](O)(C[C@H](N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-HZMBPMFUSA-N 0.000 claims 24
- 238000000034 method Methods 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 22
- 238000006243 chemical reaction Methods 0.000 claims 13
- 230000037361 pathway Effects 0.000 claims 10
- 238000004519 manufacturing process Methods 0.000 claims 9
- 239000000047 product Substances 0.000 claims 8
- 235000004279 alanine Nutrition 0.000 claims 7
- 102000004190 Enzymes Human genes 0.000 claims 6
- 108090000790 Enzymes Proteins 0.000 claims 6
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 6
- 125000003277 amino group Chemical group 0.000 claims 6
- 239000000376 reactant Substances 0.000 claims 6
- 239000011541 reaction mixture Substances 0.000 claims 4
- 238000004064 recycling Methods 0.000 claims 4
- 230000001010 compromised effect Effects 0.000 claims 3
- 239000000543 intermediate Substances 0.000 claims 3
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 claims 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical group CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims 2
- 102000003929 Transaminases Human genes 0.000 claims 2
- 108090000340 Transaminases Proteins 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000000593 degrading effect Effects 0.000 claims 2
- 230000000415 inactivating effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 229960004799 tryptophan Drugs 0.000 claims 2
- SLWQCDYJBNGHQV-UHFFFAOYSA-N 2-hydroxy-2-(1h-indol-3-ylmethyl)-4-oxopentanedioic acid Chemical compound C1=CC=C2C(CC(O)(CC(=O)C(=O)O)C(O)=O)=CNC2=C1 SLWQCDYJBNGHQV-UHFFFAOYSA-N 0.000 claims 1
- RSTKLPZEZYGQPY-UHFFFAOYSA-N 3-(indol-3-yl)pyruvic acid Chemical group C1=CC=C2C(CC(=O)C(=O)O)=CNC2=C1 RSTKLPZEZYGQPY-UHFFFAOYSA-N 0.000 claims 1
- 102000003677 Aldehyde-Lyases Human genes 0.000 claims 1
- 108090000072 Aldehyde-Lyases Proteins 0.000 claims 1
- 229930182827 D-tryptophan Natural products 0.000 claims 1
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical group CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 1
- 102000004879 Racemases and epimerases Human genes 0.000 claims 1
- 108090001066 Racemases and epimerases Proteins 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- HWXBTNAVRSUOJR-UHFFFAOYSA-N alpha-hydroxyglutaric acid Natural products OC(=O)C(O)CCC(O)=O HWXBTNAVRSUOJR-UHFFFAOYSA-N 0.000 claims 1
- 229940009533 alpha-ketoglutaric acid Drugs 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 239000006227 byproduct Substances 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 230000002860 competitive effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000000670 limiting effect Effects 0.000 claims 1
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 claims 1
- 229940076788 pyruvate Drugs 0.000 claims 1
- 229940107700 pyruvic acid Drugs 0.000 claims 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 claims 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 description 2
- 238000010367 cloning Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80310506P | 2006-05-24 | 2006-05-24 | |
| PCT/US2007/069513 WO2007140195A2 (en) | 2006-05-24 | 2007-05-23 | Methods and systems for increasing production of equilibrium reactions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009538145A JP2009538145A (ja) | 2009-11-05 |
| JP2009538145A5 true JP2009538145A5 (enExample) | 2010-05-20 |
Family
ID=38779330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009512277A Pending JP2009538145A (ja) | 2006-05-24 | 2007-05-23 | 平衡反応の収量を増加させるための方法およびシステム |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7888081B2 (enExample) |
| EP (1) | EP2038405A4 (enExample) |
| JP (1) | JP2009538145A (enExample) |
| CN (1) | CN101490249A (enExample) |
| AU (1) | AU2007267618B2 (enExample) |
| BR (1) | BRPI0711972A2 (enExample) |
| CA (1) | CA2653054A1 (enExample) |
| WO (1) | WO2007140195A2 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7297800B2 (en) * | 2001-12-27 | 2007-11-20 | Ajinomoto Co., Inc. | Process of producing glutamate derivatives |
| US8372989B2 (en) * | 2002-04-23 | 2013-02-12 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| US7572607B2 (en) * | 2002-04-23 | 2009-08-11 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| RU2307871C2 (ru) | 2002-08-26 | 2007-10-10 | Адзиномото Ко., Инк. | НОВАЯ АЛЬДОЛАЗА И СПОСОБ ПОЛУЧЕНИЯ ЗАМЕЩЕННЫХ α-КЕТОКИСЛОТ |
| EP2050821A3 (en) | 2002-12-09 | 2009-05-13 | Ajinomoto Co., Inc. | Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same |
| US7556660B2 (en) * | 2003-06-11 | 2009-07-07 | James Kevin Shurtleff | Apparatus and system for promoting a substantially complete reaction of an anhydrous hydride reactant |
| KR20060061811A (ko) * | 2003-08-01 | 2006-06-08 | 카아길, 인코포레이팃드 | 모나틴 식탁용 감미제 조성물 및 이의 제조 방법 |
| EP1653810B1 (en) * | 2003-08-14 | 2007-04-25 | Cargill, Incorporated | Chewing gum compositions comprising monatin and methods of making same |
| EP1657985A1 (en) * | 2003-08-25 | 2006-05-24 | Cargill Inc. | Beverage compositions comprising monatin and methods of making same |
| ATE498691T1 (de) * | 2003-10-21 | 2011-03-15 | Cargill Inc | Herstellung von monatin und monatinvorstufen |
| US8158389B2 (en) * | 2005-04-20 | 2012-04-17 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| JP5059746B2 (ja) * | 2005-04-20 | 2012-10-31 | カーギル，インコーポレイティド | モナチンの生体内分泌のための生成物及び方法 |
| US8076108B2 (en) | 2005-04-26 | 2011-12-13 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| US7582455B2 (en) * | 2005-04-26 | 2009-09-01 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| US20080020260A1 (en) * | 2005-11-12 | 2008-01-24 | Brydon Chris A | Apparatus, system, and method for manifolded integration of a humidification chamber for input gas for a proton exchange membrane fuel cell |
| ES2416104T3 (es) * | 2006-03-07 | 2013-07-30 | Cargill, Incorporated | Aldolasas, ácidos nucleicos que las codifican y métodos para producir y usar las mismas |
| US20090198072A1 (en) * | 2006-05-24 | 2009-08-06 | Cargill, Incorporated | Methods and systems for increasing production of equilibrium reactions |
| US7651542B2 (en) | 2006-07-27 | 2010-01-26 | Thulite, Inc | System for generating hydrogen from a chemical hydride |
| US7648786B2 (en) | 2006-07-27 | 2010-01-19 | Trulite, Inc | System for generating electricity from a chemical hydride |
| US8357214B2 (en) | 2007-04-26 | 2013-01-22 | Trulite, Inc. | Apparatus, system, and method for generating a gas from solid reactant pouches |
| KR20100061453A (ko) | 2007-07-25 | 2010-06-07 | 트루라이트 인크. | 하이브리드 전력의 생성 및 사용을 관리하는 장치, 시스템 및 방법 |
| US20090025293A1 (en) * | 2007-07-25 | 2009-01-29 | John Patton | Apparatus, system, and method for processing hydrogen gas |
| US8076107B2 (en) | 2007-10-01 | 2011-12-13 | Cargill, Incorporated | Production of monatin stereoisomers |
| US8367847B2 (en) * | 2007-10-01 | 2013-02-05 | Cargill, Incorporated | Production of monatin enantiomers |
| US8003361B2 (en) * | 2007-10-01 | 2011-08-23 | Cargill Incorporated | Production of monatin enantiomers |
| JP5683962B2 (ja) * | 2008-01-03 | 2015-03-11 | カーギル・インコーポレイテッド | アミノトランスフェラーゼおよびオキシドレダクターゼの核酸およびポリペプチドおよび使用方法 |
| WO2009088949A1 (en) * | 2008-01-03 | 2009-07-16 | Verenium Corporation | Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them |
| US8857279B2 (en) * | 2008-03-03 | 2014-10-14 | William P. Hanson | Analyte screening and detection systems and methods |
| WO2011082353A1 (en) * | 2009-12-30 | 2011-07-07 | Cargill, Incorporated | Separation and purification of monatin |
| EP2519406A4 (en) * | 2009-12-30 | 2014-03-26 | Cargill Inc | POLYMER AND METHODS FOR PREPARING AND USING POLYMER |
| US20120264948A1 (en) * | 2009-12-30 | 2012-10-18 | Cargill, Incorporated | Membrane separation and purification of monatin |
| WO2012166406A1 (en) * | 2011-05-31 | 2012-12-06 | Cargill, Incorporated | Increasing product yield and/or throughput by supersaturation of substrate |
| JP2015533501A (ja) * | 2012-10-18 | 2015-11-26 | サンド・アクチエンゲゼルシヤフト | インドリン誘導体の調製方法 |
| CN106470744B (zh) | 2014-06-13 | 2020-03-27 | 波乐思来技术股份有限公司 | 水上乘坐设施 |
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|---|---|---|---|---|
| US3002889A (en) | 1960-06-20 | 1961-10-03 | Kyowa Hakko Kogyo Kk | Method of producing l-glutamic acid |
| US3751458A (en) | 1972-03-02 | 1973-08-07 | Miles Lab | Citroylformic acid and its production |
| US4010204A (en) | 1974-04-09 | 1977-03-01 | Studiengesellschaft Kohle M.B.H. | Process for preparing condensation products |
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| ES2063443T3 (es) | 1990-01-19 | 1995-01-01 | Technology Finance Corp | Procedimiento para la produccion de 3-(1-amino-1,3-dicarboxi-3-hidroxi-but-4-il) indol. |
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| US5728555A (en) | 1996-09-30 | 1998-03-17 | Monsanto Company | Preparation of d-amino acids by direct fermentative means |
| US5994559A (en) | 1998-08-06 | 1999-11-30 | The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Synthesis of monatin-A high intensity natural sweetener |
| JP2002060382A (ja) | 2000-08-22 | 2002-02-26 | Ajinomoto Co Inc | モナティンの立体異性体及びその使用、並びにモナティン類の製造方法及びそのための中間体 |
| EP2409968A1 (en) | 2001-11-30 | 2012-01-25 | Ajinomoto Co., Inc. | Crystals of non-natural-type stereoisomer salt of monatin and use thereof |
| JP2003171365A (ja) | 2001-11-30 | 2003-06-20 | Ajinomoto Co Inc | モナティン類及びその製造中間体の製造方法並びに新規中間体 |
| CN100465156C (zh) | 2001-12-27 | 2009-03-04 | 味之素株式会社 | 谷氨酸化合物及其制备中间体的制造方法与为此所用的新型中间体 |
| DE60239072D1 (de) | 2001-12-27 | 2011-03-10 | Ajinomoto Kk | Verfahren zur herstellung von glutaminsäurederivaten |
| US7297800B2 (en) | 2001-12-27 | 2007-11-20 | Ajinomoto Co., Inc. | Process of producing glutamate derivatives |
| JP2003292484A (ja) | 2002-04-01 | 2003-10-15 | Ajinomoto Co Inc | γ−ヒドロキシアミノ酸誘導体及びモナティン類の製造方法 |
| US7572607B2 (en) | 2002-04-23 | 2009-08-11 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| US8372989B2 (en) | 2002-04-23 | 2013-02-12 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| KR100902813B1 (ko) | 2002-04-23 | 2009-06-12 | 카길 인코포레이티드 | 폴리펩티드 및 생합성 경로 |
| RU2307871C2 (ru) | 2002-08-26 | 2007-10-10 | Адзиномото Ко., Инк. | НОВАЯ АЛЬДОЛАЗА И СПОСОБ ПОЛУЧЕНИЯ ЗАМЕЩЕННЫХ α-КЕТОКИСЛОТ |
| EP2050821A3 (en) | 2002-12-09 | 2009-05-13 | Ajinomoto Co., Inc. | Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same |
| CA2512752C (en) | 2003-01-09 | 2012-05-29 | Ajinomoto Co., Inc. | Process for manufacturing a glutamic acid derivative and a pyroglutamic acid derivative and a novel intermediate in the manufacture thereof |
| JP4239600B2 (ja) | 2003-01-24 | 2009-03-18 | 味の素株式会社 | ２ｒ−モナティンの製造方法 |
| JP2004331644A (ja) | 2003-04-14 | 2004-11-25 | Kanazawa Univ Tlo Inc | モナチン類の製造法 |
| JP2004331650A (ja) | 2003-04-14 | 2004-11-25 | Kanazawa Univ Tlo Inc | モナチン類の製造法 |
| WO2005001105A1 (ja) | 2003-06-26 | 2005-01-06 | Ajinomoto Co., Inc. | モナティンの製造方法 |
| KR20060061811A (ko) | 2003-08-01 | 2006-06-08 | 카아길, 인코포레이팃드 | 모나틴 식탁용 감미제 조성물 및 이의 제조 방법 |
| EP1653810B1 (en) | 2003-08-14 | 2007-04-25 | Cargill, Incorporated | Chewing gum compositions comprising monatin and methods of making same |
| EP1657985A1 (en) | 2003-08-25 | 2006-05-24 | Cargill Inc. | Beverage compositions comprising monatin and methods of making same |
| ATE498691T1 (de) | 2003-10-21 | 2011-03-15 | Cargill Inc | Herstellung von monatin und monatinvorstufen |
| JP4500977B2 (ja) | 2003-11-05 | 2010-07-14 | 味の素株式会社 | 新規アミノ酸誘導体及び甘味剤 |
| JP5113978B2 (ja) | 2003-11-21 | 2013-01-09 | 味の素株式会社 | グルタミン酸誘導体の有機アミン塩及びその利用 |
| EP1719758B1 (en) | 2004-02-27 | 2012-02-22 | Ajinomoto Co., Inc. | Process for producing monatin |
| JP4604524B2 (ja) | 2004-03-16 | 2011-01-05 | 味の素株式会社 | 変異型アルドラーゼ、並びにこれを用いた光学活性ｉｈｏｇ及び光学活性モナティンの製造方法 |
| JP4604537B2 (ja) | 2004-03-31 | 2011-01-05 | 味の素株式会社 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| US7935377B2 (en) | 2004-06-04 | 2011-05-03 | Ajinomoto Co., Inc. | Crystals of free (2R, 4R)-monatin and use thereof |
| CA2506247C (en) | 2004-06-07 | 2012-02-21 | Ajinomoto Co., Inc. | Novel aldolase, and method for producing optically active ihog and monatin |
| KR101216575B1 (ko) | 2004-07-14 | 2012-12-31 | 아지노모토 가부시키가이샤 | (2ｒ,4ｒ)-모나틴 칼륨 염 결정 및 이를 함유하는 감미료조성물 |
| JP2007284349A (ja) | 2004-07-27 | 2007-11-01 | Ajinomoto Co Inc | モナティンまたはその塩の製造方法 |
| BRPI0517419A (pt) | 2004-10-15 | 2008-10-07 | Ajinomoto Kk | composição adoçante, bebida, alimento, composição para cavidade bucal ou produto farmacêutico, estabilizador de conservação para monatina ou um sal da mesma, métodos de conservação de monatina ou de um sal da mesma e de composição adoçante, bebida, alimento, composição para cavidade bucal ou produto farmacêutico compreendendo monatina ou um sal da mesma, e, monatina ou um sal da mesma |
| US7923231B2 (en) | 2004-12-17 | 2011-04-12 | Cargill, Incorporated | Production of glucuronic acid using myo-inositol oxygenase from cryptococcus neoformans |
| US8158389B2 (en) | 2005-04-20 | 2012-04-17 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| JP5059746B2 (ja) | 2005-04-20 | 2012-10-31 | カーギル，インコーポレイティド | モナチンの生体内分泌のための生成物及び方法 |
| US7582455B2 (en) | 2005-04-26 | 2009-09-01 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| JP5336182B2 (ja) | 2005-04-26 | 2013-11-06 | カーギル，インコーポレイティド | モナティンの立体異性体及びそれらの前駆体の製造のためのポリペプチド及び生合成経路 |
| US8076108B2 (en) | 2005-04-26 | 2011-12-13 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| ES2416104T3 (es) | 2006-03-07 | 2013-07-30 | Cargill, Incorporated | Aldolasas, ácidos nucleicos que las codifican y métodos para producir y usar las mismas |
-
2007
- 2007-05-23 AU AU2007267618A patent/AU2007267618B2/en not_active Expired - Fee Related
- 2007-05-23 WO PCT/US2007/069513 patent/WO2007140195A2/en not_active Ceased
- 2007-05-23 CN CNA200780027087XA patent/CN101490249A/zh active Pending
- 2007-05-23 CA CA002653054A patent/CA2653054A1/en not_active Abandoned
- 2007-05-23 JP JP2009512277A patent/JP2009538145A/ja active Pending
- 2007-05-23 EP EP07784058A patent/EP2038405A4/en not_active Withdrawn
- 2007-05-23 BR BRPI0711972-0A patent/BRPI0711972A2/pt not_active Application Discontinuation
- 2007-05-23 US US11/752,492 patent/US7888081B2/en not_active Expired - Fee Related
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