JP2009537139A5 - - Google Patents

Info

Publication number

JP2009537139A5

JP2009537139A5 JP2009511044A JP2009511044A JP2009537139A5 JP 2009537139 A5 JP2009537139 A5 JP 2009537139A5 JP 2009511044 A JP2009511044 A JP 2009511044A JP 2009511044 A JP2009511044 A JP 2009511044A JP 2009537139 A5 JP2009537139 A5 JP 2009537139A5

Authority

JP

Japan

Prior art keywords

composition

composition according

tetracycline compound

substituted tetracycline

compound

Prior art date

2007-05-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000004098 Tetracycline Substances 0.000 claims description 49
• 229960002180 tetracycline Drugs 0.000 claims description 49
• 229930101283 tetracycline Natural products 0.000 claims description 49
• 235000019364 tetracycline Nutrition 0.000 claims description 49
• -1 tetracycline compound Chemical class 0.000 claims description 48
• 210000004027 cell Anatomy 0.000 claims description 28
• 239000002773 nucleotide Substances 0.000 claims description 22
• 125000003729 nucleotide group Chemical group 0.000 claims description 22
• 229910052739 hydrogen Inorganic materials 0.000 claims description 20
• 239000001257 hydrogen Substances 0.000 claims description 20
• 108700020534 tetracycline resistance-encoding transposon repressor Proteins 0.000 claims description 20
• 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims description 16
• 125000000217 alkyl group Chemical group 0.000 claims description 16
• 108090000623 proteins and genes Chemical class 0.000 claims description 15
• SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims description 14
• 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims description 14
• 229960003722 doxycycline Drugs 0.000 claims description 14
• 229920001184 polypeptide Polymers 0.000 claims description 14
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 14
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 14
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 12
• 150000007523 nucleic acids Chemical class 0.000 claims description 12
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
• 108020004707 nucleic acids Proteins 0.000 claims description 11
• 102000039446 nucleic acids Human genes 0.000 claims description 11
• 150000003522 tetracyclines Chemical class 0.000 claims description 11
• 150000001875 compounds Chemical class 0.000 claims description 10
• 150000003839 salts Chemical class 0.000 claims description 10
• 108020001507 fusion proteins Proteins 0.000 claims description 9
• 102000037865 fusion proteins Human genes 0.000 claims description 9
• 150000002431 hydrogen Chemical class 0.000 claims description 9
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
• 102000004169 proteins and genes Human genes 0.000 claims description 6
• 210000000349 chromosome Anatomy 0.000 claims description 4
• NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 claims description 4
• 238000006467 substitution reaction Methods 0.000 claims description 4
• 230000035897 transcription Effects 0.000 claims description 4
• 238000013518 transcription Methods 0.000 claims description 4
• 241000700584 Simplexvirus Species 0.000 claims description 2
• 150000001413 amino acids Chemical group 0.000 claims description 2
• 230000000844 anti-bacterial effect Effects 0.000 claims description 2
• 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 claims description 2
• 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 claims description 2
• 239000002245 particle Substances 0.000 claims description 2
• 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 claims description 2
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
• 230000004927 fusion Effects 0.000 claims 1
• 238000000034 method Methods 0.000 description 44
• 230000001276 controlling effect Effects 0.000 description 4
• 239000003446 ligand Substances 0.000 description 2
• 230000001105 regulatory effect Effects 0.000 description 2
• 0 CC(C(C(*)C(C1N(C)C)[C@]2OC(C(N)=O)=C1O)C1=C2O)c2c(*)cc(C)c(O)c2C1=O Chemical compound CC(C(C(*)C(C1N(C)C)[C@]2OC(C(N)=O)=C1O)C1=C2O)c2c(*)cc(C)c(O)c2C1=O 0.000 description 1
• 108091028043 Nucleic acid sequence Proteins 0.000 description 1
• 230000033228 biological regulation Effects 0.000 description 1
• 230000001413 cellular effect Effects 0.000 description 1
• 239000000411 inducer Substances 0.000 description 1