JP2009536818A5 - - Google Patents
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- Publication number
- JP2009536818A5 JP2009536818A5 JP2009506629A JP2009506629A JP2009536818A5 JP 2009536818 A5 JP2009536818 A5 JP 2009536818A5 JP 2009506629 A JP2009506629 A JP 2009506629A JP 2009506629 A JP2009506629 A JP 2009506629A JP 2009536818 A5 JP2009536818 A5 JP 2009536818A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- polypeptide
- stx1
- fragment
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 52
- 229920001184 polypeptide Polymers 0.000 claims description 52
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 52
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 52
- 108010091769 Shiga Toxin 1 Proteins 0.000 claims description 46
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 37
- 239000012634 fragment Substances 0.000 claims description 37
- 108010079723 Shiga Toxin Proteins 0.000 claims description 29
- 201000010099 disease Diseases 0.000 claims description 26
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 26
- 108090000623 proteins and genes Proteins 0.000 claims description 17
- 102000004169 proteins and genes Human genes 0.000 claims description 17
- 239000012472 biological sample Substances 0.000 claims description 14
- 210000004027 cell Anatomy 0.000 claims description 10
- 102000037865 fusion proteins Human genes 0.000 claims description 10
- 108020001507 fusion proteins Proteins 0.000 claims description 10
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 claims description 8
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 claims description 8
- 101710204410 Scaffold protein Proteins 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 241000588724 Escherichia coli Species 0.000 claims description 7
- 208000032759 Hemolytic-Uremic Syndrome Diseases 0.000 claims description 7
- 108010090763 Shiga Toxin 2 Proteins 0.000 claims description 6
- 241000607768 Shigella Species 0.000 claims description 6
- 230000028993 immune response Effects 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 4
- 230000009918 complex formation Effects 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 210000004408 hybridoma Anatomy 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 238000002965 ELISA Methods 0.000 claims description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 210000001124 body fluid Anatomy 0.000 claims description 2
- 239000010839 body fluid Substances 0.000 claims description 2
- 230000003013 cytotoxicity Effects 0.000 claims description 2
- 231100000135 cytotoxicity Toxicity 0.000 claims description 2
- 238000000684 flow cytometry Methods 0.000 claims description 2
- 230000003053 immunization Effects 0.000 claims description 2
- 238000003018 immunoassay Methods 0.000 claims description 2
- 238000001114 immunoprecipitation Methods 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 238000006386 neutralization reaction Methods 0.000 claims description 2
- 239000000523 sample Substances 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 230000004936 stimulating effect Effects 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 238000001262 western blot Methods 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 206010040550 Shigella infections Diseases 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79391806P | 2006-04-20 | 2006-04-20 | |
| PCT/US2007/009799 WO2007124133A2 (en) | 2006-04-20 | 2007-04-20 | Methods and compositions based on shiga toxin type 1 protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009536818A JP2009536818A (ja) | 2009-10-22 |
| JP2009536818A5 true JP2009536818A5 (https=) | 2011-05-06 |
Family
ID=38625659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009506629A Pending JP2009536818A (ja) | 2006-04-20 | 2007-04-20 | 志賀毒性１型タンパク質に基づく方法および組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8293245B2 (https=) |
| EP (2) | EP2420246A1 (https=) |
| JP (1) | JP2009536818A (https=) |
| AU (1) | AU2007240614B2 (https=) |
| CA (1) | CA2646319A1 (https=) |
| MX (1) | MX2008013363A (https=) |
| WO (1) | WO2007124133A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030170248A1 (en) * | 1997-12-23 | 2003-09-11 | Jeffrey R. Stinson | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
| EP1229045A1 (en) | 2001-02-01 | 2002-08-07 | Institut Curie | Universal carrier for targeting molecules to Gb3 receptor expressing cells |
| US8293245B2 (en) | 2006-04-20 | 2012-10-23 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods and compositions based on Shiga toxin type 1 protein |
| US20090258010A1 (en) * | 2006-05-31 | 2009-10-15 | Thallion Pharmaceuticals, Inc. | Methods, compositions, and kits for treating shiga toxin associated conditions |
| WO2010085539A1 (en) | 2009-01-23 | 2010-07-29 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods and compositions based on shiga toxin type 2 protein |
| WO2010115278A1 (en) * | 2009-04-06 | 2010-10-14 | University Of Saskatchewan | Methods and compositions for treating and preventing shiga toxin-producing escherichia coli infection |
| AU2014285024A1 (en) * | 2013-07-03 | 2016-01-21 | Roka Bioscience, Inc. | Compositions, kits, and related methods for detecting and/or monitoring Shiga toxin producing Escherichia coli |
| CN104558167B (zh) * | 2014-12-26 | 2017-12-26 | 江苏省疾病预防控制中心 | 检测i型志贺毒素双抗夹心法酶联免疫试剂盒及其应用 |
| CN111902539B (zh) * | 2018-02-07 | 2025-05-16 | 吉尼松公司 | 杂合调控元件 |
| RU2732155C1 (ru) * | 2019-09-24 | 2020-09-11 | Открытое акционерное общество "Всероссийский научный Центр молекулярной диагностики и лечения" (ОАО ВНЦМДЛ) | Гуманизированное антитело или его антигенсвязывающий фрагмент (Fab) против шига-токсинов первого и/или второго типов (варианты), композиция для лечения токсических состояний, вызванных энтерогеморрагической кишечной палочкой, содержащая указанные антитела и/или Fab |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US4573986A (en) * | 1984-09-17 | 1986-03-04 | The Procter & Gamble Company | Disposable waste-containment garment |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| DE3689123T2 (de) | 1985-11-01 | 1994-03-03 | Xoma Corp | Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung. |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| JPS62292890A (ja) | 1986-06-13 | 1987-12-19 | Sanritsu Kikaku Kk | 固形潤滑材 |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| US5164298A (en) | 1988-06-24 | 1992-11-17 | Hsc Research Development Corporation | Verocytotoxin receptor assay |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6657103B1 (en) | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| RO116459B1 (ro) | 1991-07-25 | 2001-02-28 | Idec Pharma Corp | Compozitie imunogena |
| US5756096A (en) | 1991-07-25 | 1998-05-26 | Idec Pharmaceuticals Corporation | Recombinant antibodies for human therapy |
| MX9204374A (es) | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
| US5709860A (en) | 1991-07-25 | 1998-01-20 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
| AU669124B2 (en) | 1991-09-18 | 1996-05-30 | Kyowa Hakko Kirin Co., Ltd. | Process for producing humanized chimera antibody |
| ES2301158T3 (es) | 1992-07-24 | 2008-06-16 | Amgen Fremont Inc. | Produccion de anticuerpos xenogenicos. |
| US5747272A (en) | 1994-02-14 | 1998-05-05 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Detection of shiga-like toxins of enterohemoragic Escherichia coli |
| US5968894A (en) | 1994-02-22 | 1999-10-19 | Lingwood; Clifford A. | Verotoxin pharmaceutical compositions and medical treatments therewith |
| US5977322A (en) | 1995-06-14 | 1999-11-02 | The Regents Of The University Of California | High affinity human antibodies to tumor antigens |
| JP2001500730A (ja) * | 1996-09-10 | 2001-01-23 | ヘンリー エム ジャクソン ファンデーション フォージ アドバンスメント オブ ミリタリー メディシン | ヒスチジン―タグ付き志賀毒素およびトキソイド、該毒素およびトキソイドとの融合タンパク質ならびにそれらの精製及び調製方法 |
| US7910096B2 (en) | 1996-11-15 | 2011-03-22 | Trustees Of Tufts College | Human neutralizing antibodies against hemolytic uremic syndrome |
| WO1998020903A1 (en) | 1996-11-15 | 1998-05-22 | Trustees Of Tufts College | Humanized neutralizing antibodies against hemolytic uremic syndrome |
| US20020160005A1 (en) | 1996-11-15 | 2002-10-31 | Trustees Of Tufts College | Human neutralizing antibodies against hemolytic urmec syndrome |
| US20030170248A1 (en) * | 1997-12-23 | 2003-09-11 | Jeffrey R. Stinson | Humanized monoclonal antibodies that protect against shiga toxin induced disease |
| ES2270598T3 (es) | 1998-05-20 | 2007-04-01 | Teijin Limited | Anticuerpos humanizados que reconocen la verotoxina ii y linea celular que produce los mismos. |
| EP1127263A1 (en) * | 1998-10-30 | 2001-08-29 | Photonic Sensor Systems | Methods and sensors for detecting or measuring an acid or base |
| US6833268B1 (en) | 1999-06-10 | 2004-12-21 | Abgenix, Inc. | Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions |
| US7807184B2 (en) | 2003-07-21 | 2010-10-05 | Interuet International B.V. | Hybrid Shiga-like toxin |
| EP1694845B8 (en) * | 2003-11-28 | 2017-12-20 | National Research Council of Canada | Anticarcinoma antibodies and uses thereof |
| US20050226883A1 (en) | 2004-02-06 | 2005-10-13 | Paul Averback | Humanized antibody |
| ES2532985T3 (es) | 2006-02-16 | 2015-04-06 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Proteínas quiméricas de toxoide de Shiga |
| US8293245B2 (en) | 2006-04-20 | 2012-10-23 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods and compositions based on Shiga toxin type 1 protein |
| US20090258010A1 (en) | 2006-05-31 | 2009-10-15 | Thallion Pharmaceuticals, Inc. | Methods, compositions, and kits for treating shiga toxin associated conditions |
| EP2097529A4 (en) | 2006-12-29 | 2010-03-24 | Osprey Pharmaceuticals Usa Inc | METHOD FOR SELECTION AND PRODUCTION OF MODIFIED TOXINS, MODIFIED TOXINE CONJUGATES AND USES THEREOF |
| WO2010085539A1 (en) | 2009-01-23 | 2010-07-29 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods and compositions based on shiga toxin type 2 protein |
-
2007
- 2007-04-20 US US11/788,546 patent/US8293245B2/en active Active
- 2007-04-20 JP JP2009506629A patent/JP2009536818A/ja active Pending
- 2007-04-20 EP EP11179552A patent/EP2420246A1/en not_active Withdrawn
- 2007-04-20 AU AU2007240614A patent/AU2007240614B2/en not_active Ceased
- 2007-04-20 CA CA002646319A patent/CA2646319A1/en not_active Abandoned
- 2007-04-20 MX MX2008013363A patent/MX2008013363A/es not_active Application Discontinuation
- 2007-04-20 EP EP07775978A patent/EP2019684A4/en not_active Withdrawn
- 2007-04-20 WO PCT/US2007/009799 patent/WO2007124133A2/en not_active Ceased
-
2012
- 2012-10-05 US US13/645,928 patent/US20130101591A1/en not_active Abandoned
-
2013
- 2013-10-02 US US14/044,580 patent/US20140023652A1/en not_active Abandoned
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