JP2009536650A5 - - Google Patents
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- Publication number
- JP2009536650A5 JP2009536650A5 JP2009509819A JP2009509819A JP2009536650A5 JP 2009536650 A5 JP2009536650 A5 JP 2009536650A5 JP 2009509819 A JP2009509819 A JP 2009509819A JP 2009509819 A JP2009509819 A JP 2009509819A JP 2009536650 A5 JP2009536650 A5 JP 2009536650A5
- Authority
- JP
- Japan
- Prior art keywords
- heteroaryl
- ring
- optionally substituted
- aryl
- cycloalkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001072 heteroaryl group Chemical group 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 16
- 229920006395 saturated elastomer Polymers 0.000 claims 16
- -1 cycloalkynyl Chemical group 0.000 claims 15
- 125000003342 alkenyl group Chemical group 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 125000000304 alkynyl group Chemical group 0.000 claims 14
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- 125000005842 heteroatom Chemical group 0.000 claims 11
- 229910052757 nitrogen Inorganic materials 0.000 claims 11
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 229910052717 sulfur Inorganic materials 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 125000004429 atom Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79847206P | 2006-05-08 | 2006-05-08 | |
| US60/798,472 | 2006-05-08 | ||
| US83319106P | 2006-07-25 | 2006-07-25 | |
| US60/833,191 | 2006-07-25 | ||
| US92068807P | 2007-03-29 | 2007-03-29 | |
| US60/920,688 | 2007-03-29 | ||
| PCT/US2007/011134 WO2007133560A2 (en) | 2006-05-08 | 2007-05-08 | Acetylenic heteroaryl compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009536650A JP2009536650A (ja) | 2009-10-15 |
| JP2009536650A5 true JP2009536650A5 (enExample) | 2010-06-17 |
| JP5273037B2 JP5273037B2 (ja) | 2013-08-28 |
Family
ID=38694438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009509819A Expired - Fee Related JP5273037B2 (ja) | 2006-05-08 | 2007-05-08 | アセチレン性ヘテロアリール化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8461167B2 (enExample) |
| EP (1) | EP2023933A4 (enExample) |
| JP (1) | JP5273037B2 (enExample) |
| KR (1) | KR20090018104A (enExample) |
| CN (1) | CN103435595A (enExample) |
| AU (1) | AU2007249924B2 (enExample) |
| BR (1) | BRPI0710328A2 (enExample) |
| CA (1) | CA2651822A1 (enExample) |
| EA (1) | EA200870514A1 (enExample) |
| IL (3) | IL194677A (enExample) |
| MX (1) | MX2008014289A (enExample) |
| WO (1) | WO2007133560A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2495016T3 (da) * | 2005-12-23 | 2019-12-16 | Ariad Pharma Inc | Bicykliske heteroarylforbindelser |
| BRPI0710328A2 (pt) | 2006-05-08 | 2011-08-09 | Ariad Pharma Inc | composto da fórmula i, um tautomer da mesma, ou um sal farmaceuticamente aceitável, hidrato ou outro solvato do mesmo e método para o tratamento de cáncer em um mamìfero necessitado do mesmo e composição |
| MX2008014290A (es) * | 2006-05-08 | 2008-11-26 | Ariad Pharma Inc | Compuestos heteroarilicos monociclicos. |
| WO2009100536A1 (en) * | 2008-02-15 | 2009-08-20 | Methylgene Inc. | Inhibitors of kinase activity with 1,2-di-cyclyl substituted alkyne structures |
| JP5590040B2 (ja) | 2008-11-12 | 2014-09-17 | アリアド・ファーマシューティカルズ・インコーポレイテッド | キナーゼ阻害剤としてのピラジノピラジンおよび誘導体 |
| US8609638B2 (en) | 2009-10-08 | 2013-12-17 | The Board Of Trustees Of The University Of Illinois | Enzyme inhibiting compounds and methods |
| RU2477723C2 (ru) * | 2011-06-16 | 2013-03-20 | Общество С Ограниченной Ответственностью "Фьюжн Фарма" | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе |
| CN103664787B (zh) * | 2012-09-17 | 2015-09-09 | 南京圣和药业股份有限公司 | 炔杂芳环化合物及其应用 |
| CN103848829B (zh) * | 2012-11-28 | 2017-04-12 | 南京圣和药业股份有限公司 | 杂芳基炔烃化合物及其应用 |
| CA2815506C (en) | 2012-12-12 | 2018-12-11 | Ariad Pharmaceuticals, Inc. | Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
| GB2522226A (en) * | 2014-01-17 | 2015-07-22 | Agency Science Tech & Res | Heteroaryl alkyne derivatives and uses thereof |
| BR112016028674A2 (pt) * | 2014-06-06 | 2017-08-22 | Natco Pharma Ltd | ?1h-1, 8-naftiridin-2-onas como compostos antiproliferativos? |
| DK3169671T3 (da) | 2014-07-17 | 2019-09-23 | Sunshine Lake Pharma Co Ltd | 1-(5-(tert.-butyl)isoxazol-3-yl)-3-(4-((phenyl)ethynyl)phenyl)ureaderivater og relaterede forbindelser som flt3-inhibitorer til behandling af kræft |
| CA2985161A1 (en) * | 2015-05-18 | 2016-11-24 | Sun Pharma Advanced Research Company Limited | Novel amidoheteroaryl aroyl hydrazide ethynes |
| CA3158951A1 (en) | 2016-08-15 | 2018-02-22 | Purdue Research Foundation | 4-substituted aminoisoquinoline derivatives |
| EP3596049A4 (en) * | 2017-03-15 | 2021-01-13 | Sun Pharma Advanced Research Company Limited | NEW AMORPHIC DISPERSION OF CYCLOPROPANECARBOXYLIC ACID (5- {5- [N '- (2-CHLORO-6-METHYLBENZOYL) HYDRAZINOCARBONYL] -2-METHYL-PHENYLETHYNYL} -PYRIDIN-2-AMIDE |
| AU2018235446B2 (en) * | 2017-03-15 | 2022-04-07 | Sun Pharma Advanced Research Company Limited | Novel amorphous dispersion of 4-Methyl-3-quinolin-3-ylethynyl-benzoic acid N'-(2-chloro-6-methyl-benzoyl) hydrazide |
| US11746110B2 (en) * | 2018-07-17 | 2023-09-05 | Shenzhen Targetrx, Inc. | Alkynyl (hetero) aromatic ring compounds used for inhibiting protein kinase activity |
| CN110372705A (zh) * | 2019-08-05 | 2019-10-25 | 辽宁大学 | 新型取代苯甲酰胺类化合物及其药学上可接受的盐及制备方法和应用 |
| WO2022033471A1 (zh) * | 2020-08-10 | 2022-02-17 | 上海润石医药科技有限公司 | 含邻氨基吡啶炔基的化合物的盐及其制备方法和应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| GB9823871D0 (en) | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| UA73492C2 (en) | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
| HN2001000008A (es) * | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| DE10021246A1 (de) * | 2000-04-25 | 2001-10-31 | Schering Ag | Substituierte Benzoesäureamide und deren Verwendung als Arzneimittel |
| NZ525591A (en) * | 2000-10-05 | 2004-04-30 | Fujisawa Pharmaceutical Co | Benzamide compounds as Apo B secretion inhibitors |
| SE0100903D0 (sv) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| IL159811A0 (en) | 2001-07-13 | 2004-06-20 | Neurogen Corp | Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands |
| US20040110802A1 (en) | 2002-08-23 | 2004-06-10 | Atli Thorarensen | Antibacterial benzoic acid derivatives |
| AR041992A1 (es) | 2002-11-06 | 2005-06-08 | Smithkline Beecham Corp | Compuesto de piridinil benzoheterociclico, composicion farmaceutica que lo comprende y su uso para prepararla |
| GB0230089D0 (en) | 2002-12-24 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU2004276337B2 (en) * | 2003-09-24 | 2009-11-12 | Methylgene Inc. | Inhibitors of histone deacetylase |
| RU2006122853A (ru) | 2003-11-28 | 2008-01-10 | Новартис АГ (CH) | Производные диарилмочевины для лечения заболеваний, зависимых от протеинкиназы |
| ES2317079T3 (es) * | 2003-12-24 | 2009-04-16 | Astrazeneca Ab | Pirimidinas con actividad tie2 (tek). |
| US20080027076A1 (en) * | 2003-12-24 | 2008-01-31 | Astrazeneca Ab | Pyrimidines With Tie2 (Tek) Activity |
| AU2005231980B2 (en) * | 2004-04-07 | 2011-09-08 | Merck Serono Sa | 1,1'-(1,2-ethynediyl)bis-benzene derivatives as PTP 1-B inhibitors |
| EA200700243A1 (ru) | 2004-07-14 | 2007-08-31 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы лечения гепатита с |
| US7776869B2 (en) * | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
| GB0502418D0 (en) * | 2005-02-05 | 2005-03-16 | Astrazeneca Ab | Compounds |
| EP1893605A2 (en) * | 2005-03-31 | 2008-03-05 | AstraZeneca AB | Saminopyrimidine derivates with tie2 inhibiting activity |
| US20100216798A1 (en) | 2005-07-29 | 2010-08-26 | Astellas Pharma Inc | Fused heterocycles as lck inhibitors |
| EP1940843A4 (en) | 2005-08-11 | 2010-09-15 | Ariad Pharma Inc | UNSATURATED HETEROCYCLIC DERIVATIVES |
| DK2495016T3 (da) | 2005-12-23 | 2019-12-16 | Ariad Pharma Inc | Bicykliske heteroarylforbindelser |
| MX2008014290A (es) * | 2006-05-08 | 2008-11-26 | Ariad Pharma Inc | Compuestos heteroarilicos monociclicos. |
| BRPI0710328A2 (pt) | 2006-05-08 | 2011-08-09 | Ariad Pharma Inc | composto da fórmula i, um tautomer da mesma, ou um sal farmaceuticamente aceitável, hidrato ou outro solvato do mesmo e método para o tratamento de cáncer em um mamìfero necessitado do mesmo e composição |
| EP2107054A1 (en) * | 2008-04-01 | 2009-10-07 | Università Degli Studi Di Milano - Bicocca | Antiproliferative compounds and therapeutic uses thereof |
-
2007
- 2007-05-08 BR BRPI0710328-0A patent/BRPI0710328A2/pt not_active IP Right Cessation
- 2007-05-08 EA EA200870514A patent/EA200870514A1/ru unknown
- 2007-05-08 KR KR1020087029942A patent/KR20090018104A/ko not_active Abandoned
- 2007-05-08 CA CA002651822A patent/CA2651822A1/en not_active Abandoned
- 2007-05-08 WO PCT/US2007/011134 patent/WO2007133560A2/en not_active Ceased
- 2007-05-08 US US12/227,002 patent/US8461167B2/en not_active Expired - Fee Related
- 2007-05-08 MX MX2008014289A patent/MX2008014289A/es unknown
- 2007-05-08 EP EP07756231A patent/EP2023933A4/en not_active Withdrawn
- 2007-05-08 AU AU2007249924A patent/AU2007249924B2/en not_active Ceased
- 2007-05-08 CN CN201310336955XA patent/CN103435595A/zh active Pending
- 2007-05-08 JP JP2009509819A patent/JP5273037B2/ja not_active Expired - Fee Related
-
2008
- 2008-10-12 IL IL194677A patent/IL194677A/en active IP Right Grant
-
2012
- 2012-09-13 US US13/614,838 patent/US9090561B2/en not_active Expired - Fee Related
-
2013
- 2013-11-10 IL IL229350A patent/IL229350A0/en unknown
- 2013-11-10 IL IL229351A patent/IL229351A0/en unknown