JP2009530304A5 - - Google Patents

Info

Publication number

JP2009530304A5

JP2009530304A5 JP2009500521A JP2009500521A JP2009530304A5 JP 2009530304 A5 JP2009530304 A5 JP 2009530304A5 JP 2009500521 A JP2009500521 A JP 2009500521A JP 2009500521 A JP2009500521 A JP 2009500521A JP 2009530304 A5 JP2009530304 A5 JP 2009530304A5

Authority

JP

Japan

Prior art keywords

oxo

isoquinolin

dihydro

hydroxy

phenyl

Prior art date

2007-03-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 51
• -1 sulfate ester Chemical class 0.000 claims 36
• 125000000217 alkyl group Chemical group 0.000 claims 15
• 208000002193 Pain Diseases 0.000 claims 13
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 13
• 208000004296 neuralgia Diseases 0.000 claims 13
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 12
• 125000002252 acyl group Chemical group 0.000 claims 12
• 125000002102 aryl alkyloxo group Chemical group 0.000 claims 12
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 11
• 125000005843 halogen group Chemical group 0.000 claims 11
• 125000003118 aryl group Chemical group 0.000 claims 10
• 229940080818 propionamide Drugs 0.000 claims 10
• 125000000753 cycloalkyl group Chemical group 0.000 claims 9
• 201000010099 disease Diseases 0.000 claims 9
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
• 125000001072 heteroaryl group Chemical group 0.000 claims 8
• 125000003282 alkyl amino group Chemical group 0.000 claims 7
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 7
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 7
• 229910052739 hydrogen Inorganic materials 0.000 claims 7
• 239000001257 hydrogen Substances 0.000 claims 7
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 7
• 125000000547 substituted alkyl group Chemical group 0.000 claims 7
• 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 6
• 125000004442 acylamino group Chemical group 0.000 claims 6
• 125000003545 alkoxy group Chemical group 0.000 claims 6
• 125000004947 alkyl aryl amino group Chemical group 0.000 claims 6
• 125000004414 alkyl thio group Chemical group 0.000 claims 6
• 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 6
• 125000003710 aryl alkyl group Chemical group 0.000 claims 6
• 125000004391 aryl sulfonyl group Chemical group 0.000 claims 6
• 125000004093 cyano group Chemical group *C#N 0.000 claims 6
• 125000004663 dialkyl amino group Chemical group 0.000 claims 6
• 208000037765 diseases and disorders Diseases 0.000 claims 6
• 125000004404 heteroalkyl group Chemical group 0.000 claims 6
• 125000005553 heteroaryloxy group Chemical group 0.000 claims 6
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 6
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 6
• 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims 6
• 125000003107 substituted aryl group Chemical group 0.000 claims 6
• 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 6
• 150000003457 sulfones Chemical class 0.000 claims 6
• 150000003462 sulfoxides Chemical class 0.000 claims 6
• 125000003396 thiol group Chemical group [H]S* 0.000 claims 6
• 206010029240 Neuritis Diseases 0.000 claims 5
• 150000001540 azides Chemical class 0.000 claims 5
• 230000001404 mediated effect Effects 0.000 claims 5
• 208000023275 Autoimmune disease Diseases 0.000 claims 4
• 208000020925 Bipolar disease Diseases 0.000 claims 4
• 206010019233 Headaches Diseases 0.000 claims 4
• 206010020751 Hypersensitivity Diseases 0.000 claims 4
• 208000003251 Pruritus Diseases 0.000 claims 4
• 150000001408 amides Chemical class 0.000 claims 4
• 125000004104 aryloxy group Chemical group 0.000 claims 4
• 208000035475 disorder Diseases 0.000 claims 4
• 231100000869 headache Toxicity 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• 208000021722 neuropathic pain Diseases 0.000 claims 4
• 201000008482 osteoarthritis Diseases 0.000 claims 4
• 208000023504 respiratory system disease Diseases 0.000 claims 4
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 4
• 125000006833 (C1-C5) alkylene group Chemical group 0.000 claims 3
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 208000030886 Traumatic Brain injury Diseases 0.000 claims 3
• 201000011510 cancer Diseases 0.000 claims 3
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
• 125000004076 pyridyl group Chemical group 0.000 claims 3
• 208000004371 toothache Diseases 0.000 claims 3
• 230000009529 traumatic brain injury Effects 0.000 claims 3
• DOQWURXAHLPXJZ-NSHDSACASA-N (2s)-2-[5-[[2-(4-chloro-3-fluorophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(F)=C1 DOQWURXAHLPXJZ-NSHDSACASA-N 0.000 claims 2
• FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 claims 2
• JCRPRYRTXTZLCX-UHFFFAOYSA-N 2-[2,4-bis(trifluoromethyl)phenyl]-n-[2-(1,3-dihydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(C(CO)CO)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C=C1C(F)(F)F JCRPRYRTXTZLCX-UHFFFAOYSA-N 0.000 claims 2
• 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 2
• 208000019901 Anxiety disease Diseases 0.000 claims 2
• 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 2
• 206010069632 Bladder dysfunction Diseases 0.000 claims 2
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
• 208000000094 Chronic Pain Diseases 0.000 claims 2
• 208000006561 Cluster Headache Diseases 0.000 claims 2
• 208000030814 Eating disease Diseases 0.000 claims 2
• 208000034347 Faecal incontinence Diseases 0.000 claims 2
• 208000019454 Feeding and Eating disease Diseases 0.000 claims 2
• 208000014540 Functional gastrointestinal disease Diseases 0.000 claims 2
• 206010061218 Inflammation Diseases 0.000 claims 2
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
• 206010065390 Inflammatory pain Diseases 0.000 claims 2
• 208000019695 Migraine disease Diseases 0.000 claims 2
• 208000036110 Neuroinflammatory disease Diseases 0.000 claims 2
• 208000008589 Obesity Diseases 0.000 claims 2
• 208000018737 Parkinson disease Diseases 0.000 claims 2
• 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 2
• 201000004681 Psoriasis Diseases 0.000 claims 2
• 206010043269 Tension headache Diseases 0.000 claims 2
• 208000008548 Tension-Type Headache Diseases 0.000 claims 2
• 206010046543 Urinary incontinence Diseases 0.000 claims 2
• 230000002159 abnormal effect Effects 0.000 claims 2
• 208000005298 acute pain Diseases 0.000 claims 2
• 208000026935 allergic disease Diseases 0.000 claims 2
• 230000036506 anxiety Effects 0.000 claims 2
• 206010003246 arthritis Diseases 0.000 claims 2
• 208000006673 asthma Diseases 0.000 claims 2
• 201000004983 autoimmune atherosclerosis Diseases 0.000 claims 2
• 201000004982 autoimmune uveitis Diseases 0.000 claims 2
• 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
• 208000028683 bipolar I disease Diseases 0.000 claims 2
• 230000036772 blood pressure Effects 0.000 claims 2
• 201000007637 bowel dysfunction Diseases 0.000 claims 2
• 208000018912 cluster headache syndrome Diseases 0.000 claims 2
• 208000010877 cognitive disease Diseases 0.000 claims 2
• 208000012790 cranial neuralgia Diseases 0.000 claims 2
• 235000014632 disordered eating Nutrition 0.000 claims 2
• 230000004064 dysfunction Effects 0.000 claims 2
• 206010013990 dysuria Diseases 0.000 claims 2
• 206010014599 encephalitis Diseases 0.000 claims 2
• 206010015037 epilepsy Diseases 0.000 claims 2
• 238000009472 formulation Methods 0.000 claims 2
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
• 230000009610 hypersensitivity Effects 0.000 claims 2
• 230000004054 inflammatory process Effects 0.000 claims 2
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
• 230000000155 isotopic effect Effects 0.000 claims 2
• 230000007803 itching Effects 0.000 claims 2
• 150000002632 lipids Chemical class 0.000 claims 2
• 125000006217 methyl sulfide group Chemical group [H]C([H])([H])S* 0.000 claims 2
• 206010027599 migraine Diseases 0.000 claims 2
• 201000006417 multiple sclerosis Diseases 0.000 claims 2
• 208000010125 myocardial infarction Diseases 0.000 claims 2
• 230000003959 neuroinflammation Effects 0.000 claims 2
• 235000020824 obesity Nutrition 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 239000000651 prodrug Substances 0.000 claims 2
• 229940002612 prodrug Drugs 0.000 claims 2
• 210000002307 prostate Anatomy 0.000 claims 2
• 230000008085 renal dysfunction Effects 0.000 claims 2
• 230000000241 respiratory effect Effects 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 201000000980 schizophrenia Diseases 0.000 claims 2
• 208000019116 sleep disease Diseases 0.000 claims 2
• 239000012453 solvate Substances 0.000 claims 2
• 125000001424 substituent group Chemical group 0.000 claims 2
• 208000011580 syndromic disease Diseases 0.000 claims 2
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
• 238000011282 treatment Methods 0.000 claims 2
• DSZXUJXSTUHLMA-CHWSQXEVSA-N (2r)-2-(3,4-dichlorophenyl)-n-[2-[(2r)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]propanamide Chemical compound C1([C@@H](C)C(=O)NC2=C3C=CN(C(C3=CC=C2)=O)[C@@H](CO)C)=CC=C(Cl)C(Cl)=C1 DSZXUJXSTUHLMA-CHWSQXEVSA-N 0.000 claims 1
• DSZXUJXSTUHLMA-QWHCGFSZSA-N (2r)-2-(3,4-dichlorophenyl)-n-[2-[(2s)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]propanamide Chemical compound C1([C@@H](C)C(=O)NC2=C3C=CN(C(C3=CC=C2)=O)[C@H](CO)C)=CC=C(Cl)C(Cl)=C1 DSZXUJXSTUHLMA-QWHCGFSZSA-N 0.000 claims 1
• XTRJQRIAIWTBPS-GFCCVEGCSA-N (2r)-2-[1-oxo-5-[(2-pyridin-2-ylacetyl)amino]isoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=CC=N1 XTRJQRIAIWTBPS-GFCCVEGCSA-N 0.000 claims 1
• HCXWWOFRCQYQBK-SNVBAGLBSA-N (2r)-2-[1-oxo-5-[[2-(2,3,4-trifluorophenyl)acetyl]amino]isoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(F)C(F)=C1F HCXWWOFRCQYQBK-SNVBAGLBSA-N 0.000 claims 1
• DBLBGSPNGMVIRQ-SNVBAGLBSA-N (2r)-2-[1-oxo-5-[[2-(2,4,5-trifluorophenyl)acetyl]amino]isoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC(F)=C(F)C=C1F DBLBGSPNGMVIRQ-SNVBAGLBSA-N 0.000 claims 1
• UBWSKZKINXDGDU-SNVBAGLBSA-N (2r)-2-[1-oxo-5-[[2-(3,4,5-trifluorophenyl)acetyl]amino]isoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC(F)=C(F)C(F)=C1 UBWSKZKINXDGDU-SNVBAGLBSA-N 0.000 claims 1
• PIWBACGXFXXBIC-QGZVFWFLSA-N (2r)-2-[1-oxo-5-[[2-(4-phenylphenyl)acetyl]amino]isoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC(C=C1)=CC=C1C1=CC=CC=C1 PIWBACGXFXXBIC-QGZVFWFLSA-N 0.000 claims 1
• IRUWDWZQEXMDHU-GFCCVEGCSA-N (2r)-2-[1-oxo-5-[[2-[3-(trifluoromethoxy)phenyl]acetyl]amino]isoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=CC(OC(F)(F)F)=C1 IRUWDWZQEXMDHU-GFCCVEGCSA-N 0.000 claims 1
• DYKGUPFTNVUMPV-GFCCVEGCSA-N (2r)-2-[1-oxo-5-[[2-[3-(trifluoromethyl)phenyl]acetyl]amino]isoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=CC(C(F)(F)F)=C1 DYKGUPFTNVUMPV-GFCCVEGCSA-N 0.000 claims 1
• QCULFGZSGIWZKW-GFCCVEGCSA-N (2r)-2-[1-oxo-5-[[2-[4-(trifluoromethoxy)phenyl]acetyl]amino]isoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(OC(F)(F)F)C=C1 QCULFGZSGIWZKW-GFCCVEGCSA-N 0.000 claims 1
• MBCZPWIXDRKQCR-GFCCVEGCSA-N (2r)-2-[1-oxo-5-[[2-[4-(trifluoromethyl)phenyl]acetyl]amino]isoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C=C1 MBCZPWIXDRKQCR-GFCCVEGCSA-N 0.000 claims 1
• SGOBEQCEDKLAHI-FKWGRNQDSA-N (2r)-2-[5-[2-(3,4-dichlorophenyl)propanoylamino]-1-oxoisoquinolin-2-yl]-3-hydroxy-n-methylpropanamide Chemical compound C1=CC=C2C(=O)N([C@H](CO)C(=O)NC)C=CC2=C1NC(=O)C(C)C1=CC=C(Cl)C(Cl)=C1 SGOBEQCEDKLAHI-FKWGRNQDSA-N 0.000 claims 1
• BEDKKMVYNMMWSC-GAGCMDECSA-N (2r)-2-[5-[2-(4-chlorophenyl)propanoylamino]-1-oxoisoquinolin-2-yl]-3-hydroxy-n-methylpropanamide Chemical compound C1=CC=C2C(=O)N([C@H](CO)C(=O)NC)C=CC2=C1NC(=O)C(C)C1=CC=C(Cl)C=C1 BEDKKMVYNMMWSC-GAGCMDECSA-N 0.000 claims 1
• KCLJOHZTAJXHPS-VMHBGOFLSA-N (2r)-2-[5-[2-(4-chlorophenyl)propanoylamino]-1-oxoisoquinolin-2-yl]-3-hydroxypropanamide Chemical compound C=1C=CC(C(N([C@H](CO)C(N)=O)C=C2)=O)=C2C=1NC(=O)C(C)C1=CC=C(Cl)C=C1 KCLJOHZTAJXHPS-VMHBGOFLSA-N 0.000 claims 1
• RANCQHQMDFZELH-JLTOFOAXSA-N (2r)-2-[5-[[(2r)-2-(4-chlorophenyl)propanoyl]amino]-1-oxoisoquinolin-2-yl]-3-methylbutanamide Chemical compound C1([C@@H](C)C(=O)NC2=C3C=CN(C(C3=CC=C2)=O)[C@@H](C(N)=O)C(C)C)=CC=C(Cl)C=C1 RANCQHQMDFZELH-JLTOFOAXSA-N 0.000 claims 1
• IOXQWTRZWQGPCS-QVKFZJNVSA-N (2r)-2-[5-[[(2r)-2-(4-chlorophenyl)propanoyl]amino]-1-oxoisoquinolin-2-yl]-n,3-dimethylbutanamide Chemical compound C1([C@@H](C)C(=O)NC2=C3C=CN(C(C3=CC=C2)=O)[C@H](C(C)C)C(=O)NC)=CC=C(Cl)C=C1 IOXQWTRZWQGPCS-QVKFZJNVSA-N 0.000 claims 1
• XNGVXMOIWXOKBV-WAIKUNEKSA-N (2r)-2-[5-[[(2r)-2-(4-chlorophenyl)propanoyl]amino]-1-oxoisoquinolin-2-yl]-n-cyclopropyl-3-methylbutanamide Chemical compound O=C([C@@H](C(C)C)N1C(C2=CC=CC(NC(=O)[C@H](C)C=3C=CC(Cl)=CC=3)=C2C=C1)=O)NC1CC1 XNGVXMOIWXOKBV-WAIKUNEKSA-N 0.000 claims 1
• RANCQHQMDFZELH-VBKZILBWSA-N (2r)-2-[5-[[(2s)-2-(4-chlorophenyl)propanoyl]amino]-1-oxoisoquinolin-2-yl]-3-methylbutanamide Chemical compound C1([C@H](C)C(=O)NC2=C3C=CN(C(C3=CC=C2)=O)[C@@H](C(N)=O)C(C)C)=CC=C(Cl)C=C1 RANCQHQMDFZELH-VBKZILBWSA-N 0.000 claims 1
• IEKRKPGVFVYIBH-VBKZILBWSA-N (2r)-2-[5-[[(2s)-2-(4-chlorophenyl)propanoyl]amino]-1-oxoisoquinolin-2-yl]-3-methylbutanoic acid Chemical compound C1([C@H](C)C(=O)NC2=C3C=CN(C(C3=CC=C2)=O)[C@@H](C(O)=O)C(C)C)=CC=C(Cl)C=C1 IEKRKPGVFVYIBH-VBKZILBWSA-N 0.000 claims 1
• IOXQWTRZWQGPCS-YCRPNKLZSA-N (2r)-2-[5-[[(2s)-2-(4-chlorophenyl)propanoyl]amino]-1-oxoisoquinolin-2-yl]-n,3-dimethylbutanamide Chemical compound C1([C@H](C)C(=O)NC2=C3C=CN(C(C3=CC=C2)=O)[C@H](C(C)C)C(=O)NC)=CC=C(Cl)C=C1 IOXQWTRZWQGPCS-YCRPNKLZSA-N 0.000 claims 1
• XNGVXMOIWXOKBV-QMHKHESXSA-N (2r)-2-[5-[[(2s)-2-(4-chlorophenyl)propanoyl]amino]-1-oxoisoquinolin-2-yl]-n-cyclopropyl-3-methylbutanamide Chemical compound O=C([C@@H](C(C)C)N1C(C2=CC=CC(NC(=O)[C@@H](C)C=3C=CC(Cl)=CC=3)=C2C=C1)=O)NC1CC1 XNGVXMOIWXOKBV-QMHKHESXSA-N 0.000 claims 1
• DYWJVLQTKFVOBL-QWHCGFSZSA-N (2r)-2-[5-[[(2s)-2-(4-chlorophenyl)propanoyl]amino]-1-oxoisoquinolin-2-yl]propanoic acid Chemical compound C1([C@@H](C(=O)NC=2C3=C(C(N([C@H](C)C(O)=O)C=C3)=O)C=CC=2)C)=CC=C(Cl)C=C1 DYWJVLQTKFVOBL-QWHCGFSZSA-N 0.000 claims 1
• PKXXFFPDMOMDMW-LLVKDONJSA-N (2r)-2-[5-[[2-(2,4-dichlorophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C=C1Cl PKXXFFPDMOMDMW-LLVKDONJSA-N 0.000 claims 1
• QAYAWGOEOPBFNE-LLVKDONJSA-N (2r)-2-[5-[[2-(2,4-difluorophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(F)C=C1F QAYAWGOEOPBFNE-LLVKDONJSA-N 0.000 claims 1
• CJWWBMXQIXLAQR-LLVKDONJSA-N (2r)-2-[5-[[2-(2,6-difluorophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=C(F)C=CC=C1F CJWWBMXQIXLAQR-LLVKDONJSA-N 0.000 claims 1
• XTJAGSIKPFOKNE-LLVKDONJSA-N (2r)-2-[5-[[2-(2-chloro-4-fluorophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(F)C=C1Cl XTJAGSIKPFOKNE-LLVKDONJSA-N 0.000 claims 1
• PPFWRNVFOZPNDS-GFCCVEGCSA-N (2r)-2-[5-[[2-(2-chlorophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=CC=C1Cl PPFWRNVFOZPNDS-GFCCVEGCSA-N 0.000 claims 1
• OEAFBSILPFERAX-GFCCVEGCSA-N (2r)-2-[5-[[2-(2-fluorophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=CC=C1F OEAFBSILPFERAX-GFCCVEGCSA-N 0.000 claims 1
• XAXBFMIGYLFQOD-LLVKDONJSA-N (2r)-2-[5-[[2-(3,4-difluorophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(F)C(F)=C1 XAXBFMIGYLFQOD-LLVKDONJSA-N 0.000 claims 1
• NCSDALIEMJFNDB-LLVKDONJSA-N (2r)-2-[5-[[2-(3-bromo-4-fluorophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(F)C(Br)=C1 NCSDALIEMJFNDB-LLVKDONJSA-N 0.000 claims 1
• OBUGFWABVUCLGW-LLVKDONJSA-N (2r)-2-[5-[[2-(3-chloro-4-fluorophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(F)C(Cl)=C1 OBUGFWABVUCLGW-LLVKDONJSA-N 0.000 claims 1
• CFXAFLCKMLRGEE-GFCCVEGCSA-N (2r)-2-[5-[[2-(3-chlorophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=CC(Cl)=C1 CFXAFLCKMLRGEE-GFCCVEGCSA-N 0.000 claims 1
• UXTNKDMNKJLMNT-CYBMUJFWSA-N (2r)-2-[5-[[2-(3-cyanophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=CC(C#N)=C1 UXTNKDMNKJLMNT-CYBMUJFWSA-N 0.000 claims 1
• BQBLDFNECVNMCP-CYBMUJFWSA-N (2r)-2-[5-[[2-(3-fluoro-4-methylphenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(C)C(F)=C1 BQBLDFNECVNMCP-CYBMUJFWSA-N 0.000 claims 1
• MDYJWLLXBGVULZ-LLVKDONJSA-N (2r)-2-[5-[[2-(4-chloro-2-fluorophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C=C1F MDYJWLLXBGVULZ-LLVKDONJSA-N 0.000 claims 1
• DOQWURXAHLPXJZ-LLVKDONJSA-N (2r)-2-[5-[[2-(4-chloro-3-fluorophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(F)=C1 DOQWURXAHLPXJZ-LLVKDONJSA-N 0.000 claims 1
• JWFUFVMYFCQACH-GFCCVEGCSA-N (2r)-2-[5-[[2-(4-chlorophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C=C1 JWFUFVMYFCQACH-GFCCVEGCSA-N 0.000 claims 1
• OIIJVXBFASVYKD-CYBMUJFWSA-N (2r)-2-[5-[[2-(4-cyanophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(C#N)C=C1 OIIJVXBFASVYKD-CYBMUJFWSA-N 0.000 claims 1
• RBUYRPPINUFGRE-LLVKDONJSA-N (2r)-2-[5-[[2-(6-chloropyridin-3-yl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)N=C1 RBUYRPPINUFGRE-LLVKDONJSA-N 0.000 claims 1
• BWPWVTAIYVSMKU-LLVKDONJSA-N (2r)-2-[5-[[2-[2,4-bis(trifluoromethyl)phenyl]acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C=C1C(F)(F)F BWPWVTAIYVSMKU-LLVKDONJSA-N 0.000 claims 1
• PUAZQNPWRTWPFP-LLVKDONJSA-N (2r)-2-[5-[[2-[2-fluoro-3-(trifluoromethyl)phenyl]acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=CC(C(F)(F)F)=C1F PUAZQNPWRTWPFP-LLVKDONJSA-N 0.000 claims 1
• KQOJNXKJHSMKQR-LLVKDONJSA-N (2r)-2-[5-[[2-[2-fluoro-4-(trifluoromethyl)phenyl]acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C=C1F KQOJNXKJHSMKQR-LLVKDONJSA-N 0.000 claims 1
• WEIYBHOTNFPNGD-LLVKDONJSA-N (2r)-2-[5-[[2-[2-fluoro-6-(trifluoromethyl)phenyl]acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=C(F)C=CC=C1C(F)(F)F WEIYBHOTNFPNGD-LLVKDONJSA-N 0.000 claims 1
• DLGVXUUFGYFWDH-LLVKDONJSA-N (2r)-2-[5-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C(F)=C1 DLGVXUUFGYFWDH-LLVKDONJSA-N 0.000 claims 1
• OPSOBRCEJGKBAV-LLVKDONJSA-N (2r)-2-[5-[[2-[4-fluoro-2-(trifluoromethyl)phenyl]acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(F)C=C1C(F)(F)F OPSOBRCEJGKBAV-LLVKDONJSA-N 0.000 claims 1
• IZSWMBAMCJFPMZ-LLVKDONJSA-N (2r)-2-[5-[[2-[4-fluoro-3-(trifluoromethyl)phenyl]acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(F)C(C(F)(F)F)=C1 IZSWMBAMCJFPMZ-LLVKDONJSA-N 0.000 claims 1
• VIFCIENBDYQQDX-LLVKDONJSA-N (2r)-2-[6-chloro-1-oxo-5-[[2-[4-(trifluoromethyl)phenyl]acetyl]amino]isoquinolin-2-yl]propanamide Chemical compound ClC1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C=C1 VIFCIENBDYQQDX-LLVKDONJSA-N 0.000 claims 1
• MZMRGDSURPETPD-SNVBAGLBSA-N (2r)-2-[6-chloro-5-[[2-[2-fluoro-3-(trifluoromethyl)phenyl]acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound ClC1=CC=C2C(=O)N([C@@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=CC(C(F)(F)F)=C1F MZMRGDSURPETPD-SNVBAGLBSA-N 0.000 claims 1
• KGUURNWYZWNORB-GFCCVEGCSA-N (2r)-2-[6-methoxy-1-oxo-5-[[2-[4-(trifluoromethyl)phenyl]acetyl]amino]isoquinolin-2-yl]propanamide Chemical compound COC1=CC=C(C(N([C@H](C)C(N)=O)C=C2)=O)C2=C1NC(=O)CC1=CC=C(C(F)(F)F)C=C1 KGUURNWYZWNORB-GFCCVEGCSA-N 0.000 claims 1
• JJSWOPIXTAJTMG-VXGBXAGGSA-N (2r)-n-[2-[(2r)-1-amino-1-oxopropan-2-yl]-1-oxoisoquinolin-5-yl]-2-(3,4-dichlorophenyl)propanamide Chemical compound C1([C@H](C(=O)NC=2C3=C(C(N([C@H](C)C(N)=O)C=C3)=O)C=CC=2)C)=CC=C(Cl)C(Cl)=C1 JJSWOPIXTAJTMG-VXGBXAGGSA-N 0.000 claims 1
• PLKMCYUWFHRFIH-CHWSQXEVSA-N (2r)-n-[2-[(2r)-1-amino-1-oxopropan-2-yl]-1-oxoisoquinolin-5-yl]-2-(4-chlorophenyl)propanamide Chemical compound C1([C@H](C(=O)NC=2C3=C(C(N([C@H](C)C(N)=O)C=C3)=O)C=CC=2)C)=CC=C(Cl)C=C1 PLKMCYUWFHRFIH-CHWSQXEVSA-N 0.000 claims 1
• PLKMCYUWFHRFIH-OLZOCXBDSA-N (2r)-n-[2-[(2s)-1-amino-1-oxopropan-2-yl]-1-oxoisoquinolin-5-yl]-2-(4-chlorophenyl)propanamide Chemical compound C1([C@H](C(=O)NC=2C3=C(C(N([C@@H](C)C(N)=O)C=C3)=O)C=CC=2)C)=CC=C(Cl)C=C1 PLKMCYUWFHRFIH-OLZOCXBDSA-N 0.000 claims 1
• DSZXUJXSTUHLMA-OLZOCXBDSA-N (2s)-2-(3,4-dichlorophenyl)-n-[2-[(2r)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]propanamide Chemical compound C1([C@H](C)C(=O)NC2=C3C=CN(C(C3=CC=C2)=O)[C@@H](CO)C)=CC=C(Cl)C(Cl)=C1 DSZXUJXSTUHLMA-OLZOCXBDSA-N 0.000 claims 1
• DSZXUJXSTUHLMA-STQMWFEESA-N (2s)-2-(3,4-dichlorophenyl)-n-[2-[(2s)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]propanamide Chemical compound C1([C@H](C)C(=O)NC2=C3C=CN(C(C3=CC=C2)=O)[C@H](CO)C)=CC=C(Cl)C(Cl)=C1 DSZXUJXSTUHLMA-STQMWFEESA-N 0.000 claims 1
• IRKKNYFZGIKSBO-LSDHHAIUSA-N (2s)-2-(4-chlorophenyl)-n-[2-[(2r)-1-(cyclopropylamino)-1-oxopropan-2-yl]-1-oxoisoquinolin-5-yl]propanamide Chemical compound O=C([C@@H](C)N1C=CC2=C(C1=O)C=CC=C2NC(=O)[C@@H](C)C=1C=CC(Cl)=CC=1)NC1CC1 IRKKNYFZGIKSBO-LSDHHAIUSA-N 0.000 claims 1
• MBCZPWIXDRKQCR-LBPRGKRZSA-N (2s)-2-[1-oxo-5-[[2-[4-(trifluoromethyl)phenyl]acetyl]amino]isoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C=C1 MBCZPWIXDRKQCR-LBPRGKRZSA-N 0.000 claims 1
• FXDKIOBUTVXTRR-KRWDZBQOSA-N (2s)-2-[5-[[2-(3,4-dichlorophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]-3-hydroxypropanamide Chemical compound C1=CC=C2C(=O)N([C@@H](CO)C(=O)N)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(Cl)=C1 FXDKIOBUTVXTRR-KRWDZBQOSA-N 0.000 claims 1
• OBUGFWABVUCLGW-NSHDSACASA-N (2s)-2-[5-[[2-(3-chloro-4-fluorophenyl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(F)C(Cl)=C1 OBUGFWABVUCLGW-NSHDSACASA-N 0.000 claims 1
• RBUYRPPINUFGRE-NSHDSACASA-N (2s)-2-[5-[[2-(6-chloropyridin-3-yl)acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)N=C1 RBUYRPPINUFGRE-NSHDSACASA-N 0.000 claims 1
• PUAZQNPWRTWPFP-NSHDSACASA-N (2s)-2-[5-[[2-[2-fluoro-3-(trifluoromethyl)phenyl]acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=CC(C(F)(F)F)=C1F PUAZQNPWRTWPFP-NSHDSACASA-N 0.000 claims 1
• DLGVXUUFGYFWDH-NSHDSACASA-N (2s)-2-[5-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C(F)=C1 DLGVXUUFGYFWDH-NSHDSACASA-N 0.000 claims 1
• SBEDZTUSOMUEPR-KRWDZBQOSA-N (2s)-2-[5-[[2-[4-chloro-3-(trifluoromethyl)phenyl]acetyl]amino]-1-oxoisoquinolin-2-yl]-3-hydroxypropanamide Chemical compound C1=CC=C2C(=O)N([C@@H](CO)C(=O)N)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(C(F)(F)F)=C1 SBEDZTUSOMUEPR-KRWDZBQOSA-N 0.000 claims 1
• DZXYCRGGHHJZIN-NSHDSACASA-N (2s)-2-[5-[[2-[4-chloro-3-(trifluoromethyl)phenyl]acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(C(F)(F)F)=C1 DZXYCRGGHHJZIN-NSHDSACASA-N 0.000 claims 1
• IZSWMBAMCJFPMZ-NSHDSACASA-N (2s)-2-[5-[[2-[4-fluoro-3-(trifluoromethyl)phenyl]acetyl]amino]-1-oxoisoquinolin-2-yl]propanamide Chemical compound C1=CC=C2C(=O)N([C@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(F)C(C(F)(F)F)=C1 IZSWMBAMCJFPMZ-NSHDSACASA-N 0.000 claims 1
• VIFCIENBDYQQDX-NSHDSACASA-N (2s)-2-[6-chloro-1-oxo-5-[[2-[4-(trifluoromethyl)phenyl]acetyl]amino]isoquinolin-2-yl]propanamide Chemical compound ClC1=CC=C2C(=O)N([C@H](C(N)=O)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C=C1 VIFCIENBDYQQDX-NSHDSACASA-N 0.000 claims 1
• JJSWOPIXTAJTMG-NWDGAFQWSA-N (2s)-n-[2-[(2r)-1-amino-1-oxopropan-2-yl]-1-oxoisoquinolin-5-yl]-2-(3,4-dichlorophenyl)propanamide Chemical compound C1([C@@H](C(=O)NC=2C3=C(C(N([C@H](C)C(N)=O)C=C3)=O)C=CC=2)C)=CC=C(Cl)C(Cl)=C1 JJSWOPIXTAJTMG-NWDGAFQWSA-N 0.000 claims 1
• PLKMCYUWFHRFIH-QWHCGFSZSA-N (2s)-n-[2-[(2r)-1-amino-1-oxopropan-2-yl]-1-oxoisoquinolin-5-yl]-2-(4-chlorophenyl)propanamide Chemical compound C1([C@@H](C(=O)NC=2C3=C(C(N([C@H](C)C(N)=O)C=C3)=O)C=CC=2)C)=CC=C(Cl)C=C1 PLKMCYUWFHRFIH-QWHCGFSZSA-N 0.000 claims 1
• WKSFDYRQJMJNFR-NWDGAFQWSA-N (2s)-n-[2-[(2r)-1-amino-1-oxopropan-2-yl]-6-chloro-1-oxoisoquinolin-5-yl]-2-(4-chlorophenyl)propanamide Chemical compound C1([C@@H](C(=O)NC=2C3=C(C(N([C@H](C)C(N)=O)C=C3)=O)C=CC=2Cl)C)=CC=C(Cl)C=C1 WKSFDYRQJMJNFR-NWDGAFQWSA-N 0.000 claims 1
• GJTOVFROQTWBAA-NGMICRHFSA-N (2s)-n-[2-[2-amino-1-(4-chlorophenyl)-2-oxoethyl]-1-oxoisoquinolin-5-yl]-2-(4-chlorophenyl)propanamide Chemical compound O=C([C@@H](C)C=1C=CC(Cl)=CC=1)NC1=CC=CC(C2=O)=C1C=CN2C(C(N)=O)C1=CC=C(Cl)C=C1 GJTOVFROQTWBAA-NGMICRHFSA-N 0.000 claims 1
• WGQPLHUVNLVXDR-UHFFFAOYSA-N 1-(4-chlorophenyl)-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]cyclopentane-1-carboxamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)C1(C=2C=CC(Cl)=CC=2)CCCC1 WGQPLHUVNLVXDR-UHFFFAOYSA-N 0.000 claims 1
• VCLSWKVAHAJSFL-UHFFFAOYSA-N 2,3-dihydro-1,4-benzodioxine-5-carboxylic acid Chemical compound O1CCOC2=C1C=CC=C2C(=O)O VCLSWKVAHAJSFL-UHFFFAOYSA-N 0.000 claims 1
• VXEBBHMADOVPTD-UHFFFAOYSA-N 2,4-dichloro-n-[2-(1-hydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]benzamide Chemical compound C1=CC=C2C(=O)N(C(CO)C)C=CC2=C1NC(=O)C1=CC=C(Cl)C=C1Cl VXEBBHMADOVPTD-UHFFFAOYSA-N 0.000 claims 1
• NHIGVTJNMBTMHA-UHFFFAOYSA-N 2,4-dichloro-n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]benzamide Chemical compound C1=CC=C2C(=O)N(CC(C)(O)C)C=CC2=C1NC(=O)C1=CC=C(Cl)C=C1Cl NHIGVTJNMBTMHA-UHFFFAOYSA-N 0.000 claims 1
• IXCFDTJRJSSULJ-UHFFFAOYSA-N 2,4-dichloro-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]benzamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)C1=CC=C(Cl)C=C1Cl IXCFDTJRJSSULJ-UHFFFAOYSA-N 0.000 claims 1
• WTCUSGSVBPIBHQ-UHFFFAOYSA-N 2,5-dichloro-n-[2-(1-hydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]benzamide Chemical compound C1=CC=C2C(=O)N(C(CO)C)C=CC2=C1NC(=O)C1=CC(Cl)=CC=C1Cl WTCUSGSVBPIBHQ-UHFFFAOYSA-N 0.000 claims 1
• DFYLWYRVWKBFCY-UHFFFAOYSA-N 2,5-dichloro-n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]benzamide Chemical compound C1=CC=C2C(=O)N(CC(C)(O)C)C=CC2=C1NC(=O)C1=CC(Cl)=CC=C1Cl DFYLWYRVWKBFCY-UHFFFAOYSA-N 0.000 claims 1
• QKKXRLSKBNXBSJ-UHFFFAOYSA-N 2,5-dichloro-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]benzamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)C1=CC(Cl)=CC=C1Cl QKKXRLSKBNXBSJ-UHFFFAOYSA-N 0.000 claims 1
• VIVWLCJSTMIDGS-UHFFFAOYSA-N 2-(1,3-benzodioxol-5-yl)-n-[2-(1-hydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=C2OCOC2=CC(CC(=O)NC2=C3C=CN(C(C3=CC=C2)=O)C(CO)C)=C1 VIVWLCJSTMIDGS-UHFFFAOYSA-N 0.000 claims 1
• NFTTYLMVJADJBV-UHFFFAOYSA-N 2-(1,3-benzodioxol-5-yl)-n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=C2OCOC2=CC(CC(=O)NC2=C3C=CN(C(C3=CC=C2)=O)CC(C)(O)C)=C1 NFTTYLMVJADJBV-UHFFFAOYSA-N 0.000 claims 1
• LSTSYMNWVSZTLX-UHFFFAOYSA-N 2-(1,3-benzodioxol-5-yl)-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=C2OCOC2=CC(CC(=O)NC2=C3C=CN(C(C3=CC=C2)=O)CC(O)C)=C1 LSTSYMNWVSZTLX-UHFFFAOYSA-N 0.000 claims 1
• FPCUHKPXMFFADW-UHFFFAOYSA-N 2-(1,3-benzodioxol-5-yl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC2=C(NC(=O)CC=3C=C4OCOC4=CC=3)C=CC=C2C(=O)N1CC1(O)CCCCC1 FPCUHKPXMFFADW-UHFFFAOYSA-N 0.000 claims 1
• BECYULUBGXKWFT-UHFFFAOYSA-N 2-(1-benzothiophen-3-yl)-n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(CC(=O)NC3=C4C=CN(C(C4=CC=C3)=O)CC(C)(O)C)=CSC2=C1 BECYULUBGXKWFT-UHFFFAOYSA-N 0.000 claims 1
• YOQLUWGAKUFXNJ-UHFFFAOYSA-N 2-(1-benzothiophen-3-yl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC2=C(NC(=O)CC=3C4=CC=CC=C4SC=3)C=CC=C2C(=O)N1CC1(O)CCCCC1 YOQLUWGAKUFXNJ-UHFFFAOYSA-N 0.000 claims 1
• SWTRRPWJHHSXLQ-UHFFFAOYSA-N 2-(2,3-dihydro-1,4-benzodioxin-6-yl)-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound O1CCOC2=CC(CC(=O)NC3=C4C=CN(C(C4=CC=C3)=O)CCO)=CC=C21 SWTRRPWJHHSXLQ-UHFFFAOYSA-N 0.000 claims 1
• IMWFVXQHMNASPM-UHFFFAOYSA-N 2-(2,4-dichlorophenyl)-n-[2-(1,3-dihydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(C(CO)CO)C=CC2=C1NC(=O)CC1=CC=C(Cl)C=C1Cl IMWFVXQHMNASPM-UHFFFAOYSA-N 0.000 claims 1
• BHPZIAVADIPKDC-UHFFFAOYSA-N 2-(2,4-dichlorophenyl)-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)CC1=CC=C(Cl)C=C1Cl BHPZIAVADIPKDC-UHFFFAOYSA-N 0.000 claims 1
• YRRRGSJLWKMMMY-UHFFFAOYSA-N 2-(2,4-dimethoxyphenyl)-n-[2-(1-hydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound COC1=CC(OC)=CC=C1CC(=O)NC1=CC=CC2=C1C=CN(C(C)CO)C2=O YRRRGSJLWKMMMY-UHFFFAOYSA-N 0.000 claims 1
• CQTFCARQPRHCNI-UHFFFAOYSA-N 2-(2,4-dimethoxyphenyl)-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound COC1=CC(OC)=CC=C1CC(=O)NC1=CC=CC2=C1C=CN(CC(C)O)C2=O CQTFCARQPRHCNI-UHFFFAOYSA-N 0.000 claims 1
• QPPZXZSDYMFHOT-UHFFFAOYSA-N 2-(2,4-dimethoxyphenyl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound COC1=CC(OC)=CC=C1CC(=O)NC1=CC=CC(C2=O)=C1C=CN2CC1(O)CCCCC1 QPPZXZSDYMFHOT-UHFFFAOYSA-N 0.000 claims 1
• QWOMPPPKSVQFSJ-UHFFFAOYSA-N 2-(2,5-dimethoxyphenyl)-n-[2-(1-hydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound COC1=CC=C(OC)C(CC(=O)NC=2C3=C(C(N(C(C)CO)C=C3)=O)C=CC=2)=C1 QWOMPPPKSVQFSJ-UHFFFAOYSA-N 0.000 claims 1
• IGJVFTXTCBPKDO-UHFFFAOYSA-N 2-(2,5-dimethoxyphenyl)-n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound COC1=CC=C(OC)C(CC(=O)NC=2C3=C(C(N(CC(C)(C)O)C=C3)=O)C=CC=2)=C1 IGJVFTXTCBPKDO-UHFFFAOYSA-N 0.000 claims 1
• LWBMPPFGYHVAKY-UHFFFAOYSA-N 2-(2,5-dimethoxyphenyl)-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound COC1=CC=C(OC)C(CC(=O)NC=2C3=C(C(N(CCO)C=C3)=O)C=CC=2)=C1 LWBMPPFGYHVAKY-UHFFFAOYSA-N 0.000 claims 1
• IXMBHEVUDMYKSE-UHFFFAOYSA-N 2-(2,5-dimethoxyphenyl)-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound COC1=CC=C(OC)C(CC(=O)NC=2C3=C(C(N(CC(C)O)C=C3)=O)C=CC=2)=C1 IXMBHEVUDMYKSE-UHFFFAOYSA-N 0.000 claims 1
• WWDZNYHECODYRB-UHFFFAOYSA-N 2-(2,5-dimethoxyphenyl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound COC1=CC=C(OC)C(CC(=O)NC=2C3=C(C(N(CC4(O)CCCCC4)C=C3)=O)C=CC=2)=C1 WWDZNYHECODYRB-UHFFFAOYSA-N 0.000 claims 1
• ZNURHDGLWGEDSU-UHFFFAOYSA-N 2-(2,5-dimethylphenyl)-n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound CC1=CC=C(C)C(CC(=O)NC=2C3=C(C(N(CC(C)(C)O)C=C3)=O)C=CC=2)=C1 ZNURHDGLWGEDSU-UHFFFAOYSA-N 0.000 claims 1
• GCFIBWUEYAZHRL-UHFFFAOYSA-N 2-(2,5-dimethylphenyl)-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)CC1=CC(C)=CC=C1C GCFIBWUEYAZHRL-UHFFFAOYSA-N 0.000 claims 1
• ORYQETIXVRKSEF-UHFFFAOYSA-N 2-(2,5-dimethylphenyl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound CC1=CC=C(C)C(CC(=O)NC=2C3=C(C(N(CC4(O)CCCCC4)C=C3)=O)C=CC=2)=C1 ORYQETIXVRKSEF-UHFFFAOYSA-N 0.000 claims 1
• CLPXDAMFMCHXGL-UHFFFAOYSA-N 2-(2-chlorophenyl)-n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CC(C)(O)C)C=CC2=C1NC(=O)CC1=CC=CC=C1Cl CLPXDAMFMCHXGL-UHFFFAOYSA-N 0.000 claims 1
• LTODCWCBTVSSQV-UHFFFAOYSA-N 2-(2-chlorophenyl)-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)CC1=CC=CC=C1Cl LTODCWCBTVSSQV-UHFFFAOYSA-N 0.000 claims 1
• ZTRSJOYXIPIOGW-UHFFFAOYSA-N 2-(2-chlorophenyl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC2=C(NC(=O)CC=3C(=CC=CC=3)Cl)C=CC=C2C(=O)N1CC1(O)CCCCC1 ZTRSJOYXIPIOGW-UHFFFAOYSA-N 0.000 claims 1
• MDOCZUGHINYSJF-UHFFFAOYSA-N 2-(2-ethoxyphenyl)-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound CCOC1=CC=CC=C1CC(=O)NC1=CC=CC2=C1C=CN(CC(C)O)C2=O MDOCZUGHINYSJF-UHFFFAOYSA-N 0.000 claims 1
• KFFAQBACJNCVGU-UHFFFAOYSA-N 2-(2-ethoxyphenyl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound CCOC1=CC=CC=C1CC(=O)NC1=CC=CC(C2=O)=C1C=CN2CC1(O)CCCCC1 KFFAQBACJNCVGU-UHFFFAOYSA-N 0.000 claims 1
• NNKNEGSAUFTCCN-UHFFFAOYSA-N 2-(2-fluorophenyl)-n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CC(C)(O)C)C=CC2=C1NC(=O)CC1=CC=CC=C1F NNKNEGSAUFTCCN-UHFFFAOYSA-N 0.000 claims 1
• QNQOFSFHKGTEJA-UHFFFAOYSA-N 2-(2-fluorophenyl)-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)CC1=CC=CC=C1F QNQOFSFHKGTEJA-UHFFFAOYSA-N 0.000 claims 1
• SYWOZUPMYNCDCW-UHFFFAOYSA-N 2-(2-fluorophenyl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC2=C(NC(=O)CC=3C(=CC=CC=3)F)C=CC=C2C(=O)N1CC1(O)CCCCC1 SYWOZUPMYNCDCW-UHFFFAOYSA-N 0.000 claims 1
• KTJULPWERVQCKK-OAHLLOKOSA-N 2-(3,4-dichlorophenyl)-n-[1-oxo-2-[[(2r)-pyrrolidin-2-yl]methyl]isoquinolin-5-yl]acetamide Chemical compound C1=C(Cl)C(Cl)=CC=C1CC(=O)NC1=CC=CC(C2=O)=C1C=CN2C[C@@H]1NCCC1 KTJULPWERVQCKK-OAHLLOKOSA-N 0.000 claims 1
• JBJJTBSEOTWPIX-UHFFFAOYSA-N 2-(3,4-dichlorophenyl)-n-[2-(1,3-dihydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(C(CO)CO)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(Cl)=C1 JBJJTBSEOTWPIX-UHFFFAOYSA-N 0.000 claims 1
• ZQSPSPDZWSMMTJ-UHFFFAOYSA-N 2-(3,4-dichlorophenyl)-n-[2-(1-hydroxy-2-methylpropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(C(C)(CO)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(Cl)=C1 ZQSPSPDZWSMMTJ-UHFFFAOYSA-N 0.000 claims 1
• YHAZNLKCMZRNDC-UHFFFAOYSA-N 2-(3,4-dichlorophenyl)-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(Cl)=C1 YHAZNLKCMZRNDC-UHFFFAOYSA-N 0.000 claims 1
• XMTLRVCMSUMSRD-MRXNPFEDSA-N 2-(3,4-dichlorophenyl)-n-[2-[(2r)-1-hydroxy-4-methylpentan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@@H](CO)CC(C)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(Cl)=C1 XMTLRVCMSUMSRD-MRXNPFEDSA-N 0.000 claims 1
• OSJUBRBGMXRNJS-GFCCVEGCSA-N 2-(3,4-dichlorophenyl)-n-[2-[(2r)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(Cl)=C1 OSJUBRBGMXRNJS-GFCCVEGCSA-N 0.000 claims 1
• OSJUBRBGMXRNJS-LBPRGKRZSA-N 2-(3,4-dichlorophenyl)-n-[2-[(2s)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(Cl)=C1 OSJUBRBGMXRNJS-LBPRGKRZSA-N 0.000 claims 1
• IVSAWMUGSKPNDN-UHFFFAOYSA-N 2-(3,4-dichlorophenyl)-n-[2-[2-(methylamino)ethyl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CCNC)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(Cl)=C1 IVSAWMUGSKPNDN-UHFFFAOYSA-N 0.000 claims 1
• ADMLBVGOGPNSIG-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-n-[2-(1-hydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=C(OC)C(OC)=CC=C1CC(=O)NC1=CC=CC2=C1C=CN(C(C)CO)C2=O ADMLBVGOGPNSIG-UHFFFAOYSA-N 0.000 claims 1
• AFUNRJXMQFHQSQ-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=C(OC)C(OC)=CC=C1CC(=O)NC1=CC=CC(C2=O)=C1C=CN2CC1(O)CCCCC1 AFUNRJXMQFHQSQ-UHFFFAOYSA-N 0.000 claims 1
• SQUGZGLJUQFQNM-UHFFFAOYSA-N 2-(3,5-dimethoxyphenyl)-n-[2-(1-hydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound COC1=CC(OC)=CC(CC(=O)NC=2C3=C(C(N(C(C)CO)C=C3)=O)C=CC=2)=C1 SQUGZGLJUQFQNM-UHFFFAOYSA-N 0.000 claims 1
• IHTNRLDAABGKPL-UHFFFAOYSA-N 2-(3,5-dimethoxyphenyl)-n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound COC1=CC(OC)=CC(CC(=O)NC=2C3=C(C(N(CC(C)(C)O)C=C3)=O)C=CC=2)=C1 IHTNRLDAABGKPL-UHFFFAOYSA-N 0.000 claims 1
• ACYDOBKWRQZMDH-UHFFFAOYSA-N 2-(3,5-dimethoxyphenyl)-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound COC1=CC(OC)=CC(CC(=O)NC=2C3=C(C(N(CC(C)O)C=C3)=O)C=CC=2)=C1 ACYDOBKWRQZMDH-UHFFFAOYSA-N 0.000 claims 1
• VRDFNBXOQIOACC-UHFFFAOYSA-N 2-(3,5-dimethoxyphenyl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound COC1=CC(OC)=CC(CC(=O)NC=2C3=C(C(N(CC4(O)CCCCC4)C=C3)=O)C=CC=2)=C1 VRDFNBXOQIOACC-UHFFFAOYSA-N 0.000 claims 1
• ANDYXZBMTRHYSK-UHFFFAOYSA-N 2-(3,5-dimethylphenyl)-n-[2-(1-hydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(C(CO)C)C=CC2=C1NC(=O)CC1=CC(C)=CC(C)=C1 ANDYXZBMTRHYSK-UHFFFAOYSA-N 0.000 claims 1
• XAVPGMRUQTWTJQ-UHFFFAOYSA-N 2-(3,5-dimethylphenyl)-n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound CC1=CC(C)=CC(CC(=O)NC=2C3=C(C(N(CC(C)(C)O)C=C3)=O)C=CC=2)=C1 XAVPGMRUQTWTJQ-UHFFFAOYSA-N 0.000 claims 1
• HCVMEKMKPLGCEI-UHFFFAOYSA-N 2-(3,5-dimethylphenyl)-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)CC1=CC(C)=CC(C)=C1 HCVMEKMKPLGCEI-UHFFFAOYSA-N 0.000 claims 1
• NERIKWLASVRERP-UHFFFAOYSA-N 2-(3,5-dimethylphenyl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound CC1=CC(C)=CC(CC(=O)NC=2C3=C(C(N(CC4(O)CCCCC4)C=C3)=O)C=CC=2)=C1 NERIKWLASVRERP-UHFFFAOYSA-N 0.000 claims 1
• XNBYDBVPDDENDP-UHFFFAOYSA-N 2-(3-bromo-4-methoxyphenyl)-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=C(Br)C(OC)=CC=C1CC(=O)NC1=CC=CC2=C1C=CN(CCO)C2=O XNBYDBVPDDENDP-UHFFFAOYSA-N 0.000 claims 1
• CIUBDCGQLGUUEJ-UHFFFAOYSA-N 2-(3-chloro-4-fluorophenyl)-n-[2-(1-hydroxy-2-methylpropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(C(C)(CO)C)C=CC2=C1NC(=O)CC1=CC=C(F)C(Cl)=C1 CIUBDCGQLGUUEJ-UHFFFAOYSA-N 0.000 claims 1
• PMJXNWPUMRXYGK-UHFFFAOYSA-N 2-(3-chloro-4-fluorophenyl)-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)CC1=CC=C(F)C(Cl)=C1 PMJXNWPUMRXYGK-UHFFFAOYSA-N 0.000 claims 1
• VEHSOQCTZZUPOB-GFCCVEGCSA-N 2-(3-chloro-4-fluorophenyl)-n-[2-[(2r)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(F)C(Cl)=C1 VEHSOQCTZZUPOB-GFCCVEGCSA-N 0.000 claims 1
• VEHSOQCTZZUPOB-LBPRGKRZSA-N 2-(3-chloro-4-fluorophenyl)-n-[2-[(2s)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(F)C(Cl)=C1 VEHSOQCTZZUPOB-LBPRGKRZSA-N 0.000 claims 1
• KNALBZPVEMIKMH-UHFFFAOYSA-N 2-(4-chloro-2-fluorophenyl)-n-[2-(1-hydroxy-2-methylpropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(C(C)(CO)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C=C1F KNALBZPVEMIKMH-UHFFFAOYSA-N 0.000 claims 1
• MUBSUNWSXCIFPI-GFCCVEGCSA-N 2-(4-chloro-2-fluorophenyl)-n-[2-[(2r)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C=C1F MUBSUNWSXCIFPI-GFCCVEGCSA-N 0.000 claims 1
• BUCKXRYOPVRRMW-UHFFFAOYSA-N 2-(4-chloro-3-fluorophenyl)-n-[2-(1-hydroxy-2-methylpropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(C(C)(CO)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(F)=C1 BUCKXRYOPVRRMW-UHFFFAOYSA-N 0.000 claims 1
• SIVXRIZMULKJIB-UHFFFAOYSA-N 2-(4-chloro-3-fluorophenyl)-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(F)=C1 SIVXRIZMULKJIB-UHFFFAOYSA-N 0.000 claims 1
• LHSCZMRBDSGDQW-GFCCVEGCSA-N 2-(4-chloro-3-fluorophenyl)-n-[2-[(2r)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(F)=C1 LHSCZMRBDSGDQW-GFCCVEGCSA-N 0.000 claims 1
• UFSZNGPKJWFSHR-CYBMUJFWSA-N 2-(4-chloro-3-fluorophenyl)-n-[2-[(2r)-1-hydroxypropan-2-yl]-6-methyl-1-oxoisoquinolin-5-yl]acetamide Chemical compound CC1=CC=C2C(=O)N([C@@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(F)=C1 UFSZNGPKJWFSHR-CYBMUJFWSA-N 0.000 claims 1
• LHSCZMRBDSGDQW-LBPRGKRZSA-N 2-(4-chloro-3-fluorophenyl)-n-[2-[(2s)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(F)=C1 LHSCZMRBDSGDQW-LBPRGKRZSA-N 0.000 claims 1
• NNKBOZOTRMTPFO-LLVKDONJSA-N 2-(4-chloro-3-fluorophenyl)-n-[6-chloro-2-[(2r)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound ClC1=CC=C2C(=O)N([C@@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(F)=C1 NNKBOZOTRMTPFO-LLVKDONJSA-N 0.000 claims 1
• XKKXIJIKSKGNDK-KPMSDPLLSA-N 2-(4-chlorophenyl)-n-[1-oxo-2-[[(2r)-pyrrolidin-2-yl]methyl]isoquinolin-5-yl]propanamide Chemical compound C=1C=C(Cl)C=CC=1C(C)C(=O)NC1=CC=CC(C2=O)=C1C=CN2C[C@H]1CCCN1 XKKXIJIKSKGNDK-KPMSDPLLSA-N 0.000 claims 1
• XKKXIJIKSKGNDK-PKHIMPSTSA-N 2-(4-chlorophenyl)-n-[1-oxo-2-[[(2s)-pyrrolidin-2-yl]methyl]isoquinolin-5-yl]propanamide Chemical compound C=1C=C(Cl)C=CC=1C(C)C(=O)NC1=CC=CC(C2=O)=C1C=CN2C[C@@H]1CCCN1 XKKXIJIKSKGNDK-PKHIMPSTSA-N 0.000 claims 1
• ZSERUHVTDOPGNR-UHFFFAOYSA-N 2-(4-chlorophenyl)-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]-3-methylbutanamide Chemical compound C=1C=CC(C(N(CCO)C=C2)=O)=C2C=1NC(=O)C(C(C)C)C1=CC=C(Cl)C=C1 ZSERUHVTDOPGNR-UHFFFAOYSA-N 0.000 claims 1
• UMNZJXXHDVHFNE-UHFFFAOYSA-N 2-(4-chlorophenyl)-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]propanamide Chemical compound C=1C=CC(C(N(CCO)C=C2)=O)=C2C=1NC(=O)C(C)C1=CC=C(Cl)C=C1 UMNZJXXHDVHFNE-UHFFFAOYSA-N 0.000 claims 1
• YEQFCSSYFUAZHH-UHFFFAOYSA-N 2-(4-ethoxyphenyl)-n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC(OCC)=CC=C1CC(=O)NC1=CC=CC2=C1C=CN(CC(C)(C)O)C2=O YEQFCSSYFUAZHH-UHFFFAOYSA-N 0.000 claims 1
• SEVGEQILXTWYEW-UHFFFAOYSA-N 2-(4-ethoxyphenyl)-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC(OCC)=CC=C1CC(=O)NC1=CC=CC2=C1C=CN(CC(C)O)C2=O SEVGEQILXTWYEW-UHFFFAOYSA-N 0.000 claims 1
• ABNXIJKCXSATSC-UHFFFAOYSA-N 2-(4-ethoxyphenyl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC(OCC)=CC=C1CC(=O)NC1=CC=CC(C2=O)=C1C=CN2CC1(O)CCCCC1 ABNXIJKCXSATSC-UHFFFAOYSA-N 0.000 claims 1
• LTINQYPVTZOOJM-UHFFFAOYSA-N 2-(4-fluorophenyl)-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)CC1=CC=C(F)C=C1 LTINQYPVTZOOJM-UHFFFAOYSA-N 0.000 claims 1
• UHAGRLTXPWIGAQ-UHFFFAOYSA-N 2-[2,4-bis(trifluoromethyl)phenyl]-n-[2-(1-hydroxy-2-methylpropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(C(C)(CO)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C=C1C(F)(F)F UHAGRLTXPWIGAQ-UHFFFAOYSA-N 0.000 claims 1
• WBYJNDMJZGFXFL-GFCCVEGCSA-N 2-[2,4-bis(trifluoromethyl)phenyl]-n-[2-[(2r)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C=C1C(F)(F)F WBYJNDMJZGFXFL-GFCCVEGCSA-N 0.000 claims 1
• OATNOQBYVOVZJE-UHFFFAOYSA-N 2-[2,5-bis(trifluoromethyl)phenyl]-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)CC1=CC(C(F)(F)F)=CC=C1C(F)(F)F OATNOQBYVOVZJE-UHFFFAOYSA-N 0.000 claims 1
• PSQIPFWDYMRABI-UHFFFAOYSA-N 2-[2-chloro-5-(trifluoromethyl)phenyl]-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)CC1=CC(C(F)(F)F)=CC=C1Cl PSQIPFWDYMRABI-UHFFFAOYSA-N 0.000 claims 1
• FQYGXUSEPQPKAV-UHFFFAOYSA-N 2-[2-fluoro-3-(trifluoromethyl)phenyl]-n-[2-(1-hydroxy-2-methylpropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(C(C)(CO)C)C=CC2=C1NC(=O)CC1=CC=CC(C(F)(F)F)=C1F FQYGXUSEPQPKAV-UHFFFAOYSA-N 0.000 claims 1
• OHYAXGAMZSGPOJ-UHFFFAOYSA-N 2-[2-fluoro-3-(trifluoromethyl)phenyl]-n-[2-(2-hydroxyethyl)-6-(2-hydroxyethylamino)-1-oxoisoquinolin-5-yl]acetamide Chemical compound OCCNC1=CC=C(C(N(CCO)C=C2)=O)C2=C1NC(=O)CC1=CC=CC(C(F)(F)F)=C1F OHYAXGAMZSGPOJ-UHFFFAOYSA-N 0.000 claims 1
• LKZDPAFXWXYVCK-UHFFFAOYSA-N 2-[2-fluoro-3-(trifluoromethyl)phenyl]-n-[2-(2-hydroxyethyl)-6-methyl-1-oxoisoquinolin-5-yl]acetamide Chemical compound CC1=CC=C(C(N(CCO)C=C2)=O)C2=C1NC(=O)CC1=CC=CC(C(F)(F)F)=C1F LKZDPAFXWXYVCK-UHFFFAOYSA-N 0.000 claims 1
• JYTUHSPEHYJJQH-GFCCVEGCSA-N 2-[2-fluoro-3-(trifluoromethyl)phenyl]-n-[2-[(2r)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@@H](CO)C)C=CC2=C1NC(=O)CC1=CC=CC(C(F)(F)F)=C1F JYTUHSPEHYJJQH-GFCCVEGCSA-N 0.000 claims 1
• VSGLANORJMNZRC-CYBMUJFWSA-N 2-[2-fluoro-3-(trifluoromethyl)phenyl]-n-[2-[(2r)-1-hydroxypropan-2-yl]-6-methyl-1-oxoisoquinolin-5-yl]acetamide Chemical compound CC1=CC=C2C(=O)N([C@@H](CO)C)C=CC2=C1NC(=O)CC1=CC=CC(C(F)(F)F)=C1F VSGLANORJMNZRC-CYBMUJFWSA-N 0.000 claims 1
• JYTUHSPEHYJJQH-LBPRGKRZSA-N 2-[2-fluoro-3-(trifluoromethyl)phenyl]-n-[2-[(2s)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@H](CO)C)C=CC2=C1NC(=O)CC1=CC=CC(C(F)(F)F)=C1F JYTUHSPEHYJJQH-LBPRGKRZSA-N 0.000 claims 1
• JFQMENFOXPPSTE-UHFFFAOYSA-N 2-[2-fluoro-4-(trifluoromethyl)phenyl]-n-[2-(1-hydroxy-2-methylpropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(C(C)(CO)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C=C1F JFQMENFOXPPSTE-UHFFFAOYSA-N 0.000 claims 1
• UIQBFGNKKNIGPH-GFCCVEGCSA-N 2-[2-fluoro-4-(trifluoromethyl)phenyl]-n-[2-[(2r)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C=C1F UIQBFGNKKNIGPH-GFCCVEGCSA-N 0.000 claims 1
• JCNJYLCSCSKQRG-UHFFFAOYSA-N 2-[3,5-bis(trifluoromethyl)phenyl]-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 JCNJYLCSCSKQRG-UHFFFAOYSA-N 0.000 claims 1
• PUXASPGWNHWACB-UHFFFAOYSA-N 2-[3-fluoro-4-(trifluoromethyl)phenyl]-n-[2-(1-hydroxy-2-methylpropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(C(C)(CO)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C(F)=C1 PUXASPGWNHWACB-UHFFFAOYSA-N 0.000 claims 1
• PZQWKHRLURWPLE-UHFFFAOYSA-N 2-[3-fluoro-4-(trifluoromethyl)phenyl]-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C(F)=C1 PZQWKHRLURWPLE-UHFFFAOYSA-N 0.000 claims 1
• AYLWRSUFLVTPDR-UHFFFAOYSA-N 2-[3-fluoro-4-(trifluoromethyl)phenyl]-n-[2-(2-hydroxyethyl)-6-methyl-1-oxoisoquinolin-5-yl]acetamide Chemical compound CC1=CC=C(C(N(CCO)C=C2)=O)C2=C1NC(=O)CC1=CC=C(C(F)(F)F)C(F)=C1 AYLWRSUFLVTPDR-UHFFFAOYSA-N 0.000 claims 1
• CJAVZUWSKANMMF-GFCCVEGCSA-N 2-[3-fluoro-4-(trifluoromethyl)phenyl]-n-[2-[(2r)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C(F)=C1 CJAVZUWSKANMMF-GFCCVEGCSA-N 0.000 claims 1
• YWFHYHXYMFXORV-CYBMUJFWSA-N 2-[3-fluoro-4-(trifluoromethyl)phenyl]-n-[2-[(2r)-1-hydroxypropan-2-yl]-6-methyl-1-oxo-3,4-dihydroisoquinolin-5-yl]acetamide Chemical compound CC1=CC=C2C(=O)N([C@@H](CO)C)CCC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C(F)=C1 YWFHYHXYMFXORV-CYBMUJFWSA-N 0.000 claims 1
• JECILOFRRYCNDH-CYBMUJFWSA-N 2-[3-fluoro-4-(trifluoromethyl)phenyl]-n-[2-[(2r)-1-hydroxypropan-2-yl]-6-methyl-1-oxoisoquinolin-5-yl]acetamide Chemical compound CC1=CC=C2C(=O)N([C@@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C(F)=C1 JECILOFRRYCNDH-CYBMUJFWSA-N 0.000 claims 1
• CJAVZUWSKANMMF-LBPRGKRZSA-N 2-[3-fluoro-4-(trifluoromethyl)phenyl]-n-[2-[(2s)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(C(F)(F)F)C(F)=C1 CJAVZUWSKANMMF-LBPRGKRZSA-N 0.000 claims 1
• LZXHVPICTHESOD-UHFFFAOYSA-N 2-[4-chloro-2-(trifluoromethyl)phenyl]-n-[2-(1,3-dihydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(C(CO)CO)C=CC2=C1NC(=O)CC1=CC=C(Cl)C=C1C(F)(F)F LZXHVPICTHESOD-UHFFFAOYSA-N 0.000 claims 1
• QCLXXTMBDWRBNM-UHFFFAOYSA-N 2-[4-chloro-2-(trifluoromethyl)phenyl]-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)CC1=CC=C(Cl)C=C1C(F)(F)F QCLXXTMBDWRBNM-UHFFFAOYSA-N 0.000 claims 1
• YQCWKEXWNLIHRW-UHFFFAOYSA-N 2-[4-chloro-3-(trifluoromethyl)phenyl]-n-[1-oxo-2-(piperidin-4-ylmethyl)isoquinolin-5-yl]acetamide Chemical compound C1=C(Cl)C(C(F)(F)F)=CC(CC(=O)NC=2C3=C(C(N(CC4CCNCC4)C=C3)=O)C=CC=2)=C1 YQCWKEXWNLIHRW-UHFFFAOYSA-N 0.000 claims 1
• HKGHKWAHPXKDNF-OAHLLOKOSA-N 2-[4-chloro-3-(trifluoromethyl)phenyl]-n-[1-oxo-2-[[(2r)-pyrrolidin-2-yl]methyl]isoquinolin-5-yl]acetamide Chemical compound C1=C(Cl)C(C(F)(F)F)=CC(CC(=O)NC=2C3=C(C(N(C[C@@H]4NCCC4)C=C3)=O)C=CC=2)=C1 HKGHKWAHPXKDNF-OAHLLOKOSA-N 0.000 claims 1
• HKGHKWAHPXKDNF-HNNXBMFYSA-N 2-[4-chloro-3-(trifluoromethyl)phenyl]-n-[1-oxo-2-[[(2s)-pyrrolidin-2-yl]methyl]isoquinolin-5-yl]acetamide Chemical compound C1=C(Cl)C(C(F)(F)F)=CC(CC(=O)NC=2C3=C(C(N(C[C@H]4NCCC4)C=C3)=O)C=CC=2)=C1 HKGHKWAHPXKDNF-HNNXBMFYSA-N 0.000 claims 1
• VBTCMEWWWXLZMX-UHFFFAOYSA-N 2-[4-chloro-3-(trifluoromethyl)phenyl]-n-[2-(1,3-dihydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(C(CO)CO)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(C(F)(F)F)=C1 VBTCMEWWWXLZMX-UHFFFAOYSA-N 0.000 claims 1
• GLBUUCOPWVIZNE-UHFFFAOYSA-N 2-[4-chloro-3-(trifluoromethyl)phenyl]-n-[2-(1-hydroxy-2-methylpropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(C(C)(CO)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(C(F)(F)F)=C1 GLBUUCOPWVIZNE-UHFFFAOYSA-N 0.000 claims 1
• BISLKBDYESZHMH-UHFFFAOYSA-N 2-[4-chloro-3-(trifluoromethyl)phenyl]-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]propanamide Chemical compound C=1C=CC(C(N(CCO)C=C2)=O)=C2C=1NC(=O)C(C)C1=CC=C(Cl)C(C(F)(F)F)=C1 BISLKBDYESZHMH-UHFFFAOYSA-N 0.000 claims 1
• HPEXCPWRSOBFPO-MRXNPFEDSA-N 2-[4-chloro-3-(trifluoromethyl)phenyl]-n-[2-[(2r)-1-hydroxy-4-methylpentan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@@H](CO)CC(C)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(C(F)(F)F)=C1 HPEXCPWRSOBFPO-MRXNPFEDSA-N 0.000 claims 1
• XHTRUFHCZQQMOM-GFCCVEGCSA-N 2-[4-chloro-3-(trifluoromethyl)phenyl]-n-[2-[(2r)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(C(F)(F)F)=C1 XHTRUFHCZQQMOM-GFCCVEGCSA-N 0.000 claims 1
• OXAXWHGBICRZSW-UHFFFAOYSA-N 2-[4-chloro-3-(trifluoromethyl)phenyl]-n-[2-[2-(methylamino)ethyl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CCNC)C=CC2=C1NC(=O)CC1=CC=C(Cl)C(C(F)(F)F)=C1 OXAXWHGBICRZSW-UHFFFAOYSA-N 0.000 claims 1
• XTOKFBCKXUBJCE-UHFFFAOYSA-N 2-[4-fluoro-3-(trifluoromethyl)phenyl]-n-[2-(1-hydroxy-2-methylpropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(C(C)(CO)C)C=CC2=C1NC(=O)CC1=CC=C(F)C(C(F)(F)F)=C1 XTOKFBCKXUBJCE-UHFFFAOYSA-N 0.000 claims 1
• AAMIKLACARMFCS-UHFFFAOYSA-N 2-[4-fluoro-3-(trifluoromethyl)phenyl]-n-[2-(2-hydroxyethyl)-6-methyl-1-oxoisoquinolin-5-yl]acetamide Chemical compound CC1=CC=C(C(N(CCO)C=C2)=O)C2=C1NC(=O)CC1=CC=C(F)C(C(F)(F)F)=C1 AAMIKLACARMFCS-UHFFFAOYSA-N 0.000 claims 1
• ZFESFSVNBNRVFO-GFCCVEGCSA-N 2-[4-fluoro-3-(trifluoromethyl)phenyl]-n-[2-[(2r)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(F)C(C(F)(F)F)=C1 ZFESFSVNBNRVFO-GFCCVEGCSA-N 0.000 claims 1
• UTSFTJWRTXSFSI-CYBMUJFWSA-N 2-[4-fluoro-3-(trifluoromethyl)phenyl]-n-[2-[(2r)-1-hydroxypropan-2-yl]-6-methyl-1-oxoisoquinolin-5-yl]acetamide Chemical compound CC1=CC=C2C(=O)N([C@@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(F)C(C(F)(F)F)=C1 UTSFTJWRTXSFSI-CYBMUJFWSA-N 0.000 claims 1
• ZFESFSVNBNRVFO-LBPRGKRZSA-N 2-[4-fluoro-3-(trifluoromethyl)phenyl]-n-[2-[(2s)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N([C@H](CO)C)C=CC2=C1NC(=O)CC1=CC=C(F)C(C(F)(F)F)=C1 ZFESFSVNBNRVFO-LBPRGKRZSA-N 0.000 claims 1
• DNGBWHSPBDNOKD-UHFFFAOYSA-N 2-[5-chloro-2-(trifluoromethyl)phenyl]-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]acetamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)CC1=CC(Cl)=CC=C1C(F)(F)F DNGBWHSPBDNOKD-UHFFFAOYSA-N 0.000 claims 1
• ACLHGSKAAQGRSC-UHFFFAOYSA-N 2-chloro-n-[2-(1-hydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]-5-methylbenzamide Chemical compound C1=CC=C2C(=O)N(C(CO)C)C=CC2=C1NC(=O)C1=CC(C)=CC=C1Cl ACLHGSKAAQGRSC-UHFFFAOYSA-N 0.000 claims 1
• WIVVTASCOMNZJL-UHFFFAOYSA-N 2-chloro-n-[2-(1-hydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]benzamide Chemical compound C1=CC=C2C(=O)N(C(CO)C)C=CC2=C1NC(=O)C1=CC=CC=C1Cl WIVVTASCOMNZJL-UHFFFAOYSA-N 0.000 claims 1
• AMFOSJXVADGGME-UHFFFAOYSA-N 2-chloro-n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]benzamide Chemical compound C1=CC=C2C(=O)N(CC(C)(O)C)C=CC2=C1NC(=O)C1=CC=CC=C1Cl AMFOSJXVADGGME-UHFFFAOYSA-N 0.000 claims 1
• FRBPACIWDUNGTK-UHFFFAOYSA-N 2-chloro-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-3-methylbenzamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)C1=CC=CC(C)=C1Cl FRBPACIWDUNGTK-UHFFFAOYSA-N 0.000 claims 1
• GRIXCAQREJEPQX-UHFFFAOYSA-N 2-chloro-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-5-methylbenzamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)C1=CC(C)=CC=C1Cl GRIXCAQREJEPQX-UHFFFAOYSA-N 0.000 claims 1
• ITOLDJHTYYVNBX-UHFFFAOYSA-N 2-chloro-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]benzamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)C1=CC=CC=C1Cl ITOLDJHTYYVNBX-UHFFFAOYSA-N 0.000 claims 1
• LZAIZBSSQNBZCY-UHFFFAOYSA-N 2-chloro-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]-3-methylbenzamide Chemical compound CC1=CC=CC(C(=O)NC=2C3=C(C(N(CC4(O)CCCCC4)C=C3)=O)C=CC=2)=C1Cl LZAIZBSSQNBZCY-UHFFFAOYSA-N 0.000 claims 1
• SVASSZACAPUBTC-UHFFFAOYSA-N 2-chloro-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]-5-methylbenzamide Chemical compound CC1=CC=C(Cl)C(C(=O)NC=2C3=C(C(N(CC4(O)CCCCC4)C=C3)=O)C=CC=2)=C1 SVASSZACAPUBTC-UHFFFAOYSA-N 0.000 claims 1
• MQSSBVLREFSMDP-UHFFFAOYSA-N 3,4-dihydro-2h-1,5-benzodioxepine-7-carboxylic acid Chemical compound O1CCCOC2=CC(C(=O)O)=CC=C21 MQSSBVLREFSMDP-UHFFFAOYSA-N 0.000 claims 1
• HRELMQOMKXBRAM-UHFFFAOYSA-N 3,5-dichloro-n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]benzamide Chemical compound C1=CC=C2C(=O)N(CC(C)(O)C)C=CC2=C1NC(=O)C1=CC(Cl)=CC(Cl)=C1 HRELMQOMKXBRAM-UHFFFAOYSA-N 0.000 claims 1
• DEBCEULRAZGFGM-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-n-[2-(1-hydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]propanamide Chemical compound C1=C2OCOC2=CC(CCC(=O)NC2=C3C=CN(C(C3=CC=C2)=O)C(CO)C)=C1 DEBCEULRAZGFGM-UHFFFAOYSA-N 0.000 claims 1
• OYVGYBOYBLQARI-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]propanamide Chemical compound C1=C2OCOC2=CC(CCC(=O)NC2=C3C=CN(C(C3=CC=C2)=O)CC(C)(O)C)=C1 OYVGYBOYBLQARI-UHFFFAOYSA-N 0.000 claims 1
• LISVABUXXYNTCZ-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]propanamide Chemical compound C1=C2OCOC2=CC(CCC(=O)NC2=C3C=CN(C(C3=CC=C2)=O)CC(O)C)=C1 LISVABUXXYNTCZ-UHFFFAOYSA-N 0.000 claims 1
• HWNMYNKJAJPBJM-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]propanamide Chemical compound C1=CC2=C(NC(=O)CCC=3C=C4OCOC4=CC=3)C=CC=C2C(=O)N1CC1(O)CCCCC1 HWNMYNKJAJPBJM-UHFFFAOYSA-N 0.000 claims 1
• NTIJQFSGIDEVLU-UHFFFAOYSA-N 3-(2,4-dimethylphenyl)-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]propanamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)CCC1=CC=C(C)C=C1C NTIJQFSGIDEVLU-UHFFFAOYSA-N 0.000 claims 1
• SCKAWYOEEZWSIV-UHFFFAOYSA-N 3-(2,4-dimethylphenyl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]propanamide Chemical compound CC1=CC(C)=CC=C1CCC(=O)NC1=CC=CC(C2=O)=C1C=CN2CC1(O)CCCCC1 SCKAWYOEEZWSIV-UHFFFAOYSA-N 0.000 claims 1
• HNMLYNSSGXODJY-UHFFFAOYSA-N 3-(2-chlorophenyl)-n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]propanamide Chemical compound C1=CC=C2C(=O)N(CC(C)(O)C)C=CC2=C1NC(=O)CCC1=CC=CC=C1Cl HNMLYNSSGXODJY-UHFFFAOYSA-N 0.000 claims 1
• QKZQZHFVMOZMIL-UHFFFAOYSA-N 3-(2-chlorophenyl)-n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]propanamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)CCC1=CC=CC=C1Cl QKZQZHFVMOZMIL-UHFFFAOYSA-N 0.000 claims 1
• NLBUTUWTRSIAOY-UHFFFAOYSA-N 3-(2-chlorophenyl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]propanamide Chemical compound C1=CC2=C(NC(=O)CCC=3C(=CC=CC=3)Cl)C=CC=C2C(=O)N1CC1(O)CCCCC1 NLBUTUWTRSIAOY-UHFFFAOYSA-N 0.000 claims 1
• OMVAPBJSOAIWTF-UHFFFAOYSA-N 3-(3-chlorophenyl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]propanamide Chemical compound C1=CC2=C(NC(=O)CCC=3C=C(Cl)C=CC=3)C=CC=C2C(=O)N1CC1(O)CCCCC1 OMVAPBJSOAIWTF-UHFFFAOYSA-N 0.000 claims 1
• BESNTHUYAOQZKW-UHFFFAOYSA-N 3-(4-chlorophenyl)-n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]propanamide Chemical compound C1=CC2=C(NC(=O)CCC=3C=CC(Cl)=CC=3)C=CC=C2C(=O)N1CC1(O)CCCCC1 BESNTHUYAOQZKW-UHFFFAOYSA-N 0.000 claims 1
• QQIZMXRYXXSVCA-UHFFFAOYSA-N 3-[2,5-bis(trifluoromethyl)phenyl]-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]propanamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)CCC1=CC(C(F)(F)F)=CC=C1C(F)(F)F QQIZMXRYXXSVCA-UHFFFAOYSA-N 0.000 claims 1
• RXWFWRWYNQDTEJ-UHFFFAOYSA-N 3-[3,5-bis(trifluoromethyl)phenyl]-n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]propanamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)CCC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 RXWFWRWYNQDTEJ-UHFFFAOYSA-N 0.000 claims 1
• SPGJFXCHSIAFCE-UHFFFAOYSA-N 3-chloro-n-[2-(1-hydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]-2-methylbenzamide Chemical compound C1=CC=C2C(=O)N(C(CO)C)C=CC2=C1NC(=O)C1=CC=CC(Cl)=C1C SPGJFXCHSIAFCE-UHFFFAOYSA-N 0.000 claims 1
• WYTNPOILKLEMJC-UHFFFAOYSA-N 3-chloro-n-[2-(1-hydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]-4-methoxybenzamide Chemical compound C1=C(Cl)C(OC)=CC=C1C(=O)NC1=CC=CC2=C1C=CN(C(C)CO)C2=O WYTNPOILKLEMJC-UHFFFAOYSA-N 0.000 claims 1
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• KBAQFSMDNWTSRR-UHFFFAOYSA-N n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]-2-(3-methylphenyl)acetamide Chemical compound CC1=CC=CC(CC(=O)NC=2C3=C(C(N(CC(C)(C)O)C=C3)=O)C=CC=2)=C1 KBAQFSMDNWTSRR-UHFFFAOYSA-N 0.000 claims 1
• VPCFTFTUXBKPJY-UHFFFAOYSA-N n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]-2-(4-methoxyphenyl)acetamide Chemical compound C1=CC(OC)=CC=C1CC(=O)NC1=CC=CC2=C1C=CN(CC(C)(C)O)C2=O VPCFTFTUXBKPJY-UHFFFAOYSA-N 0.000 claims 1
• BTSCRIFFFOITNT-UHFFFAOYSA-N n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]-2-(4-methylphenyl)acetamide Chemical compound C1=CC(C)=CC=C1CC(=O)NC1=CC=CC2=C1C=CN(CC(C)(C)O)C2=O BTSCRIFFFOITNT-UHFFFAOYSA-N 0.000 claims 1
• ACHMEIFQDZSCEW-UHFFFAOYSA-N n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]-2-methylbenzamide Chemical compound CC1=CC=CC=C1C(=O)NC1=CC=CC2=C1C=CN(CC(C)(C)O)C2=O ACHMEIFQDZSCEW-UHFFFAOYSA-N 0.000 claims 1
• BFORAODRUBBOCC-UHFFFAOYSA-N n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]-2-naphthalen-1-ylacetamide Chemical compound C1=CC=C2C(CC(=O)NC3=C4C=CN(C(C4=CC=C3)=O)CC(C)(O)C)=CC=CC2=C1 BFORAODRUBBOCC-UHFFFAOYSA-N 0.000 claims 1
• FQZQHMFPPDKHLH-UHFFFAOYSA-N n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]-3,4-dihydro-2h-1,5-benzodioxepine-7-carboxamide Chemical compound O1CCCOC2=CC(C(=O)NC3=C4C=CN(C(C4=CC=C3)=O)CC(C)(O)C)=CC=C21 FQZQHMFPPDKHLH-UHFFFAOYSA-N 0.000 claims 1
• BUEOTKVBUDEHAW-UHFFFAOYSA-N n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]-3-(2-methylphenyl)propanamide Chemical compound CC1=CC=CC=C1CCC(=O)NC1=CC=CC2=C1C=CN(CC(C)(C)O)C2=O BUEOTKVBUDEHAW-UHFFFAOYSA-N 0.000 claims 1
• MIGXEKKAFLHAFW-UHFFFAOYSA-N n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]-3-(3-methoxyphenyl)propanamide Chemical compound COC1=CC=CC(CCC(=O)NC=2C3=C(C(N(CC(C)(C)O)C=C3)=O)C=CC=2)=C1 MIGXEKKAFLHAFW-UHFFFAOYSA-N 0.000 claims 1
• LEFAKGUDLIECCN-UHFFFAOYSA-N n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]-4-methoxy-2-methylbenzamide Chemical compound CC1=CC(OC)=CC=C1C(=O)NC1=CC=CC2=C1C=CN(CC(C)(C)O)C2=O LEFAKGUDLIECCN-UHFFFAOYSA-N 0.000 claims 1
• QGMUEISRTGXPTM-UHFFFAOYSA-N n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]-4-methoxy-3-methylbenzamide Chemical compound C1=C(C)C(OC)=CC=C1C(=O)NC1=CC=CC2=C1C=CN(CC(C)(C)O)C2=O QGMUEISRTGXPTM-UHFFFAOYSA-N 0.000 claims 1
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• UONKKEZALDMANT-UHFFFAOYSA-N n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]naphthalene-1-carboxamide Chemical compound C1=CC=C2C(C(=O)NC3=C4C=CN(C(C4=CC=C3)=O)CC(C)(O)C)=CC=CC2=C1 UONKKEZALDMANT-UHFFFAOYSA-N 0.000 claims 1
• XGGWDZYNKDPEQN-UHFFFAOYSA-N n-[2-(2-hydroxy-2-methylpropyl)-1-oxoisoquinolin-5-yl]naphthalene-2-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=C4C=CN(C(C4=CC=C3)=O)CC(C)(O)C)=CC=C21 XGGWDZYNKDPEQN-UHFFFAOYSA-N 0.000 claims 1
• GFKKWTSPOMIHSA-UHFFFAOYSA-N n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]-2,4-bis(trifluoromethyl)benzamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)C1=CC=C(C(F)(F)F)C=C1C(F)(F)F GFKKWTSPOMIHSA-UHFFFAOYSA-N 0.000 claims 1
• BCISJNHPUHUMEW-UHFFFAOYSA-N n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]-2-(3-methoxyphenyl)acetamide Chemical compound COC1=CC=CC(CC(=O)NC=2C3=C(C(N(CCO)C=C3)=O)C=CC=2)=C1 BCISJNHPUHUMEW-UHFFFAOYSA-N 0.000 claims 1
• ONIMYDOSCHKMQL-UHFFFAOYSA-N n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]-2-(4-methoxyphenyl)acetamide Chemical compound C1=CC(OC)=CC=C1CC(=O)NC1=CC=CC2=C1C=CN(CCO)C2=O ONIMYDOSCHKMQL-UHFFFAOYSA-N 0.000 claims 1
• DKKNFUCBMIILGW-UHFFFAOYSA-N n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]-2-(4-methylsulfonylphenyl)acetamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1CC(=O)NC1=CC=CC2=C1C=CN(CCO)C2=O DKKNFUCBMIILGW-UHFFFAOYSA-N 0.000 claims 1
• NWVWIWJBDYFDBS-UHFFFAOYSA-N n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]-2-phenylacetamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)CC1=CC=CC=C1 NWVWIWJBDYFDBS-UHFFFAOYSA-N 0.000 claims 1
• ILAGRTFIENVZED-UHFFFAOYSA-N n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]-2-phenylbutanamide Chemical compound C=1C=CC(C(N(CCO)C=C2)=O)=C2C=1NC(=O)C(CC)C1=CC=CC=C1 ILAGRTFIENVZED-UHFFFAOYSA-N 0.000 claims 1
• YZWIOAYQKBFPKB-UHFFFAOYSA-N n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]-3-phenylpropanamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)CCC1=CC=CC=C1 YZWIOAYQKBFPKB-UHFFFAOYSA-N 0.000 claims 1
• FZGRRGMPPNFDSN-UHFFFAOYSA-N n-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]benzamide Chemical compound C1=CC=C2C(=O)N(CCO)C=CC2=C1NC(=O)C1=CC=CC=C1 FZGRRGMPPNFDSN-UHFFFAOYSA-N 0.000 claims 1
• HLPLCWANOYTQFV-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-1-benzofuran-2-carboxamide Chemical compound C1=CC=C2OC(C(=O)NC3=C4C=CN(C(C4=CC=C3)=O)CC(O)C)=CC2=C1 HLPLCWANOYTQFV-UHFFFAOYSA-N 0.000 claims 1
• PDWFHWYLRACRRQ-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide Chemical compound O1CCOC2=C1C=CC=C2C(=O)NC1=C2C=CN(CC(O)C)C(=O)C2=CC=C1 PDWFHWYLRACRRQ-UHFFFAOYSA-N 0.000 claims 1
• IEOMHUQUVUUDFQ-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-2,3-dimethylbenzamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)C1=CC=CC(C)=C1C IEOMHUQUVUUDFQ-UHFFFAOYSA-N 0.000 claims 1
• UHIBCMDEEAOYLM-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-2,4-dimethylbenzamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)C1=CC=C(C)C=C1C UHIBCMDEEAOYLM-UHFFFAOYSA-N 0.000 claims 1
• DUFGDKPFMVBLKR-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-2,5-dimethylbenzamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)C1=CC(C)=CC=C1C DUFGDKPFMVBLKR-UHFFFAOYSA-N 0.000 claims 1
• BREGVUWTDLJTBR-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-2-(2,4,6-trimethylphenyl)acetamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)CC1=C(C)C=C(C)C=C1C BREGVUWTDLJTBR-UHFFFAOYSA-N 0.000 claims 1
• FLMHJGIQVWCQAO-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-2-(2-methoxyphenyl)acetamide Chemical compound COC1=CC=CC=C1CC(=O)NC1=CC=CC2=C1C=CN(CC(C)O)C2=O FLMHJGIQVWCQAO-UHFFFAOYSA-N 0.000 claims 1
• LFPPBAZINZJTTM-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-2-(2-methylphenyl)acetamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)CC1=CC=CC=C1C LFPPBAZINZJTTM-UHFFFAOYSA-N 0.000 claims 1
• OCWMLJKTFHUCPQ-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-2-(3-methoxyphenyl)acetamide Chemical compound COC1=CC=CC(CC(=O)NC=2C3=C(C(N(CC(C)O)C=C3)=O)C=CC=2)=C1 OCWMLJKTFHUCPQ-UHFFFAOYSA-N 0.000 claims 1
• OOEUAPZPCWOEOK-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-2-(3-methylphenyl)acetamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)CC1=CC=CC(C)=C1 OOEUAPZPCWOEOK-UHFFFAOYSA-N 0.000 claims 1
• MWCXGBDGAJXTDV-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-2-(4-methoxy-3-methylphenyl)acetamide Chemical compound C1=C(C)C(OC)=CC=C1CC(=O)NC1=CC=CC2=C1C=CN(CC(C)O)C2=O MWCXGBDGAJXTDV-UHFFFAOYSA-N 0.000 claims 1
• YVUISCLOIJJWHE-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-2-(4-methoxyphenyl)acetamide Chemical compound C1=CC(OC)=CC=C1CC(=O)NC1=CC=CC2=C1C=CN(CC(C)O)C2=O YVUISCLOIJJWHE-UHFFFAOYSA-N 0.000 claims 1
• PMDHMLYKWVLJBR-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-2-(4-methylphenyl)acetamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)CC1=CC=C(C)C=C1 PMDHMLYKWVLJBR-UHFFFAOYSA-N 0.000 claims 1
• WHGBRXYMGWHOOG-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-2-methylbenzamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)C1=CC=CC=C1C WHGBRXYMGWHOOG-UHFFFAOYSA-N 0.000 claims 1
• GSRPFJJIVYRRQI-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-2-naphthalen-1-ylacetamide Chemical compound C1=CC=C2C(CC(=O)NC3=C4C=CN(C(C4=CC=C3)=O)CC(O)C)=CC=CC2=C1 GSRPFJJIVYRRQI-UHFFFAOYSA-N 0.000 claims 1
• RHGUNUADGHVBAQ-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-2-phenylpropanamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)C(C)C1=CC=CC=C1 RHGUNUADGHVBAQ-UHFFFAOYSA-N 0.000 claims 1
• GMIAGHUEHWWOHK-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-3,5-dimethoxybenzamide Chemical compound COC1=CC(OC)=CC(C(=O)NC=2C3=C(C(N(CC(C)O)C=C3)=O)C=CC=2)=C1 GMIAGHUEHWWOHK-UHFFFAOYSA-N 0.000 claims 1
• HTNHZFWKPCDHTK-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-3-(2-methoxyphenyl)propanamide Chemical compound COC1=CC=CC=C1CCC(=O)NC1=CC=CC2=C1C=CN(CC(C)O)C2=O HTNHZFWKPCDHTK-UHFFFAOYSA-N 0.000 claims 1
• BOLCTLGFVSOVSR-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-3-(2-methylphenyl)propanamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)CCC1=CC=CC=C1C BOLCTLGFVSOVSR-UHFFFAOYSA-N 0.000 claims 1
• QAQKHFUWGMVNQD-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-3-(3-methoxyphenyl)propanamide Chemical compound COC1=CC=CC(CCC(=O)NC=2C3=C(C(N(CC(C)O)C=C3)=O)C=CC=2)=C1 QAQKHFUWGMVNQD-UHFFFAOYSA-N 0.000 claims 1
• CWJDEJLESQBAJO-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-3-(3-methylphenyl)propanamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)CCC1=CC=CC(C)=C1 CWJDEJLESQBAJO-UHFFFAOYSA-N 0.000 claims 1
• GFFRRGDHEMSWPU-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-3-(4-methoxyphenyl)propanamide Chemical compound C1=CC(OC)=CC=C1CCC(=O)NC1=CC=CC2=C1C=CN(CC(C)O)C2=O GFFRRGDHEMSWPU-UHFFFAOYSA-N 0.000 claims 1
• LGQYXFTXDFNWGS-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-3-methylbenzamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)C1=CC=CC(C)=C1 LGQYXFTXDFNWGS-UHFFFAOYSA-N 0.000 claims 1
• WJKUUWDWCQUZOH-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-4-methoxy-2-methylbenzamide Chemical compound CC1=CC(OC)=CC=C1C(=O)NC1=CC=CC2=C1C=CN(CC(C)O)C2=O WJKUUWDWCQUZOH-UHFFFAOYSA-N 0.000 claims 1
• GKBDHHOAQLTJRF-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-4-methoxy-3,5-dimethylbenzamide Chemical compound C1=C(C)C(OC)=C(C)C=C1C(=O)NC1=CC=CC2=C1C=CN(CC(C)O)C2=O GKBDHHOAQLTJRF-UHFFFAOYSA-N 0.000 claims 1
• WTXJGOUUKDGBKU-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-4-methoxy-3-methylbenzamide Chemical compound C1=C(C)C(OC)=CC=C1C(=O)NC1=CC=CC2=C1C=CN(CC(C)O)C2=O WTXJGOUUKDGBKU-UHFFFAOYSA-N 0.000 claims 1
• WYAFBQPVFRGMFQ-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-4-phenylbenzamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)C(C=C1)=CC=C1C1=CC=CC=C1 WYAFBQPVFRGMFQ-UHFFFAOYSA-N 0.000 claims 1
• QUZDZRQNIGRPGZ-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-4-phenylbutanamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)CCCC1=CC=CC=C1 QUZDZRQNIGRPGZ-UHFFFAOYSA-N 0.000 claims 1
• BXINPMFJPOFRAN-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]-5-phenylfuran-2-carboxamide Chemical compound C1=CC=C2C(=O)N(CC(O)C)C=CC2=C1NC(=O)C(O1)=CC=C1C1=CC=CC=C1 BXINPMFJPOFRAN-UHFFFAOYSA-N 0.000 claims 1
• PMLZPYUAGULZIC-UHFFFAOYSA-N n-[2-(2-hydroxypropyl)-1-oxoisoquinolin-5-yl]naphthalene-2-carboxamide Chemical compound C1=CC=CC2=CC(C(=O)NC3=C4C=CN(C(C4=CC=C3)=O)CC(O)C)=CC=C21 PMLZPYUAGULZIC-UHFFFAOYSA-N 0.000 claims 1
• UPWMEMGJQPCQKJ-UHFFFAOYSA-N n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]-1-benzofuran-2-carboxamide Chemical compound C1=CC2=C(NC(=O)C=3OC4=CC=CC=C4C=3)C=CC=C2C(=O)N1CC1(O)CCCCC1 UPWMEMGJQPCQKJ-UHFFFAOYSA-N 0.000 claims 1
• WWKWFMHOJFSPGY-UHFFFAOYSA-N n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide Chemical compound C1=CC2=C(NC(=O)C=3C=4OCCOC=4C=CC=3)C=CC=C2C(=O)N1CC1(O)CCCCC1 WWKWFMHOJFSPGY-UHFFFAOYSA-N 0.000 claims 1
• XSMRKSKNTUPPNM-UHFFFAOYSA-N n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]-2,3-dimethylbenzamide Chemical compound CC1=CC=CC(C(=O)NC=2C3=C(C(N(CC4(O)CCCCC4)C=C3)=O)C=CC=2)=C1C XSMRKSKNTUPPNM-UHFFFAOYSA-N 0.000 claims 1
• FMKHILGACZBCES-UHFFFAOYSA-N n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]-2,4-dimethylbenzamide Chemical compound CC1=CC(C)=CC=C1C(=O)NC1=CC=CC(C2=O)=C1C=CN2CC1(O)CCCCC1 FMKHILGACZBCES-UHFFFAOYSA-N 0.000 claims 1
• FCDFBXLUJLRBQD-UHFFFAOYSA-N n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]-2,5-dimethylbenzamide Chemical compound CC1=CC=C(C)C(C(=O)NC=2C3=C(C(N(CC4(O)CCCCC4)C=C3)=O)C=CC=2)=C1 FCDFBXLUJLRBQD-UHFFFAOYSA-N 0.000 claims 1
• ZUZPVKXVXFLRQS-UHFFFAOYSA-N n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]-2-(2,4,6-trimethylphenyl)acetamide Chemical compound CC1=CC(C)=CC(C)=C1CC(=O)NC1=CC=CC(C2=O)=C1C=CN2CC1(O)CCCCC1 ZUZPVKXVXFLRQS-UHFFFAOYSA-N 0.000 claims 1
• JNAWUUALUJMLEC-UHFFFAOYSA-N n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]-2-(2-methylphenyl)acetamide Chemical compound CC1=CC=CC=C1CC(=O)NC1=CC=CC(C2=O)=C1C=CN2CC1(O)CCCCC1 JNAWUUALUJMLEC-UHFFFAOYSA-N 0.000 claims 1
• KAXBPHQNXDBCRU-UHFFFAOYSA-N n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]-2-(3-methylphenyl)acetamide Chemical compound CC1=CC=CC(CC(=O)NC=2C3=C(C(N(CC4(O)CCCCC4)C=C3)=O)C=CC=2)=C1 KAXBPHQNXDBCRU-UHFFFAOYSA-N 0.000 claims 1
• NIMGAGNUQYDOMK-UHFFFAOYSA-N n-[2-[(1-hydroxycyclohexyl)methyl]-1-oxoisoquinolin-5-yl]-2-(4-methoxyphenyl)acetamide Chemical compound C1=CC(OC)=CC=C1CC(=O)NC1=CC=CC(C2=O)=C1C=CN2CC1(O)CCCCC1 NIMGAGNUQYDOMK-UHFFFAOYSA-N 0.000 claims 1
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