CN101442909B - 作为p2x7调节剂的双环杂芳基化合物及其应用 - Google Patents

作为p2x7调节剂的双环杂芳基化合物及其应用 Download PDF

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CN101442909B
CN101442909B CN2007800170265A CN200780017026A CN101442909B CN 101442909 B CN101442909 B CN 101442909B CN 2007800170265 A CN2007800170265 A CN 2007800170265A CN 200780017026 A CN200780017026 A CN 200780017026A CN 101442909 B CN101442909 B CN 101442909B
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disease
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condition
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CN101442909A (zh
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M·G·凯利
J·金凯德
Y·方
Y·曹
C·考布
S·高卢加里
Z·王
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Ivotec America Inc
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Renovis Inc
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CN2007800170265A 2006-03-16 2007-03-16 作为p2x7调节剂的双环杂芳基化合物及其应用 Active CN101442909B (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US78292306P 2006-03-16 2006-03-16
US78312106P 2006-03-16 2006-03-16
US78359006P 2006-03-16 2006-03-16
US60/783,121 2006-03-16
US60/783,590 2006-03-16
US60/782,923 2006-03-16
US83141606P 2006-07-17 2006-07-17
US60/831,416 2006-07-17
US90604907P 2007-03-09 2007-03-09
US60/906,049 2007-03-09
PCT/US2007/006735 WO2007109192A2 (en) 2006-03-16 2007-03-16 Bicycloheteroaryl compounds as p2x7 modulators and uses thereof

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CN101442909A CN101442909A (zh) 2009-05-27
CN101442909B true CN101442909B (zh) 2013-03-27

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US (2) US7816371B2 (enExample)
EP (1) EP1933622B1 (enExample)
JP (1) JP5240941B2 (enExample)
CN (1) CN101442909B (enExample)
AR (1) AR059920A1 (enExample)
BR (1) BRPI0709581A8 (enExample)
CA (1) CA2645568C (enExample)
DK (1) DK1933622T3 (enExample)
ES (1) ES2569352T3 (enExample)
MX (1) MX2008011922A (enExample)
TW (1) TWI464148B (enExample)
WO (1) WO2007109192A2 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2576643T3 (es) * 2007-03-09 2016-07-08 Second Genome, Inc. Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos
WO2009057827A1 (en) 2007-10-31 2009-05-07 Nissan Chemical Industries, Ltd. Pyridazinone derivatives and use thereof as p2x7 receptor inhibitors
ES2357682T3 (es) 2008-03-25 2011-04-28 Affectis Pharmaceuticals Ag Antagonistas de p2x7r novedosos y su utilización.
JP2011530596A (ja) * 2008-08-11 2011-12-22 プレジデント アンド フェロウズ オブ ハーバード カレッジ ｔＲＮＡ合成酵素の阻害のためのハロフジノン類似体およびそれらの使用
GB0906274D0 (en) 2009-04-09 2009-05-20 Ge Healthcare Ltd Imaging the central nervous system
CN102395562A (zh) 2009-04-14 2012-03-28 阿费克蒂斯制药股份公司 新的p2x7r拮抗剂及其用途
EP2386541A1 (en) 2010-05-14 2011-11-16 Affectis Pharmaceuticals AG Novel methods for the preparation of P2X7R antagonists
WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2013014587A1 (en) 2011-07-22 2013-01-31 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
US10155742B2 (en) 2012-01-13 2018-12-18 President And Fellows Of Harvard College Halofuginol derivatives and their use in cosmetic and pharmaceutical compositions
TWI576347B (zh) 2012-01-20 2017-04-01 艾克泰聯製藥有限公司 作為ｐ２ｘ受體拮抗劑之雜環醯胺衍生物
PL2931717T3 (pl) 2012-12-12 2017-05-31 Actelion Pharmaceuticals Ltd. Pochodne indolokarboksyamidu jako antagoniści receptora p2x7
CN104854087B (zh) 2012-12-18 2017-03-22 埃科特莱茵药品有限公司 作为p2x7受体拮抗剂的吲哚羧酰胺衍生物
WO2014115078A1 (en) 2013-01-22 2014-07-31 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
CN104918617B (zh) 2013-01-22 2017-05-10 埃科特莱茵药品有限公司 作为p2x7受体拮抗剂的杂环酰胺衍生物
JP6377245B2 (ja) * 2014-03-24 2018-08-22 グアンドン ジョンシェン ファーマシューティカル カンパニー リミテッド Ｓｍｏ阻害剤としてのキノリン誘導体
EA030824B1 (ru) * 2014-04-17 2018-10-31 Новартис Аг ПОЛИЦИКЛИЧЕСКИЕ АКТИВАТОРЫ hERG
CN105596301A (zh) * 2016-01-29 2016-05-25 中国药科大学 一种以异喹啉为基本骨架的p2x7受体拮抗剂的纳米混悬剂及其制备方法
WO2019099509A1 (en) * 2017-11-14 2019-05-23 Second Genome, Inc. Use of a p2x7 receptor antagonist to treat an inflammatory disease or disorder
EP3801525A4 (en) 2018-06-08 2022-03-23 The General Hospital Corporation PROLYL TRNA SYNTHETASE INHIBITORS
PL4125843T3 (pl) 2020-03-31 2025-09-22 Remicine IP B.V. Leczenie ciężkiego zespołu zapalnego
KR20230123471A (ko) * 2020-11-20 2023-08-23 데날리 테라퓨틱스 인크. 화합물, 조성물 및 방법
TWI825637B (zh) 2021-03-31 2023-12-11 美商輝瑞股份有限公司 啶－１，６（２ｈ，７ｈ）－二酮
WO2022232632A1 (en) * 2021-04-30 2022-11-03 Denali Therapeutics Inc. Compounds, compositions, and methods
GB2607584B (en) * 2021-06-03 2024-07-17 Stichting Medische Kliniek Velsen Composition and method of treatment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080579A1 (en) * 2002-03-25 2003-10-02 Astrazeneca Ab Novel adamantane derivatives
WO2004106305A1 (en) * 2003-06-02 2004-12-09 Astrazeneca Ab New p2x7 receptor antagonists and their use
US20050267018A1 (en) * 2003-10-14 2005-12-01 Blatt Lawrence M Macrocyclic compounds as inhibitors of viral replication

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2640829A (en) * 1950-11-10 1953-06-02 Smith Kline French Lab Isoquinolyl heterocyclic ethers
US3978066A (en) * 1973-11-06 1976-08-31 Ayerst, Mckenna And Harrison Ltd. Certain 4,6-dihydropyrrolotriazoline-quinoline derivatives
KR920008026A (ko) 1990-10-24 1992-05-27 오노 화아마슈티칼 캄파니 리미팃드 이소퀴놀리논 유도체 또는 이의 무독성 산부가염 또는 이의 수화물, 이의 제조방법 및 이를 포함하는 약제 조성물
EP1025087A1 (en) * 1997-10-24 2000-08-09 Smithkline Beecham Plc Substituted isoquinoline derivatives and their use as anticonvulsants
SE9704545D0 (sv) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
SE9704544D0 (sv) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
SE9704546D0 (sv) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
US6380193B1 (en) * 1998-05-15 2002-04-30 Guilford Pharmaceuticals Inc. Fused tricyclic compounds, methods and compositions for inhibiting PARP activity
RS50031B (sr) 1999-01-11 2008-11-28 Agouron Pharmaceuticals Inc., Triciklični inhibitori poli(adp-riboza)polimeraza
SE9901875D0 (sv) 1999-05-25 1999-05-25 Astra Pharma Prod Novel compounds
JP3873746B2 (ja) 2000-05-19 2007-01-24 アステラス製薬株式会社 トリアゾール誘導体
EP1396488A1 (en) 2001-05-23 2004-03-10 Mitsubishi Pharma Corporation Fused heterocyclic compound and medicinal use thereof
WO2003011285A1 (en) 2001-08-01 2003-02-13 Merck & Co., Inc. BENZIMIDAZO[4,5-f]ISOQUINOLINONE DERIVATIVES
GB0206876D0 (en) 2002-03-22 2002-05-01 Merck Sharp & Dohme Therapeutic agents
DE10215316C1 (de) 2002-04-02 2003-12-18 Schering Ag Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer
KR20040106451A (ko) 2002-05-03 2004-12-17 쉐링 악티엔게젤샤프트 폴로-유사 키나제 억제제로서의 티아졸리디논 및 그의 용도
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
WO2004035545A2 (en) 2002-10-18 2004-04-29 E.I. Du Pont De Nemours And Company Azolecarboxamide herbicides
ES2297386T3 (es) 2003-03-03 2008-05-01 F. Hoffmann-La Roche Ag Tetrahidroisoquinolinas 2,5-sustituidas para uso como moduladores de 5-ht6.
WO2004106324A1 (en) * 2003-05-27 2004-12-09 E.I. Dupont De Nemours And Company Azolecarboxamide herbicides
US7160894B2 (en) 2003-06-06 2007-01-09 Asahi Kasei Pharma Corporation Tricyclic compound
CN1566099A (zh) * 2003-06-13 2005-01-19 中国科学院上海药物研究所 异喹啉－1,3,4－三酮类化合物、制备方法及其用途
JP4638438B2 (ja) 2003-10-08 2011-02-23 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト テトラヒドロナフタレン誘導体類、それらの生成方法及び抗−炎症剤としてのそれらの使用
JP2007008816A (ja) 2003-10-15 2007-01-18 Ube Ind Ltd 新規イソキノリン誘導体
US7312330B2 (en) * 2003-12-24 2007-12-25 Renovis, Inc. Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
TW200530235A (en) * 2003-12-24 2005-09-16 Renovis Inc Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
SE0400284D0 (sv) 2004-02-10 2004-02-10 Astrazeneca Ab Novel compounds
WO2005105814A1 (en) 2004-04-28 2005-11-10 Incyte Corporation Tetracyclic inhibitors of janus kinases
US20050267202A1 (en) * 2004-05-19 2005-12-01 Konrad Krolikiewicz Chromanol derivatives, a process for their production and their use as anti-inflammatory agents
DE102004055633A1 (de) 2004-11-12 2006-05-18 Schering Ag 5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
JPWO2006057270A1 (ja) 2004-11-26 2008-06-05 旭化成ファーマ株式会社 含窒素３環化合物
DE102004063227A1 (de) 2004-12-22 2006-07-06 Schering Ag Tricylische Aminoalkohole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
US7297700B2 (en) 2005-03-24 2007-11-20 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
ES2576643T3 (es) * 2007-03-09 2016-07-08 Second Genome, Inc. Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080579A1 (en) * 2002-03-25 2003-10-02 Astrazeneca Ab Novel adamantane derivatives
WO2004106305A1 (en) * 2003-06-02 2004-12-09 Astrazeneca Ab New p2x7 receptor antagonists and their use
US20050267018A1 (en) * 2003-10-14 2005-12-01 Blatt Lawrence M Macrocyclic compounds as inhibitors of viral replication

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CA2645568A1 (en) 2007-09-27
US20110092476A1 (en) 2011-04-21
EP1933622A2 (en) 2008-06-25
BRPI0709581A8 (pt) 2018-12-11
WO2007109192A2 (en) 2007-09-27
WO2007109192A3 (en) 2007-11-22
EP1933622A4 (en) 2010-03-10
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HK1133787A1 (en) 2010-04-09
CA2645568C (en) 2014-11-18
TWI464148B (zh) 2014-12-11
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EP1933622B1 (en) 2016-03-09
US7816371B2 (en) 2010-10-19
BRPI0709581A2 (pt) 2011-07-19
TW200800904A (en) 2008-01-01
CN101442909A (zh) 2009-05-27
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US20070225324A1 (en) 2007-09-27

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