CA2645568C - Bicycloheteroaryl compounds as p2x7 modulators and uses thereof - Google Patents

Bicycloheteroaryl compounds as p2x7 modulators and uses thereof Download PDF

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Publication number
CA2645568C
CA2645568C CA2645568A CA2645568A CA2645568C CA 2645568 C CA2645568 C CA 2645568C CA 2645568 A CA2645568 A CA 2645568A CA 2645568 A CA2645568 A CA 2645568A CA 2645568 C CA2645568 C CA 2645568C
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substituted
unsubstituted
mol
compound according
alkyl
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Expired - Fee Related
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CA2645568A
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English (en)
French (fr)
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CA2645568A1 (en
Inventor
Michael G. Kelly
John Kincaid
Yunfeng Fang
Yeyu Cao
Carl Kaub
Sumithra Gowlugari
Zhan Wang
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Second Genome Inc
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Evotec US Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2645568A 2006-03-16 2007-03-16 Bicycloheteroaryl compounds as p2x7 modulators and uses thereof Expired - Fee Related CA2645568C (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US78359006P 2006-03-16 2006-03-16
US78292306P 2006-03-16 2006-03-16
US78312106P 2006-03-16 2006-03-16
US60/783,590 2006-03-16
US60/782,923 2006-03-16
US60/783,121 2006-03-16
US83141606P 2006-07-17 2006-07-17
US60/831,416 2006-07-17
US90604907P 2007-03-09 2007-03-09
US60/906,049 2007-03-09
PCT/US2007/006735 WO2007109192A2 (en) 2006-03-16 2007-03-16 Bicycloheteroaryl compounds as p2x7 modulators and uses thereof

Publications (2)

Publication Number Publication Date
CA2645568A1 CA2645568A1 (en) 2007-09-27
CA2645568C true CA2645568C (en) 2014-11-18

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CA2645568A Expired - Fee Related CA2645568C (en) 2006-03-16 2007-03-16 Bicycloheteroaryl compounds as p2x7 modulators and uses thereof

Country Status (12)

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US (2) US7816371B2 (enExample)
EP (1) EP1933622B1 (enExample)
JP (1) JP5240941B2 (enExample)
CN (1) CN101442909B (enExample)
AR (1) AR059920A1 (enExample)
BR (1) BRPI0709581A8 (enExample)
CA (1) CA2645568C (enExample)
DK (1) DK1933622T3 (enExample)
ES (1) ES2569352T3 (enExample)
MX (1) MX2008011922A (enExample)
TW (1) TWI464148B (enExample)
WO (1) WO2007109192A2 (enExample)

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WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
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WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
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NZ628910A (en) 2012-01-20 2016-02-26 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
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AR094053A1 (es) 2012-12-18 2015-07-08 Actelion Pharmaceuticals Ltd Derivados de indol carboxamida como antagonistas del receptor p2x₇
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EP2956457B1 (en) 2013-01-22 2016-11-23 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
BR112016021730B1 (pt) 2014-03-24 2022-09-06 Guangdong Zhongsheng Pharmaceutical Co., Ltd Derivados de quinolina como inibidores de smo
KR20160142887A (ko) * 2014-04-17 2016-12-13 노파르티스 아게 폴리시클릭 hERG 활성화제
CN105596301A (zh) * 2016-01-29 2016-05-25 中国药科大学 一种以异喹啉为基本骨架的p2x7受体拮抗剂的纳米混悬剂及其制备方法
WO2019099509A1 (en) * 2017-11-14 2019-05-23 Second Genome, Inc. Use of a p2x7 receptor antagonist to treat an inflammatory disease or disorder
US11708353B2 (en) 2018-06-08 2023-07-25 The General Hospital Corporation Inhibitors of prolyl-tRNA-synthetase
CA3178140A1 (en) 2020-03-31 2021-10-07 Nomoreitis B.V. Treatment of hyperinflammatory syndrome
IL302906A (en) * 2020-11-20 2023-07-01 Denali Therapeutics Inc Compounds, compositions, and methods
TWI825637B (zh) 2021-03-31 2023-12-11 美商輝瑞股份有限公司 啶－１，６（２ｈ，７ｈ）－二酮
EP4330236A4 (en) * 2021-04-30 2025-09-24 Denali Therapeutics Inc COMPOUNDS, COMPOSITIONS AND METHODS
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TWI464148B (zh) 2014-12-11
US7816371B2 (en) 2010-10-19
MX2008011922A (es) 2008-11-28
HK1133787A1 (en) 2010-04-09
WO2007109192A2 (en) 2007-09-27
DK1933622T3 (en) 2016-05-02
ES2569352T3 (es) 2016-05-10
US20110092476A1 (en) 2011-04-21
EP1933622A2 (en) 2008-06-25
CA2645568A1 (en) 2007-09-27
BRPI0709581A2 (pt) 2011-07-19
CN101442909B (zh) 2013-03-27
JP5240941B2 (ja) 2013-07-17
EP1933622A4 (en) 2010-03-10
BRPI0709581A8 (pt) 2018-12-11
JP2009530304A (ja) 2009-08-27
US20070225324A1 (en) 2007-09-27
EP1933622B1 (en) 2016-03-09
WO2007109192A3 (en) 2007-11-22
AR059920A1 (es) 2008-05-07
TW200800904A (en) 2008-01-01

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